Topoisomerase I Inhibitors: Current Use and Prospects
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G. Giaccone | P. Rougier | Y. Makeyev | F. Muggia | T. Furuta | A. Rajan
[1] C. Tournigand,et al. FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study , 2023, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] R. Greil,et al. Oxaliplatin, irinotecan, and cetuximab in advanced gastric cancer. First efficacy results of a multicenter phase II trial (AGMT Gastric-2) of the Arbeitsgemeinschaft Medikamentoese Tumortherapie (AGMT). , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[3] Dan L. Longo Bruce A. Chabner. Cancer chemotherapy and biotherapy , 2013 .
[4] B. Cho,et al. Belotecan for relapsing small-cell lung cancer patients initially treated with an irinotecan-containing chemotherapy: a phase II trial. , 2010, Lung cancer.
[5] J. W. Kim,et al. A multicenter phase II study of belotecan, new camptothecin analogue, in patients with previously untreated extensive stage disease small cell lung cancer. , 2010, Lung cancer.
[6] S. Blank,et al. Oxaliplatin plus continuous infusion topotecan: First stage of an ongoing phase II study for recurrent ovarian cancer: A New York Cancer Consortium study (#N01-CM62204). , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] Teruhiko Yoshida,et al. Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients , 2010, Cancer Chemotherapy and Pharmacology.
[8] E. Van Cutsem,et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. , 2009, The New England journal of medicine.
[9] C. Bokemeyer,et al. A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.
[10] D. Cella,et al. Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] T. Mikkelsen,et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] O. Ganslandt,et al. Effects of concurrent topotecan and radiation on 6-month progression-free survival in the primary treatment of glioblastoma multiforme. , 2009, International journal of radiation oncology, biology, physics.
[13] T. Furuta. Pharmacogenomics in chemotherapy for GI tract cancer , 2009, Journal of Gastroenterology.
[14] S. Yokoyama,et al. [Two cases of advanced colorectal cancer with UGT1A1*28 homozygosity treated by FOLFIRI]. , 2009, Gan to kagaku ryoho. Cancer & chemotherapy.
[15] R. Greil,et al. Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] S. Kubicka,et al. Cetuximab with irinotecan/folinic acid/5-FU as first-line treatment in advanced gastric cancer: A nonrandomized multicenter AIO phase II study. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[17] J. Crowley,et al. Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[18] Beom Soo Shin,et al. Use of an Anti-Vascular Endothelial Growth Factor Antibody in a Pharmacokinetic Strategy to Increase the Efficacy of Intraperitoneal Chemotherapy , 2009, Journal of Pharmacology and Experimental Therapeutics.
[19] Y. Pommier,et al. The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives , 2009, Molecular Cancer Therapeutics.
[20] T. Conroy,et al. A phase III randomised trial of LV5FU2 + irinotecan versus LV5FU2 alone in adjuvant high-risk colon cancer (FNCLCC Accord02/FFCD9802). , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.
[21] D. Alberts,et al. Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[22] John A Butman,et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[23] Jeffrey W. Clark,et al. Phase I and Pharmacokinetic Study of Gimatecan Given Orally Once a Week for 3 of 4 Weeks in Patients with Advanced Solid Tumors , 2009, Clinical Cancer Research.
[24] A. Friedman,et al. Bevacizumab Plus Irinotecan in Recurrent WHO Grade 3 Malignant Gliomas , 2008, Clinical Cancer Research.
[25] F. Bonnetain,et al. Phase III trial of chemotherapy with or without irinotecan in the front-line treatment of metastatic colorectal cancer in elderly patients (FFCD 2001–02 trial). Results of a planned interim analysis , 2008 .
[26] J. Zaluski,et al. Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[27] K. Inui,et al. [Role of UGT1A1*28 and UGT1A1*6 for irinotecan-induced adverse drug reaction]. , 2008, Gan to kagaku ryoho. Cancer & chemotherapy.
[28] M. Ychou,et al. Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases , 2008, Cancer Chemotherapy and Pharmacology.
[29] R. Greil,et al. Oxaliplatin, irinotecan and cetuximab in advanced gastric cancer: First results of a multicenter phase II trial (AGMT Gastric- 2 , 2008 .
[30] M. Chamberlain,et al. CPT-11 for recurrent temozolomide-refractory 1p19q co-deleted anaplastic oligodendroglioma , 2008, Journal of Neuro-Oncology.
[31] M. Chamberlain,et al. Salvage chemotherapy with CPT‐11 for recurrent temozolomide‐refractory anaplastic astrocytoma , 2008, Cancer.
[32] R. Stephens,et al. Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] A. Lièvre,et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[34] J. Panetta,et al. Population Pharmacokinetic Analysis of Topotecan in Pediatric Cancer Patients , 2007, Clinical Cancer Research.
