Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways.

[1]  B. Kong,et al.  Leptin-Promoted Human Extravillous Trophoblast Invasion Is MMP14 Dependent and Requires the Cross Talk Between Notch1 and PI3K/Akt Signaling1 , 2014, Biology of reproduction.

[2]  J. Dötsch,et al.  Leptin does not Induce an Inflammatory Response in the Murine Placenta , 2014, Hormone and Metabolic Research.

[3]  S. Agaugué,et al.  Binding of HLA-G to ITIM-Bearing Ig-like Transcript 2 Receptor Suppresses B Cell Responses , 2014, The Journal of Immunology.

[4]  W. Gu,et al.  HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation. , 2013, Placenta.

[5]  R. Rizzo,et al.  New insights into HLA-G and inflammatory diseases. , 2012, Inflammation & allergy drug targets.

[6]  Eric O Long,et al.  Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling , 2012, Proceedings of the National Academy of Sciences.

[7]  A. Duttaroy,et al.  Leptin induces tube formation in first-trimester extravillous trophoblast cells. , 2012, European journal of obstetrics, gynecology, and reproductive biology.

[8]  G. Mor,et al.  Modulation and Recruitment of Inducible Regulatory T Cells by First Trimester Trophoblast Cells , 2012, American journal of reproductive immunology.

[9]  U. Yallampalli,et al.  Adrenomedullin 2/Intermedin Regulates HLA-G in Human Trophoblasts1 , 2011, Biology of reproduction.

[10]  J. Maymó,et al.  Review: Leptin gene expression in the placenta--regulation of a key hormone in trophoblast proliferation and survival. , 2011, Placenta.

[11]  J. Maymó,et al.  17Beta-Estradiol Enhances Leptin Expression in Human Placental Cells Through Genomic and Nongenomic Actions1 , 2010, Biology of reproduction.

[12]  J. Maymó,et al.  MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. , 2010, Biochemical and biophysical research communications.

[13]  P. Zou,et al.  Inhibition of HLA-G expression via RNAi abolishes resistance of extravillous trophoblast cell line TEV-1 to NK lysis. , 2010, Placenta.

[14]  V. Sánchez-Margalet,et al.  Role of Leptin in the Activation of Immune Cells , 2010, Mediators of inflammation.

[15]  E. Carosella,et al.  ILT2/HLA‐G interaction impairs NK‐cell functions through the inhibition of the late but not the early events of the NK‐cell activating synapse , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  J. Maymó,et al.  Leptin Stimulates Protein Synthesis-Activating Translation Machinery in Human Trophoblastic Cells1 , 2009, Biology of reproduction.

[17]  G. Mor,et al.  The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71. , 2009, Placenta.

[18]  Judith E. Cartwright,et al.  Soluble HLA-G regulates motility and invasion of the trophoblast-derived cell line SGHPL-4. , 2009, Human reproduction.

[19]  R. Apps,et al.  Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti‐HLA antibodies , 2009, Immunology.

[20]  Jianying Zhou,et al.  Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis. , 2009, Molecular medicine reports.

[21]  Zhihui Liang,et al.  Dimerization of Soluble HLA-G by IgG-Fc Fragment Augments ILT2-Mediated Inhibition of T-Cell Alloresponse , 2009, Transplantation.

[22]  J. Maymó,et al.  Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway. , 2008, Archives of biochemistry and biophysics.

[23]  A. La Cava,et al.  Leptin and Inflammation. , 2008, Current immunology reviews.

[24]  R. Apps,et al.  A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1 , 2007, European journal of immunology.

[25]  G. Wallukat,et al.  Dysregulation of the Circulating and Tissue-Based Renin–Angiotensin System in Preeclampsia , 2007, Hypertension.

[26]  María P. Magariños,et al.  Leptin Promotes Cell Proliferation and Survival of Trophoblastic Cells1 , 2007, Biology of reproduction.

[27]  Liwei Lu,et al.  Role of leptin in immunity. , 2007, Cellular & molecular immunology.

[28]  Judith E. Cartwright,et al.  Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells. , 2006, Blood.

[29]  J. Roberts,et al.  Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. , 2006, Molecular human reproduction.

[30]  J. Fenton,et al.  Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. , 2006, Carcinogenesis.

[31]  K. Red-Horse,et al.  Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. , 2004, The Journal of clinical investigation.

[32]  V. Sánchez-Margalet,et al.  Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action , 2003, Clinical and experimental immunology.

