Protein tyrosine phosphatases in cancer: friends and foes!

[1]  张剑,et al.  Communication System , 2022, Wireless Power Transfer Technologies for Electric Vehicles.

[2]  Pei Wu,et al.  PTP1B expression contributes to gastric cancer progression , 2012, Medical Oncology.

[3]  C. Croce,et al.  miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ , 2012, Oncogene.

[4]  A. Rosenwald,et al.  Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin’s lymphoma and T-cell non-Hodgkin’s lymphoma , 2011, Haematologica.

[5]  B. Neel,et al.  Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu but Is Not Essential for Tumor Maintenance , 2011, Molecular Cancer Research.

[6]  D. Shalloway,et al.  Activation of Src and transformation by an RPTPα splice mutant found in human tumours , 2011, The EMBO journal.

[7]  A. Andriulli,et al.  Investigation of Multiple Susceptibility Loci for Inflammatory Bowel Disease in an Italian Cohort of Patients , 2011, PloS one.

[8]  J. Lazo,et al.  Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion , 2011, Oncogene.

[9]  N. Tonks,et al.  Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. , 2011, Genes & development.

[10]  C. Mawrin,et al.  Loss of the Protein‐Tyrosine Phosphatase DEP‐1/PTPRJ Drives Meningioma Cell Motility , 2011, Brain pathology.

[11]  F. Sigaux,et al.  PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia. , 2011, Blood.

[12]  G. Perkins,et al.  Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. , 2011, Cell metabolism.

[13]  B. Al-Lazikani,et al.  A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma , 2011, Science Translational Medicine.

[14]  J. Eyfjörd,et al.  Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome , 2011, Breast Cancer Research and Treatment.

[15]  T. Han,et al.  Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. , 2011, Cancer cell.

[16]  Shih-Chieh Lin,et al.  Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. , 2011, The Journal of clinical investigation.

[17]  E. Villa-Moruzzi Tyrosine Phosphatases in the HER2-Directed Motility of Ovarian Cancer Cells: Involvement of PTPN12, ERK5 and FAK , 2011, Analytical cellular pathology.

[18]  G. Basso,et al.  Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells , 2011, Leukemia.

[19]  P. Dennis,et al.  PTEN loss in the continuum of common cancers, rare syndromes and mouse models , 2011, Nature Reviews Cancer.

[20]  O. Yoo,et al.  The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability. , 2011, Biochemical and biophysical research communications.

[21]  M. Rao,et al.  Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase , 2011, Cell.

[22]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[23]  A Rovira,et al.  DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer , 2011, Oncogene.

[24]  E. Barillot,et al.  High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients. , 2011, Cancer research.

[25]  F. Haj,et al.  Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B , 2011, PloS one.

[26]  V. Rotter,et al.  Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer , 2011, PloS one.

[27]  Kristina Masson,et al.  Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling* , 2011, The Journal of Biological Chemistry.

[28]  Chi-Ying F. Huang,et al.  Vaccinia H1-related Phosphatase Is a Phosphatase of ErbB Receptors and Is Down-regulated in Non-small Cell Lung Cancer* , 2011, The Journal of Biological Chemistry.

[29]  S. M. Burden-Gulley,et al.  Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration , 2011, Journal of cellular biochemistry.

[30]  S. Brill,et al.  Genetic Evidence That Polysumoylation Bypasses the Need for a SUMO-Targeted Ub Ligase , 2011, Genetics.

[31]  C. Croce,et al.  Role of PTPRJ genotype in papillary thyroid carcinoma risk. , 2010, Endocrine-related cancer.

[32]  Q. Zeng,et al.  PRL‐3 phosphatase and cancer metastasis , 2010, Journal of cellular biochemistry.

[33]  Amy R. Peck,et al.  PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. , 2010, The American journal of pathology.

[34]  G. Rogler,et al.  Protein tyrosine phosphatase N2 regulates TNFα-induced signalling and cytokine secretion in human intestinal epithelial cells , 2010, Gut.

[35]  Gordon Chan,et al.  A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells. , 2010, Blood.

[36]  Rong-shan Li,et al.  PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization , 2010, Oncogene.

[37]  Morag Park,et al.  Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. , 2010, Cancer research.

[38]  M. Tremblay,et al.  In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. , 2010, Trends in cell biology.

[39]  L. Insabato,et al.  PTPD1 Supports Receptor Stability and Mitogenic Signaling in Bladder Cancer Cells* , 2010, The Journal of Biological Chemistry.

[40]  Yuan Ren,et al.  Critical role of Shp2 in tumor growth involving regulation of c-Myc. , 2010, Genes & cancer.

[41]  S. Semba,et al.  Requirement of phosphatase of regenerating liver‐3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma , 2010, Cancer science.

[42]  L. Shaw,et al.  SHP2 Mediates the Localized Activation of Fyn Downstream of the α6β4 Integrin To Promote Carcinoma Invasion , 2010, Molecular and Cellular Biology.

[43]  Tony Pawson,et al.  Phosphotyrosine Signaling: Evolving a New Cellular Communication System , 2010, Cell.

[44]  Walter Kolch,et al.  Functional proteomics to dissect tyrosine kinase signalling pathways in cancer , 2010, Nature Reviews Cancer.

[45]  K. Patterson,et al.  DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. , 2010, Biochimica et biophysica acta.

