Artificial thorax for MR imaging studies in porcine heart-lung preparations.

A double-walled magnetic resonance (MR) imaging-compatible container with a flexible diaphragm was designed to hold freshly excised porcine heart-lung preparations. The saline contents simulate MR signal of an actual chest wall. Continuous evacuation keeps the lung inflated. A variety of experiments with different imaging modalities, including angiography, under close to in vivo conditions are feasible. Access to bronchial system and lung vessels allows for various studies.

[1]  Mitchell Ri Lung deposition in freshly excised human lungs. , 1975 .

[2]  G. Fisher,et al.  In vitro models of lung toxicity. , 1987, Toxicology.

[3]  S. Jamieson,et al.  Multiple ex vivo organ preservation with warm whole blood. , 1988, The Journal of heart transplantation.

[4]  D. Ortendahl,et al.  Measuring signal-to-noise ratios in MR imaging. , 1989, Radiology.

[5]  M. Moseley,et al.  Differentiation of capillary leak and hydrostatic pulmonary edema with a macromolecular MR imaging contrast agent. , 1991, Radiology.

[6]  M. Shinzo [Serial changes of atelectasis in acute bronchial obstruction: MR imaging pathologic correlation in experimental animal model study]. , 1994, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica.

[7]  N. Müller,et al.  MRI of Infiltrative Lung Disease: Comparison with Pathologic Findings , 1994, Journal of computer assisted tomography.

[8]  G. Adam,et al.  Diagnostik der akuten Lungenembolie: Vergleich zwischen Spiral-CT und DSA im Tierexperiment , 1995 .

[9]  J Listerud,et al.  Multi‐Slice, Breathhold Imaging of the Lung with Submillisecond Echo Times , 1995, Magnetic resonance in medicine.

[10]  M. Horsfield,et al.  Optimization of a Breath-Hold Magnetic Resonance Gradient Echo Technique for the Detection of Interstitial Lung Disease , 1995, Investigative radiology.

[11]  S. Su,et al.  Resolving Anatomical Details in Lung Parenchyma: Theory and Experiment for a Structurally and Magnetically Inhomogeneous Lung Imaging Model , 1995, Magnetic resonance in medicine.

[12]  K. K. Tan,et al.  In vivo PO2 imaging in the porcine model with perfluorocarbon F-19 NMR at low field. , 1996, Magnetic resonance imaging.

[13]  J Gieseke,et al.  [A new application of MR tomography of the lung using ultra-short turbo spin echo sequences]. , 1996, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[14]  E E de Lange,et al.  MR imaging and spectroscopy using hyperpolarized 129Xe gas: Preliminary human results , 1997, Magnetic resonance in medicine.

[15]  H. Kauczor,et al.  [The helium-3 MRT of pulmonary ventilation: the initial clinical applications]. , 1997, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[16]  R. Edelman,et al.  Pulmonary disorders: ventilation-perfusion MR imaging with animal models. , 1999, Radiology.

[17]  R R Edelman,et al.  MR imaging of pulmonary parenchyma with a half-Fourier single-shot turbo spin-echo (HASTE) sequence. , 1999, European journal of radiology.

[18]  H. Schild,et al.  MRT versus CT in der Diagnostik von Pneumonien : Evaluation einer T2-gewichteten ultraschnellen Turbo-Spin-Echo-Sequenz (UTSE) , 1999 .

[19]  H. Schild,et al.  Differentiation of alveolitis and pulmonary fibrosis in rabbits with magnetic resonance imaging after intrabronchial administration of bleomycin. , 1999, Investigative radiology.

[20]  S. Park,et al.  MR imaging of solitary pulmonary lesion: Emphasis on tuberculomas and comparison with tumors , 2000, Journal of magnetic resonance imaging : JMRI.

[21]  S. Sone,et al.  Correlation between high-resolution computed tomographic, magnetic resonance and pathological findings in cases with non-cancerous but suspicious lung nodules , 2000, European Radiology.

[22]  L W Hedlund,et al.  Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Schnall,et al.  Detection and localization of pulmonary air leaks using laser‐polarized 3He MRI , 2000 .