During the past years, when the needs of society and road users have been changing considerably, a lot of attention has been paid to the solution of problems that are related to the development, upgrading, and renovation of roads that are of national significance. Design of Lithuanian rural highways focuses on the application of the methodological principles of sustainable development and the experience of foreign countries. Roads, the development process of which is influenced by natural, demographical, planning, technical, management and other factors, first, are investigated as part of the ecological system. Assessment of the factors influencing roads is quite complicated due to an intricate connection of the roads with their environment and the global system. Design of rural highways is related to road geometrical parameters, geological and hydrological conditions of a location, and usage of old pavement structure. Following an analysis of the Standards of the Lithuanian Road Design, it was found that these factors have different impacts on the rural highways in different Lithuanian regions due to different road significance, traffic volume and driving speed, technical road characteristics by components of the road, pavement structures, and soils as well as materials used for road design. The structural chart of an information database to design roads (in compliance with Lithuanian Road Standards) was drawn up. This database could be useful for designing future rural highways.