Estrogen and progesterone receptors: from molecular structures to clinical targets
暂无分享,去创建一个
Heinrich Sticht | Matthias W. Beckmann | Stephan Ellmann | Pamela L. Strissel | Reiner Strick | M. Beckmann | H. Sticht | S. Ellmann | F. Thiel | R. Strick | P. Strissel | Falk Thiel
[1] D. McDonnell,et al. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. , 1999, Endocrinology.
[2] Eva Enmark,et al. Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements* , 2000, The Journal of Biological Chemistry.
[3] P. Chambon,et al. TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors. , 1996, The EMBO journal.
[4] S. F. Arnold,et al. Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: Consequence on DNA binding , 1995, The Journal of Steroid Biochemistry and Molecular Biology.
[5] Margaret Warner,et al. Estrogen receptors: how do they signal and what are their targets. , 2007, Physiological reviews.
[6] J. Kato,et al. Isoform/variant mRNAs for sex steroid hormone receptors in humans , 2003, Trends in Endocrinology & Metabolism.
[7] J. Gustafsson,et al. Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. , 2000, The Journal of biological chemistry.
[8] B. O’Malley,et al. Reproductive functions of progesterone receptors. , 2002, Recent progress in hormone research.
[9] J. Blenis,et al. pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 , 1998, Molecular and Cellular Biology.
[10] R. Gleason,et al. Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin 'add-back' for 2 years. , 1994, Human reproduction.
[11] E. Kalkhoven,et al. Isoforms of steroid receptor co‐activator 1 differ in their ability to potentiate transcription by the oestrogen receptor , 1998, The EMBO journal.
[12] E. Baulieu,et al. Subunit composition of the molybdate-stabilized "8-9 S" nontransformed estradiol receptor purified from calf uterus. , 1987, The Journal of biological chemistry.
[13] R. Vadlamudi,et al. Functional Interactions between the Estrogen Receptor Coactivator PELP1/MNAR and Retinoblastoma Protein* , 2003, Journal of Biological Chemistry.
[14] K. Horwitz,et al. A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. , 1994, Molecular endocrinology.
[15] K. Korach,et al. Estrogen receptor null mice: what have we learned and where will they lead us? , 1999, Endocrine reviews.
[16] T. Deuel,et al. Identification, cloning, and expression of human estrogen receptor-α36, a novel variant of human estrogen receptor-α66 , 2005 .
[17] S. Schreiber,et al. Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase , 1997, Cell.
[18] J. Foekens,et al. Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer , 2000, Steroids.
[19] Y. Yamasaki,et al. Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. , 1994, The Journal of biological chemistry.
[20] P. Neven,et al. The effect of raloxifene on the incidence of ovarian cancer in postmenopausal women , 2002, Gynecologic oncology.
[21] C. Glass,et al. Molecular determinants of nuclear receptor-corepressor interaction. , 1999, Genes & development.
[22] V. Giguère,et al. Review Nuclear Receptor Signaling | The Open Access Journal of the Nuclear Receptor Signaling Atlas The NR3B subgroup: an ovERRview , 2022 .
[23] B. Katzenellenbogen,et al. The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. , 1999, Molecular endocrinology.
[24] Xiaolong Wei,et al. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. , 2006, Molecular cell.
[25] D. Singleton,et al. The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization , 2008, Molecular and Cellular Endocrinology.
[26] P B Sigler,et al. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[27] Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I. , 1993, Molecular endocrinology.
[28] P Chambon,et al. Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. , 1990, The EMBO journal.
[29] B. O’Malley,et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. , 1995, Genes & development.
[30] M. Parker,et al. Molecular Determinants of the Estrogen Receptor-Coactivator Interface , 1999, Molecular and Cellular Biology.
[31] P. Visca,et al. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. , 2005, Molecular biology of the cell.
[32] Christoph Gille,et al. STRAP: editor for STRuctural Alignments of Proteins , 2001, Bioinform..
[33] Heather Spencer Feigelson,et al. Weight Gain, Body Mass Index, Hormone Replacement Therapy, and Postmenopausal Breast Cancer in a Large Prospective Study , 2004, Cancer Epidemiology Biomarkers & Prevention.
[34] Rakesh Kumar,et al. The role of adapter protein Shc in estrogen non-genomic action , 2004, Steroids.