[46]  E. Giannoni,et al.  Src redox regulation: again in the front line. , 2010, Free radical biology & medicine.

[47]  Y. Okamoto,et al.  miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC) , 2010, British Journal of Cancer.

[48]  J. Lazo,et al.  Phosphatase of Regenerating Liver-1 Promotes Cell Migration and Invasion and Regulates Filamentous Actin Dynamics , 2010, Journal of Pharmacology and Experimental Therapeutics.

[49]  K. Gehring,et al.  An RNA Aptamer That Selectively Inhibits the Enzymatic Activity of Protein Tyrosine Phosphatase 1B in vitro , 2010, Chembiochem : a European journal of chemical biology.

[50]  Y. Wu,et al.  Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin , 2010, Oncogene.

[51]  J. Li,et al.  PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. , 2010, Cancer cell.

[52]  Satavisha Roy,et al.  Lyn kinase and ZAP70 are substrates of PTPROt in B‐cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF‐R inhibitor pazopanib , 2010, Journal of cellular biochemistry.

[53]  R. Hannoush,et al.  The chemical toolbox for monitoring protein fatty acylation and prenylation. , 2010, Nature chemical biology.

[54]  M. Lacroix-Triki,et al.  PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. , 2010, Cancer research.

[55]  B. Evers,et al.  PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells. , 2010, American journal of physiology. Cell physiology.

[56]  Pearlly Yan,et al.  Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. , 2010, Anticancer research.

[57]  D. Shalloway,et al.  Extracellular domain dependence of PTPα transforming activity , 2010, Genes to cells : devoted to molecular & cellular mechanisms.

[58]  Jie Wu,et al.  Targeting protein tyrosine phosphatases for anticancer drug discovery. , 2010, Current pharmaceutical design.

[59]  Q. Zeng,et al.  VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers , 2010, Molecular Cancer.

[60]  B. Blagoev,et al.  PTP1B Targets the Endosomal Sorting Machinery , 2010, The Journal of Biological Chemistry.

[61]  F. Oswald,et al.  Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility , 2010, Oncogene.

[62]  Pier Paolo Pandolfi,et al.  Subtle variations in Pten dose determine cancer susceptibility , 2010, Nature Genetics.

[63]  K. Yanagihara,et al.  Constitutive Suppression of PRL-3 Inhibits Invasion and Proliferation of Gastric Cancer Cell in vitro and in vivo , 2010, Pathobiology.

[64]  A. Borczuk,et al.  Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. , 2010, Carcinogenesis.

[65]  Rong-shan Li,et al.  PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. , 2010, Cancer research.

[66]  Yongping Wang,et al.  Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells* , 2010, The Journal of Biological Chemistry.

[67]  Horng-mo Lee,et al.  The investigation of Mitogen-Activated Protein kinase Phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging , 2010, BMC Cancer.

[68]  L. Lessard,et al.  The two faces of PTP1B in cancer. , 2010, Biochimica et biophysica acta.

[69]  Stefan Joos,et al.  Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells. , 2010, Cancer research.

[70]  I. Prior,et al.  Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells. , 2010, The Biochemical journal.

[71]  S. Toyooka,et al.  Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers , 2010, Journal of Cancer Research and Clinical Oncology.

[72]  T. Issad,et al.  Protein tyrosine phosphatase-1B and T-cell protein tyrosine phosphatase regulate IGF-2-induced MCF-7 cell migration. , 2010, Biochemical and biophysical research communications.

[73]  S. Hardy,et al.  Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse , 2010, PloS one.

[74]  S. Ropero,et al.  Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery , 2010, Oncogene.

[75]  O. Yoo,et al.  Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. , 2010, Life sciences.

[76]  P. Storz,et al.  Reactive oxygen species in cancer , 2010, Free radical research.

[77]  Y. Refaeli,et al.  TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas. , 2009, Blood.

[78]  C. Shou,et al.  PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling , 2009, Molecular Cancer.

[79]  A. Ferrando,et al.  Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia , 2009, Nature Genetics.

[80]  P. Mischel,et al.  An Unbiased Screen Identifies DEP-1 Tumor Suppressor as a Phosphatase Controlling EGFR Endocytosis , 2009, Current Biology.

[81]  K. Horn,et al.  PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration , 2009, Science.

[82]  T. Issad,et al.  Implication of protein tyrosine phosphatase 1B in MCF-7 cell proliferation and resistance to 4-OH tamoxifen. , 2009, Biochemical and biophysical research communications.

[83]  M. Tremblay,et al.  Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases , 2009, Science Signaling.

[84]  M. Tremblay,et al.  Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice , 2009, Glia.

[85]  J. Bixby,et al.  Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC , 2009, Journal of neurochemistry.

[86]  G. Counelis,et al.  The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. , 2009, Experimental cell research.

[87]  Hideaki Mitsui,et al.  Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis. , 2009, The American journal of pathology.

[88]  Jian-ming Li,et al.  PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly , 2009, Cancer biology & therapy.

[89]  L. Castagnoli,et al.  Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases* , 2009, The Journal of Biological Chemistry.

[90]  Luis E. Arias-Romero,et al.  Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. , 2009, Cancer research.

[91]  R. Somani,et al.  Farnesyltransferase inhibitor as anticancer agent. , 2009, Mini-Reviews in Medical Chemistry.

[92]  J. Laurence,et al.  Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. , 2009, Biochemistry.

