Severe sepsis and septic shock: review of the literature and emergency department management guidelines.

[1]  D. Elston Community-acquired methicillin-resistant Staphylococcus aureus. , 2007, Journal of the American Academy of Dermatology.

[2]  G. Olsen,et al.  A New Classification of Parapneumonic Effusions and Empyema , 2007 .

[3]  L. McCaig,et al.  National Hospital Ambulatory Medical Care Survey: 2004 emergency department summary. , 2006, Advance data.

[4]  S. Zanotti-Cavazzoni Corticosteroids for Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis , 2006 .

[5]  H. Nguyen,et al.  Early goal-directed therapy, corticosteroid, and recombinant human activated protein C for the treatment of severe sepsis and septic shock in the emergency department. , 2006, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[6]  G. Bernard,et al.  Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment* , 2005, Critical care medicine.

[7]  R. Rossaint,et al.  Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. , 2005, The New England journal of medicine.

[8]  T. Osborn,et al.  Emergency medicine and the surviving sepsis campaign: an international approach to managing severe sepsis and septic shock. , 2005, Annals of emergency medicine.

[9]  R. Wunderink,et al.  Severe community-acquired pneumonia as a cause of severe sepsis: Data from the PROWESS study* , 2005, Critical care medicine.

[10]  Larry A Nathanson,et al.  Serum lactate as a predictor of mortality in emergency department patients with infection. , 2005, Annals of emergency medicine.

[11]  F. Sebat,et al.  A multidisciplinary community hospital program for early and rapid resuscitation of shock in nontrauma patients. , 2005, Chest.

[12]  Daniel Talmor,et al.  A blueprint for a sepsis protocol. , 2005, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[13]  D. Talan,et al.  Community-associated methicillin-resistant Staphylococcus aureus: is it in your community and should it change practice? , 2005, Annals of emergency medicine.

[14]  Arnaldo Dubin,et al.  Shock on admission day is the best predictor of prolonged mechanical ventilation in the ICU. , 2005, Chest.

[15]  J. Jorgensen,et al.  Inducible clindamycin resistance in Staphylococci: should clinicians and microbiologists be concerned? , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  E. Charlebois,et al.  High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. , 2004, Annals of emergency medicine.

[17]  S. Deventer,et al.  Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxemia , 1996, Intensive Care Medicine.

[18]  J. Bruel,et al.  Acute abdomen of unknown origin: Impact of CT on diagnosis and management , 2005, Gastrointestinal Radiology.

[19]  C. Pradier,et al.  Blood pressure and arterial lactate level are early indicators of short-term survival in human septic shock , 2005, Intensive Care Medicine.

[20]  L. Chawla,et al.  Lack of equivalence between central and mixed venous oxygen saturation. , 2004, Chest.

[21]  J. Marshall,et al.  Source control in the management of severe sepsis and septic shock: An evidence-based review , 2004, Critical care medicine.

[22]  G. Bernard,et al.  The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis * , 2004, Critical care medicine.

[23]  S. L. Murphy,et al.  Deaths: final data for 2002. , 2004, National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System.

[24]  C. Natanson,et al.  Recombinant human activated protein C in sepsis: previous concerns and current usage , 2004 .

[25]  D. Annane,et al.  Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update , 2004, Critical care medicine.

[26]  G. Jacobsen,et al.  Early lactate clearance is associated with improved outcome in severe sepsis and septic shock* , 2004, Critical care medicine.

[27]  B. Beutler,et al.  Inferences, questions and possibilities in Toll-like receptor signalling , 2004, Nature.

[28]  W. Harmsen,et al.  Optimal testing parameters for blood cultures. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  C. Hartog,et al.  Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill , 2004, Intensive Care Medicine.

[30]  Robyn Norton,et al.  A comparison of albumin and saline for fluid resuscitation in the Intensive Care unit , 2005 .

[31]  Amir H Hamrahian,et al.  Measurements of serum free cortisol in critically ill patients. , 2004, The New England journal of medicine.

[32]  J. Bartlett,et al.  Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. , 2004, Archives of internal medicine.

[33]  Margaret M Parker,et al.  Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock , 2004, Critical care medicine.

[34]  Alain Cariou,et al.  Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569] , 2004, Critical care.

[35]  J. Xiang,et al.  Cumulative Clinical Trial Experience with Levofloxacin for Patients with Community-Acquired Pneumonia-Associated Pneumococcal Bacteremia , 2004 .

[36]  Todd G Nick,et al.  Estimating the degree of emergency department overcrowding in academic medical centers: results of the National ED Overcrowding Study (NEDOCS). , 2004, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[37]  J. Bartlett,et al.  Pegylated Interferon-alpha Protects Type 1 Pneumocytes Against SARS Coronavirus Infection in Macaques , 2004 .

