Unnatural nucleotide sequences in biopharmaceutics.
暂无分享,去创建一个
[1] W. E. Fahl,et al. Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[2] David A. Williams,et al. Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo. , 1995, Cancer research.
[3] Jack W. Szostak,et al. In vitro evolution of a self-alkylatlng ribozyme , 1995, Nature.
[4] W. Stemmer. DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[5] C. Khosla,et al. Efficient Sampling of Protein Sequence Space for Multiple Mutants , 1994, Bio/Technology.
[6] R. Sauer,et al. Folded proteins occur frequently in libraries of random amino acid sequences. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[7] L. Loeb,et al. Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene. , 1994, Virology.
[8] J. Scott,et al. Random peptide libraries. , 1994, Current opinion in biotechnology.
[9] M. Black,et al. Selection of new biologically active molecules from random nucleotide sequences. , 1993, Gene.
[10] M. Black,et al. Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro. , 1993, Biochemistry.
[11] N. Lehman,et al. Evolution in vitro: analysis of a lineage of ribozymes , 1993, Current Biology.
[12] R. Vile,et al. Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. , 1993, Cancer research.
[13] A Ma,et al. Binding of myc proteins to canonical and noncanonical DNA sequences , 1993, Molecular and cellular biology.
[14] Z. Ram,et al. Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors. , 1993, Journal of neurosurgery.
[15] Jack W. Szostak,et al. An RNA motif that binds ATP , 1993, Nature.
[16] D. Klatzmann,et al. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[17] C. Barbas,et al. Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[18] J. Wells,et al. Substrate phage: selection of protease substrates by monovalent phage display. , 1993, Science.
[19] L. Loeb,et al. Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[20] J. Rebek,et al. Convergent functional groups. 13. High-affinity complexation of adenosine derivatives within induced binding pockets , 1993 .
[21] L. Loeb,et al. Thymidine kinase mutants obtained by random sequence selection. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[22] N. Lehman,et al. Evolution in vitro of an RNA enzyme with altered metal dependence , 1993, Nature.
[23] G. F. Joyce,et al. Randomization of genes by PCR mutagenesis. , 1992, PCR methods and applications.
[24] R. Lerner,et al. Encoded combinatorial chemistry. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[25] Z. Ram,et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. , 1992, Science.
[26] J. Rebek,et al. Crossover Reactions Between Synthetic Replicators Yield Active and Inactive Recombinants , 1992, Science.
[27] D. Shortle,et al. A general strategy for random insertion and substitution mutagenesis: substoichiometric coupling of trinucleotide phosphoramidites. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[28] L. Loeb,et al. Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis [corrected]. , 1992, The Journal of biological chemistry.
[29] A. Arkin,et al. Optimizing Nucleotide Mixtures to Encode Specific Subsets of Amino Acids for Semi-Random Mutagenesis , 1992, Bio/Technology.
[30] P. Schatz,et al. Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[31] E. Vermaas,et al. Selection of single-stranded DNA molecules that bind and inhibit human thrombin , 1992, Nature.
[32] L. Loeb,et al. Artificial mutants generated by the insertion of random oligonucleotides into the putative nucleoside binding site of the HSV-1 thymidine kinase gene. , 1991, Biochemistry.
[33] P G Schultz,et al. At the crossroads of chemistry and immunology: catalytic antibodies. , 1991, Science.
[34] L. Loeb,et al. The association of thymidine kinase activity and thymidine transport in Escherichia coli. , 1991, Gene.
[35] César Milstein,et al. Man-made antibodies , 1991, Nature.
[36] G. Gentry,et al. Herpesviral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation. , 1990, The Journal of general virology.
[37] H. Weintraub,et al. Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. , 1990, Science.
[38] J. Szostak,et al. In vitro selection of RNA molecules that bind specific ligands , 1990, Nature.
[39] R. Barrett,et al. Peptides on phage: a vast library of peptides for identifying ligands. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[40] J. Devlin,et al. Random peptide libraries: a source of specific protein binding molecules. , 1990, Science.
[41] J. Scott,et al. Searching for peptide ligands with an epitope library. , 1990, Science.
[42] L. Gold,et al. Autogenous translational operator recognized by bacteriophage T4 DNA polymerase. , 1990, Journal of molecular biology.
[43] J. W. Little. Saturation mutagenesis of specific codons: elimination of molecules with stop codons from mixed pools of DNA. , 1990, Gene.
[44] W. Lim,et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. , 1990, Science.
[45] K. Struhl,et al. An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[46] L. Loeb,et al. Mutants generated by the insertion of random oligonucleotides into the active site of the beta-lactamase gene. , 1989, Biochemistry.
[47] K. Struhl,et al. Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein , 1989, Molecular and cellular biology.
[48] D. Richman,et al. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. , 1989, Science.
[49] G. F. Joyce. RNA evolution and the origins of life , 1989, Nature.
[50] L. Loeb,et al. DNA sequences of random origin as probes of Escherichia coli promoter architecture. , 1988, The Journal of biological chemistry.
[51] W. Summers,et al. Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity. , 1988, Virology.
[52] J Moult,et al. Bacterial resistance to beta-lactam antibiotics: crystal structure of beta-lactamase from Staphylococcus aureus PC1 at 2.5 A resolution. , 1987, Science.
[53] L. Loeb,et al. Promoters selected from random DNA sequences. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[54] Alan R. Fersht,et al. Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships , 1986, Nature.
[55] B. Larder,et al. Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide. , 1986, The Journal of general virology.
[56] Alan R. Fersht,et al. The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus) , 1984, Cell.
[57] W. Summers,et al. Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[58] S. McKnight. The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene. , 1980, Nucleic acids research.
[59] D. Mills,et al. An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. , 1967, Proceedings of the National Academy of Sciences of the United States of America.
[60] L. Loeb,et al. Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection. , 1994, Protein engineering.
[61] G. F. Joyce. Selective amplification techniques for optimization of ribozyme function , 1992 .
[62] J U Bowie,et al. Random mutagenesis of protein sequences using oligonucleotide cassettes. , 1991, Methods in enzymology.
[63] H. Weintraub,et al. Antisense RNA and DNA. , 1990, Scientific American.
[64] R. Evans,et al. Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. , 1990, Human gene therapy.
[65] J. Richards,et al. Chapter 29 Progress Toward the Rational Study of Enzyme Structure-Function Relationships , 1987 .
[66] J. Richards,et al. Progress Toward the Rational Study of Enzyme Structure-Function Relationships , 1987 .
[67] K. Struhl,et al. The use of random-sequence oligonucleotides for determining consensus sequences. , 1987, Methods in enzymology.
[68] W. McClure,et al. Mechanism and control of transcription initiation in prokaryotes. , 1985, Annual review of biochemistry.
[69] G. Elion. The chemotherapeutic exploitation of virus-specified enzymes. , 1980, Advances in enzyme regulation.