Variation of the response to the optokinetic drum among various strains of mice.

The optokinetic drum has become an appropriate tool to examine visual properties of mice. We performed baseline measurements using mice of the inbred strains C3H, C57BL/6, BALB/c, JF1, 129 and DBA/2 at the age of 8-15 weeks. Each individual C57BL/6, 129 and JF1 mouse was reliably identified as non-affected in vision by determining head-tracking responses. C3H mice were used as negative control because of their inherited retinal degeneration; as expected, they did not respond to the moving stripe pattern. Surprisingly, BALB/c and DBA/2 mice showed the same result. Electroretinography, funduscopy and histology of BALB/c mice did not reveal any abnormality concerning the structure or function of the retina and the remaining eye. Therefore, it might be assumed that BALB/c mice suffer from disturbances of the central visual system. Preliminary results from linkage analysis of the non-responding phenotype in the BALB/c mice indicate a recessive, monogenic mode of inheritance; the causative gene is located on chromosome 7, but significantly different from the albino locus. In conclusion, C57BL/6, 129 and JF1 represent appropriate inbred strains for high throughput screenings with the optokinetic drum.

[1]  M. Seeliger,et al.  Grating acuity at different luminances in wild-type mice and in mice lacking rod or cone function. , 2005, Investigative ophthalmology & visual science.

[2]  L. Pinto,et al.  Visually evoked eye movements in mouse mutants and inbred strains. A screening report. , 1984, Investigative ophthalmology & visual science.

[3]  M. Angelis,et al.  Variations of eye size parameters among different strains of mice , 2006, Mammalian Genome.

[4]  F. Schaeffel,et al.  Contrast sensitivity of wildtype mice wearing diffusers or spectacle lenses, and the effect of atropine , 2006, Vision Research.

[5]  W. Baehr,et al.  Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[6]  John S Stahl,et al.  Eye movements of the murine P/Q calcium channel mutant rocker, and the impact of aging. , 2004, Journal of neurophysiology.

[7]  I. Jackson,et al.  Presence of visual head tracking differentiates normal sighted from retinal degenerate mice , 2002, Neuroscience Letters.

[8]  R. E. Brown,et al.  Visual detection, pattern discrimination and visual acuity in 14 strains of mice , 2006, Genes, brain, and behavior.

[9]  W. Precht,et al.  Optokinetic, vestibular, and optokinetic-vestibular responses in albino and pigmented rats , 1982, Pflügers Archiv.

[10]  J. Heckenlively,et al.  Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. , 1999, Molecular vision.

[11]  Frank Schaeffel,et al.  In vivo biometry in the mouse eye with low coherence interferometry , 2004, Vision Research.

[12]  R. Lund.  Uncrossed Visual Pathways of Hooded and Albino Rats , 1965, Science.

[13]  T H Roderick,et al.  Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. , 1998, Investigative ophthalmology & visual science.

[14]  R. Liebelt,et al.  The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. , 1972, The American journal of anatomy.

[15]  K. Hoffmann,et al.  Optokinetic Deficits in Albino Ferrets (Mustela putorius furo): A Behavioral and Electrophysiological Study , 2004, The Journal of Neuroscience.

[16]  Chris I De Zeeuw,et al.  Eye movements of the murine P/Q calcium channel mutant tottering, and the impact of aging. , 2004, Journal of neurophysiology.

[17]  R M Douglas,et al.  Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system , 2005, Visual Neuroscience.

[18]  H. Fuchs,et al.  Electroretinography as a screening method for mutations causing retinal dysfunction in mice. , 2004, Investigative ophthalmology & visual science.

[19]  J. Graw,et al.  Mouse mutants as models for congenital retinal disorders. , 2005, Experimental eye research.

[20]  J. Graw.  Congenital hereditary cataracts. , 2004, The International journal of developmental biology.

[21]  R. Douglas,et al.  Behavioral assessment of visual acuity in mice and rats , 2000, Vision Research.

[22]  B. J. Winterson,et al.  Optokinetic eye movements in albino rabbits: inversion in anterior visual field. , 1978, Science.

[23]  R. Douglas,et al.  Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. , 2004, Investigative ophthalmology & visual science.

[24]  K. Ray,et al.  Tyrosinase and ocular diseases: Some novel thoughts on the molecular basis of oculocutaneous albinism type 1 , 2007, Progress in Retinal and Eye Research.

[25]  R. J. Mullen,et al.  Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimeras. , 1976, Experimental eye research.

[26]  Yan Li,et al.  Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric , 2006, BMC Neuroscience.

[27]  Steve D. M. Brown,et al.  Novel ENU-induced eye mutations in the mouse: models for human eye disease. , 2002, Human molecular genetics.