[38]  Steven D. Brown,et al.  Antimicrobial susceptibility among community-acquired respiratory tract pathogens in the USA: data from PROTEKT US 2000-01. , 2004, The Journal of infection.

[39]  John G. Bartlett,et al.  Update of Practice Guidelines for the Management of Community-Acquired Pneumonia in Immunocompetent Adults , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[40]  R. Wunderink,et al.  Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. , 2003, Chest.

[41]  C. Rosenberg,et al.  Early administration of antibiotics does not shorten time to clinical stability in patients with moderate-to-severe community-acquired pneumonia. , 2003, Chest.

[42]  K. Carroll,et al.  Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[43]  G. Pugliese,et al.  Outbreaks of Community-Associated Methicillin-Resistant Staphylococcus aureus Skin Infections , 2003, Infection Control & Hospital Epidemiology.

[44]  N. H. Steigbigel Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock , 2003, Current infectious disease reports.

[45]  M. Oh,et al.  Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[46]  S. Trzeciak,et al.  Emergency department overcrowding in the United States: an emerging threat to patient safety and public health , 2003, Emergency medicine journal : EMJ.

[47]  C. Sprung,et al.  Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone. , 2003, Critical care medicine.

[48]  D. Snydman,et al.  An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[49]  L. McCaig,et al.  National Hospital Ambulatory Medical Care Survey: 2001 emergency department summary. , 2003 .

[50]  J. Vincent,et al.  Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? , 2003, Critical care medicine.

[51]  N. Tritos Corticosteroid insufficiency in acutely ill patients. , 2003, The New England journal of medicine.

[52]  W. Aird The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. , 2003, Blood.

[53]  R. Zaragoza,et al.  The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit. , 2003, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[54]  D. Cook,et al.  Measures, markers, and mediators: Toward a staging system for clinical sepsis. A Report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25–26, 2000 , 2003, Critical care medicine.

[55]  J. Rello,et al.  Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. , 2003, Chest.

[56]  D. Mannino,et al.  The epidemiology of sepsis in the United States from 1979 through 2000. , 2003, The New England journal of medicine.

[57]  A. Evangelista,et al.  Factors associated with relative rates of antimicrobial resistance among Streptococcus pneumoniae in the United States: results from the TRUST Surveillance Program (1998-2002). , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[58]  Mitchell M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive Care Medicine.

[59]  Michael K Gould,et al.  Preventing complications of central venous catheterization. , 2003, The New England journal of medicine.

[60]  J. Burke,et al.  Infection control - a problem for patient safety. , 2003, The New England journal of medicine.

[61]  E. Paulson,et al.  Clinical practice. Suspected appendicitis. , 2003, The New England journal of medicine.

[62]  D. Calfee,et al.  Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[63]  R. Hotchkiss,et al.  The pathophysiology and treatment of sepsis. , 2003, The New England journal of medicine.

[64]  J. Helterbrand,et al.  Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis , 2003, Critical care medicine.

[65]  P. Marik,et al.  Adrenal insufficiency during septic shock* , 2003, Critical care medicine.

[66]  G. Clermont,et al.  Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis* , 2003, Critical care medicine.

[67]  R. Wunderink,et al.  Drotrecogin Alfa (activated) Improves In-hospital and 90-day Survival in Patients With Severe Sepsis and Community-acquired Pneumoni , 2003 .

[68]  J. Steingrub Prompt administration of drotrecogin alfa (activated) is associated with improved survival. , 2003 .

[69]  M. Donnino,et al.  Cryptic Septic Shock: A Sub-analysis of Early, Goal-Directed Therap , 2003 .

[70]  E. Rivers,et al.  Early goal-directed therapy prevents organ failure and mortality in severe sepsis and septic shock , 2003 .

[71]  D. Williamson,et al.  Corticosteroids for patients with septic shock. , 2003, JAMA.

[72]  Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections--Los Angeles County, California, 2002-2003. , 2003, MMWR. Morbidity and mortality weekly report.

[73]  J. Mylotte,et al.  Epidemiology of bloodstream infection in nursing home residents: evaluation in a large cohort from multiple homes. , 2002, Clinical Infectious Diseases.

[74]  Daniel J Sexton,et al.  Health CareAssociated Bloodstream Infections in Adults: A Reason To Change the Accepted Definition of Community-Acquired Infections , 2002, Annals of Internal Medicine.

[75]  Can Ince,et al.  Nitroglycerin in septic shock after intravascular volume resuscitation , 2002, The Lancet.

[76]  M. Boissinot,et al.  Toward rapid real-time molecular diagnostic to guide smart use of antimicrobials. , 2002, Current opinion in microbiology.

[77]  M. Delignette-Muller,et al.  What is the relevance of obtaining multiple blood samples for culture? A comprehensive model to optimize the strategy for diagnosing bacteremia. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[78]  J. Siegel Assessing the use of activated protein C in the treatment of severe sepsis. , 2002, The New England journal of medicine.

