Trajectory control of PbSe–γ-Fe2O3 nanoplatforms under viscous flow and an external magnetic field

The flow behavior of nanostructure clusters, consisting of chemically bonded PbSe quantum dots and magnetic gamma-Fe(2)O(3) nanoparticles, has been investigated. The clusters are regarded as model nanoplatforms with multiple functionalities, where the gamma-Fe(2)O(3) magnets serve as transport vehicles, manipulated by an external magnetic field gradient, and the quantum dots act as fluorescence tags within an optical window in the near-infrared regime. The clusters' flow was characterized by visualizing their trajectories within a viscous fluid (mimicking a blood stream), using an optical imaging method, while the trajectory pictures were analyzed by a specially developed processing package. The trajectories were examined under various flow rates, viscosities and applied magnetic field strengths. The results revealed a control of the trajectories even at low magnetic fields (<1 T), validating the use of similar nanoplatforms as active targeting constituents in personalized medicine.

[1]  G. Batchelor,et al.  An Introduction to Fluid Dynamics , 1968 .

[2]  R. Molday,et al.  Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells. , 1982, Journal of immunological methods.

[3]  Y. Bar-Shalom.  Tracking and data association , 1988 .

[4]  K. Prince,et al.  Band structure of lead sulphide , 1992 .

[5]  P. Jacobs,et al.  Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. , 1995, Magnetic resonance imaging.

[6]  K. Raj,et al.  Advances in ferrofluid technology , 1995 .

[7]  J. Popplewell,et al.  The dependence of the physical and magnetic properties of magnetic fluids on particle size , 1995 .

[8]  A. Alivisatos.  Perspectives on the Physical Chemistry of Semiconductor Nanocrystals , 1996 .

[9]  Cherie R. Kagan,et al.  Long-range resonance transfer of electronic excitations in close-packed CdSe quantum-dot solids. , 1996, Physical review. B, Condensed matter.

[10]  Maciej Zborowski,et al.  An instrument to determine the magnetophoretic mobility of labeled, biological cells and paramagnetic particles , 1999 .

[11]  Andrey A. Lipovskii,et al.  Anisotropy-induced optical transitions in PbSe and PbS spherical quantum dots , 1999 .

[12]  B. V. Bronk,et al.  A review of molecular recognition technologies for detection of biological threat agents. , 2000, Biosensors & bioelectronics.

[13]  S. Margel,et al.  Theoretical and experimental analysis of the accuracy and reproducibility of cell tracking velocimetry , 2001 .

[14]  P. Guyot-Sionnest,et al.  Interband and Intraband Optical Studies of PbSe Colloidal Quantum Dots , 2002 .

[15]  Frank W. Wise,et al.  Optical Properties of Colloidal PbSe Nanocrystals , 2002 .

[16]  Klaus Ley,et al.  Automatic tracking of rolling leukocytes in vivo. , 2002, Microvascular research.

[17]  Nikolai Gaponik,et al.  Labeling of Biocompatible Polymer Microcapsules with Near-Infrared Emitting Nanocrystals , 2003 .

[18]  V. Bulović,et al.  1.3 μm to 1.55 μm Tunable Electroluminescence from PbSe Quantum Dots Embedded within an Organic Device , 2003 .

[19]  Gary Friedman,et al.  An approach to targeted drug delivery based on uniform magnetic fields , 2003 .

[20]  G. Stucky,et al.  Cooperative Assembly of Magnetic Nanoparticles and Block Copolypeptides in Aqueous Media , 2003 .

[21]  Maciej Zborowski,et al.  Red blood cell magnetophoresis. , 2003, Biophysical journal.

[22]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[23]  R. Schaller,et al.  High efficiency carrier multiplication in PbSe nanocrystals: implications for solar energy conversion. , 2004, Physical review letters.

[24]  Vicki L. Colvin,et al.  Preparation and Characterization of Monodisperse PbSe Semiconductor Nanocrystals in a Noncoordinating Solvent , 2004 .

[25]  Igor L. Medintz,et al.  Quantum dot bioconjugates for imaging, labelling and sensing , 2005, Nature materials.

[26]  E. Sargent.  Infrared Quantum Dots , 2005 .

[27]  Richard O. Claus,et al.  Synthesis, characterization and targeting of biodegradable magnetic nanocomposite particles by external magnetic fields , 2005 .