[93]  J. Kutok,et al.  Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. , 2009, Blood.

[94]  Jian-ming Li,et al.  Over‐expression of phosphatase of regenerating liver‐3 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma , 2009, International journal of cancer.

[95]  C. Polytarchou,et al.  Nitric oxide stimulates migration of human endothelial and prostate cancer cells through up‐regulation of pleiotrophin expression and its receptor protein tyrosine phosphatase β/ζ , 2009, International journal of cancer.

[96]  S. Knapp,et al.  HD-PTP Is a Catalytically Inactive Tyrosine Phosphatase Due to a Conserved Divergence in Its Phosphatase Domain , 2009, PloS one.

[97]  N. Hynes,et al.  ErbB receptors and signaling pathways in cancer. , 2009, Current opinion in cell biology.

[98]  W. McMaster,et al.  The Leishmania Surface Protease GP63 Cleaves Multiple Intracellular Proteins and Actively Participates in p38 Mitogen-activated Protein Kinase Inactivation* , 2009, Journal of Biological Chemistry.

[99]  A. Harada,et al.  SAP‐1 is a microvillus‐specific protein tyrosine phosphatase that modulates intestinal tumorigenesis , 2009, Genes to cells : devoted to molecular & cellular mechanisms.

[100]  Qiang Xu,et al.  Phosphatase of Regenerating Liver-3 Localizes to Cyto-Membrane and Is Required for B16F1 Melanoma Cell Metastasis In Vitro and In Vivo , 2009, PloS one.

[101]  K. Ghoshal,et al.  Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity. , 2009, Molecular endocrinology.

[102]  X. Qiu,et al.  PRL‐3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up‐regulating the levels and activities of Rho‐A/C in lung cancer , 2009, Pathology.

[103]  O. Yoo,et al.  New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53 , 2009, Oncogene.

[104]  M. Tremblay The PTP Family Photo Album , 2009, Cell.

[105]  Wen Hwa Lee,et al.  Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome , 2009, Cell.

[106]  Z. Ling,et al.  Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma. , 2009, World journal of gastroenterology.

[107]  S. Castiglioni,et al.  Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP. , 2009, Cancer letters.

[108]  T. Mustelin,et al.  PTEN regulation by Akt–EGR1–ARF–PTEN axis , 2009, The EMBO journal.

[109]  K. Ghoshal,et al.  PTPROt Inactivates the Oncogenic Fusion Protein BCR/ABL and Suppresses Transformation of K562 Cells* , 2009, Journal of Biological Chemistry.

[110]  S. Cai,et al.  Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer. , 2008, Chinese medical journal.

[111]  Zhon-Yin Zhang,et al.  Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. , 2008, Journal of the American Chemical Society.

[112]  K. Khoo,et al.  Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation* , 2008, Journal of Biological Chemistry.

[113]  S. Szedlacsek,et al.  Analysis of molecular determinants of PRL-3 , 2008, Journal of cellular and molecular medicine.

[114]  H. Danielsen,et al.  The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. , 2008, Cancer research.

[115]  Y. Agazie,et al.  SHP2 is up‐regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis , 2008, Histopathology.

[116]  E. Liu,et al.  Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. , 2008, Cancer research.

[117]  S. Cai,et al.  Expression and prognostic impact of PRL‐3 in lymph node metastasis of gastric cancer: Its molecular mechanism was investigated using artificial microRNA interference , 2008, International journal of cancer.

[118]  T. Furukawa,et al.  Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. , 2008, Carcinogenesis.

[119]  R. Finn,et al.  Targeting Src in breast cancer. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

[120]  M. Tremblay,et al.  PTP1B Regulates Cortactin Tyrosine Phosphorylation by Targeting Tyr446* , 2008, Journal of Biological Chemistry.

[121]  B. Neel,et al.  Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo* , 2008, Journal of Biological Chemistry.

[122]  A. Giaccia,et al.  The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. , 2008, Molecular cell.

[123]  Pier Paolo Pandolfi,et al.  Tenets of PTEN Tumor Suppression , 2008, Cell.

[124]  D. Shalloway,et al.  Apoptosis of estrogen‐receptor negative breast cancer and colon cancer cell lines by PTPα and src RNAi , 2008, International journal of cancer.

[125]  S. Pilotti,et al.  PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells. , 2008, Cellular signalling.

[126]  J. den Hertog,et al.  Redox regulation of dimerization of the receptor protein‐tyrosine phosphatases RPTPα, LAR, RPTPμ and CD45 , 2008, The FEBS journal.

[127]  Y. Agazie,et al.  Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells , 2008, Cell Death and Differentiation.

[128]  A. Bishop,et al.  Engineered inhibitor sensitivity in the WPD loop of a protein tyrosine phosphatase. , 2008, Biochemistry.

[129]  J. Salles,et al.  The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. , 2008, Cellular signalling.

[130]  A. Östman,et al.  Protein tyrosine phosphatases: regulatory mechanisms , 2008, The FEBS journal.

[131]  H. Fearnhead,et al.  Caspases as therapeutic targets , 2008, Journal of cellular and molecular medicine.

[132]  B. Neel,et al.  The tyrosine phosphatase Shp2 (PTPN11) in cancer , 2008, Cancer and Metastasis Reviews.

[133]  N. Fotouhi,et al.  A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. , 2008, Cancer research.

[134]  A. Weiss,et al.  Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. , 2008, Immunity.

