Ouabain and Adducin for Specific Intervention on Sodium in HyperTension ( OASIS-HT ) : design of a pharmacogenomic dose-finding study

1Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium; 2Hypertension Department, University Medical Centre, Ljubljana, Slovenia; 3Sigma Tau Industrie Farmaceutiche Reunite, Pomezia, Italy; 4Department of Internal Medicine D, University Hospital of Münster, Germany; 5Division of Hypertension and Cardiovascular Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 6Divisione di Nefrologia Dialisi e Ipertensione, Ospedale San Raffaele, Dipartimento di Scienze e Techologie Biomediche, Universitá Vita-Salute, Milan, Italy; 7Department of Medicine, University Hospital of Maastricht, The Netherlands; 8Department of Internal Medicine 2, Charles University, Pilsen, The Czech Republic; 9Department of Internal Medicine, Centre Hospitalier Universitaire Amiens, France; 10First Cardiac Department, Jagiellonian University, Krakow, Poland; 11Institute of Internal Medicine, Novosibirsk, Russian Federation; 12ADAPT Centre and Blood Pressure Unit, Beaumont Hospital and Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland; 13Hospital Clínico Universitario Valencia, University of Valencia, Spain; 14Prassis Research Institute, Settimo Milanese, Italy

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