[33]  P. Bischof,et al.  Effect of Leptin on Progesterone, Human Chorionic Gonadotropin, and Interleukin-6 Secretion by Human Term Trophoblast Cells in Culture1 , 2003, Biology of reproduction.

[34]  A. Berrebi,et al.  Secretion of pro‐apoptotic intron 4‐retaining soluble HLA‐G1 by human villous trophoblast , 2002, European journal of immunology.

[35]  J. Chan,et al.  Leptin and reproduction: a review. , 2002, Fertility and sterility.

[36]  N. Rouas-Freiss,et al.  HLA-G: a shield against inflammatory aggression. , 2001, Trends in immunology.

[37]  S. Hauguel-de Mouzon,et al.  Transcriptional effect of hypoxia on placental leptin , 2001, FEBS letters.

[38]  A. Campana,et al.  Effects of leptin, interleukin-1α, interleukin-6, and transforming growth factor-β on markers of trophoblast invasive phenotype , 2001, Endocrine.

[39]  P. Haggarty,et al.  Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placenta. , 2001, Placenta.

[40]  J. Foidart,et al.  Tubal versus uterine placentation: similar HLA-G expressing extravillous cytotrophoblast invasion but different maternal leukocyte recruitment. , 2000, Tissue antigens.

[41]  P. Bischof,et al.  Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. , 2000, Molecular human reproduction.

[42]  A. Toubert,et al.  Cutting Edge: Soluble HLA-G1 Triggers CD95/CD95 Ligand-Mediated Apoptosis in Activated CD8+ Cells by Interacting with CD81 , 2000, The Journal of Immunology.

[43]  A. Campana,et al.  Modulation of human cytotrophoblastic leptin secretion by interleukin-1α and 17β-oestradiol and its effect on HCG secretion , 1999 .

[44]  M. C. Henson,et al.  Expression of Placental Leptin and Leptin Receptor Transcripts in Early Pregnancy and at Term , 1998, Obstetrics and gynecology.

[45]  K. Nakao,et al.  Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans , 1997, Nature Medicine.

[46]  P. Trayhurn,et al.  Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy , 1997, Clinical endocrinology.

[47]  R. Devos,et al.  Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. , 1995, Science.

[48]  K. Nakao,et al.  Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue , 1995, Diabetes.

[49]  K. Lim,et al.  Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. , 1995, Journal of immunology.

[50]  P. Bouteiller.  HLA-G in human early pregnancy: control of uterine immune cell activation and likely vascular remodeling. , 2015 .

[51]  B. Kong,et al.  Leptin-promoted Human Extravillous Trophoblasts Invasion Is MMP14 Dependent and Requires the Crosstalk Between Notch1 and PI3K/Akt Signaling 1 Running title: LEPTIN PROMOTES EVT CELLS INVASION BY MMP14 , 2014 .

[52]  B. Klapp,et al.  Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy. , 2013, Molecular human reproduction.

[53]  J. Maymó,et al.  Beta-Estradiol Enhances Leptin Expression in Human Placental Cells Through Genomic and Nongenomic Actions 1 , 2010 .

[54]  P. Bischof,et al.  Coculture of decidua and trophoblast to study proliferation and invasion. , 2009, Methods in molecular biology.

[55]  J. Maymó,et al.  Up-regulation of placental leptin by human chorionic gonadotropin. , 2009, Endocrinology.

[56]  A. Poggi,et al.  Calcium Calmodulin Kinase II , and lck p 56 Mediated : Evidence for the Involvement of HLA Class I Molecules Is Fas Ligand / Fas upon the Engagement of CD 8 by Soluble Apoptosis of Antigen-Specific T Lymphocytes , 2005 .

[57]  U. Markert,et al.  Signal transduction in trophoblast invasion. , 2005, Chemical immunology and allergy.

[58]  A. Warsy,et al.  Leptin concentration during different stages of pregnancy. , 2004, Clinical and experimental obstetrics & gynecology.

[59]  A. Campana,et al.  Effects of leptin, interleukin-1alpha, interleukin-6, and transforming growth factor-beta on markers of trophoblast invasive phenotype: integrins and metalloproteinases. , 2001, Endocrine.

[60]  N. Hoggard,et al.  Placental leptin. , 2000, Reviews of reproduction.

[61]  A. Campana,et al.  Modulation of human cytotrophoblastic leptin secretion by interleukin-1alpha and 17beta-oestradiol and its effect on HCG secretion. , 1999, Molecular human reproduction.

[62]  J. S. Hunt,et al.  HLA Expression at the Maternal-Fetal Interface , 1998, Developmental immunology.