论文信息 - Aprotinin reduces hypothermic mortality-an experimental model

Aprotinin reduces hypothermic mortality-an experimental model

In order to test the postulate that posthypothermic damage may be caused by protease activation, the effect of the administration of aprotinin on hypothermic mortality was investigated in anaesthetized rabbits. A group of 6 animals received 40.000 KIU aprotinin intravenously prior to the induction of hypothermia by surface cooling and this was followed by a further 35.000 KIU each hour for 5 h. The animals were cooled to 29°C and then rewarmed. A control group received equal volumes of physiological saline. The aprotinin treated animals survived, whereas all the control group died within 7 days, 5 of them within 24 h. The haemodynamic, biochemical and haematological changes in the two groups are reported.

[1] H. Mihara,et al. Changes in coagulation and fibrinolysis occurring in dogs during hypothermia. , 1985, Thrombosis research.

[2] J. Molina,et al. Brain damage in profound hypothermia. Perfusion versus circulatory arrest. , 1984, The Journal of thoracic and cardiovascular surgery.

[3] A. Urban,et al. Aprotinin in open-heart surgery of infants and children using the heart-lung machine. , 1984, Clinical therapeutics.

[4] R. Mellins,et al. Increased Circulating Bradykinin During Hypothermia and Cardiopulmonary Bypass in Children , 1979, Circulation.

[5] M. Katori. Inhibition of Kinin Formation by a Kallikrein Inhibitor during Extracorporeal Circulation in Open‐heart Surgery , 1975, Circulation.

[6] H. Kraut,et al. Das Verhalten des Kallikrein-Inhibitors gegenüber Fermenten, III. Verhalten des Kallikrein-Inhibitors aus Rinderlunge gegenüber Proteinasen , 1967 .

[7] H. Kraut,et al. Versuche zur Isolierung des Kallikrein-Inaktivators, V. Isolierung eines Kallikrein-Inaktivators aus Rinderlunge und seine Identifizierung mit dem Inaktivator aus Rinderparotis , 1964 .