Malignant melanoma of soft parts with osteoclast-rich giant cells: A rare tumour of the jejunum.

Malignant melanoma of soft parts (MMSP), first described by Franz M. Enzinger, is a rare tumour of unknown cell origin. We describe a case of a 45-year-old male who presented with a one-year history of abdominal pain, weakness, and anaemia. Computerised tomography enteroclysis showed a mass in the jejunum that was suggestive of a gastrointestinal stromal tumour. An ulceroinfiltrative lesion measuring 6.5 x 4 x 2cm was identified. Microscopy revealed typical features of MMSP with numerous osteoclasts-like giant cells. The diverse histomorphology and immunohistochemical characteristics of this case involving a rare tumour at a rare site is presented.

[1]  J. Rosai.  Comprar Rosai and Ackerman's Surgical Pathology - 2 Volume Set, 10th Edition | Juan Rosai | 9780323069694 | Mosby , 2011 .

[2]  A. Folpe,et al.  Clear cell sarcoma of tendons and aponeuroses, and osteoclast-rich tumour of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: a review and update , 2010, Journal of Clinical Pathology.

[3]  E. Mayordomo,et al.  Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts) , 2009, Modern Pathology.

[4]  C. Comin,et al.  Clear cell sarcoma of the ileum: report of a case and review of literature , 2007, Virchows Archiv.

[5]  H. Mankin,et al.  Clear cell sarcoma of soft tissues , 2007, Journal of surgical oncology.

[6]  M. Ladanyi,et al.  EWS-CREB1: A Recurrent Variant Fusion in Clear Cell Sarcoma—Association with Gastrointestinal Location and Absence of Melanocytic Differentiation , 2006, Clinical Cancer Research.

[7]  R. Hoda,et al.  Rosai and Ackerman???s Surgical Pathology , 2004 .

[8]  L. Kindblom,et al.  Clear-cell sarcoma of tendons and aponeuroses , 2004, Virchows Archiv A.

[9]  A. Franchi,et al.  An Osteoclast-Rich Tumor of the Gastrointestinal Tract with Features Resembling Clear Cell Sarcoma of Soft Parts: Reports of 6 Casesof aGIST Simulator , 2003, International journal of surgical pathology.

[10]  Y. Omuro,et al.  [Gastrointestinal cancer]. , 2003, Nihon rinsho. Japanese journal of clinical medicine.

[11]  A. Hagemeijer,et al.  Clear cell sarcoma of the stomach , 2002, Histopathology.

[12]  A. Cleton-Jansen,et al.  Malignant melanoma is genetically distinct from clear cell sarcoma of tendons and aponeurosis (malignant melanoma of soft parts) , 2001, British Journal of Cancer.

[13]  T. Ekfors,et al.  Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) in the duodenum: the first visceral case , 1993, Histopathology.

[14]  F. Sim,et al.  Clear Cell Sarcoma of Soft Tissues: Mayo Clinic Experience With 35 Cases , 1992, The American journal of surgical pathology.

[15]  E. van Marck,et al.  Malignant melanoma of soft parts. Further cytogenetic characterization. , 1992, Cancer genetics and cytogenetics.

[16]  C. Alpers,et al.  Malignant neuroendocrine tumor of the jejunum with osteoclast-like giant cells. Enzyme histochemistry distinguishes tumor cells from giant cells. , 1985, The American journal of surgical pathology.

[17]  F. Enzinger,et al.  Malignant melanoma of soft parts: A reassessment of clear cell sarcoma* , 1983, The American journal of surgical pathology.

[18]  D. Carter,et al.  Clear cell sarcoma of tendons and aponeuroses with melanin. , 1973, Archives of pathology.

[19]  F. Enzinger.  Clear‐cell sarcoma of tendons and aponeuroses. An analysis of 21 cases , 1965, Cancer.