The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation

[1]  A. Kingston-Smith,et al.  Polyphenol oxidase in leaves: is there any significance to the chloroplastic localization? , 2015, Journal of experimental botany.

[2]  Ayelet Fishman,et al.  Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins , 2014, Nature Communications.

[3]  Bing Yang,et al.  Insect prophenoloxidase: the view beyond immunity , 2014, Front. Physiol..

[4]  J. Nairn,et al.  Diverse immune functions of hemocyanins. , 2014, Developmental and comparative immunology.

[5]  B. Mikami,et al.  The crystal structure of a crustacean prophenoloxidase provides a clue to understanding the functionality of the type 3 copper proteins , 2014, The FEBS journal.

[6]  B. Lemaître,et al.  Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila , 2014, PLoS pathogens.

[7]  A. Rompel,et al.  Type-3 copper proteins: recent advances on polyphenol oxidases. , 2014, Advances in protein chemistry and structural biology.

[8]  T. Oyama,et al.  Crystal Structures of Copper-depleted and Copper-bound Fungal Pro-tyrosinase , 2013, The Journal of Biological Chemistry.

[9]  M. Strand,et al.  Hemolymph Melanization in the Silkmoth Bombyx mori Involves Formation of a High Molecular Mass Complex That Metabolizes Tyrosine* , 2013, The Journal of Biological Chemistry.

[10]  Junpeng Deng,et al.  A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein , 2012, PLoS pathogens.

[11]  Heinz Decker,et al.  Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme. , 2011, Chemical Society reviews.

[12]  Ayelet Fishman,et al.  First structures of an active bacterial tyrosinase reveal copper plasticity. , 2011, Journal of molecular biology.

[13]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[14]  J. Whitaker,et al.  Cloning, sequencing, purification, and crystal structure of Grenache (Vitis vinifera) polyphenol oxidase. , 2010, Journal of agricultural and food chemistry.

[15]  Randy J. Read,et al.  Acta Crystallographica Section D Biological , 2003 .

[16]  M. Osta,et al.  Anopheles gambiae innate immunity , 2010, Cellular microbiology.

[17]  Vincent B. Chen,et al.  Correspondence e-mail: , 2000 .

[18]  F. Solano,et al.  New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins , 2009, Pigment cell & melanoma research.

[19]  David S. Goodsell,et al.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..

[20]  Junpeng Deng,et al.  Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes , 2009, Proceedings of the National Academy of Sciences.

[21]  Wah Chiu,et al.  Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy. , 2009, Structure.

[22]  Ji-won Park,et al.  Molecular Control of Phenoloxidase-induced Melanin Synthesis in an Insect*♦ , 2008, Journal of Biological Chemistry.

[23]  L. Cerenius,et al.  The proPO-system: pros and cons for its role in invertebrate immunity. , 2008, Trends in immunology.

[24]  Haobo Jiang.  The biochemical basis of antimicrobial responses in Manduca sexta , 2008 .

[25]  L. Cerenius,et al.  Phenoloxidase Is an Important Component of the Defense against Aeromonas hydrophila Infection in a Crustacean, Pacifastacus leniusculus* , 2007, Journal of Biological Chemistry.

[26]  Haobo Jiang,et al.  Broad-spectrum antimicrobial activity of the reactive compounds generated in vitro by Manduca sexta phenoloxidase. , 2007, Insect biochemistry and molecular biology.

[27]  E. Jaenicke,et al.  Similar enzyme activation and catalysis in hemocyanins and tyrosinases. , 2007, Gene.

[28]  S. Fukuzumi,et al.  Monooxygenase activity of type 3 copper proteins. , 2007, Accounts of chemical research.

[29]  A. Mayer.  Polyphenol Oxidases in Plants and Fungi: Going Places? A Review , 2007 .

[30]  A. Mayer.  Polyphenol oxidases in plants and fungi: going places? A review. , 2006, Phytochemistry.

[31]  Wladek Minor,et al.  HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. , 2006, Acta crystallographica. Section D, Biological crystallography.

[32]  Heinz Decker,et al.  The first crystal structure of tyrosinase: all questions answered? , 2006, Angewandte Chemie.

[33]  Jie Liang,et al.  CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues , 2006, Nucleic Acids Res..

[34]  Y. Matoba,et al.  Crystallographic Evidence That the Dinuclear Copper Center of Tyrosinase Is Flexible during Catalysis* , 2006, Journal of Biological Chemistry.

[35]  Nam-Chul Ha,et al.  Crystal structure of a clip‐domain serine protease and functional roles of the clip domains , 2005, The EMBO journal.

[36]  Haobo Jiang,et al.  Manduca sexta prophenoloxidase (proPO) activation requires proPO-activating proteinase (PAP) and serine proteinase homologs (SPHs) simultaneously. , 2005, Insect biochemistry and molecular biology.

[37]  Robert Preissner,et al.  Conservation of cis prolyl bonds in proteins during evolution , 2004, Proteins.

[38]  Haobo Jiang,et al.  Prophenoloxidase (proPO) activation in Manduca sexta: an analysis of molecular interactions among proPO, proPO-activating proteinase-3, and a cofactor. , 2004, Insect biochemistry and molecular biology.

[39]  E. Jaenicke,et al.  Recent findings on phenoloxidase activity and antimicrobial activity of hemocyanins. , 2004, Developmental and comparative immunology.

[40]  L. Cerenius,et al.  The prophenoloxidase‐activating system in invertebrates , 2004, Immunological reviews.

[41]  Junpeng Deng,et al.  An improved protocol for rapid freezing of protein samples for long-term storage. , 2004, Acta crystallographica. Section D, Biological crystallography.

