Targeted disruption of the neurotrophin-3 gene with lacZ induces loss of trkC-positive neurons in sensory ganglia but not in spinal cords

[1]  R. Jaenisch,et al.  Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents , 1994, Cell.

[2]  S. McMahon,et al.  Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons , 1994, Cell.

[3]  I. Fariñas,et al.  Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development , 1994, Cell.

[4]  M. Barbacid,et al.  Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements , 1994, Nature.

[5]  M. Barbacid,et al.  Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene , 1994, Nature.

[6]  Rudolf Jaenisch,et al.  Mice lacking brain-derived neurotrophic factor develop with sensory deficits , 1994, Nature.

[7]  E. Arenas,et al.  Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo , 1994, Nature.

[8]  Yves-Alain Barde,et al.  Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion , 1994, Nature.

[9]  M. Barbacid,et al.  Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  Rhonda,et al.  Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  T. Yagi,et al.  Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ. , 1993, Oncogene.

[12]  M. Barbacid,et al.  Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death , 1993, Cell.

[13]  Y Ikawa,et al.  A novel ES cell line, TT2, with high germline-differentiating potency. , 1993, Analytical biochemistry.

[14]  I. Silos-Santiago,et al.  Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  M. Saarma,et al.  Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth , 1993, The Journal of cell biology.

[16]  E. Castrén,et al.  Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  M. Barbacid,et al.  trkC encodes multiple neurotrophin‐3 receptors with distinct biological properties and substrate specificities. , 1993, The EMBO journal.

[18]  S. McMahon,et al.  Neurotrophins promote motor neuron survival and are present in embryonic limb bud , 1993, Nature.

[19]  L. Greene,et al.  Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells , 1993, Neuron.

[20]  H. Thoenen,et al.  Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section , 1992, Nature.

[21]  P. Ernfors,et al.  Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system , 1992, Neuroscience.

[22]  Y Ikawa,et al.  Mice develop normally without tenascin. , 1992, Genes & development.

[23]  R. McKay,et al.  Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus , 1992, Neuron.

[24]  M. Bothwell,et al.  Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons , 1992, Neuron.

[25]  T. Ebendal.  Function and evolution in the NGF family and its receptors , 1992, Journal of neuroscience research.

[26]  M. Barbacid,et al.  The trkB tyrosine protein kinase is a receptor for neurotrophin-4 , 1992, Neuron.

[27]  P. Brûlet,et al.  Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene , 1992, Cell.

[28]  R. Espinosa,et al.  Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[29]  D. Goeddel,et al.  Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB , 1991, Neuron.

[30]  P. Ernfors,et al.  Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion , 1991, The European journal of neuroscience.

[31]  M. Barbacid,et al.  trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3 , 1991, Cell.

[32]  G. Yancopoulos,et al.  Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor , 1991, Cell.

[33]  M. Barbacid,et al.  The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 , 1991, Cell.

[34]  M. Barbacid,et al.  The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3 , 1991, Cell.

[35]  C. Ibáñez,et al.  Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary , 1991, Neuron.

[36]  M. Barbacid,et al.  The trk proto-oncogene encodes a receptor for nerve growth factor , 1991, Cell.

[37]  G. Yancopoulos,et al.  BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra , 1991, Nature.

[38]  Y. Ono,et al.  Regional expression of the nerve growth factor gene family in rat brain during development. , 1991, Biochemical and biophysical research communications.

[39]  L. Olson,et al.  Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family , 1990, Neuron.

[40]  L. Belluscio,et al.  NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression , 1990, Neuron.

[41]  K. Thomas,et al.  Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[42]  L. Reichardt,et al.  Molecular cloning of a human gene that is a member of the nerve growth factor family. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Yves-Alain Barde,et al.  Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture , 1990, Neuron.

[44]  L. Olson,et al.  Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Y. Kaisho,et al.  Cloning and expression of a cDNA encoding a novel human neurotrophic factor , 1990, FEBS letters.

[46]  D. Goeddel,et al.  Primary structure and biological activity of a novel human neurotrophic factor , 1990, Neuron.

[47]  Y. Barde,et al.  Binding of brain-derived neurotrophic factor to the nerve growth factor receptor , 1990, Neuron.

[48]  L. Belluscio,et al.  Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. , 1990, Science.

[49]  Y. Barde,et al.  Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family , 1990, Nature.

[50]  H. Thoenen,et al.  Molecular cloning and expression of brain-derived neurotrophic factor , 1989, Nature.

[51]  M. Capecchi,et al.  Altering the genome by homologous recombination. , 1989, Science.

[52]  Mario R. Capecchi,et al.  Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes , 1988, Nature.

[53]  E. Borrelli,et al.  Targeting of an inducible toxic phenotype in animal cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[54]  M. Capecchi,et al.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells , 1987, Cell.

[55]  W. Rutter,et al.  Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor , 1983, Nature.

[56]  M. Capecchi,et al.  Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. , 1993, Development.

[57]  E. Robertson.  Teratocarcinomas and embryonic stem cells : a practical approach , 1987 .