Rabbit as an animal model for experimental research

Animal experimentation is carried out in consultation with the veterinary wing but it is essential that be familiar with experimental protocols of animal model to be able to design an approriate study. This is more so in place where the veterinary facilities are not easily available.Span Rabbits are commonly used as subjects for screening implant material. They have gained favour for their numerous advantages even though they should be ideally used prior to testing in a larger animal model. Though experimentation on rabbits seems to be easy there are many pitfalls. Our endeavor in this article is to integrate all the data about maintaining rabbits as a model and to critically analyze it on the basis of our experimentation.

[1]  Michael A K Liebschner,et al.  Biomechanical considerations of animal models used in tissue engineering of bone. , 2004, Biomaterials.

[2]  M. Vondráková,et al.  Changes of femoral bone tissue microstructure in transgenic rabbits. , 2005, Folia biologica.

[3]  J D Mabrey,et al.  An interspecies comparison of bone fracture properties. , 1998, Bio-medical materials and engineering.

[4]  M. Boechat,et al.  Effect of sex steroids on peak bone density of growing rabbits. , 1988, The American journal of physiology.

[5]  Daniel J. Blankenberg,et al.  28-way vertebrate alignment and conservation track in the UCSC Genome Browser. , 2007, Genome research.

[6]  Bernardo Hochman,et al.  Modelos experimentais em pesquisa , 2005 .

[7]  R. G. Richards,et al.  Animal models for implant biomaterial research in bone: a review. , 2007, European cells & materials.

[8]  G. Herrero-Beaumont,et al.  Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits , 2005, Skeletal Radiology.

[9]  J. Blackshaw,et al.  The effects of repeated handling by familiar and unfamiliar people on rabbits in individual cages and group pens , 1991 .

[10]  R. Bloebaum,et al.  Comparison of human and canine external femoral morphologies in the context of total hip replacement. , 1993, Journal of biomedical materials research.

[11]  J. Wark,et al.  The potential of sheep for the study of osteopenia: current status and comparison with other animal models. , 1995, Bone.

[12]  Brigitte Reusch Rabbit Gastroenterology , 2005, Veterinary Clinics of North America: Exotic Animal Practice.

[13]  R. Bloebaum,et al.  Retrieval analysis of a hydroxyapatite-coated hip prosthesis. , 1991, Clinical orthopaedics and related research.

[14]  P. Layrolle,et al.  Experimental Animal Models in Periodontology: A Review , 2010, The open dentistry journal.

[15]  J. Hau Diseases of Domestic Rabbits, 2nd edition. , 1995 .

[16]  J. Fujimoto Chapter 49 – Laboratory Animal Anesthesia , 2002 .

[17]  M. Mitchell,et al.  RABBITS , 2009, Lancet.

[18]  A. Dannan,et al.  Animal Models in Periodontal Research: A Mini-Review of the Literature , 2007 .

[19]  P. Mbithi,et al.  Pain and Its Management in Animals , 2007 .