Fluids and their mechanics in tumour transit: shaping metastasis

[1]  Joel S. Bader,et al.  E-cadherin is required for metastasis in multiple models of breast cancer , 2019, Nature.

[2]  S. Harlepp,et al.  Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest. , 2019, Cell reports.

[3]  C. Curtis,et al.  Quantitative evidence for early metastatic seeding in colorectal cancer , 2019, Nature Genetics.

[4]  Jessica E. Rosenkrantz,et al.  Multivascular networks and functional intravascular topologies within biocompatible hydrogels , 2019, Science.

[5]  R. Weinberg,et al.  EMT and Cancer: More Than Meets the Eye. , 2019, Developmental cell.

[6]  Xin Tang,et al.  Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow. , 2019, Biophysical journal.

[7]  Eric O Long,et al.  CD28 Homolog Is a Strong Activator of Natural Killer Cells for Lysis of B7H7+ Tumor Cells , 2019, Cancer Immunology Research.

[8]  L. Santambrogio,et al.  Correction: Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation , 2019, The Journal of experimental medicine.

[9]  L. Santambrogio,et al.  Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation , 2019, The Journal of experimental medicine.

[10]  M. Swartz,et al.  Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients , 2019, The Journal of experimental medicine.

[11]  J. Massagué,et al.  Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization , 2019, eLife.

[12]  F. Delalande,et al.  Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo. , 2019, Developmental cell.

[13]  S. Noguchi,et al.  Drainage of Tumor-Derived DNA into Sentinel Lymph Nodes in Breast Cancer Patients , 2019, Pathology & Oncology Research.

[14]  K. Pantel,et al.  Liquid biopsy and minimal residual disease — latest advances and implications for cure , 2019, Nature Reviews Clinical Oncology.

[15]  R. Jain,et al.  Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. , 2019, Annual review of physiology.

[16]  N. Beerenwinkel,et al.  Neutrophils escort circulating tumour cells to enable cell cycle progression , 2019, Nature.

[17]  P. Nelson,et al.  Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy , 2019, Nature Cell Biology.

[18]  Ashley V. Makela,et al.  Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis , 2019, Oncogene.

[19]  C. Yee,et al.  Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities , 2019, Breast Cancer Research.

[20]  F. Castro-Giner,et al.  Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding , 2019, Cell.

[21]  I. Abdulkader,et al.  CTCs‐derived xenograft development in a triple negative breast cancer case , 2018, International journal of cancer.

[22]  Yang Shen,et al.  Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models. , 2018, Cancer discovery.

[23]  J. Munson,et al.  Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model , 2018, Scientific Reports.

[24]  L. Montermini,et al.  Leukocytes as a reservoir of circulating oncogenic DNA and regulatory targets of tumor‐derived extracellular vesicles , 2018, Journal of thrombosis and haemostasis : JTH.

[25]  Sierin Lim,et al.  Fluidic shear stress increases the anti-cancer effects of ROS-generating drugs in circulating tumor cells , 2018, Breast Cancer Research and Treatment.

[26]  Tara A. Lee,et al.  Interstitial flow promotes macrophage polarization toward an M2 phenotype , 2018, Molecular biology of the cell.

[27]  Dietmar W. Hutmacher,et al.  Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone , 2018, Science Translational Medicine.

[28]  Filippo Del Bene,et al.  Live tracking of inter-organ communication by endogenous exosomes in vivo , 2018, bioRxiv.

[29]  M. Davies,et al.  Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs. , 2018, Cancer research.

[30]  Hellyeh Hamidi,et al.  Every step of the way: integrins in cancer progression and metastasis , 2018, Nature Reviews Cancer.

[31]  Yousuf H. Mohammed,et al.  Removing physiological motion from intravital and clinical functional imaging data , 2018, eLife.

[32]  E. Sahai,et al.  Mechanisms and impact of altered tumour mechanics , 2018, Nature Cell Biology.

[33]  P. Paul-Gilloteaux,et al.  LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration , 2018, Nature Communications.

[34]  R. Hynes,et al.  Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation , 2018, Proceedings of the National Academy of Sciences.

[35]  K. Hahn,et al.  STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap , 2018, Nature Communications.

[36]  J. Pollard,et al.  A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation , 2018, Cell reports.