[42]  Haruki Nakamura,et al.  Announcing the worldwide Protein Data Bank , 2003, Nature Structural Biology.

[43]  Xiao-qiang Yu,et al.  Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs. , 2003, Insect biochemistry and molecular biology.

[44]  Xiao-qiang Yu,et al.  Prophenoloxidase-activating proteinase-2 from hemolymph of Manduca sexta. A bacteria-inducible serine proteinase containing two clip domains. , 2003, The Journal of biological chemistry.

[45]  Xiao-qiang Yu,et al.  Nonproteolytic serine proteinase homologs are involved in prophenoloxidase activation in the tobacco hornworm, Manduca sexta. , 2003, Insect biochemistry and molecular biology.

[46]  H. Galla,et al.  Comparative modeling of the latent form of a plant catechol oxidase using a molluskan hemocyanin structure. , 2002, Journal of inorganic biochemistry.

[47]  B. Krebs,et al.  The crystal structure of catechol oxidase: new insight into the function of type-3 copper proteins. , 2002, Accounts of chemical research.

[48]  M. Sugumaran.  Comparative biochemistry of eumelanogenesis and the protective roles of phenoloxidase and melanin in insects. , 2002, Pigment cell research.

[49]  F. Solano,et al.  Identification of active site residues involved in metal cofactor binding and stereospecific substrate recognition in Mammalian tyrosinase. Implications to the catalytic cycle. , 2002, Biochemistry.

[50]  W. Delano.  The PyMOL Molecular Graphics System , 2002 .

[51]  Shinobu Itoh,et al.  Oxygenation of Phenols to Catechols by A (μ-η2:η2-Peroxo)dicopper(II) Complex: Mechanistic Insight into the Phenolase Activity of Tyrosinase , 2001 .

[52]  H Decker,et al.  Hemocyanins and Invertebrate Evolution* , 2001, The Journal of Biological Chemistry.

[53]  M. Ashida,et al.  Cuticular Pro-phenoloxidase of the Silkworm, Bombyx mori , 2001, The Journal of Biological Chemistry.

[54]  T. Burmester.  Molecular evolution of the arthropod hemocyanin superfamily. , 2001, Molecular biology and evolution.

[55]  S. Fukuzumi,et al.  Oxygenation of phenols to catechols by a (mu-eta 2:eta 2-peroxo)dicopper(II) complex: mechanistic insight into the phenolase activity of tyrosinase. , 2001, Journal of the American Chemical Society.

[56]  R. Weissleder,et al.  Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. , 2000, Cancer research.

[57]  D. Pal,et al.  Cis peptide bonds in proteins: residues involved, their conformations, interactions and locations. , 1999, Journal of molecular biology.

[58]  F. Kafatos,et al.  A Hemocyte-like Cell Line Established from the Malaria VectorAnopheles gambiae Expresses Six Prophenoloxidase Genes* , 1999, The Journal of Biological Chemistry.

[59]  W. Oetting,et al.  Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism , 1999, Human mutation.

[60]  James C. Sacchettini,et al.  Crystal structure of a plant catechol oxidase containing a dicopper center , 1998, Nature Structural Biology.

[61]  H. Decker,et al.  Tarantula Hemocyanin Shows Phenoloxidase Activity* , 1998, The Journal of Biological Chemistry.

[62]  S. Y. Lee,et al.  In vitro activation of pro-phenol-oxidase by two kinds of pro-phenol-oxidase-activating factors isolated from hemolymph of coleopteran, Holotrichia diomphalia larvae. , 1998, European journal of biochemistry.

[63]  P. Brey,et al.  Molecular cloning and chromosomal localization of a prophenoloxidase cDNA from the malaria vector Anopheles gambiae , 1998, Insect molecular biology.

[64]  Haobo Jiang,et al.  Molecular cloning of cDNAs for two pro-phenol oxidase subunits from the malaria vector, Anopheles gambiae. , 1997, Insect biochemistry and molecular biology.

[65]  M. Ashida.  Recent advances in research on the insect prophenoloxidase cascade , 1997 .

[66]  N. Chosa,et al.  Activation of prophenoloxidase A1 by an activating enzyme in Drosophila melanogaster. , 1997, Insect biochemistry and molecular biology.

[67]  E. Solomon,et al.  Multicopper Oxidases and Oxygenases. , 1996, Chemical reviews.

[68]  J. H. Law,et al.  Proenzyme of Manduca sexta phenol oxidase: purification, activation, substrate specificity of the active enzyme, and molecular cloning. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[69]  M. Ochiai,et al.  Molecular cloning of insect pro-phenol oxidase: a copper-containing protein homologous to arthropod hemocyanin. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[70]  J N Rodríguez-López,et al.  Tyrosinase: a comprehensive review of its mechanism. , 1995, Biochimica et biophysica acta.

[71]  T. Huang,et al.  cDNA cloning of prophenoloxidase from the freshwater crayfish Pacifastacus leniusculus and its activation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[72]  Bart Hazes,et al.  Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences , 1994, Proteins.

[73]  N. Asada,et al.  Activation of prophenoloxidase with 2-propanol and other organic compounds in Drosophila melanogaster. , 1993, Insect biochemistry and molecular biology.

[74]  W G Hol,et al.  Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. , 1994, Journal of molecular biology.

[75]  C. Mangum.  Oxygen transport in invertebrates. , 1985, The American journal of physiology.

[76]  H. Duckworth,et al.  Physicochemical and kinetic properties of mushroom tyrosinase. , 1970, The Journal of biological chemistry.