Chapter 1 – Brain Development

The human brain has been described as the most complicated biological object in existence. Yet the brain is the substrate for sophisticated human behavior, so perhaps it’s complexity is predictable. The development of the brain follows a genetic blueprint and this blueprint organizes basic structures and connections in the brain. But brain development is also sensitive to the environment. An individual’s experiences can dictate connections to be dismantled or retained in the wiring circuitry of the brain. Two main cell types, neurons and glia, comprise the brain and they appear in various forms at different phases of brain development. In maturity, the brain has approximately 86 billion neurons and about the same number of glial cells. The process of transforming the embryonic neural plate to the exquisitely complex and fully developed brain, is the topic of discussion in this chapter.

[1]  Samuel Bernard,et al.  Neurogenesis in the Striatum of the Adult Human Brain , 2014, Cell.

[2]  Jon H. Kaas,et al.  Evolution and Development of the Mammalian Cerebral Cortex , 2014, Brain, Behavior and Evolution.

[3]  Sumio Sugano,et al.  The functional consequences of alternative promoter use in mammalian genomes. , 2008, Trends in genetics : TIG.

[4]  M. Götz,et al.  Radial glia – from boring cables to stem cell stars , 2013, Development.

[5]  M. Szyf,et al.  Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse , 2012, Biological Psychiatry.

[6]  I. Weaver,et al.  FROM MATERNAL CARE TO GENE EXPRESSION: DNA METHYLATION AND THE MATERNAL PROGRAMMING OF STRESS RESPONSES , 2002, Endocrine research.

[7]  C. Walsh,et al.  Genetic Changes Shaping the Human Brain , 2015 .

[8]  B. J. Casey,et al.  Structural and functional brain development and its relation to cognitive development , 2000, Biological Psychology.

[9]  Terry L. Jernigan,et al.  The Basics of Brain Development , 2010, Neuropsychology Review.

[10]  A. Espinosa,et al.  Fate-Restricted Neural Progenitors in the Mammalian Cerebral Cortex , 2012, Science.

[11]  Patrick O. McGowan,et al.  Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats , 2011, PloS one.

[12]  J. Sweatt,et al.  Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene , 2009, Biological Psychiatry.

[13]  S. Pääbo The Human Condition—A Molecular Approach , 2014, Cell.

[14]  M. McCarthy,et al.  Epigenetic Underpinnings of Developmental Sex Differences in the Brain , 2011, Neuroendocrinology.

[15]  M. Giustetto,et al.  Synaptic Pruning by Microglia Is Necessary for Normal Brain Development , 2011, Science.

[16]  J. Rothstein,et al.  Oligodendroglia: metabolic supporters of axons. , 2013, Trends in cell biology.

[17]  M. McCarthy,et al.  At the frontier of epigenetics of brain sex differences , 2015, Front. Behav. Neurosci..

[18]  Kiyoto Kasai,et al.  DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients , 2013, Neuroscience Research.

[19]  I. Weaver,et al.  Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Penninx,et al.  Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484) , 2014, Molecular Psychiatry.

[21]  J. Sanes,et al.  Chemoaffinity Revisited: Dscams, Protocadherins, and Neural Circuit Assembly , 2010, Cell.

[22]  Patrick O. McGowan,et al.  Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain , 2008, PloS one.

[23]  Y. Okamoto,et al.  DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression , 2011, PloS one.

[24]  Patrick O. McGowan,et al.  Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus , 2012, Proceedings of the National Academy of Sciences.

[25]  C. Shatz The developing brain. , 1992, Scientific American.

[26]  Moriah E. Thomason,et al.  Age-related increases in long-range connectivity in fetal functional neural connectivity networks in utero , 2014, Developmental Cognitive Neuroscience.

[27]  F. Perera,et al.  DNA methylation of BDNF as a biomarker of early-life adversity , 2014, Proceedings of the National Academy of Sciences.

[28]  T. Jernigan,et al.  Construction of the human forebrain. , 2017, Wiley interdisciplinary reviews. Cognitive science.

[29]  A. Parent,et al.  Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites , 2001, Molecular and Cellular Endocrinology.

[30]  W. Chan,et al.  Proliferation and apoptosis in the developing human neocortex , 2002, The Anatomical record.

[31]  R. Khazipov,et al.  Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery , 2006, Science.

[32]  M. Meaney,et al.  Variations in Maternal Care Alter GABAA Receptor Subunit Expression in Brain Regions Associated with Fear , 2003, Neuropsychopharmacology.

[33]  Michael Papsdorf,et al.  Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses , 2008, Epigenetics.

[34]  Melissa J. Green,et al.  Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis , 2011, Molecular Psychiatry.