[79]  H. S. Warren,et al.  Risks and benefits of activated protein C treatment for severe sepsis. , 2002, The New England journal of medicine.

[80]  Cam Donaldson,et al.  An economic evaluation of activated protein C treatment for severe sepsis. , 2002, The New England journal of medicine.

[81]  J. Vincent,et al.  Anemia and blood transfusion in critically ill patients. , 2002, JAMA.

[82]  J. Karlowsky,et al.  Trends in Antimicrobial Resistance among Urinary Tract Infection Isolates of Escherichia coli from Female Outpatients in the United States , 2002, Antimicrobial Agents and Chemotherapy.

[83]  J. Karlowsky,et al.  Longitudinal Assessment of Antipneumococcal Susceptibility in the United States , 2002, Antimicrobial Agents and Chemotherapy.

[84]  D. Schwartz,et al.  Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremia. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[85]  A. Shorr,et al.  D-dimer correlates with proinflammatory cytokine levels and outcomes in critically ill patients. , 2002, Chest.

[86]  Y. Kupfer,et al.  Goal-directed therapy for severe sepsis. , 2002, The New England journal of medicine.

[87]  T. Calandra,et al.  Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer , 2002 .

[88]  P. Cornbleet Clinical utility of the band count. , 2002, Clinics in laboratory medicine.

[89]  A. Evangelista,et al.  Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: results from the TRUST Surveillance Program, 1999-2000. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[90]  G. Moore,et al.  Effects of a medical emergency team on reduction of incidence of and mortality from unexpected cardiac arrests in hospital: preliminary study , 2002, BMJ : British Medical Journal.

[91]  A. Tunkel,et al.  Treatment of bacterial meningitis , 2002, Current infectious disease reports.

[92]  C. Esmon Protein C pathway in sepsis , 2002, Annals of medicine.

[93]  M. Fink Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration? , 2002, Critical care clinics.

[94]  A. Evangelista,et al.  Susceptibility to fluoroquinolones among commonly isolated Gram-negative bacilli in 2000: TRUST and TSN data for the United States. Tracking Resistance in the United States Today. The Surveillance Network. , 2002, International journal of antimicrobial agents.

[95]  M. Pfaller,et al.  Frequency of pathogen occurrence and antimicrobial susceptibility among community-acquired respiratory tract infections in the respiratory surveillance program study: microbiology from the medical office practice environment. , 2001, The American journal of medicine.

[96]  E. Ivers,et al.  Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock , 2001 .

[97]  G. Bernard,et al.  Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis , 2001, Critical care medicine.

[98]  T. Ng,et al.  Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results of a Hong Kong multicentre study in 2000. , 2001, The Journal of antimicrobial chemotherapy.

[99]  K. Walley,et al.  Physiology of vasopressin relevant to management of septic shock. , 2001, Chest.

[100]  J. Karlowsky,et al.  Prevalence of antimicrobial resistance among urinary tract pathogens isolated from female outpatients across the US in 1999. , 2001, International journal of antimicrobial agents.

[101]  D. Chittock,et al.  The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series , 2001, Intensive Care Medicine.

[102]  K. Polderman,et al.  Inter-observer variability in APACHE II scoring: effect of strict guidelines and training , 2001, Intensive Care Medicine.

[103]  G. Clermont,et al.  Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care , 2001, Critical care medicine.

[104]  Derek C. Angus,et al.  Epidemiology of sepsis: An update , 2001, Critical care medicine.

[105]  W. Stamm,et al.  Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in women: a nationwide analysis. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[106]  S. Wann,et al.  Clinical characteristics of emphysematous pyelonephritis. , 2001, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[107]  D. Ander,et al.  Central venous oxygen saturation monitoring in the critically ill patient , 2001, Current opinion in critical care.

[108]  C. Bradley Activated protein C in severe sepsis. , 2001, Intensive & critical care nursing.

[109]  L. Mermel,et al.  Guidelines for the Management of Intravascular Catheter-Related Infections , 2001, Infection Control & Hospital Epidemiology.

[110]  J Ean,et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis. , 2001, The New England journal of medicine.

[111]  J. Marshall,et al.  Source control in the management of sepsis , 2001, Intensive Care Medicine.

[112]  T. Calandra,et al.  Antibiotics in sepsis , 2001, Intensive Care Medicine.

[113]  D. Pinsky,et al.  The endothelial response to oxygen deprivation: biology and clinical implications , 2001, Intensive Care Medicine.

[114]  M. Fink Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. , 2001, Critical care clinics.

[115]  Methicillin-resistant Staphylococcus aureus skin or soft tissue infections in a state prison--Mississippi, 2000. , 2001, MMWR. Morbidity and mortality weekly report.

[116]  H. Qiu,et al.  Prognostic value of dobutamine stress test in patients with septic shock. , 2001, Acta pharmacologica Sinica.