[135]  F. Zhan,et al.  Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. , 2008, Blood.

[136]  G. Hostetter,et al.  Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells , 2008, Molecular Cancer Therapeutics.

[137]  F. Melchior,et al.  Concepts in sumoylation: a decade on , 2007, Nature Reviews Molecular Cell Biology.

[138]  M. Tremblay,et al.  Protein Tyrosine Phosphatases: Emerging Regulators of Apoptosis , 2007, Cell cycle.

[139]  J. Bjorge,et al.  PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. , 2007, Cancer research.

[140]  Bo Zhou,et al.  Phosphatase Activity, Trimerization, and the C-terminal Polybasic Region Are All Required for PRL1-mediated Cell Growth and Migration* , 2007, Journal of Biological Chemistry.

[141]  M. Kruhlak,et al.  Rapid T cell receptor‐mediated SHP‐1 S591 phosphorylation regulates SHP‐1 cellular localization and phosphatase activity , 2007, Journal of leukocyte biology.

[142]  Michalis V. Karamouzis,et al.  Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets , 2007, Nature Reviews Drug Discovery.

[143]  Nayoung Kim,et al.  Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in Platelets , 2007, Molecular and Cellular Biology.

[144]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[145]  S. Manjeet,et al.  Cell suicide and caspases. , 2007, Vascular pharmacology.

[146]  M. Grever,et al.  Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia , 2007, Clinical Cancer Research.

[147]  S. Sahu,et al.  Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. , 2007, American journal of physiology. Cell physiology.

[148]  M. Tremblay,et al.  TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}. , 2007, Blood.

[149]  S. Mohammed,et al.  The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. , 2007, Cancer research.

[150]  Q. Zeng,et al.  PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. , 2007, Cancer research.

[151]  B. Neel,et al.  Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. , 2007, Cancer research.

[152]  B. Kennedy,et al.  Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis , 2007, Nature Genetics.

[153]  J. Inazawa,et al.  A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity , 2007, Oncogene.

[154]  B. Neel,et al.  The role of Shp2 (PTPN11) in cancer. , 2007, Current opinion in genetics & development.

[155]  D. Barford,et al.  Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. , 2007, Biochemistry.

[156]  J. Lazo,et al.  PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. , 2007, Cancer research.

[157]  I. Lossos,et al.  T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6 , 2007, Molecular and Cellular Biology.

[158]  S. H. Baek,et al.  SUMOylation code in cancer development and metastasis. , 2006, Molecules and Cells.

[159]  J. Kuhlmann,et al.  Hydrophobic modifications of Ras proteins by isoprenoid groups and fatty acids--More than just membrane anchoring. , 2006, Biochimica et biophysica acta.

[160]  S. Hardy,et al.  Caspase-3 Regulates Catalytic Activity and Scaffolding Functions of the Protein Tyrosine Phosphatase PEST, a Novel Modulator of the Apoptotic Response , 2006, Molecular and Cellular Biology.

[161]  R. Aguiar,et al.  Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation. , 2006, Blood.

[162]  N. Tonks,et al.  Protein tyrosine phosphatases: from genes, to function, to disease , 2006, Nature Reviews Molecular Cell Biology.

[163]  M. Olivier,et al.  Role of Host Protein Tyrosine Phosphatase SHP-1 in Leishmania donovani-Induced Inhibition of Nitric Oxide Production , 2006, Infection and Immunity.

[164]  R. Lai,et al.  Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. , 2006, Blood.

[165]  A. Östman,et al.  DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients , 2006, Oncogene.

[166]  C. Chi,et al.  Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. , 2006, Cancer letters.

[167]  I. Ng,et al.  Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma , 2006, Hepatology.

[168]  S. Kamhawi Phlebotomine sand flies and Leishmania parasites: friends or foes? , 2006, Trends in parasitology.

[169]  M. Westphal,et al.  RNA interference targeting protein tyrosine phosphatase ζ/receptor‐type protein tyrosine phosphatase β suppresses glioblastoma growth in vitro and in vivo , 2006 .

[170]  Keiko Takahashi,et al.  A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis. , 2006, Blood.

[171]  C. Croce,et al.  Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis. , 2006, DNA and cell biology.

[172]  G. Viglietto,et al.  The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. , 2006, Cancer research.

[173]  M. Tremblay,et al.  T-Cell Protein Tyrosine Phosphatase (Tcptp) Is a Negative Regulator of Colony-Stimulating Factor 1 Signaling and Macrophage Differentiation , 2006, Molecular and Cellular Biology.

[174]  G. Delsol,et al.  SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling. , 2006, Blood.

[175]  Fabio Cerignoli,et al.  Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence , 2006, Nature Cell Biology.

[176]  P. di Sant'Agnese,et al.  Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer , 2006, The Prostate.

[177]  A. Cox,et al.  PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. , 2006, Cancer research.

[178]  S. Polo,et al.  Endocytosis Conducts the Cell Signaling Orchestra , 2006, Cell.

[179]  Tak W. Mak,et al.  Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis , 2006, Nature Reviews Cancer.

[180]  Jane Kuo,et al.  Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. , 2006, Cancer research.

[181]  K. Klinger,et al.  Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function , 2006, Molecular Cancer Therapeutics.

[182]  M. Tremblay,et al.  Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. , 2005, Cancer research.