[35]  H. Steiger,et al.  Methylation of BDNF in women with bulimic eating syndromes: Associations with childhood abuse and borderline personality disorder , 2014, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[36]  D. Attwell,et al.  Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate , 2011, The Journal of Neuroscience.

[37]  F. Champagne Epigenetic mechanisms and the transgenerational effects of maternal care , 2008, Frontiers in Neuroendocrinology.

[38]  Gustavo Turecki,et al.  Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse , 2009, Nature Neuroscience.

[39]  A. Malafosse,et al.  Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene , 2013, Translational Psychiatry.

[40]  N. Bresolin,et al.  Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII , 2012, Neuropsychopharmacology.

[41]  Tamara Aid,et al.  Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters☆ , 2007, Genomics.

[42]  Serena J Counsell,et al.  The emergence of functional architecture during early brain development , 2017, NeuroImage.

[43]  M. Esteller,et al.  Cancer epigenomics: beyond genomics. , 2012, Current opinion in genetics & development.

[44]  Daniel J. Miller,et al.  Prolonged myelination in human neocortical evolution , 2012, Proceedings of the National Academy of Sciences.

[45]  Michael J Meaney,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[46]  E. Aronica,et al.  Ontogenetic modifications of neuronal excitability during brain maturation: Developmental changes of neurotransmitter receptors , 2011, Epilepsia.

[47]  J. Nabekura,et al.  Microglia: actively surveying and shaping neuronal circuit structure and function , 2013, Trends in Neurosciences.

[48]  Michael J Meaney,et al.  Epigenetics and parental effects , 2010, BioEssays : news and reviews in molecular, cellular and developmental biology.

[49]  B. Finlay,et al.  Translating developmental time across mammalian species , 2001, Neuroscience.

[50]  D. Geschwind,et al.  Cortical Evolution: Judge the Brain by Its Cover , 2013, Neuron.

[51]  W. Greenough,et al.  Experience and brain development. , 1987, Child development.

[52]  S. Anderson,et al.  The origin and specification of cortical interneurons , 2006, Nature Reviews Neuroscience.

[53]  S. Fatemi,et al.  The involvement of Reelin in neurodevelopmental disorders , 2013, Neuropharmacology.

[54]  James E. Goldman,et al.  Cell migration in the normal and pathological postnatal mammalian brain , 2009, Progress in Neurobiology.

[55]  W. Nelson,et al.  Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. , 2008, Biochimica et biophysica acta.

[56]  A. Bird,et al.  Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals , 2003, Nature Genetics.

[57]  B. Kolb,et al.  Preconception paternal stress in rats alters dendritic morphology and connectivity in the brain of developing male and female offspring , 2015, Neuroscience.

[58]  U. Müller,et al.  Shaping Our Minds: Stem and Progenitor Cell Diversity in the Mammalian Neocortex , 2013, Neuron.

[59]  M. Szyf,et al.  Genome-wide methylation changes in the brains of suicide completers. , 2013, The American journal of psychiatry.

[60]  R. Mychasiuk,et al.  Parental enrichment and offspring development: Modifications to brain, behavior and the epigenome , 2012, Behavioural Brain Research.

[61]  Gavin J. Clowry,et al.  The Early Fetal Development of Human Neocortical GABAergic Interneurons , 2013, Cerebral cortex.

[62]  P. Bregestovski,et al.  Excitatory GABA: How a Correct Observation May Turn Out to be an Experimental Artifact , 2012, Front. Pharmacol..

[63]  R. Mychasiuk,et al.  Paternal stress prior to conception alters DNA methylation and behaviour of developing rat offspring , 2013, Neuroscience.

[64]  M. Meaney,et al.  Nongenomic transmission across generations of maternal behavior and stress responses in the rat. , 1999, Science.

[65]  G. Elston Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function. , 2003, Cerebral cortex.

[66]  B. Stevens,et al.  Microglia Function in Central Nervous System Development and Plasticity. , 2015, Cold Spring Harbor perspectives in biology.

[67]  Frances A Champagne,et al.  Epigenetic influences on brain development and plasticity , 2009, Current Opinion in Neurobiology.

[68]  G. Xi,et al.  Human Cortex Development: Estimates of Neuronal Numbers Indicate Major Loss Late During Gestation , 1996, Journal of neuropathology and experimental neurology.

[69]  Heiko J. Luhmann,et al.  Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! , 2012, Front. Cell. Neurosci..

[70]  Michael J Meaney,et al.  Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. , 2007, Trends in molecular medicine.

[71]  Hwai-Jong Cheng,et al.  Axon pruning: an essential step underlying the developmental plasticity of neuronal connections , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.