[117]  E. Mylonakis,et al.  Infective endocarditis in adults. , 2001, The New England journal of medicine.

[118]  M. Cetron,et al.  Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. , 2000, The New England journal of medicine.

[119]  E. Bouza,et al.  Monotherapy versus combination therapy for bacterial infections. , 2000, The Medical clinics of North America.

[120]  J. Acar,et al.  Antibiotic synergy and antagonism. , 2000, The Medical clinics of North America.

[121]  J. Groeneveld Albumin and artificial colloids in fluid management: where does the clinical evidence of their utility stand? , 2000, Critical care.

[122]  B. Littenberg,et al.  Medical and surgical treatment of parapneumonic effusions : an evidence-based guideline. , 2000, Chest.

[123]  H. Okabe,et al.  Activated Protein C Reduces the Ischemia/Reperfusion-Induced Spinal Cord Injury in Rats by Inhibiting Neutrophil Activation , 2000, Annals of surgery.

[124]  X Viviand,et al.  Effect of norepinephrine on the outcome of septic shock , 2000, Critical care medicine.

[125]  G Sherman,et al.  The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. , 2000, Chest.

[126]  A. Groeneveld Tonometry of partial carbon dioxide tension in gastric mucosa: use of saline, buffer solutions, gastric juice or air , 2000, Critical care.

[127]  W. Stortenbeek [Serum lactate levels as an indicator of tissue hypoxia in severely ill patients]. , 2000, Nederlands tijdschrift voor geneeskunde.

[128]  A. Wilmer,et al.  Thrombocytopenia and prognosis in intensive care , 2000, Critical care medicine.

[129]  D. Schoenfeld,et al.  Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , 2000, The New England journal of medicine.

[130]  J. Bakker,et al.  [Serum lactate level as a indicator of tissue hypoxia in severely ill patients]. , 2000, Nederlands tijdschrift voor geneeskunde.

[131]  C. Tseng,et al.  Emphysematous Pyelonephritis Clinicoradiological Classification, Management, Prognosis, and Pathogenesis , 2002 .

[132]  D. Annane,et al.  A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. , 2000, JAMA.

[133]  D. Norman,et al.  Fever in the elderly. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[134]  A. Bartelink,et al.  [Serum lactate level as an indicator of tissue hypoxia in severely ill patients]. , 2000, Nederlands tijdschrift voor geneeskunde.

[135]  J. Todd,et al.  Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection. , 1999, The Pediatric infectious disease journal.

[136]  R. Grounds,et al.  A prospective study of the use of a dobutamine stress test to identify outcome in patients with sepsis, severe sepsis, or septic shock. , 1999, Critical care medicine.

[137]  J. Young,et al.  The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. , 1999, The Journal of trauma.

[138]  M. Rodríguez-Carballeira,et al.  Emergence and Dissemination of Quinolone-ResistantEscherichia coli in the Community , 1999, Antimicrobial Agents and Chemotherapy.

[139]  J. Bourdarias,et al.  Clinical Investigations in Critical CarePersistent Preload Defect in Severe Sepsis Despite Fluid Loading: A Longitudinal Echocardiographic Study in Patients With Septic Shock , 1999 .

[140]  R. Townsend,et al.  Low-dose vasopressin in the treatment of vasodilatory septic shock. , 1999, The Journal of trauma.

[141]  J. Barkhausen,et al.  Impact of CT in Patients with Sepsis of unknown Origin , 1999, Acta radiologica.

[142]  G. Velmahos,et al.  Abdominal computed tomography for the diagnosis of intra-abdominal sepsis in critically injured patients: fishing in murky waters. , 1999, Archives of surgery.

[143]  D. Low,et al.  Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network. , 1999 .

[144]  D E Low,et al.  Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network. , 1999, The New England journal of medicine.

[145]  C. Riedl,et al.  Bacterial Colonization of Ureteral Stents , 1999, European Urology.

[146]  S. Opal,et al.  Clinical trials for severe sepsis. Past failures, and future hopes. , 1999, Infectious disease clinics of North America.

[147]  H. Smithline,et al.  Adrenal dysfunction in hemodynamically unstable patients in the emergency department. , 1999, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[148]  M. Haller,et al.  Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. , 1999, Critical care medicine.

[149]  N. Kuppermann,et al.  Immature neutrophils in the blood smears of young febrile children. , 1999, Archives of pediatrics & adolescent medicine.

[150]  G. Wells,et al.  A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. , 1999, The New England journal of medicine.

[151]  G Sherman,et al.  Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. , 1999, Chest.

[152]  J. E. Carceller Practice parameters for hemodynamic support of sepsis in adult patients in sepsis , 1999 .

[153]  V. Yu,et al.  Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: a commentary. , 1999, International journal of antimicrobial agents.

[154]  J. Vincent,et al.  Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. , 1999, Critical care medicine.