[37]  Triantafyllos Stylianopoulos,et al.  Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. , 2018, Trends in cancer.

[38]  Z. Bago-Horvath,et al.  Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice , 2018, Science.

[39]  Eelco F. J. Meijer,et al.  Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice , 2018, Science.

[40]  André M. N. Silva,et al.  Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation , 2018, Nature Cell Biology.

[41]  V. Weaver,et al.  Feeling Stress: The Mechanics of Cancer Progression and Aggression , 2018, Front. Cell Dev. Biol..

[42]  T. Padera,et al.  Growth and Immune Evasion of Lymph Node Metastasis , 2018, Front. Oncol..

[43]  H. Lee,et al.  TAZ responds to fluid shear stress to regulate the cell cycle , 2018, Cell cycle.

[44]  Ian A. Swinburne,et al.  Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms , 2018, Science.

[45]  M. King,et al.  Effect of circulating tumor cell aggregate configuration on hemodynamic transport and wall contact. , 2017, Mathematical biosciences.

[46]  J. Condeelis,et al.  A permanent window for the murine lung enables high-resolution imaging of cancer metastasis , 2017, Nature Methods.

[47]  V. Weaver,et al.  Tissue Force Programs Cell Fate and Tumor Aggression. , 2017, Cancer discovery.

[48]  K. Gray,et al.  Vascular endothelial cell mechanosensing: New insights gained from biomimetic microfluidic models. , 2017, Seminars in cell & developmental biology.

[49]  R. Jain,et al.  Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy , 2017, Science Translational Medicine.

[50]  Sean C Warren,et al.  A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts. , 2017, Cell reports.

[51]  Stefan Offermanns,et al.  Intravascular Survival and Extravasation of Tumor Cells. , 2017, Cancer cell.

[52]  N. Paul,et al.  Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells , 2017, bioRxiv.

[53]  Stephen T. C. Wong,et al.  Platelets reduce anoikis and promote metastasis by activating YAP1 signaling , 2017, Nature Communications.

[54]  T. Petrova,et al.  Microenvironmental regulation of tumour angiogenesis , 2017, Nature Reviews Cancer.

[55]  Shin-Lei Peng,et al.  Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI , 2017, Scientific Reports.

[56]  Johannes G. Reiter,et al.  Origins of lymphatic and distant metastases in human colorectal cancer , 2017, Science.

[57]  S. Puig,et al.  Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine , 2017, Nature.

[58]  M. Verma,et al.  Detecting circulating tumor material and digital pathology imaging during pancreatic cancer progression , 2017, World journal of gastrointestinal oncology.

[59]  S. Harlepp,et al.  Hemodynamic forces can be accurately measured in vivo with optical tweezers , 2017, bioRxiv.

[60]  A. Gesierich,et al.  Completion Dissection or Observation for Sentinel‐Node Metastasis in Melanoma , 2017, The New England journal of medicine.

[61]  R. Brink,et al.  In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors , 2017, Proceedings of the National Academy of Sciences.

[62]  Eran Sharon,et al.  Perioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial , 2017, Clinical Cancer Research.

[63]  Chris I. Jones,et al.  Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line , 2017, The Journal of Biological Chemistry.

[64]  D. Conway,et al.  A Protocol for Using Förster Resonance Energy Transfer (FRET)-force Biosensors to Measure Mechanical Forces across the Nuclear LINC Complex. , 2017, Journal of visualized experiments : JoVE.

[65]  Max Nobis,et al.  Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis , 2017, Science Translational Medicine.

[66]  Yang Liu,et al.  Effects of flowing RBCs on adhesion of a circulating tumor cell in microvessels , 2017, Biomechanics and modeling in mechanobiology.

[67]  W. Woodward,et al.  Inflammatory breast cancer: a model for investigating cluster-based dissemination , 2017, npj Breast Cancer.

[68]  Thomas R. Cox,et al.  Pre-metastatic niches: organ-specific homes for metastases , 2017, Nature Reviews Cancer.

[69]  A. Walch,et al.  Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis , 2017, PloS one.

[70]  Lei Chen,et al.  Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells , 2017, Oncotarget.

[71]  Sridhar Ramaswamy,et al.  Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination , 2017, Nature Communications.