[183]  A. Bardelli,et al.  PRL-3 Phosphatase Is Implicated in Ovarian Cancer Growth , 2005, Clinical Cancer Research.

[184]  P. Pelicci,et al.  G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv , 2005, The EMBO journal.

[185]  A. Fedorov,et al.  Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. , 2005, Biochemistry.

[186]  R. Roskoski,et al.  Src kinase regulation by phosphorylation and dephosphorylation. , 2005, Biochemical and biophysical research communications.

[187]  F. Eisenhaber,et al.  Refinement and prediction of protein prenylation motifs , 2005, Genome Biology.

[188]  D. Barford,et al.  Functions and mechanisms of redox regulation of cysteine-based phosphatases. , 2005, Antioxidants & redox signaling.

[189]  M. Tartaglia,et al.  Somatic PTPN11 mutations in childhood acute myeloid leukaemia , 2005, British journal of haematology.

[190]  S. Mueller,et al.  Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. , 2005, Neuro-oncology.

[191]  M. Seabra,et al.  Fatty acylation and prenylation of proteins: what's hot in fat. , 2005, Current opinion in cell biology.

[192]  M. Levis,et al.  FLT3/ITD Mutation Signaling Includes Suppression of SHP-1* , 2005, Journal of Biological Chemistry.

[193]  Haruo Saito,et al.  Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45 , 2005, The Journal of experimental medicine.

[194]  J. Kutok,et al.  Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. , 2005, Cancer cell.

[195]  H. Chung,et al.  Gene copy number change events at chromosome 20 and their association with recurrence in gastric cancer patients. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[196]  Jae Hoon Kim,et al.  Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. , 2005, Journal of molecular biology.

[197]  A. Fusco,et al.  The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis , 2004, Oncogene.

[198]  C. Croce,et al.  Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo. , 2004, Carcinogenesis.

[199]  A. Ferrando,et al.  Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia , 2004, Nature Genetics.

[200]  C. Morrison,et al.  Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[201]  N. Bottini,et al.  Control of vesicle fusion by a tyrosine phosphatase , 2004, Nature Cell Biology.

[202]  A. Weiss,et al.  Regulated Expression of the Receptor-Like Tyrosine Phosphatase CD148 on Hemopoietic Cells1 , 2004, The Journal of Immunology.

[203]  P. Herrlich,et al.  UVA inactivates protein tyrosine phosphatases by calpain‐mediated degradation , 2004, EMBO reports.

[204]  D. Gilliland,et al.  Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation , 2004, Nature Medicine.

[205]  Wang Shen,et al.  Allosteric inhibition of protein tyrosine phosphatase 1B , 2004, Nature Structural &Molecular Biology.

[206]  A. Fusco,et al.  The Expression of the Phosphotyrosine Phosphatase DEP-1/PTPη Dictates the Responsivity of Glioma Cells to Somatostatin Inhibition of Cell Proliferation* , 2004, Journal of Biological Chemistry.

[207]  Joanna M. Sasin,et al.  Protein Tyrosine Phosphatases in the Human Genome , 2004, Cell.

[208]  Erica S. Johnson,et al.  Protein modification by SUMO. , 2004, Annual review of biochemistry.

[209]  F. Claessens,et al.  Differential effect of small ubiquitin-like modifier (SUMO)-ylation of the androgen receptor in the control of cooperativity on selective versus canonical response elements. , 2004, Molecular endocrinology.

[210]  Giovanni Parmigiani,et al.  Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers , 2004, Science.

[211]  E. Newell,et al.  T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. , 2004, Blood.

[212]  M. Loh,et al.  Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. , 2004, Blood.

[213]  R. Jove,et al.  Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor* , 2004, Journal of Biological Chemistry.

[214]  B. Neel,et al.  Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. , 2004, Molecular cell.

[215]  M. Tremblay,et al.  The role of protein tyrosine phosphatase 1B in Ras signaling , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[216]  D. Crowell,et al.  Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases. , 2003, Cancer letters.

[217]  K. Hayashi,et al.  Activated Proliferation of B-Cell Lymphomas/Leukemias with the SHP1 Gene Silencing by Aberrant CpG Methylation , 2003, Laboratory Investigation.

[218]  Carol L. Williams The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences. , 2003, Cellular signalling.

[219]  C. Wu,et al.  SHP‐1 suppresses cancer cell growth by promoting degradation of JAK kinases , 2003, Journal of cellular biochemistry.

[220]  M. Westphal,et al.  Expression and Function of the Receptor Protein Tyrosine Phosphatase ζ and Its Ligand Pleiotrophin in Human Astrocytomas , 2003, Journal of neuropathology and experimental neurology.

[221]  K. Kinzler,et al.  PRL-3 expression in metastatic cancers. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[222]  M. Westphal,et al.  A role for receptor tyrosine phosphataseζ in glioma cell migration , 2003, Oncogene.

[223]  Yusuke Nakamura,et al.  Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53 , 2003, Oncogene.

[224]  M. Kasuga,et al.  Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma , 2003, Oncogene.

[225]  N. Tonks PTP1B: From the sidelines to the front lines! , 2003, FEBS letters.

[226]  Miles Congreve,et al.  Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B , 2003, Nature.

[227]  Michael P. Myers,et al.  Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate , 2003, Nature.

[228]  F. Motoi,et al.  Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. , 2003, The American journal of pathology.

[229]  H. Friess,et al.  Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells. , 2003, Gastroenterology.

