IRS proteins and diabetic complications
暂无分享,去创建一个
[1] M. White. Mechanism of Insulin Action , 2016 .
[2] G. King,et al. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture , 2016, Diabetes.
[3] Yaling Han,et al. Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus , 2016, Cardiovascular Diabetology.
[4] S. Yagihashi,et al. The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: effects on peripheral sensory nerve function, structure and molecular changes , 2016, Journal of neurochemistry.
[5] Á. Valverde,et al. IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes. , 2015, Biochimica et biophysica acta.
[6] Haobo Li,et al. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. , 2015, Clinical science.
[7] H. Kume,et al. Stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in type 2 diabetes with nephropathy. , 2015, Biochemical and biophysical research communications.
[8] R. Walker,et al. Sodium Salicylate Reduced Insulin Resistance in the Retina of a Type 2 Diabetic Rat Model , 2015, PloS one.
[9] J. Steinle,et al. Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line , 2014, Molecular vision.
[10] R. Walker,et al. Pioglitazone Normalizes Insulin Signaling in the Diabetic Rat Retina through Reduction in Tumor Necrosis Factor α and Suppressor of Cytokine Signaling 3* , 2014, The Journal of Biological Chemistry.
[11] M. Pinazo-Durán,et al. Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse. , 2014, Experimental eye research.
[12] M. White,et al. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★ , 2013, Molecular metabolism.
[13] M. White,et al. Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance , 2013, Diabetes.
[14] Xinmin Zhou,et al. Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence , 2013, Cardiovascular Diabetology.
[15] A. Bhanwer,et al. Polymorphisms in PPARγ (Pro12Ala, C1431T), IRS1 (G972R), IRS2 (G1057D) and Coronary artery disease , 2013, International Journal of Diabetes in Developing Countries.
[16] C. Taniguchi,et al. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes , 2013, Nature Medicine.
[17] C. Taniguchi,et al. A liver HIF-2α/IRS2 pathway sensitizes hepatic insulin signaling and is modulated by VEGF inhibition , 2013, Nature Medicine.
[18] Á. Valverde,et al. Insulin directly stimulates VEGF-A production in the glomerular podocyte. , 2013, American journal of physiology. Renal physiology.
[19] M. White,et al. Insulin receptor substrate‐2 is expressed in kidney epithelium and up‐regulated in diabetic nephropathy , 2013, The FEBS journal.
[20] Noemi Lois,et al. Advances in our understanding of diabetic retinopathy. , 2013, Clinical science.
[21] M. White,et al. Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells , 2013, Molecular and Cellular Biology.
[22] Sheng-Xi Wu,et al. Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. , 2013, Pain physician.
[23] Liang-Miin Tsai,et al. Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population , 2012, Journal of Biomedical Science.
[24] L. Almasy,et al. The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling , 2012, Diabetes.
[25] M. White,et al. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 , 2012, Diabetologia.
[26] E. Feldman,et al. Insulin-like growth factors in the peripheral nervous system. , 2012, Endocrinology and metabolism clinics of North America.
[27] J. Steinle,et al. TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis. , 2012, Cellular signalling.
[28] J. Schneider,et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. , 2012, The Journal of clinical investigation.
[29] D. Munoz,et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. , 2012, The Journal of clinical investigation.
[30] P. Pedarzani,et al. Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity , 2012, PloS one.
[31] M. Irwin,et al. PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. , 2012, Clinical science.
[32] S. Bahouth,et al. Silencing of insulin receptor substrate–1 increases cell death in retinal Müller cells , 2012, Molecular vision.
[33] P. Ghezzi,et al. Beneficial Effects of PKF275-055, a Novel, Selective, Orally Bioavailable, Long-Acting Dipeptidyl Peptidase IV Inhibitor in Streptozotocin-Induced Diabetic Peripheral Neuropathy , 2012, Journal of Pharmacology and Experimental Therapeutics.
[34] Eduardo D. Martín,et al. IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation , 2011, Cerebral cortex.
[35] S. Satchell,et al. Diabetic nephropathy. , 2012, Clinical medicine.
[36] S. Bahouth,et al. Role of β-adrenergic receptor regulation of TNF-α and insulin signaling in retinal Muller cells. , 2011, Investigative ophthalmology & visual science.
[37] S. Houser,et al. Inhibition of PKC&agr;/&bgr; With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury , 2011, Circulation research.
[38] E. Davidson,et al. Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin: Effect on Vascular and Neural Complications , 2011, Experimental diabetes research.
[39] S. Rich,et al. An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes. , 2011, Kidney international.
[40] D. Brazil,et al. Insulin receptor substrate 2 and FoxO3a signalling are involved in E‐cadherin expression and transforming growth factor‐β1‐induced repression in kidney epithelial cells , 2011, The FEBS journal.
[41] D. Wright,et al. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy , 2011, Experimental diabetes research.