[72]  T. Stylianopoulos The Solid Mechanics of Cancer and Strategies for Improved Therapy. , 2017, Journal of biomechanical engineering.

[73]  E. Sevick-Muraca,et al.  Fluid shear stress activates YAP1 to promote cancer cell motility , 2017, Nature Communications.

[74]  Kathy Qian Luo,et al.  High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System , 2017, Scientific Reports.

[75]  Edward Ryder,et al.  Genome-wide in vivo screen identifies novel host regulators of metastatic colonization , 2017, Nature.

[76]  A. Rowat,et al.  Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling , 2016, Journal of Cell Science.

[77]  Rainer Spang,et al.  Early dissemination seeds metastasis in breast cancer , 2016, Nature.

[78]  J. Condeelis,et al.  Mechanism of early dissemination and metastasis in Her2+ mammary cancer , 2016, Nature.

[79]  Giuseppe Antonacci,et al.  Biomechanics of subcellular structures by non-invasive Brillouin microscopy , 2016, Scientific Reports.

[80]  Xuetao Cao,et al.  Characteristics and Significance of the Pre-metastatic Niche. , 2016, Cancer cell.

[81]  Crispin J. Miller,et al.  Vasculogenic mimicry in small cell lung cancer , 2016, Nature Communications.

[82]  Qi Zhang,et al.  Circulating tumor cell clusters: What we know and what we expect (Review) , 2016, International journal of oncology.

[83]  L. Goertz,et al.  Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis , 2016, Oncotarget.

[84]  M. Pasparakis,et al.  Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis , 2016, Nature.

[85]  Brett E. Bouma,et al.  In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography , 2016, Scientific Reports.

[86]  E. Tan,et al.  High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin , 2016, Oncotarget.

[87]  N. Dhomen,et al.  Application of sequencing, liquid biopsies and patient-derived xenografts for personalized medicine in melanoma , 2016 .

[88]  T. Michiue,et al.  Wide and high resolution tension measurement using FRET in embryo , 2016, Scientific Reports.

[89]  T. Stylianopoulos,et al.  Biphasic modeling of brain tumor biomechanics and response to radiation treatment. , 2016, Journal of biomechanics.

[90]  Travis S. Emery,et al.  Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells , 2016, Scientific Reports.

[91]  C. McCall,et al.  Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone , 2016, Science Translational Medicine.

[92]  D. Ricard,et al.  Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma , 2016, Oncogene.

[93]  Mehmet Toner,et al.  Clusters of circulating tumor cells traverse capillary-sized vessels , 2016, Proceedings of the National Academy of Sciences.

[94]  F. Vannberg,et al.  Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node , 2016, Scientific Reports.

[95]  Jan Lammerding,et al.  Nuclear envelope rupture and repair during cancer cell migration , 2016, Science.

[96]  R. Voituriez,et al.  ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death , 2016, Science.

[97]  Melissa M. Sprachman,et al.  SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions , 2016, Science.

[98]  M. Headley,et al.  Visualization of immediate immune responses to pioneer metastatic cells in the lung , 2016, Nature.

[99]  A. van Oudenaarden,et al.  Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity , 2016, Cell reports.

[100]  N. Dhomen,et al.  Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma. , 2016, Cancer discovery.

[101]  D. Ferrari,et al.  Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination , 2016, Nature Communications.

[102]  James E. Verdone,et al.  Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters , 2016, Proceedings of the National Academy of Sciences.

[103]  J. Massagué,et al.  Metastatic colonization by circulating tumour cells , 2016, Nature.

[104]  Christopher A. Lemmon,et al.  Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension. , 2016, Biophysical journal.

[105]  Shereen R Kadir,et al.  Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue , 2015, Cell reports.

[106]  Yohsuke Imai,et al.  Flow of a circulating tumor cell and red blood cells in microvessels. , 2015, Physical review. E, Statistical, nonlinear, and soft matter physics.

[107]  J. Lammerding,et al.  Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. , 2015, American journal of physiology. Cell physiology.

[108]  R. Datar,et al.  Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer. , 2015, Cancer research.

[109]  Mingming Wu,et al.  Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model. , 2015, Integrative biology : quantitative biosciences from nano to macro.

[110]  C. Dive,et al.  Development of a circulating miRNA assay to monitor tumor burden: From mouse to man , 2015, Molecular oncology.

