Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics.

Advances in chemistry and physics are providing an expanding array of nanostructured materials with unique and powerful optical properties. These nanomaterials provide a new set of tools that are available to biomedical engineers, biologists, and medical scientists who seek new tools as biosensors and probes of biological fluids, cells, and tissue chemistry and function. Nanomaterials are also being used to develop optically controlled devices for applications such as modulated drug delivery as well as optical therapeutics. This review discusses applications that have been successfully demonstrated using nanomaterials including semiconductor nanocrystals, gold nanoparticles, gold nanoshells, and silver plasmon resonant particles.

[1]  D. Balding,et al.  HLA Sequence Polymorphism and the Origin of Humans , 2006 .

[2]  S. L. Westcott,et al.  Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery. , 2000, Journal of biomedical materials research.

[3]  Naomi J. Halas,et al.  Nanoengineering of optical resonances , 1998 .

[4]  J. Storhoff,et al.  Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. , 1997, Science.

[5]  Hedi Mattoussi,et al.  Avidin: a natural bridge for quantum dot-antibody conjugates. , 2002, Journal of the American Chemical Society.

[6]  David A. Schultz,et al.  Single-target molecule detection with nonbleaching multicolor optical immunolabels. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[7]  S. Nie,et al.  Quantum dot bioconjugates for ultrasensitive nonisotopic detection. , 1998, Science.

[8]  S. Nie,et al.  Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules , 2001, Nature Biotechnology.

[9]  Ashleyj . Welch,et al.  Optical-Thermal Response of Laser-Irradiated Tissue , 1995 .

[10]  Naomi J. Halas,et al.  Plasmon Resonance Shifts of Au-Coated Au 2 S Nanoshells: Insight into Multicomponent Nanoparticle Growth , 1997 .

[11]  S. Nie,et al.  Luminescent quantum dots for multiplexed biological detection and imaging. , 2002, Current opinion in biotechnology.

[12]  S. Oldenburg,et al.  Base pair mismatch recognition using plasmon resonant particle labels. , 2002, Analytical biochemistry.

[13]  Albert Cerussi,et al.  Noninvasive functional optical spectroscopy of human breast tissue , 2001, Proceedings of the National Academy of Sciences of the United States of America.