[35] John Sampson,et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[36] C. Fuchs,et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[37] E. Shimizu,et al. Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. , 2007, Therapeutic drug monitoring.
[38] F. Giuliante,et al. Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases , 2007, British Journal of Cancer.
[39] D. Shin,et al. Irinotecan plus carboplatin for patients with extensive-disease small cell lung cancer: P1-226 , 2007 .
[40] P. Foggi,et al. Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma , 2007, British Journal of Cancer.
[41] H. Naman,et al. Phase II study of UFT with leucovorin and irinotecan (TEGAFIRI): first-line therapy for metastatic colorectal cancer , 2007, British Journal of Cancer.
[42] Richard J Stephens,et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial , 2007, The Lancet.
[43] J. von Pawel,et al. Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[44] L. Crinò,et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[45] Darell D. Bigner,et al. Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma , 2007, Clinical Cancer Research.
[46] D. Alberts,et al. Proceedings of a GOG workshop on intraperitoneal therapy for ovarian cancer. , 2006, Gynecologic oncology.
[47] T. Ciuleanu,et al. Phase III trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[48] R. Ho,et al. A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells. , 2006, Journal of pharmaceutical sciences.
[49] L. Schwartz,et al. Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[50] H. Lenz,et al. Molecular determinants of irinotecan efficacy , 2006, International journal of cancer.
[51] Balram Chowbay,et al. Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients , 2006, Pharmacogenetics and genomics.
[52] L. Mariani,et al. Irinotecan, Fluorouracil and Folinic ACID (FOLFIRI) as Effective Treatment Combination for Patients with Advanced Gastric Cancer in Poor Clinical Condition , 2006, Tumori.
[53] A. Reuss,et al. Randomized phase III trial of topotecan following carboplatin and paclitaxel in first-line treatment of advanced ovarian cancer: a gynecologic cancer intergroup trial of the AGO-OVAR and GINECO. , 2006, Journal of the National Cancer Institute.
[54] H. Saka,et al. Phase I and pharmacokinetic study of edotecarin, a novel topoisomerase I inhibitor, administered once every 3 weeks in patients with solid tumors , 2006, Cancer Chemotherapy and Pharmacology.
[55] H. Hurwitz,et al. A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel topoisomerase I inhibitor, in patients with advanced solid tumors , 2006, Cancer Chemotherapy and Pharmacology.
[56] F. Shepherd,et al. Phase III study comparing oral topotecan to intravenous docetaxel in patients with pretreated advanced non-small-cell lung cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[57] N. Hanna,et al. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[58] H. Hochster,et al. Topotecan continuous infusion: CA-125 responses including patients pretreated with other schedules of topotecan. , 2006, The oncologist.
[59] J. Bae,et al. Phase II study of docetaxel and irinotecan combination chemotherapy in metastatic gastric carcinoma , 2006, British Journal of Cancer.
[60] E. Plimack,et al. Prolonged topotecan infusion with cisplatin in the first-line treatment of ovarian cancer: an NYGOG and ECOG study. , 2006, Gynecologic oncology.
[61] Jeffrey W. Clark,et al. A Phase II Trial of Irinotecan in Patients with Previously Untreated Advanced Esophageal and Gastric Adenocarcinoma , 2005, Digestive Diseases and Sciences.
[62] Sang Lee,et al. Phase I Study of Combined Pegylated Liposomal Doxorubicin with Protracted Daily Topotecan for Ovarian Cancer , 2005, Clinical Cancer Research.
[63] C. Bokemeyer,et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[64] D. Miller,et al. Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[65] J. Herndon,et al. Phase II trial of karenitecin in patients with relapsed or refractory non-small cell lung cancer (CALGB 30004). , 2005, Lung cancer.
[66] R. Mirimanoff,et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. , 2005, The New England journal of medicine.
[67] Shigeki Sugiura,et al. ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS , 2005, Drug Metabolism and Disposition.
[68] J. Zaluski,et al. Irinotecan in combination with 5-fluorouracil and folinic acid or with cisplatin in patients with advanced gastric or esophageal-gastric junction adenocarcinoma: results of a randomized phase II study. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[69] D. Sargent,et al. Mortality associated with daily bolus 5‐fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin , 2004, Cancer.
[70] F. Zunino,et al. Efficacy of the Novel Camptothecin Gimatecan against Orthotopic and Metastatic Human Tumor Xenograft Models , 2004, Clinical Cancer Research.
[71] D. Arsène,et al. Randomized multicenter phase II trial of a biweekly regimen of fluorouracil and leucovorin (LV5FU2), LV5FU2 plus cisplatin, or LV5FU2 plus irinotecan in patients with previously untreated metastatic gastric cancer: a Federation Francophone de Cancerologie Digestive Group Study--FFCD 9803. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[72] P. Houghton,et al. Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[73] B. Monk,et al. Cisplatin and irinotecan in squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group. , 2004, Gynecologic oncology.
