Real-Time Simulations of Synchronization in a Conductance-Based Neuronal Network with a Digital FPGA Hardware-Core

A FPGA hardware core has been designed for real-time network simulations with up to 400 physiologically realistic, conductance-based neurons of the Hodgkin-Huxley type. A PC-FPGA interface allows easy parameter adjustment and on-line display of basic synchronization measures like field potentials, spike times or color-coded voltages of the complete array. Simulations of 20 ·20 gap-junction coupled 4-dimensional neurons reveal remarkable alterations of the synchronization states and impulse patterns during linearly increasing coupling strengths.

[1]  Hans A Braun,et al.  Neural Synchronization at Tonic-to-Bursting Transitions , 2007, Journal of biological physics.

[2]  Idan Segev,et al.  Subthreshold oscillations and resonant frequency in guinea‐pig cortical neurons: physiology and modelling. , 1995, The Journal of physiology.

[3]  Martin Tobias Huber,et al.  Stimulus-response curves of a neuronal model for noisy subthreshold oscillations and related spike generation. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[4]  José L. Núñez-Yáñez,et al.  A biophysically accurate floating point somatic neuroprocessor , 2009, 2009 International Conference on Field Programmable Logic and Applications.

[5]  K. Schäfer,et al.  Oscillation and noise determine signal transduction in shark multimodal sensory cells , 1994, Nature.

[6]  H A Braun,et al.  Neurones and synapses for systemic models of psychiatric disorders. , 2010, Pharmacopsychiatry.

[7]  David A. McCormick,et al.  Are thalamocortical rhythms the rosetta stone of a subset of neurological disorders? , 1999, Nature Medicine.

[8]  Eugene M. Izhikevich,et al.  Simple model of spiking neurons , 2003, IEEE Trans. Neural Networks.

[9]  H. Bade,et al.  Static and dynamic discharge patterns of bursting cold fibers related to hypothetical receptor mechanisms , 1980, Pflügers Archiv.

[10]  R. Llinás,et al.  Bursting of thalamic neurons and states of vigilance. , 2006, Journal of neurophysiology.

[11]  Frank Moss,et al.  Noise-induced precursors of tonic-to-bursting transitions in hypothalamic neurons and in a conductance-based model. , 2011, Chaos.

[12]  Horst Schneider,et al.  A computational study of the interdependencies between neuronal impulse pattern, noise effects and synchronization , 2010, Journal of Physiology-Paris.