A novel pH‐ and thermo‐sensitive PVP/CMC semi‐IPN hydrogel: Swelling, phase behavior, and drug release study

Poly(N-vinyl-pyrrolidone) (PVP) hydrogel has been considered as a very interesting and promising thermosensitive material. The most vital shortcoming of PVP hydrogel as thermosensitive material is that it does not exhibit thermosensitivity under usual conditions. In this work, semi-interpenetrating polymer network (semi-IPN) hydrogels based on PVP and carboxymethylcellulose (CMC) were prepared. The volume phase transition temperature (VPTT) of the hydrogels was determined by swelling behavior and differential scanning calorimetry (DSC). The results showed that the VPTT was significantly dependent on CMC content and the pH of the swelling medium. The amount of CMC in the semi-IPN hydrogels was 0.050, 0.075, and 0.100 g, the VPTT in buffer solution of pH 1.2 was 29.9 °C, 27.5 °C and 24.5 °C, respectively. In addition, the VPTT occurred in buffer solution of pH 1.2, but did not appear in alkaline medium. Bovine serum albumin (BSA) as a model drug was loaded and the in vitro release studies were carried out in different buffer solutions and at different temperatures. The results of this study suggest that PVP/CMC semi-IPN hydrogels could serve as potential candidates for protein drug delivery in the intestine. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1749–1756, 2010

[1]  Chaoliang He,et al.  Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release , 2009 .

[2]  K. Marra,et al.  Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. , 2009, Biomaterials.

[3]  Nicolas H Voelcker,et al.  Stimuli-responsive interfaces and systems for the control of protein-surface and cell-surface interactions. , 2009, Biomaterials.

[4]  A. Yakimansky,et al.  Thermo- and pH-sensitivity of aqueous poly(N-vinylpyrrolidone) solutions in the presence of organic acids , 2009 .

[5]  Yanling Luo,et al.  Poly(MAA-co-AN) hydrogels with improved mechanical properties for theophylline controlled delivery. , 2009, Acta biomaterialia.

[6]  P. Ascenzi,et al.  Poly(N-isopropylacrylamide-co-acrylamide) cross-linked thermoresponsive microspheres obtained from preformed polymers: Influence of the physico-chemical characteristics of drugs on their release profiles. , 2009, Acta biomaterialia.

[7]  Anil Kumar Bajpai,et al.  Responsive polymers in controlled drug delivery , 2008 .

[8]  T. Caykara,et al.  Thermo‐ and pH‐induced phase transitions and network parameters of poly(N‐isopropylacrylamide‐ co‐2‐acrylamido‐2‐methyl‐propanosulfonic acid) hydrogels , 2008 .

[9]  W. Lyoo,et al.  Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. , 2008, International journal of pharmaceutics.

[10]  Trong-Ming Don,et al.  Preparation of thermo-responsive acrylic hydrogels useful for the application in transdermal drug delivery systems , 2008 .

[11]  Michael J Yaszemski,et al.  Synthesis and evaluation of novel biodegradable hydrogels based on poly(ethylene glycol) and sebacic acid as tissue engineering scaffolds. , 2008, Biomacromolecules.

[12]  M. Kokabi,et al.  PVA–clay nanocomposite hydrogels for wound dressing , 2007 .

[13]  Ying Zhang,et al.  Synthesis of a chemically-crosslinked thermo-sensitive hydrogel film and in situ encapsulation of model protein drugs , 2006 .

[14]  A. Güner,et al.  Intermolecular interactions between bovine serum albumin and certain water‐soluble polymers at various temperatures , 2006 .

[15]  Mingzhu Liu,et al.  Synthesis and characterization of pH-sensitivity semi-IPN hydrogel based on hydrogen bond between poly(N-vinylpyrrolidone) and poly(acrylic acid) , 2006 .

[16]  S. A. G. Alla,et al.  Temperature and pH responsive behaviours of CMC/AAc hydrogels prepared by electron beam irradiation , 2006 .

[17]  John G. Lyons,et al.  The synthesis, characterisation, phase behaviour and swelling of temperature sensitive physically crosslinked poly(1-vinyl-2-pyrrolidinone)/poly(N-isopropylacrylamide) hydrogels , 2006 .

[18]  A. Bajpai,et al.  Preparation and characterization of tetracycline‐loaded interpenetrating polymer networks of carboxymethyl cellulose and poly(acrylic acid): water sorption and drug release study , 2005 .

[19]  A. Concheiro,et al.  Temperature-sensitive chitosan-poly(N-isopropylacrylamide) interpenetrated networks with enhanced loading capacity and controlled release properties. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[20]  Yi-Yan Yang,et al.  Evaluating proteins release from, and their interactions with, thermosensitive poly (N-isopropylacrylamide) hydrogels. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[21]  Wen-Fu Lee,et al.  Investigation of charge effects on drug release behavior for ionic thermosensitive hydrogels , 2002 .

[22]  You Han Bae,et al.  Thermosensitive sol-gel reversible hydrogels. , 2002, Advanced drug delivery reviews.

[23]  Wen-Fu Lee,et al.  Studies on preparation and swelling properties of the N‐isopropylacrylamide/chitosan semi‐IPN and IPN hydrogels , 2001 .

[24]  A. Hardikar,et al.  pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[25]  N. Peppas,et al.  Hydrogels in Pharmaceutical Formulations , 1999 .

[26]  Y. Lee,et al.  Effect of polyelectrolyte on the lower critical solution temperature of poly(N-isopropyl acrylamide) in the poly(NIPAAm-co-acrylic acid) hydrogel , 2000 .

[27]  G. Barone,et al.  On the Nature of the Temperature-Induced Transition From the Molten Globule to the Unfolded State of Globular Proteins , 1999 .

[28]  O. Güven,et al.  The effect of external stimuli on the equilibrium swelling properties of poly(N-vinyl 2-pyrrolidone/itaconic acid) poly-electrolyte hydrogels , 1999 .

[29]  Norihiro Kato,et al.  An energy-saving method of heating for a chemomechanical poly(N-isopropylacrylamide) gel with Joule's heat , 1998 .

[30]  B. Bijsterbosch,et al.  Persistence Length of Carboxymethyl Cellulose As Evaluated from Size Exclusion Chromatography and Potentiometric Titrations , 1998 .

[31]  J. Román,et al.  Water sorption of flexible networks based on 2-hydroxyethyl methacrylate-triethylenglycol dimethacrylate copolymers , 1997 .

[32]  L. Gargallo,et al.  Phase separation behaviour of polymers in water. Temperature and surfactant effect , 1997 .

[33]  A. Tuncel,et al.  Thermoresponsive isopropylacrylamide‐vinylpyrrolidone copolymer by radiation polymerization , 1997 .

[34]  Thomas Sun,et al.  Aggregation Behavior in the Semidilute Poly(N-vinyl-2-pyrrolidone)/Water System , 1996 .

[35]  Sun,et al.  Pressure-induced reentrant phase behavior in the poly(N-vinyl-2-pyrrolidone)-water system. , 1996, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[36]  V. Pillai,et al.  Water sorption and water binding properties of crosslinked polyacrylamides : effect of macromolecular structure and crosslinking , 1995 .

[37]  A. Güner,et al.  Effects of inorganic salts on the properties of aqueous poly(vinylpyrrolidone) solutions , 1994 .