Hemorrhagic Shock

Abstract Hemorrhagic shock has been studied extensively in the adult population, but evidence is lacking in the pediatric population. Unlike adults, pediatric patients tolerate hypovolemia with less hypotension until they have reached significant blood volume loss. It is imperative they receive prompt intravenous access, crystalloid resuscitation, followed by blood product transfusion. A hemoglobin goal of 7 g/dL has been translated to the pediatric population without evidence of poor outcomes. Massive transfusion protocols involving a 1:1:1 ratio of red blood cells:fresh frozen plasma:platelets has been recommended although further evidence is needed. With the transfusion of multiple blood products, consideration must be taken into account for the side effects, including electrolyte imbalance and lung injury.

[1]  I. Roberts,et al.  Antifibrinolytic drugs for acute traumatic injury. , 2015, The Cochrane database of systematic reviews.

[2]  A. Peitzman,et al.  Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps , 2015, Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors.

[3]  J. Mosier,et al.  Optimizing oxygen delivery in the critically ill: the utility of lactate and central venous oxygen saturation (ScvO2) as a roadmap of resuscitation in shock. , 2014, The Journal of emergency medicine.

[4]  R. Burd,et al.  Damage Control Resuscitation: Permissive Hypotension and Massive Transfusion Protocols , 2014, Pediatric emergency care.

[5]  R. Nadler,et al.  Tranexamic acid at the point of injury: The Israeli combined civilian and military experience , 2014, The journal of trauma and acute care surgery.

[6]  A. Vogel,et al.  Acute coagulopathy in pediatric trauma , 2014, Current opinion in pediatrics.

[7]  L. Olcay,et al.  Citrate metabolism and its complications in non-massive blood transfusions: association with decompensated metabolic alkalosis+respiratory acidosis and serum electrolyte levels. , 2014, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[8]  J. Pittet,et al.  Coagulopathy After Severe Pediatric Trauma , 2014, Shock.

[9]  G. Velmahos,et al.  Damage Control Resuscitation In Trauma , 2014, Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.

[10]  P. Rhee,et al.  The impact of blood product ratios in massively transfused pediatric trauma patients. , 2013, American journal of surgery.

[11]  Robert Wand,et al.  Prehospital use of tranexamic acid for hemorrhagic shock in primary and secondary air medical evacuation. , 2013, Air medical journal.

[12]  J. Stensballe,et al.  Transfusion in critically ill children: an ongoing dilemma , 2013, Acta anaesthesiologica Scandinavica.

[13]  A. Peitzman,et al.  Use of a massive transfusion protocol in nontrauma patients: activate away. , 2013, Journal of the American College of Surgeons.

[14]  J. Groner,et al.  A pediatric massive transfusion protocol , 2012, The journal of trauma and acute care surgery.

[15]  Kenny Galvez,et al.  Tromboelastografía: nuevos conceptos en la fisiología de la hemostasia y su correlación con la coagulopatía asociada al trauma , 2012 .

[16]  R. Dellinger,et al.  Lactate as a hemodynamic marker in the critically ill , 2012, Current opinion in critical care.

[17]  K. Brohi,et al.  Acute traumatic coagulopathy , 2012, Current opinion in anaesthesiology.

[18]  Kirk A Easley,et al.  Coagulopathy is prevalent and associated with adverse outcomes in transfused pediatric trauma patients. , 2012, The Journal of pediatrics.

[19]  M. Egi,et al.  Effect of tranexamic acid on blood loss in pediatric cardiac surgery: a randomized trial , 2011, Journal of Anesthesia.

[20]  K. Ker,et al.  Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. , 2011, The Cochrane database of systematic reviews.

[21]  N. Robinson,et al.  Bleeding and Transfusion , 2011 .

[22]  J. Lavoie.  Blood transfusion risks and alternative strategies in pediatric patients , 2011, Paediatric anaesthesia.

[23]  W. Adamson,et al.  Massive transfusion and blood product use in the pediatric trauma patient. , 2010, Seminars in pediatric surgery.

[24]  John B Holcomb,et al.  Resuscitation and transfusion principles for traumatic hemorrhagic shock. , 2009, Blood reviews.

[25]  J. Calhoun,et al.  Treatment of War Wounds: A Historical Review , 2009, Clinical orthopaedics and related research.

[26]  J. Sprung,et al.  Cardiac Arrests Associated with Hyperkalemia During Red Blood Cell Transfusion: A Case Series , 2008, Anesthesia and analgesia.

[27]  J. Pickard,et al.  Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage. , 2007, Journal of neurosurgery.

[28]  J. Scholz,et al.  Impact of Norepinephrine and Fluid on Cerebral Oxygenation in Experimental Hemorrhagic Shock , 2007, Pediatric Research.

[29]  M. van Meurs,et al.  EARLY ORGAN-SPECIFIC ENDOTHELIAL ACTIVATION DURING HEMORRHAGIC SHOCK AND RESUSCITATION , 2007, Shock.

[30]  J. Jahr,et al.  Blood substitutes as pharmacotherapies in clinical practice , 2007, Current opinion in anaesthesiology.

[31]  Ryan Woodman,et al.  Preserving cardiac output with beta-adrenergic receptor blockade and inhibiting the Bezold-Jarisch reflex during resuscitation from hemorrhage. , 2007, The Journal of trauma.

[32]  K. Maślanka,et al.  Transfusion‐related acute lung injury and leucocyte‐reacting antibodies , 2007, Vox sanguinis.

[33]  J. Ryan,et al.  Use of Provocative Angiography to Localize Site in Recurrent Gastrointestinal Bleeding , 2007, CardioVascular and Interventional Radiology.

[34]  J. Jallo,et al.  Hypertonic saline: a clinical review , 2007, Neurosurgical Review.

[35]  C. Bridges.  Valid comparisons of antifibrinolytic agents used in cardiac surgery. , 2007, Circulation.

[36]  Jeremiah R. Brown,et al.  Meta-Analysis Comparing the Effectiveness and Adverse Outcomes of Antifibrinolytic Agents in Cardiac Surgery , 2007, Circulation.

[37]  J. Albes,et al.  Cost reduction of perioperative coagulation management in cardiac surgery: value of "bedside" thrombelastography (ROTEM). , 2007, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[38]  K. Zhao,et al.  INHIBITION OF L-TYPE CALCIUM CHANNELS IN ARTERIOLAR SMOOTH MUSCLE CELLS IS INVOLVED IN THE PATHOGENESIS OF VASCULAR HYPOREACTIVITY IN SEVERE SHOCK , 2007, Shock.

[39]  K. Tracey,et al.  Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling1 , 2007, The Journal of Immunology.

[40]  Paul M Ness,et al.  Oxygen therapeutics: pursuit of an alternative to the donor red blood cell. , 2007, Archives of pathology & laboratory medicine.

[41]  M. Cohen,et al.  Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway? , 2007, Annals of surgery.

[42]  C. Wade,et al.  Early versus late recombinant factor VIIa in combat trauma patients requiring massive transfusion. , 2007, The Journal of trauma.

[43]  W. Lees,et al.  Endovascular management of major arterial hemorrhage as a complication of inflammatory pancreatic disease. , 2007, Journal of vascular and interventional radiology : JVIR.

[44]  J. Collet,et al.  Transfusion strategies for patients in pediatric intensive care units. , 2007, The New England journal of medicine.

[45]  David B Hoyt,et al.  From "leaky buckets" to vascular injuries: understanding models of uncontrolled hemorrhage. , 2007, Journal of the American College of Surgeons.

[46]  R. Benjamin,et al.  Transfusion‐related acute lung injury surveillance (2003‐2005) and the potential impact of the selective use of plasma from male donors in the American Red Cross , 2007, Transfusion.

[47]  E. Bulger,et al.  Hypertonic Resuscitation Modulates the Inflammatory Response in Patients With Traumatic Hemorrhagic Shock , 2007, Annals of surgery.

[48]  J. Holcomb,et al.  Coagulopathy : Its Pathophysiology and Treatment in the Injured Patient , 2015 .

[49]  S. Kozek-Langenecker,et al.  Management of massive operative blood loss. , 2007, Minerva anestesiologica.

[50]  E. Faist,et al.  Depressed T cell-derived IFN-γ following trauma-hemorrhage: a potential mechanism for diminished APC responses , 2007, Langenbeck's Archives of Surgery.

[51]  G. Schmid-Schönbein,et al.  PANCREATIC ENZYMES GENERATE CYTOTOXIC MEDIATORS IN THE INTESTINE , 2007, Shock.

[52]  P. Cisek,et al.  Ruptured abdominal aortic aneurysm: does trauma center designation affect outcome? , 2007, Annals of vascular surgery.

[53]  Mona Motamedi,et al.  Improved survival after introduction of an emergency endovascular therapy protocol for ruptured abdominal aortic aneurysms. , 2007, Journal of vascular surgery.

