论文信息 - An Efficient and Simple Route to Prospective Biologically Active Isoindoloquinazoline, Pyrimidine and Thiazine Derivatives Using 2-Amino-N-Arylbenzamidine and Related Compounds as Starting Materials

An Efficient and Simple Route to Prospective Biologically Active Isoindoloquinazoline, Pyrimidine and Thiazine Derivatives Using 2-Amino-N-Arylbenzamidine and Related Compounds as Starting Materials

The reaction of (Z)-2-amino-N`-arylbenzamidines 1, 2-amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxamide (4) and 4-amino-5-substituted-2-(phenylamino)thiophene-3-carboxamides 12 with o-phthalaldehyde (2), terephthalaldehyde (9), and 4-formyl[2.2]paracyclophane (16) in ethanol under reflux conditions afforded isoindoloquinazoline, thienopyrimidine, pyrimidine and thiazine derivatives, respectively. The products were characterized based on their spectroscopic data and elemental analysis. Graphical Abstract An Efficient and Simple Route to Prospective Biologically Active Isoindoloquinazoline, Pyrimidine and Thiazine Derivatives Using 2-Amino-N-Arylbenzamidine and Related Compounds as Starting Materials

A. G. El-Deen | F. Abdel-latif | K. M. El-Shaieb

[1] H. G. Franck. Compounds with Condensed Thiophene Rings, von H. D. Hartough u. S. L. Meisel. The Chemistry of Heterocyclic Compounds. A Series of Monographs. Herausgeg. von A. Weissberger. Interscience Publishers, New York. 1954. 1. Aufl. XV, 515 S., gebd. $ 16.50 , 1954 .