A novel Colony Stimulating Factor 3 Receptor activating mutation identified in a patient with chronic neutrophilic leukemia

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[1]  B. Druker,et al.  Mutant-SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms , 2021, bioRxiv.

[2]  Philipp W. Raess,et al.  Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  O. Abdel-Wahab,et al.  A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia. , 2018, Cancer research.

[4]  K. Komurov,et al.  Enhanced MAPK signaling is essential for CSF3R induced leukemia , 2016, Leukemia.

[5]  Jason E. Farrar,et al.  CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML. , 2016, Blood.

[6]  G. Boucher,et al.  Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. , 2016, Blood.

[7]  B. Druker,et al.  Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor Dimerization* , 2014, The Journal of Biological Chemistry.

[8]  T. George,et al.  The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment. , 2013, Blood.

[9]  Angela G. Fleischman,et al.  Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. , 2013, The New England journal of medicine.

[10]  R. Beekman,et al.  Prevalence of a new auto-activating colony stimulating factor 3 receptor mutation (CSF3R-T595I) in acute myeloid leukemia and severe congenital neutropenia , 2013, Haematologica.

[11]  J. Tyner,et al.  CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia , 2013, Leukemia.

[12]  R. Beekman,et al.  Granulocyte colony-stimulating factor receptor signaling: implications for G-CSF responses and leukemic progression in severe congenital neutropenia. , 2013, Hematology/oncology clinics of North America.

[13]  W. Vainchenker,et al.  An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia , 2009, The Journal of experimental medicine.

[14]  K. Welte,et al.  Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. , 1995, The New England journal of medicine.