[54]  J. Vincent,et al.  Management of bleeding following major trauma: a European guideline , 2007, Critical Care.

[55]  A. Hoeft,et al.  Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. , 2007, JAMA.

[56]  B. Allaouchiche,et al.  Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography , 2007, Journal of thrombosis and haemostasis : JTH.

[57]  Michael A Dubick,et al.  Damage control resuscitation: directly addressing the early coagulopathy of trauma. , 2007, The Journal of trauma.

[58]  K. Lillemoe,et al.  Improved Outcomes in Postoperative and Pancreatitis-related Visceral Pseudoaneurysms , 2007, Journal of Gastrointestinal Surgery.

[59]  W. Mutschler,et al.  Massive blood transfusion and outcome in 1062 polytrauma patients: a prospective study based on the Trauma Registry of the German Trauma Society , 2007, Vox sanguinis.

[60]  R. Rossaint,et al.  Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials , 2006, Critical care.

[61]  Jing Xu,et al.  Effect of arginine vasopressin on vascular reactivity and calcium sensitivity after hemorrhagic shock in rats and its relationship to Rho-kinase. , 2006, The Journal of trauma.

[62]  A. Kiss,et al.  Recombinant activated coagulation factor VII and bleeding trauma patients. , 2006, The Journal of trauma.

[63]  L. McIntyre,et al.  Can we safely restrict transfusion in trauma patients? , 2006, Current opinion in critical care.

[64]  D. Adams,et al.  Effective management of refractory postcardiotomy bleeding with the use of recombinant activated factor VII. , 2006, The Annals of thoracic surgery.

[65]  Roger J Lewis,et al.  Prehospital hypotension is a predictor of the need for an emergent, therapeutic operation in trauma patients with normal systolic blood pressure in the emergency department. , 2006, The Journal of trauma.

[66]  D. Almeida,et al.  PULSE PRESSURE RESPIRATORY VARIATION AS EARLY MARKER OF CARDIAC OUTPUT FALL IN EXPERIMENTAL HEMORRHAGIC SHOCK , 2006, Artificial organs.

[67]  J. Scholz,et al.  Cerebral Metabolism Assessed with Microdialysis in Uncontrolled Hemorrhagic Shock After Penetrating Liver Trauma , 2006, Anesthesia and analgesia.

[68]  R. Rossaint,et al.  KEY ISSUES IN ADVANCED BLEEDING CARE IN TRAUMA , 2006, Shock.

[69]  E. Deitch,et al.  Intensive care unit management of the trauma patient , 2006, Critical care medicine.

[70]  Rolf Rossaint,et al.  Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding – a European perspective , 2006, Critical care.

[71]  Christoph Hörmann,et al.  Influence of negative expiratory pressure ventilation on hemodynamic variables during severe hemorrhagic shock , 2006, Critical care medicine.

[72]  N. Abumrad,et al.  THE CELLULAR, METABOLIC, AND SYSTEMIC CONSEQUENCES OF AGGRESSIVE FLUID RESUSCITATION STRATEGIES , 2006, Shock.

[73]  B. Levy.  Lactate and shock state: the metabolic view , 2006, Current opinion in critical care.

[74]  S. Rizoli,et al.  Recombinant factor VIIa and the surgical patient , 2006, Current opinion in critical care.

[75]  M. Schreiber,et al.  Fluid resuscitation increases inflammatory gene transcription after traumatic injury. , 2006, The Journal of trauma.

[76]  S. Mallett,et al.  Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. , 2006, Journal of cardiothoracic and vascular anesthesia.

[77]  D. Kessel,et al.  Endovascular treatment of visceral aneurysms associated with pancreatitis and a suggested classification with therapeutic implications. , 2006, Journal of vascular and interventional radiology : JVIR.

[78]  J. Differding,et al.  Resuscitation with normal saline (NS) vs. lactated ringers (LR) modulates hypercoagulability and leads to increased blood loss in an uncontrolled hemorrhagic shock swine model. , 2006, The Journal of trauma.

[79]  Christian Krettek,et al.  Staged management and outcome of combined pelvic and liver trauma. An international experience of the deadly duo. , 2006, Injury.

[80]  J. Holcomb,et al.  Fresh whole blood transfusion: a controversial military practice. , 2006, The Journal of trauma.

[81]  T. Scalea,et al.  HYPOTENSIVE HEMORRHAGE INCREASES CALCIUM UPTAKE CAPACITY AND BCL-XL CONTENT OF LIVER MITOCHONDRIA , 2006, Shock.

[82]  T. Bacchella,et al.  Hypertonic saline solution increases cerebral perfusion pressure during clinical orthotopic liver transplantation for fulminant hepatic failure: preliminary results. , 2006, Clinics.

[83]  J. Hess,et al.  Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma. , 2006, The Journal of trauma.

[84]  J. Hess,et al.  Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol. , 2006, The Journal of trauma.

[85]  J. Hess,et al.  The coagulopathy of trauma versus disseminated intravascular coagulation. , 2006, The Journal of trauma.

[86]  O. Gajic,et al.  Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury , 2006, Critical care medicine.

[87]  J. Mcfarland,et al.  Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodies. , 2006, Critical care medicine.

[88]  David B Hoyt,et al.  Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma , 2006, Transfusion.

[89]  D. Dwyre,et al.  Transfusion-Related Acute Lung Injury (TRALI): Current Clinical and Pathophysiologic Considerations , 2006, Lung.

[90]  A. Bradbury,et al.  Hypotensive resuscitation in patients with ruptured abdominal aortic aneurysm. , 2006, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[91]  L. Poli-de-Figueiredo,et al.  Volume replacement with lactated Ringer's or 3% hypertonic saline solution during combined experimental hemorrhagic shock and traumatic brain injury. , 2006, The Journal of trauma.

[92]  Y. Vodovotz,et al.  Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[93]  E. Moore,et al.  World Journal of Emergency Surgery Open Access Emergency Department Thoracotomy for the Critically Injured Patient: Objectives, Indications, and Outcomes , 2022 .

[94]  Y. Vodovotz,et al.  Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. , 2006, Journal of the American College of Surgeons.

[95]  I. Chaudry,et al.  Influence of gender and age on T-cell responses in a murine model of trauma-hemorrhage: differences between circulating and tissue-fixed cells. , 2006, Journal of applied physiology.

[96]  Po-Huang Lee,et al.  Safety and hemostatic effect of recombinant activated factor VII in cirrhotic patients undergoing partial hepatectomy: a multicenter, randomized, double-blind, placebo-controlled trial. , 2006, American journal of surgery.

[97]  I. C. Tudor,et al.  The risk associated with aprotinin in cardiac surgery. , 2006, The New England journal of medicine.

[98]  M. Salhab,et al.  Impact of Delay on Survival in Patients with Ruptured Abdominal Aortic Aneurysm , 2006, Vascular.

[99]  N. Curzen,et al.  Thrombelastography: Current clinical applications and its potential role in interventional cardiology , 2006, Platelets.

[100]  Y. W. Ng,et al.  A mathematical model for fresh frozen plasma transfusion strategies during major trauma resuscitation with ongoing hemorrhage. , 2005, Canadian journal of surgery. Journal canadien de chirurgie.

[101]  T. Scalea,et al.  Safety of uncrossmatched type-O red cells for resuscitation from hemorrhagic shock. , 2005, The Journal of trauma.

[102]  D. Demetriades,et al.  Serum bicarbonate may replace the arterial base deficit in the trauma intensive care unit. , 2005, American journal of surgery.

[103]  F. Dal-Pizzol,et al.  Hypertonic saline and hemorrhagic shock: hepatocellular function and integrity after six hours of treatment. , 2005, Acta cirurgica brasileira.

[104]  C. Wade,et al.  The epidemiology and modern management of traumatic hemorrhage: US and international perspectives , 2005, Critical care.

[105]  J. Dunning,et al.  Can the use of thromboelastography predict and decrease bleeding and blood and blood product requirements in adult patients undergoing cardiac surgery? , 2005, Interactive cardiovascular and thoracic surgery.

[106]  C. Samama,et al.  The coagulopathy of massive transfusion , 2005, Vox sanguinis.

[107]  A. Bradbury,et al.  Serum lactate and base deficit as predictors of mortality after ruptured abdominal aortic aneurysm repair. , 2005, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[108]  M. Cinat,et al.  Is Field Hypotension a Reliable Indicator of Significant Injury in Trauma Patients who are Normotensive on Arrival to the Emergency Department? , 2005, The American surgeon.

[109]  J. Haukoos,et al.  The Effect of Older Blood on Mortality, Need for ICU Care, and the Length of ICU Stay after Major Trauma , 2005, The American surgeon.

[110]  P. Fall,et al.  Lactic Acidosis: From Sour Milk to Septic Shock , 2005, Journal of intensive care medicine.

