Outcome of Patients Treated With Porous Tantalum Acetabular Implants for Neoplastic Periacetabular Lesions.

INTRODUCTION The periacetabular region is a common location for nonprimary neoplastic tumors. Although these tumors were historically treated with a cemented acetabular implant, we previously reported on the short-term follow-up on the use of a tantalum acetabular shell to reconstruct these defects. This study expands our previous report on longer follow-up, with specific emphasis on patient and implant survivorship, radiographic results, and clinical outcomes. METHODS Fifty-eight patients (32 women and 26 men) were treated using a tantalum acetabular implant and total hip arthroplasty to reconstruct a nonprimary neoplastic process between 2001 and 2014. The mean age and body mass index were 62 years and 28 kg/m, respectively. The most common diagnosis was metastatic disease (n = 29). The patients' medical records and radiographs were reviewed to assess Harris hip scores and radiographic fixation. The mean follow-up for surviving patients was 8 years. RESULTS At the most recent follow-up, 41 patients were dead of the disease and 17 were alive with the disease and no cases of acetabular implant revision were reported. Two patients had a progressive radiolucent line; however, they also had radiographic evidence of local disease progression. After reconstruction, patients had a significant (P = 0.0001) increase in their Harris hip score (37 vs. 72). DISCUSSION In patients with periacetabular metastatic diseases and hematologic malignancies treated with total hip arthroplasty, a highly porous tantalum revision-type shell fixed with multiple screws, and supplemental support with acetabular augments or cup-cage reinforcement, can successfully provide patients with a stable, well-fixed, and durable construct, with no cases of mechanical failure at mid-term follow-up.

[1]  F. Sim,et al.  Tantalum Acetabular Cups Provide Secure Fixation in THA after Pelvic Irradiation at Minimum 5-year Followup , 2012, Clinical orthopaedics and related research.

[2]  F. Sim,et al.  Surgical Technique: Porous Tantalum Reconstruction for Destructive Nonprimary Periacetabular Tumors , 2012, Clinical orthopaedics and related research.

[3]  G. Letson,et al.  Endoprosthetic proximal femur replacement: metastatic versus primary tumors. , 2009, Surgical oncology.

[4]  F. Sim,et al.  Preliminary Results of Tantalum Acetabular Components for THA after Pelvic Radiation , 2006, Clinical orthopaedics and related research.

[5]  F. Sim,et al.  Advances and challenges in diagnosis and management of skeletal metastases. , 2006, Orthopedics.

[6]  J. Healey,et al.  Survival in patients operated on for pathologic fracture: implications for end-of-life orthopedic care. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  F. Sim,et al.  Patient survival after hip arthroplasty for metastatic disease of the hip. , 2004, The Journal of bone and joint surgery. American volume.

[8]  J. Wunder,et al.  Functional and Oncological Outcome of Acetabular Reconstruction for the Treatment of Metastatic Disease* , 2000, The Journal of bone and joint surgery. American volume.

[9]  P. Gustafson,et al.  The Harrington reconstruction for advanced periacetabular metastatic destruction: Good outcome in 32 patients , 2000, Acta orthopaedica Scandinavica.

[10]  A. Davis,et al.  Complex acetabular reconstruction for metastatic tumor. , 1995, The Journal of arthroplasty.

[11]  J. Lawrence,et al.  Acetabular defect classification and surgical reconstruction in revision arthroplasty. A 6-year follow-up evaluation. , 1994, The Journal of arthroplasty.

[12]  R. Walker,et al.  Pelvic reconstruction/total hip arthroplasty for metastatic acetabular insufficiency. , 1993, Clinical orthopaedics and related research.

[13]  E. McFadden,et al.  Toxicity and response criteria of the Eastern Cooperative Oncology Group , 1982, American journal of clinical oncology.

[14]  K. Harrington The management of acetabular insufficiency secondary to metastatic malignant disease. , 1981, The Journal of bone and joint surgery. American volume.