[111]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[112]  D. Vestweber How leukocytes cross the vascular endothelium , 2015, Nature Reviews Immunology.

[113]  B. Goud,et al.  Integrin endosomal signalling suppresses anoikis , 2015, Nature Cell Biology.

[114]  R. Deberardinis,et al.  Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.

[115]  L. J. Liu,et al.  Interstitial hydraulic conductivity and interstitial fluid pressure for avascular or poorly vascularized tumors. , 2015, Journal of theoretical biology.

[116]  B. Fabry,et al.  Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness. , 2015, Biophysical journal.

[117]  Yarong Wang,et al.  Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. , 2015, Cancer discovery.

[118]  P. Hordijk,et al.  Cell-stiffness-induced mechanosignaling – a key driver of leukocyte transendothelial migration , 2015, Journal of Cell Science.

[119]  Prahlad T. Ram,et al.  The ZNF304-integrin axis protects against anoikis in cancer , 2015, Nature Communications.

[120]  R. Linding,et al.  The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase , 2015, Nature.

[121]  Jacco van Rheenen,et al.  In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior , 2015, Cell.

[122]  Michael A. Hollingsworth,et al.  Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver , 2015, Nature Cell Biology.

[123]  Peter Kuhn,et al.  A physical sciences network characterization of circulating tumor cell aggregate transport. , 2015, American journal of physiology. Cell physiology.

[124]  J. Utikal,et al.  von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. , 2015, Blood.

[125]  K. Barbee,et al.  An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion. , 2015, Integrative biology : quantitative biosciences from nano to macro.

[126]  Andrew D. Wong,et al.  Human brain microvascular endothelial cells resist elongation due to shear stress. , 2015, Microvascular research.

[127]  H. Yao,et al.  Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy* , 2015, The Journal of Biological Chemistry.

[128]  Kaamran Raahemifar,et al.  Effect of Fluid Friction on Interstitial Fluid Flow Coupled with Blood Flow through Solid Tumor Microvascular Network , 2015, Comput. Math. Methods Medicine.

[129]  Yusuke Yoshioka,et al.  Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier , 2015, Nature Communications.

[130]  M. Detmar,et al.  Intravital and Whole-Organ Imaging Reveals Capture of Melanoma-Derived Antigen by Lymph Node Subcapsular Macrophages Leading to Widespread Deposition on Follicular Dendritic Cells , 2015, Front. Immunol..

[131]  O. McCarty,et al.  The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation. , 2015, American journal of physiology. Cell physiology.

[132]  Hideo Saji,et al.  Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. , 2015, Journal of pharmaceutical sciences.

[133]  Yuki Takahashi,et al.  Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice , 2015, Journal of extracellular vesicles.

[134]  Silvia Caponi,et al.  Biomechanics of fibrous proteins of the extracellular matrix studied by Brillouin scattering , 2014, Journal of The Royal Society Interface.

[135]  Ben S. Wittner,et al.  Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells , 2014, Cell reports.

[136]  Amy E. Robertson,et al.  Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. , 2014, Cell reports.

[137]  M. Davidson,et al.  Direct observation of α-actinin tension and recruitment at focal adhesions during contact growth. , 2014, Experimental cell research.

[138]  Sridhar Ramaswamy,et al.  Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis , 2014, Cell.

[139]  R. Hynes,et al.  Platelets guide the formation of early metastatic niches , 2014, Proceedings of the National Academy of Sciences.

[140]  R. Jain,et al.  The role of mechanical forces in tumor growth and therapy. , 2014, Annual review of biomedical engineering.

[141]  Mahmood Ayub,et al.  Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer , 2014, Nature Medicine.

[142]  O. Weisz,et al.  Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia , 2014, Proceedings of the National Academy of Sciences.

[143]  Gaudenz Danuser,et al.  Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration , 2014, Cell.

[144]  Gerhard Gompper,et al.  Margination of micro- and nano-particles in blood flow and its effect on drug delivery , 2014, Scientific Reports.

[145]  Max Nobis,et al.  The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues , 2014, Cell reports.

[146]  D. Goldstein,et al.  Role of pancreatic stellate cells in chemoresistance in pancreatic cancer , 2014, Front. Physiol..