[111]  E. Moore,et al.  Insights from studies of blood substitutes in trauma. , 2005, Shock.

[112]  Melvin T. Alexander,et al.  Determinants of futility of administration of recombinant factor VIIa in trauma. , 2005, The Journal of trauma.

[113]  A. Morey,et al.  Factor VIIa for correction of traumatic coagulopathy. , 2005, The Journal of urology.

[114]  Eduardo C. Ayuste,et al.  Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications of conventional Ringer's solution. , 2005, The Journal of trauma.

[115]  W. Loomis,et al.  Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy. , 2005, The Journal of trauma.

[116]  I. Chaudry,et al.  Role of thromboxane in producing hepatic injury during hepatic stress. , 2005, Archives of surgery.

[117]  E. Deitch,et al.  Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition. , 2005, The Journal of trauma.

[118]  J. García-Valdecasas,et al.  Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation , 2005, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[119]  H. Cryer,et al.  The effect of hypertonic saline resuscitation on responses to severe hemorrhagic shock by the skeletal muscle, intestinal, and renal microcirculation systems: seeing is believing. , 2005, American journal of surgery.

[120]  A. Salim,et al.  Use of serum bicarbonate measurement in place of arterial base deficit in the surgical intensive care unit. , 2005, Archives of surgery.

[121]  R Rossaint,et al.  Coagulopathy and blood component transfusion in trauma. , 2005, British journal of anaesthesia.

[122]  I. Chaudry,et al.  Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches , 2005, Langenbeck's Archives of Surgery.

[123]  Michael D Pasquale,et al.  "Low-dose" recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhage. , 2005, The Journal of trauma.

[124]  C. Wade,et al.  Endpoints in clinical trials of fluid resuscitation of patients with traumatic injuries , 2005, Transfusion.

[125]  R. Rossaint,et al.  Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. , 2005, The Journal of trauma.

[126]  J. Bux.  Transfusion‐related acute lung injury (TRALI): a serious adverse event of blood transfusion , 2005, Vox sanguinis.

[127]  E. Childs,et al.  EVIDENCE OF TRANSCELLULAR ALBUMIN TRANSPORT after HEMORRHAGIC SHOCK , 2005, Shock.

[128]  Jing Xu,et al.  THE ROLE OF CALCIUM DESENSITIZATION IN VASCULAR HYPOREACTIVITY AND ITS REGULATION AFTER HEMORRHAGIC SHOCK IN THE RAT , 2005, Shock.

[129]  Walter L Biffl,et al.  Transfer Times to Definitive Care Facilities Are Too Long: A Consequence of an Immature Trauma System , 2005, Annals of surgery.

[130]  T. Scalea,et al.  Lactate and base deficit in trauma: does alcohol or drug use impair their predictive accuracy? , 2005, The Journal of trauma.

[131]  J. Siegel,et al.  Bench-to-bedside review: Oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock , 2005, Critical care.

[132]  P. Rhee,et al.  Combat Casualty Care Research: From Bench to the Battlefield , 2005, World Journal of Surgery.

[133]  H. Büller,et al.  Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: A systematic review , 2005, Critical care medicine.

[134]  M. Michaelson,et al.  Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force , 2005, Journal of thrombosis and haemostasis : JTH.

[135]  J. Ingerslev,et al.  Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrate. , 2005, British journal of anaesthesia.

[136]  A. Harken,et al.  Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-α receptor , 2005 .

[137]  E. Childs,et al.  Hypothermia reduces microvascular permeability and reactive oxygen species expression after hemorrhagic shock. , 2005, The Journal of trauma.

[138]  Joseph Cuschieri,et al.  The role of repeat angiography in the management of pelvic fractures. , 2005, The Journal of trauma.

[139]  I. Roberts,et al.  Antifibrinolytic agents in traumatic hemorrhage: a large scale randomized controlled trial is needed. , 2005, Croatian medical journal.

[140]  G. Schmid-Schönbein,et al.  A New Hypothesis for Microvascular Inflammation in Shock and Multiorgan Failure: Self‐Digestion by Pancreatic Enzymes , 2005, Microcirculation.

[141]  R. Bilkovski,et al.  Targeted resuscitation strategies after injury , 2004, Current opinion in critical care.

[142]  J. Kiang,et al.  Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury , 2004, Cell Research.

[143]  Robertson Davenport,et al.  Toward an understanding of transfusion‐related acute lung injury: statement of a consensus panel , 2004, Transfusion.

[144]  Mihae Yu,et al.  Uncompensated metabolic acidosis: an underrecognized risk factor for subsequent intubation requirement. , 2004, The Journal of trauma.

[145]  G. Schmid-Schönbein,et al.  PANCREATIC PROTEASES AND INFLAMMATORY MEDIATORS IN PERITONEAL FLUID DURING SPLANCHNIC ARTERIAL OCCLUSION AND REPERFUSION , 2004, Shock.

[146]  L. Aledort.  Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity , 2004, Journal of thrombosis and haemostasis : JTH.

[147]  P. Pepe,et al.  Detrimental hemodynamic effects of assisted ventilation in hemorrhagic states , 2004, Critical care medicine.

[148]  G. Schmid-Schönbein,et al.  Improvement in early symptoms of shock by delayed intestinal protease inhibition. , 2004, Archives of surgery.

[149]  G. Wang,et al.  Effects of glycine and methylprednisolone on hemorrhagic shock in rats. , 2004, Chinese medical journal.

[150]  A. May,et al.  Complications after 344 damage-control open celiotomies. , 2004, The Journal of trauma.

[151]  A. Elhan,et al.  Admission lactate level and the APACHE II score are the most useful predictors of prognosis following torso trauma. , 2004, Injury.

[152]  S. Rajwal,et al.  The use of recalcified citrated whole blood – a pragmatic approach for thromboelastography in children , 2004, Paediatric anaesthesia.

[153]  I. Harris,et al.  Guidelines for the management of haemodynamically unstable pelvic fracture patients , 2004, ANZ journal of surgery.

[154]  R. Coimbra,et al.  Resuscitation Affects Microcirculatory Polymorphonuclear Leukocyte Behavior After Hemorrhagic Shock: Role of Hypertonic Saline and Pentoxifylline , 2004, Experimental biology and medicine.

[155]  J. Kolsen-Petersen.  Immune effect of hypertonic saline: fact or fiction? , 2004, Acta anaesthesiologica Scandinavica.

[156]  D. Hoyt,et al.  The Use of Recombinant Factor VIIa for Severe Intractable Bleeding During Spine Surgery , 2004, Spine.

[157]  Robyn Norton,et al.  A comparison of albumin and saline for fluid resuscitation in the Intensive Care unit , 2005 .

[158]  J. Kellum,et al.  Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury* , 2004, Critical care medicine.

[159]  G. Gutierrez,et al.  Clinical review: Hemorrhagic shock , 2004, Critical care.

[160]  J. Tepas,et al.  Evaluation of Initial Base Deficit as a Prognosticator of Outcome in the Pediatric Trauma Population , 2004, The American surgeon.

[161]  E. Moore,et al.  TRANSFUSION OF THE INJURED PATIENT: PROCEED WITH CAUTION , 2004, Shock.

[162]  C. Samama,et al.  Transfusion massive et coagulopathie-: physiopathologie et implications cliniques , 2004, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[163]  R. Hardaway.  Wound shock: a history of its study and treatment by military surgeons. , 2004, Military medicine.

[164]  J. Ponsford,et al.  Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. , 2004, JAMA.

[165]  E. Deitch,et al.  Trauma-hemorrhagic shock-induced up-regulation of endothelial cell adhesion molecules is blunted by mesenteric lymph duct ligation , 2004, Critical care medicine.

[166]  Richard L. Sohn,et al.  Prognostic Determinants in Duodenal Injuries , 2004, The American surgeon.

[167]  Raywin R Huang,et al.  Hypothermia is an Independent Predictor of Mortality in Ruptured Abdominal Aortic Aneurysms , 2004, Vascular and endovascular surgery.

[168]  A. Burroughs,et al.  Thromboelastography with citrated blood: comparability with native blood, stability of citrate storage and effect of repeated sampling , 2004, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[169]  I. Finlay,et al.  Damage control laparotomy , 2004, The British journal of surgery.

[170]  M. Levy,et al.  The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States* , 2004, Critical care medicine.

[171]  J. Schumacher,et al.  Organ-Specific Extravasation of Albumin-Bound Evans Blue During Nonresuscitated Hemorrhagic Shock in Rats , 2003, Shock.

[172]  D. Waldman,et al.  Superselective microcoil embolization for the treatment of lower gastrointestinal hemorrhage. , 2003, Journal of vascular and interventional radiology : JVIR.

[173]  G. Rozycki,et al.  Changing patterns in the management of penetrating abdominal trauma: the more things change, the more they stay the same. , 2003, The Journal of trauma.