[230]  J. Licht,et al.  Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia , 2003, Nature Genetics.

[231]  B. Neel,et al.  The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. , 2003, Trends in biochemical sciences.

[232]  M. Corada,et al.  Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148 , 2003, The Journal of cell biology.

[233]  J. den Hertog,et al.  Redox-regulated Rotational Coupling of Receptor Protein-tyrosine Phosphatase α Dimers* , 2003, The Journal of Biological Chemistry.

[234]  C. Harris,et al.  Radical causes of cancer , 2003, Nature Reviews Cancer.

[235]  Paul A. Fleming,et al.  A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development , 2003, Molecular and Cellular Biology.

[236]  C. Pallen Protein tyrosine phosphatase alpha (PTPalpha): a Src family kinase activator and mediator of multiple biological effects. , 2003, Current topics in medicinal chemistry.

[237]  N. Tonks,et al.  Hepatocyte Growth Factor Receptor Tyrosine Kinase Met Is a Substrate of the Receptor Protein-tyrosine Phosphatase DEP-1* , 2003, The Journal of Biological Chemistry.

[238]  Mattias Höglund,et al.  Frequent amplification of 8q24, 11q, 17q, and 20q‐specific genes in pancreatic cancer , 2002, Genes, chromosomes & cancer.

[239]  W. Sellers,et al.  Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft. , 2002, Cancer research.

[240]  Jing Wang,et al.  The Tyrosine Phosphatase PRL-1 Localizes to the Endoplasmic Reticulum and the Mitotic Spindle and Is Required for Normal Mitosis* , 2002, The Journal of Biological Chemistry.

[241]  S. Vicent,et al.  CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential , 2002, Oncogene.

[242]  Cestmir Vlcek,et al.  Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers , 2002, Nature Genetics.

[243]  D. Shalloway,et al.  Mitotic Activation of Protein-tyrosine Phosphatase α and Regulation of Its Src-mediated Transforming Activity by Its Sites of Protein Kinase C Phosphorylation* , 2002, The Journal of Biological Chemistry.

[244]  L. Buscail,et al.  Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1. , 2002, The Journal of clinical endocrinology and metabolism.

[245]  A. Ullrich,et al.  The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta. , 2002, Biochemistry.

[246]  W. Cavenee,et al.  The Protein Tyrosine Phosphatase TCPTP Suppresses the Tumorigenicity of Glioblastoma Cells Expressing a Mutant Epidermal Growth Factor Receptor* , 2001, The Journal of Biological Chemistry.

[247]  D. Shalloway,et al.  Two mechanisms activate PTPα during mitosis , 2001 .

[248]  Michael A. Choti,et al.  A Phosphatase Associated with Metastasis of Colorectal Cancer , 2001, Science.

[249]  B. Kemp,et al.  Cellular Stress Regulates the Nucleocytoplasmic Distribution of the Protein-tyrosine Phosphatase TCPTP* , 2001, The Journal of Biological Chemistry.

[250]  M. Quon,et al.  Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. , 2001, Molecular endocrinology.

[251]  U. Lorenz,et al.  Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation , 2001, Leukemia.

[252]  A. Elson,et al.  Regulation of Protein-tyrosine Phosphatases α and ε by Calpain-mediated Proteolytic Cleavage* , 2001, The Journal of Biological Chemistry.

[253]  Hsien-yu Wang,et al.  Insulin Stimulates Tyrosine Phosphorylation and Inactivation of Protein-tyrosine Phosphatase 1B in Vivo * , 2001, The Journal of Biological Chemistry.

[254]  N. Tonks,et al.  The Reciprocal Role of Egr-1 and Sp Family Proteins in Regulation of the PTP1B Promoter in Response to the p210 Bcr-Abl Oncoprotein-tyrosine Kinase* , 2001, The Journal of Biological Chemistry.

[255]  J. Bjorge,et al.  Identification of Protein-tyrosine Phosphatase 1B as the Major Tyrosine Phosphatase Activity Capable of Dephosphorylating and Activating c-Src in Several Human Breast Cancer Cell Lines* , 2000, The Journal of Biological Chemistry.

[256]  N. Aoki,et al.  A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b* , 2000, The Journal of Biological Chemistry.

[257]  D. Barford,et al.  Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. , 2000, Molecular cell.

[258]  J. Schlessinger,et al.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[259]  S. Ménard,et al.  Expression of protein tyrosine phosphatase alpha (RPTPα) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo , 2000, Oncogene.

[260]  M. Berridge,et al.  The versatility and universality of calcium signalling , 2000, Nature Reviews Molecular Cell Biology.

[261]  H. Horstmann,et al.  Prenylation-dependent Association of Protein-tyrosine Phosphatases PRL-1, -2, and -3 with the Plasma Membrane and the Early Endosome* , 2000, The Journal of Biological Chemistry.

[262]  K. Hirokawa,et al.  Expression of protein tyrosine phosphatases and its significance in esophageal cancer. , 2000, Experimental and molecular pathology.

[263]  R. Vilella,et al.  Site-selective Dephosphorylation of the Platelet-derived Growth Factor β-Receptor by the Receptor-like Protein-tyrosine Phosphatase DEP-1* , 2000, The Journal of Biological Chemistry.

[264]  M. Noda,et al.  Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ , 2000 .

[265]  D. Shalloway,et al.  A phosphotyrosine displacement mechanism for activation of Src by PTPα , 2000, The EMBO journal.