[35] R. Evans,et al. A transcriptional co-repressor that interacts with nuclear hormone receptors , 1995, Nature.
[36] D. McDonnell,et al. Development of peptide antagonists that target estrogen receptor–cofactor interactions , 2000, The Journal of Steroid Biochemistry and Molecular Biology.
[37] D. Lannigan. Estrogen receptor phosphorylation , 2003, Steroids.
[38] H. Ward. Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels , 1973, British medical journal.
[39] Paul Tempst,et al. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex , 1999, Nature.
[40] P. Meltzer,et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. , 1997, Science.
[41] Eric S Manas,et al. Structure-based design of estrogen receptor-beta selective ligands. , 2004, Journal of the American Chemical Society.
[42] H. Schulz,et al. Role of Endocytosis in Cellular Uptake of Sex Steroids , 2005, Cell.
[43] B. O’Malley,et al. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. , 2007, Molecular cell.
[44] C. Clarke,et al. Effect of overexpression of progesterone receptor A on endogenous progestin-sensitive endpoints in breast cancer cells. , 1999, Molecular endocrinology.
[45] E. Resnick,et al. Ligand-independent activation of pituitary ER: dependence on PKA-stimulated pathways. , 2001, Endocrinology.
[46] O. Silvennoinen,et al. ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. , 2000, Molecular endocrinology.
[47] P. Thomas,et al. Identification of membrane progestin receptors in human breast cancer cell lines and biopsies and their potential involvement in breast cancer , 2007, Steroids.
[48] C. Christiansen,et al. EFFECTS OF RALOXIFENE ON BONE MINERAL DENSITY, SERUM CHOLESTEROL CONCENTRATIONS, AND UTERINE ENDOMETRIUM IN POSTMENOPAUSAL WOMEN , 1998 .
[49] J. Ruderman,et al. Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[50] J. Gustafsson,et al. Structural Insights into Corepressor Recognition by Antagonist-bound Estrogen Receptors* , 2007, Journal of Biological Chemistry.
[51] Neil J McKenna,et al. A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex , 1999, Cell.
[52] D. Cramer,et al. Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization. , 2003, American journal of obstetrics and gynecology.
[53] Y. Sheng,et al. The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[54] B. Harvey,et al. A Gαs protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon , 2003, Molecular and Cellular Endocrinology.
[55] M. Tzukerman,et al. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. , 1994, Molecular endocrinology.
[56] S. Yen,et al. Preliminary report on the treatment of endometriosis with low-dose mifepristone (RU 486). , 1998, American journal of obstetrics and gynecology.
[57] Martin C Frith,et al. Genomic targets of nuclear estrogen receptors. , 2004, Molecular endocrinology.
[58] R. Hubbard,et al. A structural biologist's view of the oestrogen receptor , 2000, The Journal of Steroid Biochemistry and Molecular Biology.
[59] M. Lazar,et al. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors , 1999, Nature.
[60] M. Beckmann,et al. Proliferation and cell–cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-β , 2006, Journal of Molecular Medicine.
[61] D. Edwards,et al. Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements. , 2006, Molecular endocrinology.
[62] L. Sahlin,et al. Different expression of estrogen receptors alpha and beta in human myometrium and leiomyoma during the proliferative phase of the menstrual cycle and after GnRHa treatment. , 2001, Gynecological Endocrinology.
[63] R. Strick,et al. Multiple effects of bioflavonoids on gene regulation, cell proliferation and apoptosis: natural compounds move into the lime light of cancer research. , 2005, Leukemia research.
[64] B. Katzenellenbogen,et al. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. , 1994, The Journal of biological chemistry.
[65] S. Koide,et al. Understanding the human estrogen receptor-alpha using targeted mutagenesis , 2006, Molecular and Cellular Endocrinology.
[66] Tudor I. Oprea,et al. GPR30: a novel therapeutic target in estrogen-related disease. , 2008, Trends in pharmacological sciences.
[67] Takashi Suzuki,et al. Progesterone Receptor A and B Isoforms in the Human Breast and Its Disorders , 2001, Japanese journal of cancer research : Gann.
[68] D. Picard,et al. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. , 1996, The EMBO journal.