[155]  H. Brodt,et al.  Influence of antimicrobial treatment on mortality in septicemia. , 1999, Journal of chemotherapy.

[156]  D. Cook,et al.  Crystalloids vs. colloids in fluid resuscitation: a systematic review. , 1999, Critical care medicine.

[157]  Leibovici,et al.  The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection , 1998, Journal of internal medicine.

[158]  T. Dorman,et al.  Radial artery pressure monitoring underestimates central arterial pressure during vasopressor therapy in critically ill surgical patients. , 1998, Critical care medicine.

[159]  C. Roehrborn,et al.  Optimal method of urgent decompression of the collecting system for obstruction and infection due to ureteral calculi. , 1998, The Journal of urology.

[160]  Edwards Jd,et al.  Importance of the sampling site for measurement of mixed venous oxgen saturation in shock , 1998 .

[161]  S. Henderson,et al.  Bedside emergency department ultrasonography plus radiography of the kidneys, ureters, and bladder vs intravenous pyelography in the evaluation of suspected ureteral colic. , 1998, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[162]  M. Kollef,et al.  A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients. , 1998, Critical care medicine.

[163]  P. Bollaert,et al.  Reversal of late septic shock with supraphysiologic doses of hydrocortisone. , 1998, Critical care medicine.

[164]  S. Nasraway,et al.  Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock , 1998, The Lancet.

[165]  G. Schierhout,et al.  Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials , 1998, BMJ.

[166]  T. Kossmann,et al.  Differentiation of necrotizing fasciitis and cellulitis using MR imaging. , 1998, AJR. American journal of roentgenology.

[167]  O. Mimoz,et al.  Cefepime and amikacin synergy in vitro and in vivo against a ceftazidime-resistant strain of Enterobacter cloacae. , 1998, The Journal of antimicrobial chemotherapy.

[168]  S. Nasraway,et al.  Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. , 1998, Lancet.

[169]  J. Edwards,et al.  Importance of the sampling site for measurement of mixed venous oxygen saturation in shock. , 1998, Critical care medicine.

[170]  M. Haeney The role of the complement cascade in sepsis. , 1998, The Journal of antimicrobial chemotherapy.

[171]  M. Fine,et al.  Quality of care, process, and outcomes in elderly patients with pneumonia. , 1997, JAMA.

[172]  H. Bruining,et al.  Corticosteroid therapy in severe illness. , 1997, The New England journal of medicine.

[173]  M. Oz,et al.  Vasopressin pressor hypersensitivity in vasodilatory septic shock. , 1997, Critical care medicine.

[174]  D. Bates,et al.  Epidemiology of sepsis syndrome in 8 academic medical centers. , 1997, JAMA.

[175]  S. Opal,et al.  Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. , 1997, Critical care medicine.

[176]  A. Friedman,et al.  Necrotizing fasciitis: CT characteristics. , 1997, Radiology.

[177]  L. Leibovici,et al.  Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study , 1997, Antimicrobial agents and chemotherapy.

[178]  E. Gallagher,et al.  Agreement between peripheral venous and arterial lactate levels. , 1997, Annals of emergency medicine.

[179]  C. Ichai,et al.  Reliability of anion gap as an indicator of blood lactate in critically ill patients , 1997, Intensive Care Medicine.

[180]  Y. S. Zhou,et al.  Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. , 1997, The Journal of clinical investigation.

[181]  G. Bernard,et al.  The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. , 1997, The New England journal of medicine.

[182]  J. Vincent,et al.  Dear SIRS, I'm sorry to say that I don't like you... , 1997, Critical care medicine.

[183]  F. Schildberg,et al.  Klebsiella pneumoniae Necrotizing F asciitis Associated w ith D iabetes a nd L iver C irrhosis , 2000 .

[184]  J A Kufera,et al.  Necrotizing soft tissue infections. Risk factors for mortality and strategies for management. , 1996, Annals of surgery.

[185]  M. Grzybowski,et al.  Systemic inflammatory response syndrome criteria and lactic acidosis in the detection of critical illness among patients presenting to an emergency department , 1996 .

[186]  F Doyon,et al.  Bacteremia and severe sepsis in adults: a multicenter prospective survey in ICUs and wards of 24 hospitals. French Bacteremia-Sepsis Study Group. , 1996, American journal of respiratory and critical care medicine.

[187]  J. Carlet,et al.  INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. , 1996, Critical care medicine.

[188]  C. Sprung,et al.  Multiple Organ Dysfunction Score , 1996 .

[189]  R. Bone,et al.  Sir Isaac Newton, sepsis, SIRS, and CARS. , 1996, Critical care medicine.

[190]  M. Weinstein Current blood culture methods and systems: clinical concepts, technology, and interpretation of results. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[191]  S. Wilson,et al.  Intraabdominal abscesses: image-guided diagnosis and therapy. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[192]  S. Willatts,et al.  Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. , 1996, Critical care medicine.