[42] E. Feldman,et al. Cortical neurons develop insulin resistance and blunted Akt signaling: a potential mechanism contributing to enhanced ischemic injury in diabetes. , 2011, Antioxidants & redox signaling.
[43] R. Ward. NHS Kidney Care , 2011 .
[44] C. Kahn,et al. Insulin signaling to the glomerular podocyte is critical for normal kidney function. , 2010, Cell metabolism.
[45] Amoolya H. Singh,et al. A nuclear complex of rictor and insulin receptor substrate-2 is associated with albuminuria in diabetic mice. , 2010, Metabolic syndrome and related disorders.
[46] C. Kahn,et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. , 2010, Cell metabolism.
[47] Rosemary O’Connor,et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling , 2010, Neurobiology of Aging.
[48] M. White,et al. Irs1 serine 307 promotes insulin sensitivity in mice. , 2010, Cell metabolism.
[49] DCCT and EDIC : The Diabetes Control and Complications Trial and Follow-up Study , 2010 .
[50] S. Cook,et al. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction. , 2010, European heart journal.
[51] J. H. Park,et al. Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats. , 2009, Archives of medical research.
[52] H. Krum,et al. Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy , 2009, Circulation. Heart failure.
[53] A. Barber,et al. Retinal ganglion cells in diabetes , 2008, Journal of Physiology.
[54] G. Glazner,et al. Distal Degenerative Sensory Neuropathy in a Long-Term Type 2 Diabetes Rat Model , 2008, Diabetes.
[55] D. Zochodne. Diabetes mellitus and the peripheral nervous system: Manifestations and mechanisms , 2007, Muscle & nerve.
[56] J. Tavaré,et al. Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes , 2007, Diabetes.
[57] C. Kahn,et al. Essential Role of Insulin and Insulin-Like Growth Factor 1 Receptor Signaling in Cardiac Development and Function , 2006, Molecular and Cellular Biology.
[58] G. Striker,et al. Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis. , 2006, Endocrinology.
[59] P. Fort,et al. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. , 2006, Diabetes.
[60] Liakishev Aa. [Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. Results of the DCCT/EDIC study]. , 2006 .
[61] B. Zinman,et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. , 2005, The New England journal of medicine.
[62] J. Tavaré,et al. The human glomerular podocyte is a novel target for insulin action. , 2005, Diabetes.
[63] Y. Terauchi,et al. Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. , 2005, Journal of the American Society of Nephrology : JASN.
[64] Jimmy D Bell,et al. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. , 2005, The Journal of clinical investigation.
[65] Jens C. Brüning,et al. The role of insulin receptor signaling in the brain , 2005, Trends in Endocrinology & Metabolism.
[66] J. Kushner,et al. Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells , 2005, The Journal of Neuroscience.
[67] Jimmy D Bell,et al. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. , 2005, Journal of Clinical Investigation.
[68] B. Paulweber,et al. Lack of association of the Gly972Arg mutation of the insulin receptor substrate‐1 gene with coronary artery disease in the Austrian population , 2004, Journal of internal medicine.
[69] M. McCarthy,et al. Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease , 1995, Diabetologia.
[70] J. Kushner,et al. Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation , 2003, The Journal of Neuroscience.
[71] E. Feskens,et al. Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies , 2003, Diabetologia.
[72] J. Haigh,et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. , 2003, The Journal of clinical investigation.
[73] L. Rossetti,et al. Hypothalamic insulin signaling is required for inhibition of glucose production , 2002, Nature Medicine.
[74] G. Eknoyan,et al. On improving outcomes and quality of dialysis care, and more. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[75] Ethan M Balk,et al. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[76] M. White,et al. Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action* , 2002, The Journal of Biological Chemistry.
[77] Kdoqi Disclaimer. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[78] M. White,et al. Regulation of Insulin/Insulin-like Growth Factor-1 Signaling by Proteasome-mediated Degradation of Insulin Receptor Substrate-2* , 2001, The Journal of Biological Chemistry.
[79] Michael Karin,et al. Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.
[80] G. Shulman,et al. Prevention of fat-induced insulin resistance by salicylate. , 2001, The Journal of clinical investigation.
[81] R. Klein,et al. Role of brain insulin receptor in control of body weight and reproduction. , 2006, Science.
[82] M. White,et al. [Letters to nature] , 1975, Nature.
[83] Roger Davis,et al. The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 * , 2000, The Journal of Biological Chemistry.
[84] A. Montali,et al. A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease. , 1999, Arteriosclerosis, thrombosis, and vascular biology.
[85] M. White,et al. Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling , 1999, Nature Genetics.
[86] O. Pedersen,et al. Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians. , 1998, Diabetes.
[87] G. Shulman,et al. Disruption of IRS-2 causes type 2 diabetes in mice , 1998, Nature.
[88] Nadine Bazilinski,et al. Brenner and Rector's The Kidney , 1997 .
[89] C. Kahn,et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.
[90] M. White,et al. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase. , 1993, Endocrinology.
[91] M. Czech. Insulin action. , 1981, The American journal of medicine.