[174]  A. Hagiwara,et al.  Predictors of death in patients with life-threatening pelvic hemorrhage after successful transcatheter arterial embolization. , 2003, The Journal of trauma.

[175]  G. Schmid-Schönbein,et al.  Pancreatic Digestive Enzymes Are Potent Generators of Mediators for Leukocyte Activation and Mortality , 2003, Shock.

[176]  Mauricio Lynn,et al.  Early coagulopathy predicts mortality in trauma. , 2003, The Journal of trauma.

[177]  S. Matoba,et al.  The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts , 2003, Basic Research in Cardiology.

[178]  C. Cocanour,et al.  Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. , 2003, Archives of surgery.

[179]  S. Cohn,et al.  Gastric tonometry: the role of mucosal pH measurement in the management of trauma. , 2003, Chest.

[180]  Gregory P Victorino,et al.  Does tachycardia correlate with hypotension after trauma? , 2003, Journal of the American College of Surgeons.

[181]  P. Rhee,et al.  Searching for the optimal resuscitation method: recommendations for the initial fluid resuscitation of combat casualties. , 2003, The Journal of trauma.

[182]  H. Reynolds,et al.  Selective arterial embolization for control of lower gastrointestinal bleeding: recommendations for a clinical management pathway. , 2003, Current surgery.

[183]  Raul Coimbra,et al.  Diagnosis and monitoring of hemorrhagic shock during the initial resuscitation of multiple trauma patients: a review. , 2003, The Journal of emergency medicine.

[184]  John B Holcomb,et al.  Blood pressure at which rebleeding occurs after resuscitation in swine with aortic injury. , 2003, The Journal of trauma.

[185]  C. Wade,et al.  Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating trauma. , 2003, The Journal of trauma.

[186]  S. Kleinman,et al.  Risks associated with transfusion of cellular blood components in Canada. , 2003, Transfusion medicine reviews.

[187]  A. Hirshberg,et al.  Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation. , 2003, The Journal of trauma.

[188]  J Wayne Meredith,et al.  External fixation or arteriogram in bleeding pelvic fracture: initial therapy guided by markers of arterial hemorrhage. , 2003, The Journal of trauma.

[189]  David B Hoyt,et al.  The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury. , 2003, The Journal of trauma.

[190]  S. Moochhala,et al.  Preservation of neurological functions by nitric oxide synthase inhibitors following hemorrhagic shock , 2003, Neuropharmacology.

[191]  K. Kurth,et al.  Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial , 2003, The Lancet.

[192]  D. Partrick,et al.  Is hypotension a reliable indicator of blood loss from traumatic injury in children? , 2002, American journal of surgery.

[193]  P. Reilly,et al.  Abdominal compartment syndrome in the open abdomen. , 2002, Archives of surgery.

[194]  A. Seely,et al.  Hypertonic Saline Resuscitation of Hemorrhagic Shock Diminishes Neutrophil Rolling and Adherence to Endothelium and Reduces In Vivo Vascular Leakage , 2002, Annals of surgery.

[195]  J. Wood,et al.  In Vivo Visualization of Reactive Oxidants and Leukocyte-Endothelial Adherence Following Hemorrhagic Shock , 2002, Shock.

[196]  K. Davis,et al.  Resuscitation in the pediatric trauma population: admission base deficit remains an important prognostic indicator. , 2002, The Journal of trauma.

[197]  William C. Shoemaker,et al.  Meta-analysis of hemodynamic optimization in high-risk patients* , 2002, Critical care medicine.

[198]  S. Stramer,et al.  Current prevalence and incidence of infectious disease markers and estimated window‐period risk in the American Red Cross blood donor population , 2002, Transfusion.

[199]  W. Erber.  Massive blood transfusion in the elective surgical setting. , 2002, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[200]  S. Vaslef,et al.  Massive transfusion exceeding 50 units of blood products in trauma patients. , 2002, The Journal of trauma.

[201]  M. Hallisey,et al.  The Changing Paradigm for the Treatment of Colonic Hemorrhage , 2002, Diseases of the colon and rectum.

[202]  E. Moore,et al.  Increased rate of infection associated with transfusion of old blood after severe injury. , 2002, Archives of surgery.

[203]  Thomas M Scalea,et al.  Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality. , 2002, The Journal of trauma.

[204]  K. Kregel,et al.  Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. , 2002, Journal of applied physiology.

[205]  G. Schmid-Schönbein,et al.  Protease Inhibition in the Intestinal Lumen: Attenuation of Systemic Inflammation and Early Indicators of Multiple Organ Failure in Shock , 2002, Shock.

[206]  N. Topley,et al.  Increased neutrophil migratory activity after major trauma: A factor in the etiology of acute respiratory distress syndrome? , 2002, Critical care medicine.

[207]  Simon C Watkins,et al.  The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock , 2002, Shock.

[208]  E. Moore,et al.  Secondary abdominal compartment syndrome is a highly lethal event. , 2001, American journal of surgery.

[209]  S. Stern,et al.  Low-volume fluid resuscitation for presumed hemorrhagic shock: helpful or harmful? , 2001, Current opinion in critical care.

[210]  E. Deitch,et al.  Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption. , 2001, The Journal of trauma.

[211]  O. Trentz,et al.  Control of Severe Hemorrhage Using C-Clamp and Pelvic Packing in Multiply Injured Patients With Pelvic Ring Disruption , 2001, Journal of orthopaedic trauma.

[212]  S. Magder,et al.  The use of respiratory variations in right atrial pressure to predict the cardiac output response to PEEP. , 2001, Journal of critical care.

[213]  P M Reilly,et al.  Evolution in damage control for exsanguinating penetrating abdominal injury. , 2001, The Journal of trauma.

[214]  E. Moore,et al.  Phospholipase A(2)--derived neutral lipids from posthemorrhagic shock mesenteric lymph prime the neutrophil oxidative burst. , 2001, Surgery.

[215]  L. Toledo-Pereyra,et al.  Adhesion molecules and hemorrhagic shock. , 2001, The Journal of trauma.

[216]  P. Reilly,et al.  THE MESENTERIC HEMODYNAMIC RESPONSE TO CIRCULATORY SHOCK: AN OVERVIEW , 2001, Shock.

[217]  P. Coriat,et al.  Voluven®, a Lower Substituted Novel Hydroxyethyl Starch (HES 130/0.4), Causes Fewer Effects on Coagulation in Major Orthopedic Surgery than HES 200/0.5 , 2001, Anesthesia and analgesia.

[218]  D. Pierson,et al.  Trauma critical care. , 2001, American journal of respiratory and critical care medicine.

[219]  E. Moore,et al.  Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction. , 2001, The Journal of trauma.

[220]  Simon C Watkins,et al.  Impaired Gut Contractility Following Hemorrhagic Shock is Accompanied by IL-6 and G-CSF Production and Neutrophil Infiltration , 2001, Digestive Diseases and Sciences.

[221]  G. Schmid-Schönbein,et al.  Pancreatic Enzymes and Microvascular Cell Activation in Multiorgan Failure , 2001, Microcirculation.

[222]  G. Lyons,et al.  Thromboelastography Identifies Sex-Related Differences in Coagulation , 2000, Anesthesia and analgesia.

[223]  D H Jenkins,et al.  Damage control: collective review. , 2000, The Journal of trauma.

[224]  O. Rotstein,et al.  Novel strategies for immunomodulation after trauma: revisiting hypertonic saline as a resuscitation strategy for hemorrhagic shock. , 2000, The Journal of trauma.

[225]  J. Feyh,et al.  Coagulation effects of a recently developed hydroxyethyl starch (HES 130/0.4) compared to hydroxyethyl starches with higher molecular weight , 2000, Acta anaesthesiologica Scandinavica.

[226]  H Belzberg,et al.  Endpoints of Resuscitation of Critically Injured Patients: Normal or Supranormal?: A Prospective Randomized Trial , 2000, Annals of surgery.

[227]  T. Tadros,et al.  Trauma- and sepsis-induced hepatic ischemia and reperfusion injury: role of angiotensin II. , 2000, Archives of surgery.

[228]  B J Tortella,et al.  The utility of venous lactate to triage injured patients in the trauma center. , 2000, Journal of the American College of Surgeons.

[229]  B. Seifert,et al.  Citrate Storage Affects Thrombelastograph® Analysis , 2000, Anesthesiology.

[230]  P. Reilly,et al.  MESENTERIC VASOCONSTRICTION IN RESPONSE TO HEMORRHAGIC SHOCK , 2000, Shock.

[231]  D. Burris,et al.  Human neutrophil activation and increased adhesion by various resuscitation fluids , 2000, Critical care medicine.

[232]  E. Moore,et al.  Age of transfused blood is an independent risk factor for postinjury multiple organ failure. , 1999, American journal of surgery.

