An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast.

Abstract Explosive blast has been extensively used as a tactical weapon in Operation Iraqi Freedom (OIF) and more recently in Operation Enduring Freedom (OEF). The polytraumatic nature of blast inj...

[1]  I Cernak,et al.  Ultrastructural and functional characteristics of blast injury-induced neurotrauma. , 2001, The Journal of trauma.

[2]  Geoffrey T Manley,et al.  Controlled cortical impact in swine: pathophysiology and biomechanics. , 2006, Journal of neurotrauma.

[3]  Roger Hartl,et al.  Maintaining cerebral perfusion after polytrauma using arginine vasopressin: a classic drug revisited. , 2008, Critical care medicine.

[4]  E. Ling,et al.  The response of neurons and microglia to blast injury in the rat brain , 1995, Neuropathology and applied neurobiology.

[5]  Rachel P Berger,et al.  Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making , 2008, Current opinion in critical care.

[6]  Charles W Hoge,et al.  Mild traumatic brain injury in U.S. Soldiers returning from Iraq. , 2008, The New England journal of medicine.

[7]  M. MacIver,et al.  Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission. , 2005, Cerebral cortex.

[8]  William P Schecter,et al.  Blast lung injury: clinical manifestations, treatment, and outcome. , 2005, American journal of surgery.

[9]  Denes V Agoston,et al.  Proteomic biomarkers for blast neurotrauma: targeting cerebral edema, inflammation, and neuronal death cascades. , 2009, Journal of neurotrauma.

[10]  T F Massoud,et al.  Histopathologic characteristics of a chronic arteriovenous malformation in a swine model: preliminary study. , 2000, AJNR. American journal of neuroradiology.

[11]  Guy Rosenthal,et al.  Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation. , 2008, Journal of neurosurgery.

[12]  A. Suneson,et al.  Physiological changes in pigs exposed to a blast wave from a detonating high-explosive charge. , 2000, Military medicine.

[13]  S. Haj‐Yahia,et al.  Hypothermia at 10°C Reduces Neurologic Injury After Hypothermic Circulatory Arrest in the Pig , 2008, Journal of cardiac surgery.

[14]  E. Ling,et al.  Studies of the choroid plexus and its associated epiplexus cells in the lateral ventricles of rats following an exposure to a single non-penetrative blast. , 1996, Archives of histology and cytology.

[15]  G Lallement,et al.  Delta activity as an early indicator for soman-induced brain damage: a review. , 2001, Neurotoxicology.

[16]  Kazuyoshi Takayama,et al.  Pressure-dependent effect of shock waves on rat brain: induction of neuronal apoptosis mediated by a caspase-dependent pathway. , 2007, Journal of neurosurgery.

[17]  Ying-Lai Huang,et al.  Impulse noise transiently increased the permeability of nerve and glial cell membranes, an effect accentuated by a recent brain injury. , 2003, Journal of neurotrauma.

[18]  E. Ling,et al.  Ultrastructural changes of macroglial cells in the rat brain following an exposure to a non-penetrative blast. , 1997, Annals of the Academy of Medicine, Singapore.

[19]  Jan Harm Koolstra,et al.  Development of the Micro Architecture and Mineralization of the Basilar Part of the Pig Occipital Bone , 2008, Connective tissue research.

[20]  Nancy D Denslow,et al.  Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry , 2008, Journal of neurochemistry.

[21]  Susan S. Margulies,et al.  Neurobehavioral functional deficits following closed head injury in the neonatal pig , 2007, Experimental Neurology.

[22]  R. Bauman,et al.  Visual system degeneration induced by blast overpressure. , 1997, Toxicology.

[23]  I Cernak,et al.  Involvement of the central nervous system in the general response to pulmonary blast injury. , 1996, The Journal of trauma.

[24]  Peter J. Kirkpatrick,et al.  Continuous Assessment of Cerebral Autoregulation in Subarachnoid Hemorrhage , 2004, Anesthesia and analgesia.

[25]  F. Tortella,et al.  Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury , 2006, Journal of neurochemistry.

[26]  James Ecklund,et al.  WARTIME TRAUMATIC CEREBRAL VASOSPASM: RECENT REVIEW OF COMBAT CASUALTIES , 2006, Neurosurgery.

[27]  Bernd Walter,et al.  Stereotactic approach and electrophysiological characterization of thalamic reticular and dorsolateral nuclei of the juvenile pig. , 2006, Acta neurobiologiae experimentalis.

[28]  F. Snaps,et al.  Relevant radiological anatomy of the pig as a training model in interventional radiology , 1998, European Radiology.

[29]  Gary S. Settles,et al.  High-speed imaging of shock waves, explosions and gunshots , 2006 .

[30]  J. van Dommelen,et al.  The influence of test conditions on characterization of the mechanical properties of brain tissue. , 2008, Journal of biomechanical engineering.

[31]  Feng Bao,et al.  Exposure to short-lasting impulse noise causes neuronal c-Jun expression and induction of apoptosis in the adult rat brain. , 2002, Journal of neurotrauma.

[32]  Marc A de Moya,et al.  Cerebrovascular resuscitation after polytrauma and fluid restriction. , 2007, Journal of the American College of Surgeons.