Information value of the rodent bioassay

Tests for human carcinogens using lifetime rodent bioassays are expensive, time-consuming and give uncertain results. For most chemicals such tests are not cost-effective.

[1]  M. Pike,et al.  A carcinogenic potency database of the standardized results of animal bioassays , 1984, Environmental health perspectives.

[2]  H S Rosenkranz,et al.  Evaluating batteries of short-term genotoxicity tests. , 1986, Mutagenesis.

[3]  D. Bleyl,et al.  IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs vol. 1 to 42. Supplement 7. 440 Seiten. International Agency for Research on Cancer, Lyon 1987. Preis: 65, – s.Fr , 1989 .

[4]  E Zeiger,et al.  Carcinogenicity of mutagens: predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity. , 1987, Cancer research.

[5]  Lester B. Lave,et al.  Cost-effectiveness of short-term tests for carcinogenicity , 1986, Nature.

[6]  H S Rosenkranz,et al.  The carcinogenicity prediction and battery selection (CPBS) method: a Bayesian approach. , 1985, Mutation research.

[7]  D. Clayson ICPEMC publication no. 13 the need for biological risk assessment in reaching decisions about carcinogens (MTR07214) , 1987 .

[8]  H S Rosenkranz,et al.  Prediction of environmental carcinogens: a strategy for the mid-1980s. , 1984, Environmental mutagenesis.

[9]  B H Margolin,et al.  Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. , 1987, Science.

[10]  J H Weisburger,et al.  Carcinogen testing: current problems and new approaches. , 1981, Science.

[11]  Charles Levenstein The Dilemma of Toxic Substance Regulation , 1989 .

[12]  B. Ames,et al.  Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. , 1986, Environmental health perspectives.

[13]  Lester B. Lave,et al.  Screening Toxic Chemicals: How Accurate Must Tests Be? , 1988 .

[14]  L B Lave,et al.  Scientific and cost-effectiveness criteria in selecting batteries of short-term tests. , 1988, Mutation research.

[15]  J. Huff,et al.  On the proportion of positive results in carcinogenicity studies in animals. , 1985, Environmental mutagenesis.

[16]  H. Rosenkranz,et al.  Structure-activity relationships (SARs) among mutagens and carcinogens: a review. , 1986, Environmental mutagenesis.

[17]  Lester Lave,et al.  The Strategy of Social Regulation , 1981 .

[18]  L. Gold,et al.  Ranking possible carcinogenic hazards. , 1987, Science.

[19]  International commission for protection against environmental mutageus and carcinogeus: The need for biological risk assessment in reaching decisions about carcinogens , 1987 .

[20]  Lester B. Lave,et al.  A Model for Selecting Short-Term Tests of Carcinogenicity , 1983 .

[21]  F. K. Ennever,et al.  The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans. , 1987, Mutagenesis.