[233]  P. Wang,et al.  Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review). , 1999, International journal of molecular medicine.

[234]  K. Davis,et al.  Secondary abdominal compartment syndrome: an underappreciated manifestation of severe hemorrhagic shock. , 1999, The Journal of trauma.

[235]  L. Toledo-Pereyra,et al.  Upregulation of lung chemokines associated with hemorrhage is reversed with a small molecule multiple selectin inhibitor. , 1999, Journal of the American College of Surgeons.

[236]  R. Bünger,et al.  Intravenous pyruvate prolongs survival during hemorrhagic shock in swine. , 1999, The American journal of physiology.

[237]  M. Syrjälä,et al.  Massive blood transfusion exceeding 50 units of plasma poor red cells or whole blood: the survival rate and the occurrence of leukopenia and acidosis. , 1999, Injury.

[238]  S. Wilson,et al.  Improved survival following massive transfusion in patients who have undergone trauma. , 1999, Archives of surgery.

[239]  A B Fontaine,et al.  Endovascular techniques in the damage control setting. , 1999, Radiographics : a review publication of the Radiological Society of North America, Inc.

[240]  J. Rauwerda,et al.  The renin-angiotensin system in swine during hypovolaemic shock combined with low-flow ischaemia of the sigmoid colon. , 1999, Cardiovascular surgery.

[241]  N. Enomoto,et al.  Glycine improves survival after hemorrhagic shock in the rat. , 1999, Shock.

[242]  A. Peitzman,et al.  Trauma center maturation: quantification of process and outcome. , 1999, Annals of surgery.

[243]  T. Lindsay,et al.  A CD18 monoclonal antibody reduces multiple organ injury in a model of ruptured abdominal aortic aneurysm. , 1999, American journal of physiology. Heart and circulatory physiology.

[244]  T. Billiar,et al.  Novel roles of nitric oxide in hemorrhagic shock. , 1999, Shock.

[245]  K. Messmer,et al.  Hypertonic saline dextran attenuates leukocyte accumulation in the liver after hemorrhagic shock and resuscitation. , 1999, The Journal of trauma.

[246]  G. Wells,et al.  A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. , 1999, The New England journal of medicine.

[247]  M. Wilson,et al.  Complement activation mediates intestinal injury after resuscitation from hemorrhagic shock. , 1999, The Journal of trauma.

[248]  E. Moore,et al.  Staged Physiologic Restoration and Damage Control Surgery , 1998, World Journal of Surgery.

[249]  E. Deitch,et al.  POST‐HEMORRHAGIC SHOCK MESENTERIC LYMPH IS CYTOTOXIC TO ENDOTHELIAL CELLS AND ACTIVATES NEUTROPHILS , 1998, Shock.

[250]  L. Mildh,et al.  Hepatosplanchnic and peripheral tissue oxygenation during treatment of hemorrhagic shock: the effects of pentoxifylline administration. , 1998, Annals of surgery.

[251]  B. Seifert,et al.  Compromised Blood Coagulation: An In Vitro Comparison of Hydroxyethyl Starch 130/0.4 and Hydroxyethyl Starch 200/0.5 Using Thrombelastography , 1998, Anesthesia and analgesia.

[252]  M. Wilson,et al.  Complement inhibition prevents gut ischemia and endothelial cell dysfunction after hemorrhage/resuscitation. , 1998, Surgery.

[253]  M. Clemens,et al.  Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats. , 1998, The Journal of clinical investigation.

[254]  G. Velmahos,et al.  Is there a limit to massive blood transfusion after severe trauma? , 1998, Archives of surgery.

[255]  J. Meredith,et al.  Redefining cardiovascular performance during resuscitation: ventricular stroke work, power, and the pressure-volume diagram. , 1998, The Journal of trauma.

[256]  G. Velmahos,et al.  Relative bradycardia in patients with traumatic hypotension. , 1998, The Journal of trauma.

[257]  Simon C Watkins,et al.  Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. , 1998, American journal of physiology. Lung cellular and molecular physiology.

[258]  R. Ivatury,et al.  In search of the optimal end points of resuscitation in trauma patients: a review. , 1998, The Journal of trauma.

[259]  O. Kirton,et al.  Failure of splanchnic resuscitation in the acutely injured trauma patient correlates with multiple organ system failure and length of stay in the ICU. , 1998, Chest.

[260]  G. Schierhout,et al.  Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials , 1998, BMJ.

[261]  R. Larsen,et al.  Pentoxifylline prevention of altered hepatocyte calcium regulation during hemorrhagic shock/resuscitation. , 1998, Critical care medicine.

[262]  Y. Ohnishi,et al.  INHIBITION OF NITRIC OXIDE SYNTHESIS AGGRAVATES MYOCARDIAL ISCHEMIA IN HEMORRHAGIC SHOCK IN CONSTANT PRESSURE MODEL , 1998, Shock.

[263]  H S Snyder,et al.  Significance of the initial spun hematocrit in trauma patients. , 1998, The American journal of emergency medicine.

[264]  H. Junger,et al.  HYPERTONIC SALINE RESUSCITATION: A TOOL TO MODULATE IMMUNE FUNCTION IN TRAUMA PATIENTS? , 1997, Shock.

[265]  J. Lederer,et al.  Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection. , 1997, Annals of surgery.

[266]  S. Guarini,et al.  Adrenocorticotropin normalizes the blood levels of nitric oxide in hemorrhage-shocked rats. , 1997, European journal of pharmacology.

[267]  J. Kline,et al.  Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock. , 1997, Journal of molecular and cellular cardiology.

[268]  T. Fabian,et al.  Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies. , 1997, Surgery.

[269]  L. Chan,et al.  The significance of out-of-hospital hypotension in blunt trauma patients. , 1997, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[270]  L. Shaffer,et al.  Successful Treatment of Acquired Hemophilia with Oral Immunosuppressive Therapy , 1997, Annals of Internal Medicine.

[271]  S. Ogawa,et al.  Characterization of energy metabolism and blood flow distribution in myocardial ischemia in hemorrhagic shock. , 1997, The American journal of physiology.

[272]  M. Rotondo,et al.  The damage control sequence and underlying logic. , 1997, The Surgical clinics of North America.

[273]  M. Wilson,et al.  Alternatives in the management of penetrating injuries to the iliac vessels. , 1997, The Journal of trauma.

[274]  G. Kramer,et al.  Efficacy of hypertonic saline dextran (HSD) in patients with traumatic hypotension: meta‐analysis of individual patient data , 1997, Acta anaesthesiologica Scandinavica. Supplementum.

[275]  P. Gosling,et al.  Prediction of posttraumatic adult respiratory distress syndrome by albumin excretion rate eight hours after admission. , 1997, The Journal of trauma.

[276]  A. Sauaia,et al.  Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. , 1997, The Journal of trauma.

[277]  C. Wade,et al.  Individual patient cohort analysis of the efficacy of hypertonic saline/dextran in patients with traumatic brain injury and hypotension. , 1997, The Journal of trauma.

[278]  N. Paradis,et al.  Hematocrit as a predictor of significant injury after penetrating trauma. , 1997, The American journal of emergency medicine.

[279]  W. Loomis,et al.  Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock. , 1997, The Journal of trauma.

[280]  I. Chaudry,et al.  Administration of ATP-MgCl2 after trauma-hemorrhage and resuscitation restores the depressed cardiac performance. , 1997, The Journal of surgical research.

[281]  C. Kaufmann,et al.  Usefulness of thrombelastography in assessment of trauma patient coagulation. , 1997, The Journal of trauma.

[282]  H S Snyder,et al.  Prospective crossover study of the effect of phlebotomy and intravenous crystalloid on hematocrit. , 1997, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[283]  Jeffrey S. Young,et al.  Coagulopathy in severe closed head injury: is empiric therapy warranted? , 1997, The American surgeon.

[284]  A. Webb,et al.  Comparison of commonly used clinical indicators of hypovolaemia with gastrointestinal tonometry , 1997, Intensive Care Medicine.

[285]  S. Ruchholtz,et al.  Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. , 1997, The Journal of trauma.

[286]  A W Asimos,et al.  Admission base deficit predicts transfusion requirements and risk of complications. , 1997, The Journal of trauma.

[287]  C. Szabó,et al.  K(ATP)-channel inhibition improves hemodynamics and cellular energetics in hemorrhagic shock. , 1997, The American journal of physiology.

[288]  P. Schumacker,et al.  Transit time heterogeneity in canine small intestine: significance for oxygen transport. , 1997, The Journal of clinical investigation.

[289]  E. Moore,et al.  Thomas G. Orr Memorial Lecture. Staged laparotomy for the hypothermia, acidosis, and coagulopathy syndrome. , 1996, American journal of surgery.

[290]  R. L. Fulton,et al.  Operative strategies for management of abdominal aortic gunshot wounds. , 1996, Surgery.