[69] A. Jungbauer,et al. Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy? , 2005, The Journal of Steroid Biochemistry and Molecular Biology.
[70] P. Giangrande,et al. Mapping and Characterization of the Functional Domains Responsible for the Differential Activity of the A and B Isoforms of the Human Progesterone Receptor* , 1997, The Journal of Biological Chemistry.
[71] K. Chwalisz,et al. Effects of the progesterone antagonists onapristone (ZK 98 299) and ZK 136 799 on surgically induced endometriosis in intact rats. , 1996, Human Reproduction.
[72] A. Tiltman. The effect of progestins on the mitotic activity of uterine fibromyomas. , 1985, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.
[73] Anthony W. Norman,et al. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model , 2004, Nature Reviews Drug Discovery.
[74] A. Jemal,et al. Cancer Statistics, 2007 , 2007, CA: a cancer journal for clinicians.
[75] Harry Hollema,et al. Risk and prognosis of endometrial cancer after tamoxifen for breast cancer , 2000, The Lancet.
[76] H. Croxatto. Mifepristone for luteal phase contraception. , 2003, Contraception.
[77] Myles Brown,et al. Molecular Determinants for the Tissue Specificity of SERMs , 2002, Science.
[78] M. Parker,et al. Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[79] Thorsten Heinzel,et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor , 1995, Nature.
[80] John A. Katzenellenbogen,et al. The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site , 1997, Steroids.
[81] M. Beckmann,et al. Transcriptional analysis of steroid hormone receptors in smooth muscle uterine leiomyoma tumors of postmenopausal patients , 2007, The Journal of Steroid Biochemistry and Molecular Biology.
[82] R. Coombes,et al. Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization. , 1999, Molecular and cellular biology.
[83] David M. Heery,et al. A signature motif in transcriptional co-activators mediates binding to nuclear receptors , 1997, Nature.
[84] M. Parker,et al. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. , 1993, Journal of cell science.
[85] Simak Ali,et al. Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization , 1999, Molecular and Cellular Biology.
[86] D. Gertig,et al. Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[87] V. Jordan,et al. Chemoprevention of breast cancer with selective oestrogen-receptor modulators , 2007, Nature Reviews Cancer.
[88] E. Weiderpass,et al. No Association between Progesterone Receptor Gene +331G/A Polymorphism and Endometrial Cancer , 2006, Cancer Epidemiology Biomarkers & Prevention.
[89] S. Jiang,et al. Estrogen receptor corepressors -- a role in human breast cancer? , 2003, Endocrine-related cancer.
[90] F. Gannon,et al. Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. , 2000, The EMBO journal.
[91] K. Korach,et al. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[92] M. Beckmann,et al. Hormones and hormone antagonists: mechanisms of action in carcinogenesis of endometrial and breast cancer. , 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[93] D. L. Bain,et al. Nuclear receptor structure: implications for function. , 2007, Annual review of physiology.
[94] D. Lannigan,et al. Estradiol-induced Phosphorylation of Serine 118 in the Estrogen Receptor Is Independent of p42/p44 Mitogen-activated Protein Kinase* , 1998, The Journal of Biological Chemistry.
[95] S. Baker,et al. PTEN function in normal and neoplastic growth. , 2006, Cancer letters.
[96] F. Gannon,et al. Identification of a new isoform of the human estrogen receptor‐alpha (hER‐α) that is encoded by distinct transcripts and that is able to repress hER‐α activation function 1 , 2000 .
[97] M. Gross,et al. Raloxifene, an oestrogen‐receptor‐β‐targeted therapy, inhibits androgen‐independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial , 2006, BJU international.
[98] E. Levin,et al. Nature of functional estrogen receptors at the plasma membrane. , 2006, Molecular endocrinology.
[99] A. Floore,et al. Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. , 2004, Cancer cell.
[100] K. Horwitz,et al. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. , 1997, Molecular endocrinology.
[101] Xiaolong Wei,et al. MUC1 Oncoprotein Stabilizes and Activates Estrogen Receptor α , 2006 .
[102] F. DeMayo,et al. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. , 2000, Science.
[103] G. Colditz,et al. A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[104] J. Gustafsson,et al. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[105] Zhijian Gao,et al. Effects of progesterone on growth factor expression in human uterine leiomyoma , 2003, Steroids.