[266]  Stuart A. Aaronson,et al.  Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression , 2000, Molecular and Cellular Biology.

[267]  A. Elson Protein tyrosine phosphatase ε increases the risk of mammary hyperplasia and mammary tumors in transgenic mice , 1999, Oncogene.

[268]  D. Kufe,et al.  Functional Interaction between SHPTP1 and the Lyn Tyrosine Kinase in the Apoptotic Response to DNA Damage* , 1999, The Journal of Biological Chemistry.

[269]  F. Autschbach,et al.  Expression of the membrane protein tyrosine phosphatase CD148 in human tissues. , 1999, Tissue antigens.

[270]  E K Rowinsky,et al.  Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[271]  M. Thangaraju,et al.  Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2* , 1999, The Journal of Biological Chemistry.

[272]  T. Tenev,et al.  The transmembrane protein tyrosine phosphatase RPTPσ modulates signaling of the epidermal growth factor receptor in A431 cells , 1999, Oncogene.

[273]  Michael Karin,et al.  Is NF‐κB the sensor of oxidative stress? , 1999 .

[274]  K. Lim,et al.  Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn , 1999, Current Biology.

[275]  J. Sap,et al.  Receptor protein tyrosine phosphatase α activates Src-family kinases and controls integrin-mediated responses in fibroblasts , 1999, Current Biology.

[276]  H. Nam,et al.  Crystal Structure of the Tandem Phosphatase Domains of RPTP LAR , 1999, Cell.

[277]  H. Kosmehl,et al.  Expression of the transmembrane protein tyrosine phosphatase RPTPα in human oral squamous cell carcinoma , 1999, Histochemistry and Cell Biology.

[278]  Ying Wang,et al.  Phosphorylation of CD45 by Casein Kinase 2 , 1999, The Journal of Biological Chemistry.

[279]  B. Kennedy,et al.  Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. , 1999, Science.

[280]  G. Hannon,et al.  Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[281]  F. Rendu,et al.  Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. , 1998, Biochemical and biophysical research communications.

[282]  R. Hay,et al.  SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. , 1998, Molecular cell.

[283]  B. Franza,et al.  Protein Tyrosine Phosphatase 1B Antagonizes Signalling by Oncoprotein Tyrosine Kinase p210 bcr-abl In Vivo , 1998, Molecular and Cellular Biology.

[284]  Y. Tan,et al.  Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. , 1998, Biochemical and biophysical research communications.

[285]  J. Chernoff,et al.  Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand , 1998, Molecular and Cellular Biology.

[286]  D S Lawrence,et al.  Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[287]  J. Chernoff,et al.  Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. , 1997, The Biochemical journal.

[288]  John Wagner,et al.  Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice , 1997, The Journal of experimental medicine.

[289]  W. K. Alfred Yung,et al.  Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers , 1997, Nature Genetics.

[290]  M. Wigler,et al.  PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.

[291]  D. Crowell,et al.  Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. , 1996, Cancer letters.

[292]  P. Majerus,et al.  The Properties of the Protein Tyrosine Phosphatase PTPMEG* , 1996, The Journal of Biological Chemistry.

[293]  S. Lipkowitz,et al.  The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells. , 1996, Cancer research.

[294]  C. Disteche,et al.  Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells. , 1996, Circulation research.

[295]  P. Meltzer,et al.  Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. , 1996, Cancer research.

[296]  P. Traber,et al.  Expression of PRL-1 nuclear PTPase is associated with proliferation in liver but with differentiation in intestine. , 1996, The American journal of physiology.

[297]  T. Pawson,et al.  The Tyrosine Phosphatase PTP1C Associates with Vav, Grb2, and mSos1 in Hematopoietic Cells (*) , 1996, The Journal of Biological Chemistry.

[298]  C. Cartwright,et al.  Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. , 1995, Oncogene.

[299]  E. Fischer,et al.  COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus , 1995, The Journal of cell biology.

[300]  D. Smith,et al.  Increased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas , 1995 .

[301]  D. Koshland,et al.  Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. , 1995, Molecular biology of the cell.

[302]  D. Barford,et al.  Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. , 1995, Science.

[303]  J. Schlessinger,et al.  Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[304]  N. Tonks,et al.  Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[305]  N. Tonks,et al.  PTP‐PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. , 1994, The EMBO journal.

[306]  J. Sap,et al.  Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2. , 1994, The Journal of biological chemistry.

[307]  C. Walsh,et al.  Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[308]  T. Hunter,et al.  Phosphorylation of receptor protein‐tyrosine phosphatase alpha on Tyr789, a binding site for the SH3‐SH2‐SH3 adaptor protein GRB‐2 in vivo. , 1994, The EMBO journal.

[309]  R. Bast,et al.  Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas. , 1994, American journal of obstetrics and gynecology.

[310]  D. Barford,et al.  Crystal structure of human protein tyrosine phosphatase 1B. , 1994, Science.

[311]  R. Bast,et al.  Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression. , 1994, Journal of the National Cancer Institute.

[312]  J. Dixon,et al.  Dissecting the catalytic mechanism of protein-tyrosine phosphatases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[313]  J. Frangioni,et al.  Calpain‐catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP‐1B) in human platelets. , 1993, The EMBO journal.

[314]  D. Brautigan,et al.  Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid , 1993, Molecular and Cellular Biochemistry.