[193]  P. Marik,et al.  The effects of neuromuscular paralysis on systemic and splanchnic oxygen utilization in mechanically ventilated patients. , 1996, Chest.

[194]  M A Basha,et al.  Is it time to reposition vasopressors and inotropes in sepsis? , 1996, Critical care medicine.

[195]  R. Nowak,et al.  Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. , 1996, The American journal of emergency medicine.

[196]  J. Vincent,et al.  Serial blood lactate levels can predict the development of multiple organ failure following septic shock. , 1996, American journal of surgery.

[197]  J. Ménard,et al.  Is presentation of bacteremia in the elderly the same as in younger patients? , 1996, The American journal of medicine.

[198]  P. Pelosi,et al.  A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. , 1996, The New England journal of medicine.

[199]  P. Pelosi,et al.  A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients , 1995 .

[200]  C. Sprung,et al.  Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. , 1995, Critical care medicine.

[201]  F Doyon,et al.  Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. , 1995, JAMA.

[202]  François Gouin,et al.  Incidence, Risk Factors, and Outcome of Severe Sepsis and Septic Shock in Adults: A Multicenter Prospective Study in Intensive Care Units , 1995 .

[203]  J. Dhainaut,et al.  CDP571, a humanized antibody to human tumor necrosis factor-alpha: safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group. , 1995, Critical care medicine.

[204]  D. Stevens Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. , 1995, Emerging infectious diseases.

[205]  S. Piscitelli,et al.  Development of Resistance During Antimicrobial Therapy: A Review of Antibiotic Classes and Patient Characteristics in 173 Studies , 1995, Pharmacotherapy.

[206]  M. Malangoni,et al.  Determinants of mortality for necrotizing soft-tissue infections. , 1995, Annals of surgery.

[207]  G. Koch,et al.  Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial , 1995 .

[208]  S. Nasraway,et al.  Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. , 1995, JAMA.

[209]  R. Simon,et al.  Adrenal insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels. , 1995, The American journal of medicine.

[210]  D. Pittet,et al.  The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. , 1995, JAMA.

[211]  E. Fishman,et al.  Spiral CT of the kidneys: role in characterization of renal disease. Part I: Nonneoplastic disease. , 1995, Critical reviews in diagnostic imaging.

[212]  C. Manthous,et al.  The effect of mechanical ventilation on oxygen consumption in critically ill patients. , 1995, American journal of respiratory and critical care medicine.

[213]  B. Chernow,et al.  The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations. , 1994, JAMA.

[214]  J. Westengard,et al.  Band neutrophil counts are unnecessary for the diagnosis of infection in patients with normal total leukocyte counts. , 1994, American journal of clinical pathology.

[215]  G. Gazelle,et al.  Abdominal abscess. Imaging and intervention. , 1994, Radiologic clinics of North America.

[216]  C. Hinds,et al.  Elevation of systemic oxygen delivery in the treatment of critically ill patients. , 1994, The New England journal of medicine.

[217]  R. F. Johnston,et al.  Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial , 1994 .

[218]  S. Opal,et al.  Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. , 1994, JAMA.

[219]  R. Dalton,et al.  Arterial or mixed venous lactate measurement in critically ill children. Is there a difference? , 1994, Acta paediatrica.

[220]  S. Opal,et al.  Initial evaluation of human recombinant interleukin‐1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open‐label, placebocontrolled multicenter trial , 1994, Critical care medicine.

[221]  D. Remick,et al.  Clinical safety, tolerability, and pharmacokinetics of murine monoclonal antibody to human tumor necrosis factor-alpha. , 1994, The Journal of infectious diseases.

[222]  R. Novak The beleaguered band count. , 1993, Clinics in laboratory medicine.

[223]  J. Verhoef,et al.  The sepsis syndrome in a Dutch university hospital. Clinical observations. , 1993, Archives of internal medicine.

[224]  T. Scalea,et al.  Lactate clearance and survival following injury. , 1993, The Journal of trauma.

[225]  J. Takala,et al.  Regional blood flow and oxygen transport in septic shock , 1993, Critical care medicine.

[226]  E. Faragher,et al.  Influence of cardiac output on the correlation between mixed venous and central venous oxygen saturation. , 1993, British journal of anaesthesia.

[227]  L. Mermel,et al.  Detection of Bacteremia in Adults: Consequences of Culturing an Inadequate Volume of Blood , 1993, Annals of Internal Medicine.

[228]  D. Powars,et al.  Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. , 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[229]  L. Papazian,et al.  Norepinephrine or Dopamine for the Treatment of Hyperdynamic Septic Shock , 1993 .

[230]  R. Carlson,et al.  Fluid resuscitation in circulatory shock. , 1993, Critical care clinics.