[106] B. O’Malley,et al. Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily , 1995, Science.
[107] Y. Shang. Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis , 2006, Nature Reviews Cancer.
[108] D. Dalley,et al. Breast Cancer in Men—Should Aromatase Inhibitors Become First‐Line Hormonal Treatment? , 2008, The breast journal.
[109] W. Delano. The PyMOL Molecular Graphics System , 2002 .
[110] Ie-Ming Shih,et al. Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis. , 2008, American journal of obstetrics and gynecology.
[111] D. McDonnell,et al. The Estrogen Receptor -isoform (er) of the Human Estrogen Receptor Modulates Er␣ Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens* , 2022 .
[112] D. Edwards,et al. Progesterone receptor transcription and non-transcription signaling mechanisms , 2003, Steroids.
[113] S. Mumby,et al. Direct interactions with G α i and G βγ mediate nongenomic signaling by estrogen receptor α . , 2007, Molecular endocrinology.
[114] G. Mor,et al. Low-grade endometrial stromal sarcoma: hormonal aspects. , 2003, Gynecologic oncology.
[115] O. Park-Sarge,et al. Printed in U.S.A. Copyright © 1999 by The Endocrine Society Characterization of Estrogen Receptor- � (ER�) Messenger Ribonucleic Acid and Protein Expression in Rat Granulosa Cells* , 1999 .
[116] H. Randeva,et al. Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. , 2006, Molecular endocrinology.
[117] C. Klinge. Estrogen receptor interaction with estrogen response elements. , 2001, Nucleic acids research.
[118] P. Kyzas,et al. Estrogen receptor beta (ERβ) protein expression correlates with BAG-1 and prognosis in brain glial tumours , 2006, Journal of Neuro-Oncology.
[119] A. Paulussen,et al. Two functionally relevant polymorphisms in the human progesterone receptor gene (+331 G/A and progins) and the predisposition for breast and/or ovarian cancer. , 2006, Gynecologic oncology.
[120] T. Soderling,et al. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 , 1996, Molecular and cellular biology.
[121] R. Métivier,et al. The human estrogen receptor-alpha isoform hERalpha46 antagonizes the proliferative influence of hERalpha66 in MCF7 breast cancer cells. , 2005, Endocrinology.
[122] Eva Enmark,et al. Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Human Estrogen Receptor �-Gene Structure, Chromosomal Localization, and Expression Pattern* , 2022 .
[123] E. Lam,et al. Estrogen receptor β2 negatively regulates the transactivation of estrogen receptor α in human breast cancer cells , 2007 .
[124] J. Shine,et al. Sequence and expression of human estrogen receptor complementary DNA. , 1986, Science.
[125] D. Larsson,et al. Membrane progesterone receptor gamma: Tissue distribution and expression in ciliated cells in the fallopian tube , 2007, Molecular reproduction and development.
[126] C. Green,et al. Two separate mechanisms for ligand-independent activation of the estrogen receptor. , 1997, Molecular endocrinology.
[127] J. Weed,et al. The progesterone therapy of human uterine leiomyomas. , 1949, The Journal of clinical endocrinology and metabolism.
[128] A. Sahin,et al. Molecular Cloning and Characterization of PELP1, a Novel Human Coregulator of Estrogen Receptor α , 2001 .
[129] D. Moras,et al. Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism* , 2001, The Journal of Biological Chemistry.
[130] N. Weigel,et al. 8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein , 2000, Molecular and Cellular Biology.
[131] Wendy Shelly,et al. Selective Estrogen Receptor Modulators: An Update on Recent Clinical Findings , 2008, Obstetrical & gynecological survey.
[132] J. Myers,et al. The Classical Progesterone Receptor Associates with p42 MAPK and Is Involved in Phosphatidylinositol 3-Kinase Signaling inXenopus Oocytes* , 2001, The Journal of Biological Chemistry.
[133] P. Chambon,et al. Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes. , 1990, The Journal of biological chemistry.
[134] M. Tsai,et al. The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily , 1999, Molecular and Cellular Biology.
[135] C. Nappi,et al. Loss of oestrogen receptor β, high PCNA and p53 expression and aneuploidy as markers of worse prognosis in ovarian granulosa cell tumours , 2003, Histopathology.