[315]  A. Ullrich,et al.  Differential activities of protein tyrosine phosphatases in intact cells. , 1993, The Journal of biological chemistry.

[316]  B. Franza,et al.  Multi‐site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation. , 1993, The EMBO journal.

[317]  Xinyang Zheng,et al.  Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase , 1992, Nature.

[318]  J. Dixon,et al.  Expression of a protein tyrosine phosphatase in normal and v-src- transformed mouse 3T3 fibroblasts , 1992, The Journal of cell biology.

[319]  B. Neel,et al.  The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence , 1992, Cell.

[320]  D. Hill,et al.  Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene. , 1992, Cancer research.

[321]  J. Dixon,et al.  Cloning and expression of a protein-tyrosine-phosphatase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[322]  E. Krebs,et al.  cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[323]  E. Krebs,et al.  Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[324]  N. Tonks,et al.  Characterization of the major protein-tyrosine-phosphatases of human placenta. , 1988, The Journal of biological chemistry.

[325]  N. Tonks,et al.  Purification of the major protein-tyrosine-phosphatases of human placenta. , 1988, The Journal of biological chemistry.

[326]  H. Varmus,et al.  Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein , 1978, Cell.

[327]  R. Erikson,et al.  Protein kinase activity associated with the avian sarcoma virus src gene product. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[328]  S. Hardy,et al.  Impact of oncogenic protein tyrosine phosphatases in cancer. , 2012, Anti-cancer agents in medicinal chemistry.

[329]  E. Zabarovsky,et al.  Tumor suppressor dual‐specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial‐mesenchymal transition (EMT)‐associated phenotype , 2012, International journal of cancer.

[330]  S. Brady-Kalnay,et al.  Tumor-derived extracellular fragments of receptor protein tyrosine phosphatases (RPTPs) as cancer molecular diagnostic tools. , 2011, Anti-cancer agents in medicinal chemistry.

[331]  S. Leedham,et al.  Inflammatory bowel disease and colon cancer. , 2011, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[332]  L. Tabernero,et al.  Dual-specificity MAP kinase phosphatases as targets of cancer treatment. , 2011, Anti-cancer agents in medicinal chemistry.

[333]  Q. Zeng,et al.  Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis. , 2011, Cancer research.

[334]  S. Hardy,et al.  Inside the human cancer tyrosine phosphatome , 2010, Nature Reviews Cancer.

[335]  N. Gray,et al.  Targeting cancer with small molecule kinase inhibitors , 2009, Nature Reviews Cancer.

[336]  Y. Li,et al.  Evaluation of PRL-3 expression, and its correlation with angiogenesis and invasion in hepatocellular carcinoma. , 2008, International journal of molecular medicine.

[337]  S. Cai,et al.  High Expression of PRL-3 can Promote Growth of Gastric Cancer and Exhibits a Poor Prognostic Impact on Patients , 2008, Annals of Surgical Oncology.

[338]  G. Reynolds,et al.  Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. , 2008, Blood.

[339]  F. Haj,et al.  Regulation of protein tyrosine phosphatase 1B by sumoylation , 2007, Nature Cell Biology.

[340]  Xiuli Jiang,et al.  Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. , 2007, Cancer research.

[341]  Charis Eng,et al.  Cancer phenomics: RET and PTEN as illustrative models , 2007, Nature Reviews Cancer.

[342]  M. Westphal,et al.  RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. , 2006, Journal of neurochemistry.

[343]  Rui Wang,et al.  Molecular dynamics simulations of interaction between protein-tyrosine phosphatase 1B and a bidentate inhibitor , 2006, Acta Pharmacologica Sinica.

[344]  M. Tremblay,et al.  Substrate-trapping techniques in the identification of cellular PTP targets. , 2005, Methods.

[345]  Yan Zhang,et al.  A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. , 2004, Nature genetics.

[346]  Y. Sugimoto,et al.  Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7. , 2004, Oncogene.

[347]  J. den Hertog,et al.  Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers. , 2003, The Journal of biological chemistry.

[348]  M. Westphal,et al.  A role for receptor tyrosine phosphatase zeta in glioma cell migration. , 2003, Oncogene.

[349]  N. Aoki,et al.  A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. , 2002, Molecular endocrinology.

[350]  D. Shalloway,et al.  Two mechanisms activate PTPalpha during mitosis. , 2001, The EMBO journal.

[351]  A. Elson,et al.  Regulation of protein-tyrosine phosphatases alpha and epsilon by calpain-mediated proteolytic cleavage. , 2001, The Journal of biological chemistry.

[352]  M. Noda,et al.  Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[353]  F. Melchior,et al.  SUMO--nonclassical ubiquitin. , 2000, Annual review of cell and developmental biology.

[354]  M. Karin,et al.  Is NF-kappaB the sensor of oxidative stress? , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[355]  A. Elson Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. , 1999, Oncogene.

[356]  内田亨 Insulin Stimulates the Phosphorylation of Tyr[538] and the Catalytic Activity of PTP1C,a Protein Tyrosine Phosphatase with Src Homology-2 Domains(インスリン刺激によるSrc Homology-2 Domainを有するチロシンホスファターゼ、PTP1Cのチロシン538のりん酸化と酵素作用の活性化) , 1997 .

[357]  T. Onytiganis Development of ''substrate-trapping'' mutants to identify physiological substrates of protein tyrosine phosphatases , 1997 .