Expanding fields of genetically altered cells in head and neck squamous carcinogenesis.

[1]  K. Schepman,et al.  Concomitant leukoplakia in patients with oral squamous cell carcinoma. , 2008, Oral diseases.

[2]  C. R. Leemans,et al.  Genetically Altered Fields as Origin of Locally Recurrent Head and Neck Cancer , 2004, Clinical Cancer Research.

[3]  M. Washington,et al.  TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.

[4]  I. Mackenzie.  Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa. , 2004, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[5]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[6]  E. Luebeck,et al.  Multistage carcinogenesis and the incidence of human cancer , 2003, Genes, chromosomes & cancer.

[7]  Michael F. Clarke,et al.  Applying the principles of stem-cell biology to cancer , 2003, Nature Reviews Cancer.

[8]  Alan Ashworth,et al.  Stem cells and breast cancer: A field in transit , 2003, Nature Reviews Cancer.

[9]  Martin A. Nowak,et al.  The significance of unstable chromosomes in colorectal cancer , 2003, Nature Reviews Cancer.

[10]  F. Watt,et al.  Contribution of stem cells and differentiated cells to epidermal tumours , 2003, Nature Reviews Cancer.

[11]  A. Balmain,et al.  Stem-cell hierarchy in skin cancer , 2003, Nature Reviews Cancer.

[12]  C. R. Leemans,et al.  A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. , 2003, Cancer research.

[13]  P. V. van Diest,et al.  Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx , 2003, The Journal of pathology.

[14]  G. Snow,et al.  Mutated p53 as a molecular marker for the diagnosis of head and neck cancer , 2002, The Journal of pathology.

[15]  William C Hahn,et al.  Rules for making human tumor cells. , 2002, The New England journal of medicine.

[16]  C. R. Leemans,et al.  Multiple head and neck tumors frequently originate from a single preneoplastic lesion. , 2002, The American journal of pathology.

[17]  T. Axéll,et al.  Oral leukoplakia: a proposal for uniform reporting. , 2002, Oral oncology.

[18]  R. Stern,et al.  p53 mutation in nonmelanoma skin cancers occurring in psoralen ultraviolet a-treated patients: evidence for heterogeneity and field cancerization. , 2002, The Journal of investigative dermatology.

[19]  B. Nickoloff,et al.  Estimation of size of clonal unit for keratinocytes in normal human skin. , 2002, Archives of pathology & laboratory medicine.

[20]  M. Höglund,et al.  Cyclin D1 amplification in chromosomal band 11q13 is associated with overrepresentation of 3q21–q29 in head and neck carcinomas , 2002, International journal of cancer.

[21]  A. Cheng,et al.  Multiple molecular alterations of FHIT in betel‐associated oral carcinoma , 2002, The Journal of pathology.

[22]  G. Snow,et al.  Second primary tumors and field cancerization in oral and oropharyngeal cancer: Molecular techniques provide new insights and definitions , 2002 .

[23]  D. Sidransky,et al.  Head and neck cancer. , 2001, The New England journal of medicine.

[24]  W. Hittelman.  Genetic Instability in Epithelial Tissues at Risk for Cancer , 2001, Annals of the New York Academy of Sciences.

[25]  D. Zelterman,et al.  Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[26]  K. Hemminki,et al.  Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer. , 2001, European journal of cancer.

[27]  C. R. Leemans,et al.  Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[28]  S. Gollin.  Chromosomal alterations in squamous cell carcinomas of the head and neck: Window to the biology of disease , 2001, Head & neck.

[29]  R. A’Hern,et al.  A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization. , 2000, Cancer research.

[30]  J. Langdon,et al.  Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[31]  P J Slootweg,et al.  Oral field cancerization: carcinogen-induced independent events or micrometastatic deposits? , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[32]  Carissa A. Sanchez,et al.  p53-mutant clones and field effects in Barrett's esophagus. , 1999, Cancer research.

[33]  J. Garlick,et al.  Cell interactions control the fate of malignant keratinocytes in an organotypic model of early neoplasia. , 1999, The Journal of investigative dermatology.

[34]  M. Quer,et al.  Second neoplasm in patients with head and neck cancer , 1999, Head & neck.

[35]  N. Wright,et al.  Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets , 1999, The Journal of pathology.

[36]  O. Yoshida,et al.  Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract. , 1998, Cancer research.

[37]  W. Hong,et al.  Dysregulated cyclin D1 expression early in head and neck tumorigenesis: in vivo evidence for an association with subsequent gene amplification , 1998, Oncogene.

[38]  J. Jen,et al.  Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. , 1998, Journal of the National Cancer Institute.

[39]  K. Schepman,et al.  Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. , 1998, Oral oncology.

[40]  J. Garlick,et al.  Normal keratinocytes suppress early stages of neoplastic progression in stratified epithelium. , 1998, Cancer research.

[41]  Y. Miller,et al.  Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. , 1997, The Journal of clinical investigation.

[42]  I. Mackenzie,et al.  Retroviral transduction of murine epidermal stem cells demonstrates clonal units of epidermal structure. , 1997, The Journal of investigative dermatology.

[43]  K. Schepman,et al.  Oral leukoplakia: a clinicopathological review. , 1997, Oral oncology.

[44]  R. Iggo,et al.  Field cancerisation and polyclonal p53 mutation in the upper aero- digestive tract , 1997, Oncogene.

[45]  R. Tarone,et al.  Frequent clones of p53-mutated keratinocytes in normal human skin. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Califano,et al.  11:40 AM: A Genetic Progression Model for Head and Neck Cancer: Implications for Field Cancerization , 1996 .

[47]  E. Gabrielson,et al.  Multiple head and neck tumors: evidence for a common clonal origin. , 1996, Cancer research.

[48]  R H Hruban,et al.  Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. , 1995, The New England journal of medicine.

[49]  S. Yuspa,et al.  A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice. , 1992, Cancer research.

[50]  S. Yuspa,et al.  Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters. , 1990, Cancer research.

[51]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[52]  G. Snow,et al.  Multiple primary tumours in oral cancer. , 1986, International journal of oral and maxillofacial surgery.

[53]  S. Lippman,et al.  Detection of chromosome instability of tissue fields at risk: In situ hybridization , 1996, Journal of cellular biochemistry. Supplement.

[54]  A. Harłozińska,et al.  Field effect of human colon carcinoma on normal mucosa: relevance of carcinoembryonic antigen expression. , 1996, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[55]  G. Snow,et al.  Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor , 1994, Cancer.

[56]  T. Sato,et al.  Multiple primary tumors in patients with head and neck cancer. , 1985, Auris, nasus, larynx.

[57]  S. Warren.  Multiple primary malignant tumors. A survey of the literature and a statistical study , 1932 .