[74] A. Grothey,et al. Capecitabine/ irinotecan (CapIri) and capecitabine/oxaliplatin (CapOx) are active second-line protocols in patients with advanced colorectal cancer (ACRC) after failure of first-line combination therapy: Results of a randomized phase II study. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[75] J. Berlin,et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.
[76] E. Thiel,et al. Response of relapsed or refractory primary central nervous system lymphoma (PCNSL) to topotecan , 2004, Neurology.
[77] E. Thiel,et al. Phase I/II trial of topotecan given as continuous infusion in combination with oxaliplatin in 5-FU-pretreated patients with colorectal cancer , 2004, Cancer Chemotherapy and Pharmacology.
[78] M. Gruber,et al. Temozolomide in Combination With Irinotecan for Treatment of Recurrent Malignant Glioma , 2004, American journal of clinical oncology.
[79] M. Ducreux,et al. Irinotecan is active in chemonaive patients with metastatic gastric cancer: a phase II multicentric trial , 2003, British Journal of Cancer.
[80] A. Grothey,et al. 295 Capecitabine plus irinotecan (CAPIRI) vs capecitabine plus oxaliplatin (CAPOX) as first-line therapy of advanced colorectal cancer (ACRC): updated results of a randomized phase II trial , 2003 .
[81] Sharon Marsh,et al. Irinotecan pathway genotype analysis to predict pharmacokinetics. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[82] G. Broggi,et al. Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma , 2003, Journal of Neuro-Oncology.
[83] E. Raymond,et al. Multicentre phase II study and pharmacokinetic analysis of irinotecan in chemotherapy-naïve patients with glioblastoma. , 2003, Annals of oncology : official journal of the European Society for Medical Oncology.
[84] W. Hinkelbein,et al. A pilot study of irinotecan (CPT-11) as single-agent therapy in patients with locally advanced or metastatic esophageal carcinoma , 2003, International Journal of Colorectal Disease.
[85] M. Tan,et al. A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[86] M. Ducreux,et al. Antitumour activity of three second-line treatment combinations in patients with metastatic colorectal cancer after optimal 5-FU regimen failure: a randomised, multicentre phase II study. , 2002, Annals of oncology : official journal of the European Society for Medical Oncology.
[87] J. Kuhn. Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report. , 2002, Oncology.
[88] G. Hudes. Boosting bioavailability of topotecan: what do we gain? , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[89] L. Stewart,et al. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials , 2002, The Lancet.
[90] M. Bernstein,et al. Influence of Phenytoin on the Disposition of Irinotecan: A Case Report , 2002, Journal of pediatric hematology/oncology.
[91] J. Ajani,et al. CPT‐11 plus cisplatin in patients with advanced, untreated gastric or gastroesophageal junction carcinoma , 2002, Cancer.
[92] K. Mori,et al. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. , 2002, The New England journal of medicine.
[93] J. Berlin,et al. A phase II study of irinotecan with 5-fluorouracil and leucovorin in patients with previously untreated gastric adenocarcinoma. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.
[94] Z L Gokaslan,et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. , 2001, Journal of neurosurgery.
[95] D Guthrie,et al. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[96] J. Hoeijmakers. Genome maintenance mechanisms for preventing cancer , 2001, Nature.
[97] H. Saka,et al. Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. , 2000, Cancer research.
[98] B. Giovanella,et al. Combined Radiation and 9‐Nitrocamptothecin (Rubitecan) in the Treatment of Locally Advanced Pancreatic Cancer , 2000, Annals of the New York Academy of Sciences.
[99] L. Saltz,et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. , 2000, The New England journal of medicine.
[100] G. Weiss,et al. A Phase II Trial of Topotecan in Esophageal Carcinoma: A Southwest Oncology Group Study (SWOG 9339) , 2000, Investigational New Drugs.
[101] U. Brinkmann,et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[102] R. James,et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial , 2000, The Lancet.
[103] S. Lipsitz,et al. Treatment of squamous cell esophageal cancer with topotecan: an Eastern Cooperative Oncology Group Study (E2293). , 2000, American journal of clinical oncology.
[104] G. Schwartz,et al. Phase II trial of weekly irinotecan plus cisplatin in advanced esophageal cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[105] H. Shibahara,et al. A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma. , 1999, Japanese journal of clinical oncology.
[106] C. Runowicz,et al. Activity and pharmacodynamics of 21-Day topotecan infusion in patients with ovarian cancer previously treated with platinum-based chemotherapy. New York Gynecologic Oncology Group. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[107] R. McLendon,et al. Irinotecan therapy in adults with recurrent or progressive malignant glioma. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[108] R. McLendon,et al. Topotecan treatment of adults with primary malignant glioma , 1999, Cancer.