[147]  Samy Lamouille,et al.  Molecular mechanisms of epithelial–mesenchymal transition , 2014, Nature Reviews Molecular Cell Biology.

[148]  S. Stacker,et al.  Lymphangiogenesis and lymphatic vessel remodelling in cancer , 2014, Nature Reviews Cancer.

[149]  D. Ingber,et al.  Mechanotransduction of fluid stresses governs 3D cell migration , 2014, Proceedings of the National Academy of Sciences.

[150]  N Stone,et al.  Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy. , 2014, The Analyst.

[151]  P. Crocker,et al.  CD169 mediates the capture of exosomes in spleen and lymph node. , 2014, Blood.

[152]  Jonathan B. Freund,et al.  Numerical Simulation of Flowing Blood Cells , 2014 .

[153]  Shun-Fu Chang,et al.  Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK. , 2013, Biochimica et biophysica acta.

[154]  Theodore F. Towse,et al.  Clinical feasibility of noninvasive visualization of lymphatic flow with principles of spin labeling MR imaging: implications for lymphedema assessment. , 2013, Radiology.

[155]  A. Ridley,et al.  Crossing the endothelial barrier during metastasis , 2013, Nature Reviews Cancer.

[156]  M. Liebling,et al.  Pulse propagation by a capacitive mechanism drives embryonic blood flow , 2013, Development.

[157]  Rakesh K. Jain,et al.  Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels , 2013, Nature Communications.

[158]  R. Kamm,et al.  Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[159]  Robert A. Weinberg,et al.  Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity , 2013, Cell.

[160]  Enrico Gratton,et al.  Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1 , 2013, Current Biology.

[161]  Mina J. Bissell,et al.  The perivascular niche regulates breast tumor dormancy , 2013, Nature Cell Biology.

[162]  Savas Tasoglu,et al.  Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules , 2013, Proceedings of the National Academy of Sciences.

[163]  Tim Holland-Letz,et al.  Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay , 2013, Nature Biotechnology.

[164]  Andrés J. García,et al.  Cyclic mechanical reinforcement of integrin-ligand interactions. , 2013, Molecular cell.

[165]  M. King,et al.  Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress , 2013, Front. Oncol..

[166]  Sridhar Ramaswamy,et al.  Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition , 2013, Science.

[167]  Michael Sixt,et al.  Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients , 2013, Science.

[168]  M. King,et al.  Fluid shear stress sensitizes cancer cells to receptor-mediated apoptosis via trimeric death receptors , 2013, New journal of physics.

[169]  P. Koumoutsakos,et al.  The Fluid Mechanics of Cancer and Its Therapy , 2013 .

[170]  Michael D. Henry,et al.  Resistance to Fluid Shear Stress Is a Conserved Biophysical Property of Malignant Cells , 2012, PloS one.

[171]  R. Alon,et al.  Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts. , 2012, Current opinion in cell biology.

[172]  F. Sachs,et al.  Interplay between Cytoskeletal Stresses and Cell Adaptation under Chronic Flow , 2012, PloS one.

[173]  Katarzyna A. Rejniak,et al.  Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model , 2012, Front. Oncol..

[174]  E. Kanso,et al.  Modeling and Simulation of Procoagulant Circulating Tumor Cells in Flow , 2012, Front. Oncol..

[175]  Triantafyllos Stylianopoulos,et al.  Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors , 2012, Proceedings of the National Academy of Sciences.

[176]  Paul Kubes,et al.  Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. , 2012, Cancer research.

[177]  Brendon M. Baker,et al.  Rapid casting of patterned vascular networks for perfusable engineered 3D tissues , 2012, Nature materials.

[178]  Gema Moreno-Bueno,et al.  Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.

[179]  Carlos Cuevas,et al.  Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[180]  M. Swartz,et al.  Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity , 2012, Nature Reviews Cancer.

[181]  Silvia Muro,et al.  Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[182]  Maximilian Reichert,et al.  EMT and Dissemination Precede Pancreatic Tumor Formation , 2012, Cell.

[183]  E. Kikuchi,et al.  Prognonstic impact of renin-angiotensin system blockade in localised upper-tract urothelial carcinoma , 2011, British Journal of Cancer.

[184]  S. Dorsey,et al.  From Mouse to Man , 2011, Annual Review of Nursing Research.