[231]  O. Goletti,et al.  Percutaneous ultrasound‐guided drainage of intra‐abdominal abscesses , 1993, The British journal of surgery.

[232]  W. Shoemaker,et al.  Unreliability of blood pressure and heart rate to evaluate cardiac output in emergency resuscitation and critical illness , 1993, Critical care medicine.

[233]  L. Papazian,et al.  Norepinephrine or dopamine for the treatment of hyperdynamic septic shock? , 1992, Chest.

[234]  D. Gerding,et al.  Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy , 1992, Antimicrobial Agents and Chemotherapy.

[235]  D. Pinsky,et al.  Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. , 1992, The Journal of clinical investigation.

[236]  M. Stoller,et al.  Pyonephrosis: diagnosis and treatment. , 1992, British journal of urology.

[237]  G. Guyatt,et al.  Rules of evidence and clinical recommendations on the use of antithrombotic agents. , 1992, Chest.

[238]  K. Cartwright,et al.  Early treatment with parenteral penicillin in meningococcal disease. , 1992, BMJ.

[239]  J. E. Carceller American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis , 1992, Critical care medicine.

[240]  W. Knaus,et al.  Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. , 1992, Chest.

[241]  Ó. Bielsa,et al.  [Percutaneous drainage of renal and perirenal abscesses]. , 1992, Actas urologicas espanolas.

[242]  S. Morris,et al.  Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels. , 1992, The American journal of physiology.

[243]  C. Chopin,et al.  Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. , 1992, Chest.

[244]  R. Light Pleural diseases. , 1992, Disease-a-month : DM.

[245]  M. C. Townsend,et al.  Experience with phenylephrine as a component of the pharmacologie support of septic shock , 1991, Critical care medicine.

[246]  T. Inamatsu [Pseudomonas aeruginosa bacteremia]. , 1991, Nihon rinsho. Japanese journal of clinical medicine.

[247]  E. Rackow,et al.  Pathophysiology and treatment of septic shock. , 1991, JAMA.

[248]  L. Nilsson,et al.  Synergic post-antibiotic effect of amikacin in combination with beta-lactam antibiotics on gram-negative bacteria. , 1991, The Journal of antimicrobial chemotherapy.

[249]  B. Allolio,et al.  Cortisol response to corticotropin and survival in septic shock , 1991, The Lancet.

[250]  D. Ashbaugh,et al.  Empyema thoracis. Factors influencing morbidity and mortality. , 1991, Chest.

[251]  J. Parrillo,et al.  Cardiovascular dysfunction in septic shock. , 1991, Chest.

[252]  M. C. Townsend,et al.  High-Dose Phenylephrine Infusion in the Hemodynamic Support of Septic Shock , 1990, DICP : the annals of pharmacotherapy.

[253]  K. Marotti,et al.  Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene , 1990, Nature.

[254]  J. Cronan,et al.  Percutaneous drainage of renal and perirenal abscesses: results in 30 patients. , 1990, AJR. American journal of roentgenology.

[255]  W. Köhler Streptococcal toxic shock syndrome. , 1990, Zentralblatt fur Bakteriologie : international journal of medical microbiology.

[256]  P. Papadakos,et al.  Low sensitivity of the anion gap as a screen to detect hyperlactatemia in critically ill patients. , 1989, Critical care medicine.

[257]  E. Lang Renal, perirenal, and pararenal abscesses: percutaneous drainage. , 1990, Radiology.

[258]  V. Yu,et al.  Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients. , 1989, The American journal of medicine.

[259]  D. Amsterdam The development of resistance during antimicrobial therapy , 1989 .

[260]  S. Cain,et al.  Comparison of central-venous to mixed-venous oxygen saturation during changes in oxygen supply/demand. , 1989, Chest.

[261]  B. Meyers,et al.  Bloodstream infections in the elderly. , 1989, The American journal of medicine.

[262]  W. Shoemaker,et al.  Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. , 1988, Chest.

[263]  M. Weil,et al.  Relationship of oxygen delivery and mixed venous oxygenation to lactic acidosis in patients with sepsis and acute myocardial infarction. , 1988, Critical care medicine.

[264]  T. Scalea,et al.  Central venous blood oxygen saturation: an early, accurate measurement of volume during hemorrhage. , 1986, The Journal of trauma.

[265]  J W Warren,et al.  Catheter-associated urinary tract infections. , 2012, Critical care nurse.

[266]  D Greenwood,et al.  An analysis of community and hospital-acquired bacteraemia in a large teaching hospital in the United Kingdom. , 1987, The Quarterly journal of medicine.

[267]  M. Weil,et al.  Comparison of blood lactate concentrations in central venous, pulmonary artery, and arterial blood. , 1987, Critical care medicine.

[268]  A. Chang,et al.  Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. , 1987, The Journal of clinical investigation.

[269]  M. Aronson,et al.  Diagnostic Decision: Blood Cultures , 1987 .