[109] J. Carmichael,et al. Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[110] J. Kuhn,et al. Pharmacology of irinotecan. , 1998, Oncology.
[111] R. Labianca,et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer , 1998, The Lancet.
[112] K. Hasumi,et al. A phase II study of combined CPT-11 and mitomycin-C in platinum refractory clear cell and mucinous ovarian carcinoma. , 1998, Annals of the Academy of Medicine, Singapore.
[113] J. O’Leary,et al. Camptothecins: a review of their development and schedules of administration. , 1998, European journal of cancer.
[114] H. Saka,et al. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. , 1998, Annals of oncology : official journal of the European Society for Medical Oncology.
[115] H. Rosing,et al. Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[116] G. Schwartz,et al. A phase II study of topotecan administered five times daily in patients with advanced gastric cancer. , 1997, American journal of clinical oncology.
[117] D W Nebert,et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. , 1997, Pharmacogenetics.
[118] A Gordon,et al. Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[119] E. Estey,et al. Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia. , 1996, Blood.
[120] K. Ushijima,et al. [Combination of irinotecan hydrochloride (CPT-11) and cisplatin as a new regimen for patients with advanced ovarian cancer]. , 1996, Nihon Sanka Fujinka Gakkai zasshi.
[121] S. Sallan,et al. Phase II evaluation of topotecan for pediatric central nervous system tumors , 1996 .
[122] J. Verweij,et al. Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor. , 1996, British Journal of Cancer.
[123] E. Eisenhauer,et al. Phase II study of topotecan in patients with recurrent malignant glioma , 1996 .
[124] J. Wanders,et al. Topotecan in colorectal cancer: a phase II study of the EORTC early clinical trials group. , 1995, Annals of oncology : official journal of the European Society for Medical Oncology.
[125] S. Baker,et al. Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors , 1995, Cancer Chemotherapy and Pharmacology.
[126] S. Baker,et al. Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[127] T. Taguchi,et al. [Late phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer. CPT-11 Gastrointestinal Cancer Study Group]. , 1994, Gan to kagaku ryoho. Cancer & chemotherapy.
[128] H. Hochster,et al. Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[129] W. Furman,et al. Phase I study of topotecan for pediatric patients with malignant solid tumors. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[130] Georg Breier,et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo , 1992, Nature.
[131] F. D. Zeman. Proceedings Of A Conference , 1949 .
[132] B. Scheithauer,et al. Phase II trial of two different irinotecan schedules with pharmacokinetic analysis in patients with recurrent glioma: North Central Cancer Treatment Group results , 2008, Journal of Neuro-Oncology.
[133] R. Berardi,et al. Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.
[134] P. Wen,et al. Topotecan as salvage therapy for relapsed or refractory primary central nervous system lymphoma , 2007, Journal of Neuro-Oncology.
[135] M. Zucchetti,et al. Concerted escalation of dose and dosing duration in a phase I study of the oral camptothecin gimatecan (ST1481) in patients with advanced solid tumors. , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.
[136] L. Seymour,et al. A National Cancer Institute of Canada Clinical Trials Group Study--IND.135: Phase I/II study of irinotecan (camptosar), oxaliplatin and raltitrexed (tomudex) (COT) in patients with advanced colorectal cancer. , 2006, European journal of cancer.
[137] Susan M. Chang,et al. A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. , 2006, Neuro-oncology.
[138] H. Lenz,et al. Pharmacogenomics and colorectal cancer. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[139] Daniel J Sargent,et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[140] S. Balcerzak,et al. Phase II trial of topotecan in advanced gastric cancer: A Southwest Oncology Group study , 2004, Investigational New Drugs.
[141] L. Assersohn,et al. Phase II study of irinotecan and 5-fluorouracil/leucovorin in patients with primary refractory or relapsed advanced oesophageal and gastric carcinoma. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[142] E. Estey,et al. Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: Results of a randomized phase I/II study , 2004, Investigational New Drugs.
[143] M. Chamberlain. Salvage Chemotherapy with CPT-11 for Recurrent Glioblastoma Multiforme , 2004, Journal of Neuro-Oncology.
[144] Y. Sugiyama,et al. The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. , 2002, Drug metabolism and pharmacokinetics.
[145] C. Verschraegen,et al. The camptothecins : unfolding their anticancer potential , 2000 .
[146] C. Takimoto,et al. Plasma and cerebrospinal fluid pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in nonhuman primates , 1998, Cancer Chemotherapy and Pharmacology.
[147] S. Culine,et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[148] P. Rougier,et al. Efficacy of CPT-11 (irinotecan) as a single agent in metastatic colorectal cancer. , 1996, European journal of cancer.
[149] P. Pantazis,et al. The camptothecins : from discovery to the patient , 1996 .