[185]  K. Pantel,et al.  Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ , 2011, International journal of cancer.

[186]  Richard O Hynes,et al.  Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. , 2011, Cancer cell.

[187]  K. Salaita,et al.  Visualizing mechanical tension across membrane receptors with a fluorescent sensor , 2011, Nature Methods.

[188]  Robert A. Weinberg,et al.  Tumor Metastasis: Molecular Insights and Evolving Paradigms , 2011, Cell.

[189]  T. Ishikawa,et al.  Inertial migration of cancer cells in blood flow in microchannels , 2011, Biomedical Microdevices.

[190]  S. Chien,et al.  Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. , 2011, Nature communications.

[191]  Denis Wirtz,et al.  The physics of cancer: the role of physical interactions and mechanical forces in metastasis , 2011, Nature Reviews Cancer.

[192]  William J. Polacheck,et al.  Interstitial flow influences direction of tumor cell migration through competing mechanisms , 2011, Proceedings of the National Academy of Sciences.

[193]  S. Wickline,et al.  Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. , 2011, Cancer research.

[194]  John M. Tarbell,et al.  Fluid Shear Stress Regulates the Invasive Potential of Glioma Cells via Modulation of Migratory Activity and Matrix Metalloproteinase Expression , 2011, PloS one.

[195]  John M. Tarbell,et al.  Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts , 2011, Annals of Biomedical Engineering.

[196]  Efstathios Karathanasis,et al.  The effects of particle size, density and shape on margination of nanoparticles in microcirculation , 2011, Nanotechnology.

[197]  R. Jain,et al.  Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation , 2011, Proceedings of the National Academy of Sciences.

[198]  C. Holmes,et al.  The platelet contribution to cancer progression , 2011, Journal of thrombosis and haemostasis : JTH.

[199]  R. Jain,et al.  Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors , 2011, Proceedings of the National Academy of Sciences.

[200]  F. Sachs,et al.  Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor , 2011, Journal of Cell Science.

[201]  Dai Fukumura,et al.  Malignant cells facilitate lung metastasis by bringing their own soil , 2010, Proceedings of the National Academy of Sciences.

[202]  J. Levick,et al.  Microvascular fluid exchange and the revised Starling principle. , 2010, Cardiovascular research.

[203]  Jing Yang,et al.  Visualizing extravasation dynamics of metastatic tumor cells , 2010, Journal of Cell Science.

[204]  Carson K. Lam,et al.  Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization , 2010, Nature.

[205]  B. Nieswandt,et al.  Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. , 2010, The Journal of investigative dermatology.

[206]  S. Guido,et al.  Microconfined flow behavior of red blood cells in vitro , 2009 .

[207]  M. Rubin,et al.  Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. , 2009, Cancer research.

[208]  D. Tarin,et al.  Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression , 2009, Nature Medicine.

[209]  S. T. Mees,et al.  Metastatic tumor cell arrest in the liver–lumen occlusion and specific adhesion are not exclusive , 2009, International Journal of Colorectal Disease.

[210]  Valerie M. Weaver,et al.  A tense situation: forcing tumour progression , 2009, Nature Reviews Cancer.

[211]  M. Frame,et al.  Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. , 2009, Chemistry & biology.

[212]  Merryn H. Tawhai,et al.  Modelling pulmonary blood flow , 2008, Respiratory Physiology & Neurobiology.

[213]  Eric Leung,et al.  Interstitial permeability and elasticity in human cervix cancer. , 2008, Microvascular research.

[214]  Petra Krystek,et al.  Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. , 2008, Biomaterials.

[215]  S. Chien,et al.  Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad , 2008, Proceedings of the National Academy of Sciences.

[216]  Arnold P. G. Hoeks,et al.  Wall shear stress as measured in vivo: consequences for the design of the arterial system , 2008, Medical & Biological Engineering & Computing.

[217]  R. Eils,et al.  Systemic spread is an early step in breast cancer. , 2008, Cancer cell.

[218]  F. Entschladen,et al.  Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction , 2007, Cellular and Molecular Life Sciences.

[219]  S. L. Gonias,et al.  High-resolution imaging of the dynamic tumor cell–vascular interface in transparent zebrafish , 2007, Proceedings of the National Academy of Sciences.