[270]  K. Lobdell,et al.  Splanchnic and total body oxygen consumption differences in septic and injured patients. , 1987, Surgery.

[271]  D. Sackett,et al.  Rules of evidence and clinical recommendations on the use of antithrombotic agents. , 1989, Chest.

[272]  D. Ilstrup,et al.  Blood cultures: issues and controversies. , 1986, Reviews of infectious diseases.

[273]  P. Gennis,et al.  The clinical utility of the leukocyte differential in emergency medicine. , 1986, American journal of clinical pathology.

[274]  M. Callaham Inaccuracy and expense of the leukocyte count in making urgent clinical decisions. , 1986, Annals of emergency medicine.

[275]  E. Draper,et al.  APACHE II: A severity of disease classification system , 1985, Critical care medicine.

[276]  J. Shelhamer,et al.  A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. , 1985, The Journal of clinical investigation.

[277]  J. McCue Improved mortality in gram-negative bacillary bacteremia. , 1985, Archives of internal medicine.

[278]  H. Eichler,et al.  Effect of Ketanserin on Phenylephrine‐Dependent Changes in Splanchnic Hemodynamics and Systemic Blood Pressure in Healthy Subjects , 1985, Journal of cardiovascular pharmacology.

[279]  J. Parrillo Cardiovascular dysfunction in septic shock: new insights into a deadly disease. , 1985, International journal of cardiology.

[280]  Morris Dl,et al.  Hemodynamic Characteristics of Patients with Hypothermia Due to Occult Infection and Other Causes , 1985 .

[281]  M. Sande,et al.  Hemodynamic characteristics of patients with hypothermia due to occult infection and other causes. , 1985, Annals of internal medicine.

[282]  Z. Barbaric Percutaneous nephrostomy for urinary tract obstruction. , 1984, AJR. American journal of roentgenology.

[283]  J. Vincent,et al.  Serial lactate determinations during circulatory shock , 1983, Critical care medicine.

[284]  M. Weinstein,et al.  The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. , 1983, Reviews of infectious diseases.

[285]  M. Weinstein,et al.  The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. , 1983, Reviews of infectious diseases.

[286]  S. Gerzof Percutaneous drainage of renal and perinephric abscess , 1981, Urologic radiology.

[287]  P. Koehler,et al.  Diagnosis of abdominal abscesses with computed tomography, ultrasound, and 111In leukocyte scans. , 1980, Radiology.

[288]  W. R. Mccabe,et al.  Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. , 1980, The American journal of medicine.

[289]  J. Fisher,et al.  Necrotizing fasciitis. Importance of roentgenographic studies for soft-tissue gas. , 1979, JAMA.

[290]  P. Gross,et al.  Bacteremia in a community hospital: spectrum and mortality. , 1977, Archives of internal medicine.

[291]  A. Chow,et al.  Clindamycin for treatment of sepsis caused by decubitus ulcers. , 1977, The Journal of infectious diseases.

[292]  A. Chow,et al.  Sepsis associated with decubitus ulcers. , 1976, The American journal of medicine.

[293]  W. Schumer Steroids in the Treatment of Clinical Septic Shock , 1976, Annals of surgery.

[294]  Joseph Lee,et al.  Central Venous Oxygen Saturation in Shock: A Study in Man , 1972, Anesthesiology.

[295]  A. Medeiros,et al.  Recent experience with bacillemia due to gram-negative organisms. , 1971, The Journal of infectious diseases.

[296]  R. Bryant,et al.  Factors affecting mortality of gram-negative rod bacteremia. , 1971, Archives of internal medicine.

[297]  E. Rapaport,et al.  Critical Assessment of Use of Central Venous Oxygen Saturation as a Mirror of Mixed Venous Oxygen in Severely Ill Cardiac Patients , 1969, Circulation.

[298]  H. Dupont,et al.  INFECTIONS DUE TO GRAM-NEGATIVE ORGANISMS: AN ANALYSIS OF 860 PATIENTS WITH BACTEREMIA AT THE UNIVERSITY OF MINNESOTA MEDICAL CENTER, 1958–1966 , 1969, Medicine.

[299]  J. Lewis,et al.  Gram-negative bacteremia. , 1969, The Johns Hopkins medical journal.

[300]  D. Harrison,et al.  Measurement of Central Venous Oxygen Saturation in Patients with Myocardial Infarction , 1968, Circulation.

[301]  K. Vosti,et al.  The importance of underlying disease in patients with gram-negative bacteremia. , 1968, Archives of internal medicine.

[302]  E. Frank A SHOCK TEAM IN A GENERAL HOSPITAL , 1967, Anesthesia and analgesia.

[303]  G. Jackson,et al.  Gram-Negative Bacteremia: I. Etiology and Ecology , 1962 .

[304]  R. Fairbrother Blood cultures. , 1949, The Practitioner.