[28]  Maya Brumer,et al.  PbSe/PbS and PbSe/PbSexS1–x Core/Shell Nanocrystals , 2005 .

[29]  S. Margel,et al.  Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions. , 2005, The Analyst.

[30]  J. Dobson.  Magnetic nanoparticles for drug delivery , 2006 .

[31]  D. Das,et al.  Temperature dependent rheological property of copper oxide nanoparticles suspension (nanofluid). , 2006, Journal of nanoscience and nanotechnology.

[32]  E P Furlani,et al.  Analytical model of magnetic nanoparticle transport and capture in the microvasculature. , 2006, Physical review. E, Statistical, nonlinear, and soft matter physics.

[33]  Shuming Nie,et al.  Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. , 2006, Nanomedicine.

[34]  A. Q. Le Quang,et al.  Air-stable PbSe/PbS and PbSe/PbSexS1-x core-shell nanocrystal quantum dots and their applications. , 2006, The journal of physical chemistry. B.

[35]  Paul W. Fieguth,et al.  Probabilistic Model-Based Cell Tracking , 2006, Int. J. Biomed. Imaging.

[36]  V. Rotello,et al.  Surface modification using cubic silsesquioxane ligands. Facile synthesis of water-soluble metal oxide nanoparticles , 2006 .

[37]  Jean-Marie Devoisselle,et al.  Magnetic nanoparticles and their applications in medicine. , 2006, Nanomedicine.

[38]  L. Etgar,et al.  Hierarchical Conjugate Structure of γ-Fe2O3 Nanoparticles and PbSe Quantum Dots for Biological Applications , 2007 .

[39]  B. Wilson,et al.  Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation , 2007, Proceedings of the National Academy of Sciences.

[40]  Mathias Hoehn,et al.  Cell tracking using magnetic resonance imaging , 2007, The Journal of physiology.

[41]  Oliver T. Bruns,et al.  Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents. , 2007, Nano letters.

[42]  Petros Koumoutsakos,et al.  A novel supervised trajectory segmentation algorithm identifies distinct types of human adenovirus motion in host cells. , 2007, Journal of structural biology.

[43]  Namrata Vaswani,et al.  IEEE TRANSACTIONS ON IMAGE PROCESSING 1 A Generic Framework for Tracking using Particle Filter with Dynamic Shape Prior , 2022 .

[44]  K. Jain,et al.  Cancer biomarkers: current issues and future directions. , 2007, Current opinion in molecular therapeutics.

[45]  E. P. Furlani,et al.  A model for predicting magnetic targeting of multifunctional particles in the microvasculature , 2006, physics/0612116.

[46]  W. Cai,et al.  Monodisperse water-soluble magnetite nanoparticles prepared by polyol process for high-performance magnetic resonance imaging. , 2007, Chemical communications.

[47]  Thomas J. Meade,et al.  Multimodal MRI contrast agents , 2007, JBIC Journal of Biological Inorganic Chemistry.

[48]  A. Safavy,et al.  Design and development of water-soluble curcumin conjugates as potential anticancer agents. , 2007, Journal of medicinal chemistry.

[49]  H. Gronemeyer,et al.  A new era of cancer therapy: cancer cell targeted therapies are coming of age. , 2008, The international journal of biochemistry & cell biology.

[50]  Oleg V. Michailovich,et al.  Dynamic Denoising of Tracking Sequences , 2008, IEEE Transactions on Image Processing.

[51]  Yang Zhao,et al.  Differences in magnetically induced motion of diamagnetic, paramagnetic, and superparamagnetic microparticles detected by cell tracking velocimetry. , 2008, The Analyst.

[52]  R. Schaller,et al.  Scaling of multiexciton lifetimes in semiconductor nanocrystals , 2008 .

[53]  K K Jain,et al.  Recent Advances in Nanooncology , 2008, Technology in cancer research & treatment.

[54]  Taeghwan Hyeon,et al.  Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. , 2009, Chemical Society reviews.

[55]  L. Etgar,et al.  Optical and magnetic properties of conjugate structures of PbSe quantum dots and gamma-Fe(2)O(3) nanoparticles. , 2009, Chemphyschem : a European journal of chemical physics and physical chemistry.