TWO CASES OF ACQUIRED TOXOPLASMIC LYMPHADENITIS. Light and Electron Microscopic and Immunohistochemical Studies

We report two cases of acquired toxoplasmic lymphadenitis, one with toxoplasmic cysts and the organisms of Toxoplasma gondii and the other with the organisms only. These cysts and organisms were observed in paraffin‐embedded sections, touch smears and ultrathin sections for electron microscopy. Touch smears were especially valuable for the quick and accurate diagnosis of toxoplasmic lymphadenitis. We also studied immature sinus histiocytosis (ISH) in these cases. The predominant cells of ISH were confirmed to be B lymphocytes immunohistochemically, the majority being positive for polyclonal surface IgM. ISH was observed in the perifollicular and paracortical areas surrounding post‐capillary venules (PCV), whereas the sinuses were only partially involved.

[1]  V. Desmet,et al.  Immature sinus histiocytosis. Light- and electron-microscopic features, immunologic phenotype, and relationship with marginal zone lymphocytes. , 1985, The American journal of pathology.

[2]  K. Lennert,et al.  Immature sinus histiocytes. Their identification as a novel B-cell population. , 1984, The American journal of pathology.

[3]  H. Rappaport,et al.  "Monocytoid" cells in reactive follicular hyperplasia with and without multifocal histiocytic reactions: an immunohistochemical study of 21 cases including suspected cases of toxoplasmic lymphadenitis. , 1984, American journal of clinical pathology.

[4]  C. Cohen,et al.  Toxoplasma cyst with toxoplasmic lymphadenitis. , 1984, Human pathology.

[5]  N. Harris,et al.  Characterization of immature sinus histiocytes (monocytoid cells) in reactive lymph nodes by use of monoclonal antibodies. , 1984, Human pathology.

[6]  A. Cengi̇z,et al.  [Toxoplasmic lymphadenitis]. , 1983, Mikrobiyoloji bulteni.

[7]  J. Aisner,et al.  Acquired toxoplasmic lymphadenitis with demonstration of the cyst form. , 1983, American journal of clinical pathology.

[8]  S. Hsu,et al.  Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. , 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[9]  M. Miettinen.  Histological differential diagnosis between lymph node toxoplasmosis and other benign lymph node hyperplasias , 1981, Histopathology.

[10]  J. Remington,et al.  Toxoplasmosis in the adult--an overview. , 1978, The New England journal of medicine.

[11]  Prof. Dr. med. Karl Lennert,et al.  Malignant Lymphomas Other than Hodgkin’s Disease , 1978, Handbuch der Speziellen Pathologischen Anatomie und Histologie.

[12]  I. W. Mclean,et al.  PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY , 1974, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[13]  R. Dorfman,et al.  Value of lymph-node biopsy in the diagnosis of acute acquired toxoplasmosis. , 1973, The New England journal of medicine.

[14]  L. Sobin,et al.  A proposal for a standardized system of reporting human lymph node morphology in relation to immunological function , 1973, Bulletin of the World Health Organization.

[15]  G. Gray,et al.  The posterior cervical lymph node in toxoplasmosis. , 1972, The American journal of pathology.

[16]  K. Walls,et al.  Electron microscopic studies of Toxoplasma gondii in fresh and frozen tissue. , 1968, Archives of pathology.

[17]  R. Hartsock.  Postvaccinial lymphadenitis. Hyperplasia of lymphoid tissue that simulates malignant lymphomas , 1968, Cancer.

[18]  M. L. Melton,et al.  The fine structure and reproduction of Toxoplasma gondii. , 1968, The Journal of parasitology.

[19]  W. Dameshek,et al.  "Immunoblasts" and "immunocytes"--an attempt at a functional nomenclature. , 1963, Blood.

[20]  A. Stansfeld.  The histological diagnosis of toxoplasmic lymphadenitis , 1961, Journal of clinical pathology.

[21]  K. Lennert.  Lymphknoten Diagnostik in Schnitt und Ausstrich , 1961 .

[22]  H. Pinkerton,et al.  Benign acquired toxoplasmosis with subsequent pregnancy. , 1953, American journal of clinical pathology.