[220]  France,et al.  Following red blood cells in a pulmonary capillary , 2007, 0710.5399.

[221]  M. Swartz,et al.  Interstitial flow and its effects in soft tissues. , 2007, Annual review of biomedical engineering.

[222]  Philip S Low,et al.  In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry , 2007, Proceedings of the National Academy of Sciences.

[223]  Melody A Swartz,et al.  Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. , 2007, Cancer cell.

[224]  Gerard L. Coté,et al.  Image Correlation Algorithm for Measuring Lymphocyte Velocity and Diameter Changes in Contracting Microlymphatics , 2007, Annals of Biomedical Engineering.

[225]  Gerard L Cote,et al.  Lymph Flow, Shear Stress, and Lymphocyte Velocity in Rat Mesenteric Prenodal Lymphatics , 2006, Microcirculation.

[226]  Richard T. Lee,et al.  Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics* , 2006, Journal of Biological Chemistry.

[227]  M. Neeman,et al.  Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype. , 2006, Cancer research.

[228]  R. Hynes,et al.  Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide? , 2006, Cell cycle.

[229]  S. Rafii,et al.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche , 2005, Nature.

[230]  W. Aird,et al.  Spatial and temporal dynamics of the endothelium , 2005, Journal of thrombosis and haemostasis : JTH.

[231]  Liang Hu,et al.  Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis. , 2004, Blood.

[232]  D. Peeper,et al.  Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB , 2004, Nature.

[233]  R. Jain,et al.  Endothelial Nitric Oxide Synthase Regulates Microlymphatic Flow via Collecting Lymphatics , 2004, Circulation research.

[234]  S. Nee More than meets the eye , 2004, Nature.

[235]  R. Jain,et al.  Solid stress generated by spheroid growth estimated using a linear poroelasticity model. , 2003, Microvascular research.

[236]  M. Matsuda,et al.  Activity of Rho-family GTPases during cell division as visualized with FRET-based probes , 2003, The Journal of cell biology.

[237]  S. Nathanson,et al.  Insights into the mechanisms of lymph node metastasis , 2003, Cancer.

[238]  Cheng Zhu,et al.  Direct observation of catch bonds involving cell-adhesion molecules , 2003, Nature.

[239]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[240]  W. Hatzmann,et al.  Realtime visualization of tumor cell/endothelial cell interactions during transmigration across the endothelial barrier , 2002, Journal of Cancer Research and Clinical Oncology.

[241]  M. Matsuda,et al.  Activation of Rac and Cdc42 Video Imaged by Fluorescent Resonance Energy Transfer-Based Single-Molecule Probes in the Membrane of Living Cells , 2002, Molecular and Cellular Biology.

[242]  R K Jain,et al.  Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[243]  I. Macdonald,et al.  Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. , 2000, Cancer research.

[244]  Klaus Ley,et al.  CD24 mediates rolling of breast carcinoma cells on P‐selectin , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[245]  K. Luzzi,et al.  Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. , 1998, The American journal of pathology.

[246]  L. Murray,et al.  Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? , 1998, The Lancet.

[247]  M. Terasaki,et al.  Large Plasma Membrane Disruptions Are Rapidly Resealed by Ca2+-dependent Vesicle–Vesicle Fusion Events , 1997, The Journal of cell biology.

[248]  G. Schmid-Schönbein,et al.  The leukocyte response to fluid stress. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[249]  R. Jain,et al.  Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors. , 1997, Microvascular research.

[250]  J D Briers,et al.  Laser speckle contrast analysis (LASCA): a nonscanning, full-field technique for monitoring capillary blood flow. , 1996, Journal of biomedical optics.

[251]  R. C. Johnson,et al.  Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[252]  K. Kärre Express yourself or die: peptides, MHC molecules, and NK cells. , 1995, Science.

[253]  R K Jain,et al.  Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[254]  K. Matre,et al.  Blood velocity distribution in the human ascending aorta. , 1987, Circulation.

[255]  M. Hennerici,et al.  Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity--Part 1. Examination technique and normal values. , 1987, Surgical neurology.

[256]  T Takishima,et al.  Phasic Blood Flow Velocity Pattern in Epimyocardial Microvessels in the Beating Canine Left Ventricle , 1986, Circulation research.