[291]  J. Morris,et al.  The trauma celiotomy: the evolving concepts of damage control. , 1996, Current problems in surgery.

[292]  C. Szabó.  THE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA‐REPERFUSION INJURY , 1996, Shock.

[293]  H. Bitterman,et al.  Effects of oxygen on regional hemodynamics in hemorrhagic shock. , 1996, The American journal of physiology.

[294]  R. L. Fulton,et al.  Predicting the need to pack early for severe intra-abdominal hemorrhage. , 1996, The Journal of trauma.

[295]  N. Christou,et al.  SYSTEMIC INFLAMMATORY RESPONSE SYNDROME: INTERACTIONS BETWEEN IMMUNE CELLS AND THE ENDOTHELIUM , 1996, Shock.

[296]  E. Faist,et al.  Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation , 1996, World Journal of Surgery.

[297]  A. Sauaia,et al.  Early Risk Factors for Postinjury Multiple Organ Failure , 1996, World Journal of Surgery.

[298]  J. Ludbrook,et al.  Roles of carotid baroreceptor and cardiac afferents in hemodynamic responses to acute central hypovolemia. , 1996, The American journal of physiology.

[299]  J. Yelle,et al.  Adult respiratory distress syndrome: A systematic overview of incidence and risk factors , 1996 .

[300]  T. Scalea,et al.  Serum lactate is not predicted by anion gap or base excess after trauma resuscitation. , 1996, The Journal of trauma.

[301]  Richard W. Davis.  Massive blood transfusion in a tertiary referral hospital , 1996, The Medical journal of Australia.

[302]  J. Kelton,et al.  A prospective study to determine the frequency and clinical significance of alloimmunization post‐transfusion , 1995, British journal of haematology.

[303]  J. Vincent,et al.  Correlation of serial blood lactate levels to organ failure and mortality after trauma. , 1995, The American journal of emergency medicine.

[304]  K. Kobayashi,et al.  Bile and bilirubin excretion in relation to hepatic energy status during hemorrhagic shock and hypoxemia in rabbits. , 1995, The Journal of trauma.

[305]  A. Sauaia,et al.  Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. , 1995, The Journal of trauma.

[306]  R H West,et al.  Outcome of patients with haemorrhagic shock: an indicator of performance in a trauma centre. , 1995, Journal of the Royal College of Surgeons of Edinburgh.

[307]  C. Valeri,et al.  Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats. , 1995, The American journal of physiology.

[308]  N. Vaziri,et al.  Soluble cytokine receptors and receptor antagonists are sequentially released after trauma. , 1995, The Journal of trauma.

[309]  J. Revelly,et al.  Effect of epinephrine on oxygen consumption and delivery during progressive hemorrhage. , 1995, Critical care medicine.

[310]  R. Turnage,et al.  Neutrophil Regulation of Splanchnic Blood Flow After Hemorrhagic Shock , 1995, Annals of surgery.

[311]  W. Shoemaker,et al.  Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. , 1995, The Journal of trauma.

[312]  H A Schwid,et al.  The Effect of Graded Hemorrhage and Intravascular Volume Replacement on Systolic Pressure Variation in Humans During Mechanical and Spontaneous Ventilation , 1995, Anesthesia and analgesia.

[313]  C. E. Hock,et al.  Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock. , 1995, Critical care medicine.

[314]  S. Siram,et al.  Evaluation of massive volume replacement in the penetrating trauma patient. , 1994, Journal of the National Medical Association.

[315]  G. Granger,et al.  Trauma causes sustained elevation of soluble tumor necrosis factor receptors. , 1994, Journal of the American College of Surgeons.

[316]  A. Groeneveld,et al.  Splanchnic tonometry: a review of physiology, methodology, and clinical applications. , 1994, Journal of critical care.

[317]  E. Bulger,et al.  Death in the operating room : an analysis of a multi-center experience , 1994 .

[318]  J. Duranteau,et al.  Heterogeneous regional vascular responses to simulated transient hypovolemia in man , 1994, Intensive Care Medicine.

[319]  W C Watson,et al.  Limiting initial resuscitation of uncontrolled hemorrhage reduces internal bleeding and subsequent volume requirements. , 1994, The Journal of trauma.

[320]  K. Prasad,et al.  Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: effect of SOD and catalase. , 1994, Circulatory shock.

[321]  D. Gann,et al.  A Circulating Shock Protein Depolarizes Cells in Hemorrhage and Sepsis , 1994, Annals of surgery.

[322]  G. A. Braga,et al.  A QUANTITATIVE ANALYSIS OF TRANSCAPILLARY REFILL IN SEVERE HEMORRHAGIC HYPOTENSION IN DOGS , 1994, Shock.

[323]  R. Sauerwein,et al.  Cytokine Patterns in Patients After Major Vascular Surgery, Hemorrhagic Shock, and Severe Blunt Trauma Relation with Subsequent Adult Respiratory Distress Syndrome and Multiple Organ Failure , 1993, Annals of surgery.

[324]  K. Hirao,et al.  Changes in the hepatic oxygenation state during hemorrhage and following epinephrine or dextran infusion as assessed by near-infrared spectroscopy. , 1993, Circulatory shock.

[325]  T. Scalea,et al.  Lactate clearance and survival following injury. , 1993, The Journal of trauma.

[326]  R. Fischer,et al.  A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. The effect of added dextran 70. The Multicenter Group for the Study of Hypertonic Saline in Trauma Patients. , 1993, Archives of surgery.

[327]  P. Guillou,et al.  Biological variation in the development of sepsis after surgery or trauma , 1993, The Lancet.

[328]  K. Sharp,et al.  The Staged Celiotomy for Trauma Issues in Unpacking and Reconstruction , 1993, Annals of surgery.

[329]  C G Cayten,et al.  A study of pneumatic antishock garments in severely hypotensive trauma patients. , 1993, The Journal of trauma.

[330]  B. Lewis,et al.  Obscure gastrointestinal bleeding. , 1993, The Mount Sinai journal of medicine, New York.

[331]  Å. Nygren,et al.  Major differences in trauma care between hospitals in Sweden: a preliminary report. , 1993, Quality assurance in health care : the official journal of the International Society for Quality Assurance in Health Care.

[332]  E Thoburn,et al.  System care improves trauma outcome: patient care errors dominate reduced preventable death rate. , 1993, The Journal of emergency medicine.

[333]  R. Fiddian-Green.  Associations between intramucosal acidosis in the gut and organ failure , 1993, Critical care medicine.

[334]  P. Reilly,et al.  Vasoactive mediators and splanchnic perfusion , 1993, Critical care medicine.

[335]  U. Haglund.  Systemic mediators released from the gut in critical illness , 1993, Critical care medicine.

[336]  M Hashmonai,et al.  ["Controlled" resuscitation for "uncontrolled" hemorrhagic shock]. , 1993, Harefuah.

[337]  S B Olsen,et al.  Abdominal vascular trauma: a review of 106 injuries. , 1992, The American surgeon.

[338]  W. Pan,et al.  Altered cellular calcium regulation and hepatic glucose production during hemorrhagic shock. , 1992, Circulatory shock.

[339]  J. Morris,et al.  Base deficit stratifies mortality and determines therapy. , 1992, The Journal of trauma.

[340]  M. Rotondo,et al.  'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury. , 1992, The Journal of trauma.

[341]  W. Shoemaker,et al.  Role of oxygen debt in the development of organ failure sepsis, and death in high-risk surgical patients. , 1992, Chest.

[342]  R. Martin,et al.  Abbreviated laparotomy and planned reoperation for critically injured patients. , 1992, Annals of surgery.

[343]  K. Sharp,et al.  Abdominal packing for surgically uncontrollable hemorrhage. , 1992, Annals of surgery.

[344]  E. DeMaria,et al.  Coronary vasomotor dysfunction following hemorrhagic shock. , 1992, The Journal of surgical research.

[345]  F. Sawano,et al.  Spatial and temporal differing control of sympathetic activities during hemorrhage. , 1992, The American journal of physiology.

[346]  D. Birolini,et al.  Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room. , 1992, Surgery.

[347]  J. Falk,et al.  Lactic acidosis in critical illness , 1992, Critical care medicine.

[348]  T. Scalea,et al.  Hemodynamic responses to shock in young trauma Patients: Need for invasive monitoring , 1991, Critical care medicine.

[349]  C. Valeri,et al.  Nitric oxide inhibition in rats improves blood pressure and renal function during hypovolemic shock. , 1991, The American journal of physiology.

[350]  R. Rothlein,et al.  Role of ICAM-1 in neutrophil-mediated lung vascular injury after occlusion and reperfusion. , 1991, The American journal of physiology.

[351]  M. Vassar,et al.  7.5% sodium chloride/dextran for resuscitation of trauma patients undergoing helicopter transport. , 1991, Archives of surgery.