[136] D. Poirier,et al. Antiestrogenic properties of keoxifene,trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells , 1989, Breast Cancer Research and Treatment.
[137] G. Pelletier,et al. Immunocytochemical Localization of Estrogen Receptors α and β in the Human Reproductive Organs , 2000 .
[138] G. Pelletier,et al. Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. , 2000, The Journal of clinical endocrinology and metabolism.
[139] B. Howard,et al. The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases , 1996, Cell.
[140] L. Hartmann,et al. Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice. , 2003, The New England journal of medicine.
[141] A. Shaaban,et al. Declining Estrogen Receptor-&bgr; Expression Defines Malignant Progression of Human Breast Neoplasia , 2003, The American journal of surgical pathology.
[142] J. Lees,et al. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. , 1992, The EMBO journal.
[143] C. Lange,et al. Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: Role of mitogen-activated protein kinases and cell cycle regulators , 2005, Steroids.
[144] Yih-Leong Chang,et al. The significance of estrogen receptor beta in 301 surgically treated non-small cell lung cancers. , 2005, The Journal of thoracic and cardiovascular surgery.
[145] P. Thomas,et al. Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors α and β in transfected cells , 2006 .
[146] T. Wiese,et al. Rapid screening of environmental chemicals for estrogen receptor binding capacity. , 1998, Environmental health perspectives.
[147] Shawn P Williams,et al. A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. , 2007, Molecular endocrinology.
[148] J. Chen,et al. The SRC family of nuclear receptor coactivators. , 2000, Gene.
[149] P. Sismondi,et al. Role of Coactivators and Corepressors in Steroid and Nuclear Receptor Signaling: Potential Markers of Tumor Growth and Drug Sensitivity , 2001, The International journal of biological markers.
[150] E. Lam,et al. Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. , 2007, Cancer research.
[151] M. Stallcup,et al. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities. , 1998, Molecular Endocrinology.
[152] K. Bramlett,et al. Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors. , 2002, Molecular genetics and metabolism.
[153] D. Edwards,et al. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. , 2001, Molecular cell.
[154] P. Sigler,et al. Atomic structure of progesterone complexed with its receptor , 1998, Nature.
[155] Sandip K. Mishra,et al. Potential Role of a Novel Transcriptional Coactivator PELP1 in Histone H1 Displacement in Cancer Cells , 2004, Cancer Research.
[156] J. Gustafsson,et al. Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. , 2001, Cancer research.
[157] Xiaohong Gu. Helix 12 in the human estrogen receptor (hER) is essential for the hER function by overcoming nucleosome repression in yeast , 2002, Journal of cellular biochemistry.
[158] R. Sainson,et al. A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane* , 2007, Journal of Biological Chemistry.
[159] J. Schouten,et al. Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis. , 2006, Human reproduction.
[160] P. Thomas,et al. Molecular characterization of three forms of putative membrane-bound progestin receptors and their tissue-distribution in channel catfish, Ictalurus punctatus. , 2005, Journal of molecular endocrinology.
[161] C. Turck,et al. Growth Factors Signal to Steroid Receptors through Mitogen-activated Protein Kinase Regulation of p160 Coactivator Activity* , 2001, The Journal of Biological Chemistry.
[162] P. Thomas,et al. Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells. , 2006, The Journal of endocrinology.
[163] Eric R. Prossnitz,et al. A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling , 2005, Science.
[164] Lei Li,et al. Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[165] K. Inoki,et al. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling , 2008, The EMBO journal.
[166] P. Chambon,et al. Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. , 1997, Gene.
[167] D. Agard,et al. Estrogen receptor pathways to AP-1 , 2000, The Journal of Steroid Biochemistry and Molecular Biology.
[168] W. Zwart,et al. PKA‐induced resistance to tamoxifen is associated with an altered orientation of ERα towards co‐activator SRC‐1 , 2007, The EMBO journal.
[169] Charles David Jones,et al. Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels. , 1983, Life sciences.
[170] David A. Agard,et al. The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen , 1998, Cell.
[171] V. D. Paola,et al. Raloxifene in breast cancer prevention , 2008 .