[257]  N L Browse,et al.  Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study. , 1986, Stroke.

[258]  P Bongrand,et al.  Cell adhesion. Competition between nonspecific repulsion and specific bonding. , 1984, Biophysical journal.

[259]  R. Aaslid,et al.  Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. , 1982, Journal of neurosurgery.

[260]  Ivanov Kp,et al.  Blood flow velocity in capillaries of brain and muscles and its physiological significance , 1981 .

[261]  G. I. Bell A theoretical model for adhesion between cells mediated by multivalent ligands , 1979, Cell Biochemistry and Biophysics.

[262]  E. Bernstein,et al.  Quantitative Ultrasonographic Studies of Lower Extremity Flow Velocities in Health and Disease , 1976, Circulation.

[263]  M Intaglietta,et al.  Capillary flow velocity measurements in vivo and in situ by television methods. , 1975, Microvascular research.

[264]  J. D. Coffman,et al.  Venous Flow Velocity, Venous Volume and Arterial Blood Flow , 1975, Circulation.

[265]  R. Startup Migration , 1970, Encyclopedic Dictionary of Archaeology.

[266]  M. Brookes Arteriolar blockade: a method of measuring blood flow rates in the skeleton. , 1970, Journal of anatomy.

[267]  C. Stewart,et al.  Antimetastatic effects associated with platelet reduction. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[268]  A. C. Burton,et al.  The physics of blood flood in capillaries. II. The capillary resistance to flow. , 1962, Biophysical journal.

[269]  A. C. Burton,et al.  The physics of blood flow in capillaries. III. The pressure required to deform erythrocytes in acid-citrate-dextrose. , 1962, Biophysical journal.

[270]  A C BURTON,et al.  The physics of blood flow in capillaries. I. The nature of the motion. , 1961, Biophysical journal.

[271]  Mohamed Badawy,et al.  A Validation Study , 2020 .

[272]  G. Gundersen,et al.  The LINC Complex , 2018, Methods in Molecular Biology.

[273]  D. Conway,et al.  Using Nesprin Tension Sensors to Measure Force on the LINC Complex. , 2018, Methods in molecular biology.

[274]  Katarzyna A Rejniak,et al.  Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment. , 2016, Advances in experimental medicine and biology.

[275]  D. Haber,et al.  Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity. , 2016, Cold Spring Harbor symposia on quantitative biology.

[276]  Yuri V. Vassilevski,et al.  Methods of blood flow modelling , 2016 .

[277]  R. Matkowski,et al.  Circulating Tumor , 2014 .

[278]  Hanlin Gao,et al.  UC Office of the President Recent Work Title Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis , 2014 .

[279]  Brendon M. Baker,et al.  Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues , 2012 .

[280]  A. Sood,et al.  Cancer esearch oenvironment and Immunology Sympathetic Nervous System Induces a Metastatic R tch in Primary Breast Cancer , 2010 .

[281]  Jochen Herms,et al.  Real-time imaging reveals the single steps of brain metastasis formation , 2010, Nature Medicine.

[282]  S. Goodman,et al.  Circulating mutant DNA to assess tumor dynamics , 2008, Nature Medicine.

[283]  L. Liotta,et al.  Endothelialization of embolized tumor cells during metastasis formation , 2005, Clinical & Experimental Metastasis.

[284]  I. Macdonald,et al.  Metastasis: Dissemination and growth of cancer cells in metastatic sites , 2002, Nature Reviews Cancer.

[285]  A. Al-Mehdi,et al.  Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis , 2000, Nature Medicine.

[286]  R K Jain,et al.  Transport of molecules, particles, and cells in solid tumors. , 1999, Annual review of biomedical engineering.

[287]  D. Ku BLOOD FLOW IN ARTERIES , 1997 .

[288]  R K Jain,et al.  Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. , 1989, Microvascular research.

[289]  T. Togawa,et al.  Adaptive regulation of wall shear stress optimizing vascular tree function. , 1984, Bulletin of mathematical biology.

[290]  L. Weiss,et al.  Metastatic patterns and target organ arterial blood flow. , 1981, Invasion & metastasis.

[291]  Levkovich YuI,et al.  Blood flow velocity in capillaries of brain and muscles and its physiological significance. , 1981, Microvascular research.