[352]  D. Huestis,et al.  Blood warming: current applications and techniques , 1991, Transfusion.

[353]  D. Trunkey,et al.  Blood component supplementation during massive transfusion of AS-1 red cells in trauma patients. , 1991, The Journal of trauma.

[354]  F. Sjöberg,et al.  Extracellular muscle surface pO2 and pH heterogeneity during hypovolemia and after reperfusion. , 1991, Circulatory shock.

[355]  P. Myllynen,et al.  Survival after massive transfusions exceeding four blood volumes in patients with blunt injuries. , 1991, The American surgeon.

[356]  P. Pepe,et al.  Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial. , 1991, Annals of surgery.

[357]  F. Hawker.  Liver Dysfunction in Critical Illness , 1991, Anaesthesia and intensive care.

[358]  N. Hayashi,et al.  A clinical study of acute gastrointestinal hemorrhage associated with various shock states. , 1991, The American journal of gastroenterology.

[359]  J. Vincent,et al.  Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. , 1991, Chest.

[360]  D R Holtgrave,et al.  Colloids versus crystalloids in fluid resuscitation: an analysis of randomized controlled trials. , 1991, The Journal of family practice.

[361]  J Ludbrook,et al.  Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. , 1991, The American journal of physiology.

[362]  R. Berg.  Bacterial translocation from the gastrointestinal tract. , 1990, Trends in microbiology.

[363]  I. Chaudry,et al.  Hemorrhage and resuscitation: immunological aspects. , 1990, The American journal of physiology.

[364]  J. Vincent,et al.  Dobutamine administration in septic shock: addition to a standard protocol. , 1990, Critical care medicine.

[365]  S. Vatner,et al.  Relative roles of cardiac receptors and arterial baroreceptors during hemorrhage in conscious dogs. , 1990, Circulation research.

[366]  N. Madias,et al.  Arteriovenous acid-base disparity in circulatory failure: studies on mechanism. , 1989, The American journal of physiology.

[367]  J. Horton.  Calcium-channel blockade in canine hemorrhagic shock. , 1989, The American journal of physiology.

[368]  C. Wade,et al.  Oxygen delivery and demand in conscious pigs subjected to fixed-volume hemorrhage and resuscitated with 7.5% NaCl in 6% Dextran. , 1989, Circulatory shock.

[369]  F. Cerra,et al.  The hypermetabolism. Multiple organ failure syndrome. , 1989, Chest.

[370]  K. Tremper,et al.  Changes in cardiac output after acute blood loss and position change in man. , 1989, Critical care medicine.

[371]  J. Ludbrook,et al.  Haemodynamic Responses to Acute Blood Loss: New Roles for the Heart, Brain and Endogenous Opioids , 1989, Anaesthesia and intensive care.

[372]  P E Pepe,et al.  Prospective MAST study in 911 patients. , 1989, The Journal of trauma.

[373]  V. Velanovich,et al.  Crystalloid versus colloid fluid resuscitation: a meta-analysis of mortality. , 1989, Surgery.

[374]  K D Stamler,et al.  Effect of crystalloid infusion on hematocrit in nonbleeding patients, with applications to clinical traumatology. , 1989, Annals of emergency medicine.

[375]  D. Reich,et al.  Trendelenburg position and passive leg raising do not significantly improve cardiopulmonary performance in the anesthetized patient with coronary artery disease , 1989, Critical care medicine.

[376]  R. Douglas,et al.  Metabolic response to sepsis and trauma , 1989, The British journal of surgery.

[377]  W. Shoemaker,et al.  Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. , 1988, Chest.

[378]  G. Buchko,et al.  Acute Hemorrhage and Oxygen Free Radicals , 1988, Angiology.

[379]  G. Schmid-Schönbein,et al.  Granulocytes and No‐Reflow Phenomenon in Irreversible Hemorrhagic Shock , 1988, Circulation research.

[380]  H. Redl,et al.  The 'lung in shock' as a result of hypovolemic-traumatic shock in baboons. , 1987, The Journal of trauma.

[381]  T. Raffin,et al.  Importance of venous return, venous resistance, and mean circulatory pressure in the physiology and management of shock. , 1987, Chest.

[382]  G. Jurkovich,et al.  Hypothermia in trauma victims: an ominous predictor of survival. , 1987, The Journal of trauma.

[383]  R. Wilson,et al.  Outcome of massive transfusion exceeding two blood volumes in trauma and emergency surgery. , 1987, The Journal of trauma.

[384]  M. Sayeed.  Ion transport in circulatory and/or septic shock. , 1987, The American journal of physiology.

[385]  G. Radda,et al.  Acute renal failure in hemorrhagic hypotension: cellular energetics and renal function. , 1986, Kidney international.

[386]  A D Mangelsdorff,et al.  Prospective randomized evaluation of antishock MAST in post-traumatic hypotension. , 1986, The Journal of trauma.

[387]  A. Bidani,et al.  Hemodynamically mediated acute renal failure. , 1986, The New England journal of medicine.

[388]  N. Secher,et al.  Vagal slowing of the heart during haemorrhage: observations from 20 consecutive hypotensive patients. , 1986, British medical journal.

[389]  G. Shaftan,et al.  Percutaneous transcatheter embolization for massive bleeding from pelvic fractures. , 1985, The Journal of trauma.

[390]  F. Pearce,et al.  Extracellular-intracellular lactate gradients in skeletal muscle during hemorrhagic shock in the rat. , 1985, Surgery.

[391]  P. Neame,et al.  Coagulopathy related to dilution and hypotension during massive transfusion , 1985, Critical care medicine.

[392]  G. Zuckerman,et al.  Prospective evaluation of the risk of upper gastrointestinal bleeding after admission to a medical intensive care unit. , 1984, The American journal of medicine.

[393]  R. Anderson,et al.  Characteristics of ventricular function in severe hemorrhagic shock. , 1983, Surgery.

[394]  I. Chaudry.  Cellular mechanisms in shock and ischemia and their correction. , 1983, The American journal of physiology.

[395]  J. Mannick,et al.  Depression of cellular immunity after multiple trauma in the absence of sepsis. , 1983, The Journal of trauma.

[396]  E. Moore,et al.  Outcome of resuscitative thoracotomy and descending aortic occlusion performed in the operating room. , 1983, The Journal of trauma.

[397]  J. Vincent,et al.  Serial lactate determinations during circulatory shock , 1983, Critical care medicine.

[398]  H H Stone,et al.  Management of the Major Coagulopathy with Onset during Laparotomy , 1983, Annals of surgery.

[399]  M. Aubier,et al.  Respiratory muscle contribution to lactic acidosis in low cardiac output. , 1982, The American review of respiratory disease.

[400]  M. Ercan,et al.  Liver blood flow rate and glucose metabolism in hemorrhagic hypotension and shock. , 1982, The Journal of trauma.

[401]  W. Shoemaker,et al.  Sequential perioperative lactate determination. Physiological and clinical implications , 1982, Critical care medicine.

[402]  J. Caprini,et al.  Comparison of Thrombelastography with Common Coagulation Tests , 1981, Thrombosis and Haemostasis.

[403]  R. Frantz,et al.  Sequential hemodynamic and oxygen transport responses in hypovolemia, anemia, and hypoxia. , 1980, The American journal of physiology.

[404]  P. Malmberg,et al.  Effect of increased blood-oxygen affinity on oxygen transport in hemorrhagic shock. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[405]  R. Woodson.  Physiological significance of oxygen dissociation curve shifts , 1979, Critical care medicine.

[406]  R. T. Jones,et al.  A clinicopathologic study of hepatic dysfunction following shock. , 1976, Surgery, gynecology & obstetrics.

[407]  C. Rothe,et al.  Vascular Capacitance and Fluid Shifts in Dogs during Prolonged Hemorrhagic Hypotension , 1976, Circulation research.

[408]  B. Zweifach,et al.  The interplay of central and peripheral factors in irreversible hemorrhagic shock. , 1975, Progress in cardiovascular diseases.

[409]  S. Vatner,et al.  Effects of hemorrhage on regional blood flow distribution in dogs and primates. , 1974, The Journal of clinical investigation.

[410]  B. Zweifach.  Mechanisms of Blood Flow and Fluid Exchange in Microvessels: Hemorrhagic Hypotension Model , 1974, Anesthesiology.

[411]  A. M. Lefer,et al.  Pancreatic Hypoperfusion and the Production of a Myocardial Depressant Factor in Hemorrhagic Shock , 1974, Annals of surgery.

[412]  A. W. Shafer,et al.  Acute changes in oxyhemoglobin affinity. Effects on oxygen transport and utilization. , 1973, The Journal of clinical investigation.

[413]  D. Simmons,et al.  Hepatic lactate uptake during decreased liver perfusion and hyposemia. , 1972, The American journal of physiology.