[172] B. O’Malley,et al. Progesterone-binding components of chick oviduct. I. Preliminary characterization of cytoplasmic components. , 1970, The Journal of biological chemistry.
[173] A. Jemal,et al. Cancer Statistics, 2008 , 2008, CA: a cancer journal for clinicians.
[174] A. Shaaban,et al. Risk for Subsequent Development of Breast Cancer: Authors' Reply , 2003 .
[175] Richard G. W. Anderson,et al. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. , 2000, Circulation research.
[176] Simak Ali,et al. Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera , 2002, Oncogene.
[177] T. Wu,et al. Focus on endometrial and cervical cancer. , 2004, Cancer cell.
[178] D. Edwards. The Role of Coactivators and Corepressors in the Biology and Mechanism of Action of Steroid Hormone Receptors , 2000, Journal of Mammary Gland Biology and Neoplasia.
[179] F. Penault-Llorca,et al. Endometrial histopathology in 700 patients treated with tamoxifen for breast cancer. , 2000, Gynecologic oncology.
[180] J. Graham,et al. Progesterone receptors - animal models and cell signaling in breast cancer: Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells , 2002, Breast Cancer Research.
[181] P. Pujol,et al. Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. , 2004, Endocrine-related cancer.
[182] P. Chambon,et al. Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex , 1990, Cell.
[183] M. Beckmann,et al. Early aberrant insulin‐like growth factor signaling in the progression to endometrial carcinoma is augmented by tamoxifen , 2008, International journal of cancer.
[184] A. Takeshita,et al. CBP-dependent and independent enhancing activity of steroid receptor coactivator-1 in thyroid hormone receptor-mediated transactivation , 1999, Molecular and Cellular Endocrinology.
[185] N. Koszewski,et al. Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding. , 1992, The Journal of biological chemistry.
[186] T. Willson,et al. Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition , 2002, Cell.
[187] K. Bland,et al. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. , 2000, Molecular endocrinology.
[188] Christopher J. Barnes,et al. The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor α to the plasma membrane , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[189] Luyang Sun,et al. Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis , 2005, Nature.
[190] P. Thomas,et al. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[191] R. Kumar,et al. Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. , 2001, The Journal of biological chemistry.
[192] H. Burger,et al. Molecular pathogenesis of granulosa cell tumours , 2002, Molecular and Cellular Endocrinology.
[193] D. Livingston,et al. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[195] B. Katzenellenbogen,et al. Printed in U.S.A. Copyright © 2000 by The Endocrine Society A Role for Akt in Mediating the Estrogenic Functions of Epidermal Growth Factor and Insulin-Like Growth Factor I* , 2000 .
[196] J. Gosden,et al. Localization of the human oestrogen receptor gene to chromosome 6q24----q27 by in situ hybridization. , 1986, Cytogenetics and cell genetics.
[197] K. Kovács,et al. Comparative analysis of cyclin D1 and oestrogen receptor (α and β) levels in human leiomyoma and adjacent myometrium , 2001 .
[198] M. Thun,et al. No association between the progesterone receptor gene +331G/A polymorphism and breast cancer. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[199] R. Métivier,et al. The Human Estrogen Receptor-α Isoform hERα46 Antagonizes the Proliferative Influence of hERα66 in MCF7 Breast Cancer Cells , 2005 .
[200] H. Bryant,et al. Raloxifene: A selective estrogen receptor modulator , 1994, Journal of Bone and Mineral Metabolism.
[201] J. Thomsen,et al. Mechanisms of estrogen action. , 2001, Physiological reviews.
[202] R. Lanz,et al. Nuclear receptor coregulators: cellular and molecular biology. , 1999, Endocrine reviews.
[203] H. Risch,et al. PGR +331 A/G and Increased Risk of Epithelial Ovarian Cancer , 2006, Cancer Epidemiology Biomarkers & Prevention.
[204] J. Gustafsson,et al. Cloning of a novel receptor expressed in rat prostate and ovary. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[205] Carol S. Lim,et al. Effect of initial subcellular localization of progesterone receptor on import kinetics and transcriptional activity. , 2005, Molecular pharmaceutics.
[206] D. Philibert,et al. RU 38486: a potent antiglucocorticoid in vitro and in vivo. , 1985, Journal of steroid biochemistry.