Metal‐chelating 3‐hydroxypyrimidine‐2,4‐diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication
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[1] Michael Boeckh,et al. Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic‐Cell Transplantation , 2017, The New England journal of medicine.
[2] S. Chou. A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance , 2017, Antiviral research.
[3] S. Chou. Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds , 2017, Antimicrobial Agents and Chemotherapy.
[4] G. Boivin,et al. Drug Susceptibility and Replicative Capacity of Multidrug-Resistant Recombinant Human Cytomegalovirus Harboring Mutations in UL56 and UL54 Genes , 2017, Antimicrobial Agents and Chemotherapy.
[5] Wendy J M van Zuylen,et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. , 2017, The Lancet. Infectious diseases.
[6] M. Messerle,et al. Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex Formation , 2017, Journal of Virology.
[7] Yan Wang,et al. Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage , 2016, Journal of Virology.
[8] Andrew D. Huber,et al. 3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H. , 2016, Journal of medicinal chemistry.
[9] S. Sarafianos,et al. Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H. , 2016, Journal of medicinal chemistry.
[10] S. Sarafianos,et al. 3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. , 2016, Journal of medicinal chemistry.
[11] L. Tang,et al. Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors. , 2016, Biochemistry.
[12] L. Tang,et al. Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism , 2015, Nucleic acids research.
[13] S. Chou. Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance , 2015, Antimicrobial Agents and Chemotherapy.
[14] S. Sarafianos,et al. Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities , 2014, Journal of medicinal chemistry.
[15] J. Tavis,et al. Inhibitors of Nucleotidyltransferase Superfamily Enzymes Suppress Herpes Simplex Virus Replication , 2014, Antimicrobial Agents and Chemotherapy.
[16] D. Dreyfus,et al. HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses , 2014, mBio.
[17] H. Zimmermann,et al. Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants Selected In Vitro after Letermovir (AIC246) Exposure , 2013, Antimicrobial Agents and Chemotherapy.
[18] J. Baines. Herpes simplex virus capsid assembly and DNA packaging: a present and future antiviral drug target. , 2011, Trends in microbiology.
[19] Amina Ahmed. Antiviral treatment of cytomegalovirus infection. , 2011, Infectious disorders drug targets.
[20] H. Zimmermann,et al. The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral Terminase , 2011, Journal of Virology.
[21] E. De Clercq,et al. A time-of–drug addition approach to target identification of antiviral compounds , 2011, Nature Protocols.
[22] Y. Pommier,et al. 6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase. , 2011, Bioorganic & medicinal chemistry letters.
[23] Yves Pommier,et al. 3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase. , 2011, Journal of Medicinal Chemistry.
[24] S. Chou,et al. Antiviral Drug Resistance of Human Cytomegalovirus , 2010, Clinical Microbiology Reviews.
[25] P. Mas,et al. Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain , 2010, Proceedings of the National Academy of Sciences.
[26] M. Rossmann,et al. Genome packaging in viruses. , 2010, Current opinion in structural biology.
[27] H. Zimmermann,et al. InVitro and In Vivo Activities of the Novel Anticytomegalovirus Compound AIC246 , 2010, Antimicrobial Agents and Chemotherapy.
[28] E. De Clercq,et al. Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus. , 2008, Journal of virological methods.
[29] S. Bouaziz,et al. New Functional Domains of Human Cytomegalovirus pUL89 predicted by Sequence Analysis and Three-Dimensional Modelling of the Catalytic Site DEXDc , 2007, Antiviral therapy.
[30] W. Bresnahan,et al. Interaction between the Human Cytomegalovirus UL82 Gene Product (pp71) and hDaxx Regulates Immediate-Early Gene Expression and Viral Replication , 2005, Journal of Virology.
[31] G. Boivin,et al. Human Cytomegalovirus Resistance to Antiviral Drugs , 2005, Antimicrobial Agents and Chemotherapy.
[32] F. Baldanti,et al. Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs. , 2004, Human immunology.
[33] A. Holzenburg,et al. The terminase subunits pUL56 and pUL89 of human cytomegalovirus are DNA-metabolizing proteins with toroidal structure. , 2002, Nucleic acids research.
[34] J. Trappe,et al. Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action. , 2001, The Journal of antimicrobial chemotherapy.
[35] H. Klenk,et al. A Novel Nonnucleoside Inhibitor Specifically Targets Cytomegalovirus DNA Maturation via the UL89 and UL56 Gene Products , 2001, Journal of Virology.
[36] M. Marschall,et al. Recombinant Green Fluorescent Protein-Expressing Human Cytomegalovirus as a Tool for Screening Antiviral Agents , 2000, Antimicrobial Agents and Chemotherapy.
[37] J. Baines,et al. Proteolytic Cleavage of the Amino Terminus of the UL15 Gene Product of Herpes Simplex Virus Type 1 Is Coupled with Maturation of Viral DNA into Unit-Length Genomes , 1999, Journal of Virology.
[38] L. Townsend,et al. Inhibition of Human Cytomegalovirus DNA Maturation by a Benzimidazole Ribonucleoside Is Mediated through the UL89 Gene Product , 1998, Journal of Virology.