[414]  F. Rodkey,et al.  Changes in the Oxyhemoglobin Dissociation Curve and Peripheral Blood after Acute Red Cell Mass Depletion and Subsequent Red Cell Mass Restoration in Baboons , 1971, Annals of surgery.

[415]  K. Melmon,et al.  Redistribution of Cardiac Output during Hemorrhage in the Unanesthetized Monkey , 1970, Circulation research.

[416]  M H Weil,et al.  Experimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock) , 1970, Circulation.

[417]  F. Eldridge,et al.  Effect of respiratory alkalosis on blood lactate and pyruvate in humans. , 1968, Journal of applied physiology.

[418]  S. Chien.  Role of the sympathetic nervous system in hemorrhage. , 1967, Physiological reviews.

[419]  A M Harper,et al.  Autoregulation of cerebral blood flow: influence of the arterial blood pressure on the blood flow through the cerebral cortex. , 1966, Journal of neurology, neurosurgery, and psychiatry.

[420]  M. Weil,et al.  EXCESS LACTATE: AN INDEX OF REVERSIBILITY OF SHOCK IN HUMAN PATIENTS. , 1964, Science.

[421]  S. Sarnoff,et al.  Insufficient coronary flow and myocardial failure as a complication factor in late hemorrhagic shock. , 1954, The American journal of physiology.

[422]  S. Susen,et al.  The pathogenesis of transfusion-related acute lung injury , 2012 .

[423]  A. Cooper.  chapter 14 – EARLY ASSESSMENT AND MANAGEMENT OF TRAUMA , 2010 .

[424]  D. Mozingo.  Effects of a Restrictive Blood Transfusion Policy on Outcomes in Children With Burn Injury , 2008 .

[425]  Z. Yen,et al.  Delayed fluid resuscitation in hemorrhagic shock induces proinflammatory cytokine response. , 2007, Annals of emergency medicine.

[426]  C. Cocanour,et al.  Fresh frozen plasma should be given earlier to patients requiring massive transfusion. , 2007, The Journal of trauma.

[427]  D. Hoyt,et al.  Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis. , 2007, The Journal of trauma.

[428]  P. Kumar,et al.  Prevention and treatment of major blood loss. , 2007, The New England journal of medicine.

[429]  C. Chung,et al.  Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[430]  Shahriar Zehtabchi,et al.  Diagnostic performance of serial haematocrit measurements in identifying major injury in adult trauma patients. , 2006, Injury.

[431]  W. Owens,et al.  Emergency thoracotomy in thoracic trauma-a review. , 2006, Injury.

[432]  D. Triulzi.  Transfusion-related acute lung injury: an update. , 2006, Hematology. American Society of Hematology. Education Program.

[433]  R. K. Webb,et al.  The P50 is reduced in critically ill patients , 2005, Intensive Care Medicine.

[434]  W. Shoemaker,et al.  Measurement of tissue perfusion by oxygen transport patterns in experimental shock and in high-risk surgical patients , 2005, Intensive Care Medicine.

[435]  L. Strate,et al.  Predictors of utilization of early colonoscopy vs. radiography for severe lower intestinal bleeding. , 2005, Gastrointestinal endoscopy.

[436]  S. H-Idrissi.  Pediatric trauma , 2016 .

[437]  Dougald M Monroe,et al.  Safety profile of recombinant factor VIIa. , 2004, Seminars in hematology.

[438]  J. Vincent,et al.  Toe temperature versus transcutaneous oxygen tension monitoring during acute circulatory failure , 2004, Intensive Care Medicine.

[439]  W. Shoemaker.  Relation of oxygen transport patterns to the pathophysiology and therapy of shock states , 2004, Intensive Care Medicine.

[440]  I Roberts,et al.  Antifibrinolytic drugs for acute traumatic injury. , 2004, The Cochrane database of systematic reviews.

[441]  D. Tweardy,et al.  Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavening , 2003, Archives of Orthopaedic and Trauma Surgery.

[442]  F Bunn,et al.  Timing and volume of fluid administration for patients with bleeding. , 2003, The Cochrane database of systematic reviews.

[443]  M. Blajchman.  Incidence and significance of the bacterial contamination of blood components. , 2002, Developments in biologicals.

[444]  J. Liu,et al.  The role of membrane potential and calcium kinetic changes in the pathogenesis of vascular hyporeactivity during severe shock. , 2000, Chinese medical journal.

[445]  D. Cook,et al.  Crystalloids vs. colloids in fluid resuscitation: a systematic review. , 1999, Critical care medicine.

[446]  A. De Maio,et al.  Heat shock proteins: facts, thoughts, and dreams. , 1999, Shock.

[447]  James W. Davis,et al.  Base deficit is superior to pH in evaluating clearance of acidosis after traumatic shock. , 1998, The Journal of trauma.

[448]  K. Kaups,et al.  Base deficit in the elderly: a marker of severe injury and death. , 1998, The Journal of trauma.

[449]  S. Kleinman,et al.  The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. , 1996, The New England journal of medicine.

[450]  A. Sauaia,et al.  Early predictors of postinjury multiple organ failure. , 1994, Archives of surgery.

[451]  P. Crone,et al.  Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: a prospective, randomized, controlled study. , 1994, Critical care medicine.

[452]  M. Boermeester,et al.  Clinical significance of translocation. , 1994, Gut.

[453]  E. N. Wardle,et al.  Acute renal failure and multiorgan failure. , 1994, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[454]  O. Ljungqvist,et al.  Pretreatment with glucose infusion prevents fatal outcome after hemorrhage in food deprived rats. , 1993, Circulatory shock.

[455]  C. Thiemermann,et al.  Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[456]  M. Reivich,et al.  Role of the L-arginine-nitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion. , 1992, Circulatory shock.

[457]  Z. Ba,et al.  Measurement of hepatic blood flow after severe hemorrhage: lack of restoration despite adequate resuscitation. , 1992, The American journal of physiology.

[458]  C. Szabó,et al.  Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat. , 1992, Circulatory shock.

[459]  F. Camu,et al.  Prostaglandin synthetase inhibitor treatment and the regulatory role of prostaglandins on organ perfusion. , 1992, Acta anaesthesiologica Belgica.

[460]  R. Zager.  Adenine nucleotide changes in kidney, liver, and small intestine during different forms of ischemic injury. , 1991, Circulation research.

[461]  J. Morris,et al.  Massive transfusion: outcome in blunt trauma patients. , 1991, The Journal of trauma.

[462]  M. Pinsky,et al.  Flow redistribution during progressive hemorrhage is a determinant of critical O2 delivery. , 1991, Journal of applied physiology.

[463]  Mary Fran Hazinski Rn Msn Faan Faha Ferc.  Nursing Care of the Critically Ill Child , 1991 .

[464]  M. Vassar,et al.  Use of a 7.5% NaCl/6% Dextran 70 solution in the resuscitation of injured patients in the emergency room. , 1989, Progress in clinical and biological research.

[465]  P. Henneman,et al.  Effect of crystalloid infusion on hematocrit and intravascular volume in healthy, nonbleeding subjects. , 1989, Annals of emergency medicine.

[466]  I. Chaudry,et al.  Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. , 1987, Archives of surgery.

[467]  R. Bond,et al.  Vascular adrenergic interactions during hemorrhagic shock. , 1985, Federation proceedings.

[468]  E. Craig,et al.  The heat shock response. , 1985, CRC critical reviews in biochemistry.

[469]  N. Secher,et al.  Bradycardia during severe but reversible hypovolemic shock in man. , 1984, Circulatory shock.

[470]  O B Paulson,et al.  Cerebral autoregulation. , 1984, Stroke.

[471]  B. Brenner,et al.  Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. , 1983, Kidney international.

[472]  A. Peitzman,et al.  Neutrophil migratory activity in severe hemorrhagic shock. , 1983, Circulatory shock.

[473]  M H Weil,et al.  Blood lactate as prognostic indicator of survival in patients with acute myocardial infarction. , 1982, Circulatory shock.

[474]  R. Woodson.  Functional consequences of altered blood oxygen affinity. , 1981, Acta biologica et medica Germanica.

[475]  G. Wolff,et al.  Effect of hemorrhagic shock on intrapulmonary right-to-left shunt (QS/QT) and dead space (VD/VT). , 1976, Respiration; international review of thoracic diseases.

[476]  B. Rush.  Irreversibility in the post-transfusion phase of hemorrhagic shock. , 1971, Advances in experimental medicine and biology.

[477]  M. Weil,et al.  Proposed reclassification of shock states with special reference to distributive defects. , 1971, Advances in experimental medicine and biology.

[478]  A. S. Relman.  Lactic acidosis. , 1971, Transactions of the American Clinical and Climatological Association.

[479]  E. Babcock.  The management of shock. , 1966, The Journal of the Maine Medical Association.

[480]  A A BULLOCK,et al.  Acute blood loss. , 1957, The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society.