Increased CCL2 and IL‐8 in the bone marrow microenvironment in acute lymphoblastic leukemia

The interactions of acute lymphoblastic leukemia (ALL) blasts with bone marrow (BM) stromal cells have a positive impact on leukemia cell survival. In the present study, we proposed to identify and investigate the role of molecules critically involved in leukemia—microenvironment crosstalk.

[1]  C. Abram,et al.  The ins and outs of leukocyte integrin signaling. , 2009, Annual review of immunology.

[2]  R. A. Etten.  Aberrant cytokine signaling in leukemia , 2007, Oncogene.

[3]  A. Ho,et al.  Molecular and Secretory Profiles of Human Mesenchymal Stromal Cells and Their Abilities to Maintain Primitive Hematopoietic Progenitors , 2007, Stem cells.

[4]  M. Endres,et al.  Towards in situ tissue repair: Human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2 , 2007, Journal of cellular biochemistry.

[5]  J. Juarez,et al.  Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia. , 2007, Haematologica.

[6]  S. Sallan,et al.  Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival. , 2006, Experimental hematology.

[7]  G. Basso,et al.  Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage. , 2006, Leukemia research.

[8]  T. Nagasawa.  Microenvironmental niches in the bone marrow required for B-cell development , 2006, Nature Reviews Immunology.

[9]  K. Do,et al.  Angiogenic factors may have a different prognostic role in adult acute lymphoblastic leukemia. , 2005, Blood.

[10]  Xunbin Wei,et al.  In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment , 2005, Nature.

[11]  L. Gibson,et al.  VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli , 2005, Leukemia.

[12]  R. Gentleman,et al.  Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival. , 2004, Blood.

[13]  D. Fulcher,et al.  Chemokine Receptor Expression in B-cell Lymphoproliferative Disorders , 2004, Leukemia & lymphoma.

[14]  J. Juarez,et al.  Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro , 2003, Leukemia.

[15]  Ø. Bruserud,et al.  In vitro culture of human acute lymphoblastic leukemia (ALL) cells in serum-free media; a comparison of native ALL blasts, ALL cell lines and virus-transformed B cell lines. , 2003, Leukemia research.

[16]  D. Campana,et al.  Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase , 2003, British journal of haematology.

[17]  K. Do,et al.  Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia , 2003, British journal of haematology.

[18]  H. Arai,et al.  Distinct Signaling Pathways for MCP-1-dependent Integrin Activation and Chemotaxis* , 2001, The Journal of Biological Chemistry.

[19]  J. Dürig,et al.  Differential expression of chemokine receptors in B cell malignancies , 2001, Leukemia.

[20]  L. Gibson,et al.  Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. , 2000, Blood.

[21]  F. Marincola,et al.  Thrombopoietin and Chemokine mRNA Expression in Patient Post‐Chemotherapy and In Vitro Cytokine‐Treated Marrow Stromal Cell Layers , 2000, Stem cells.

[22]  S. Gangemi,et al.  In Vitro Interleukin-8 Production by Monocytes Treated with Lithium Chloride from Breast Cancer Patients , 2000, Tumori.

[23]  C. Figdor,et al.  High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. , 1999, Blood.

[24]  M. Shikami,et al.  Survival of human leukaemic B‐cell precursors is supported by stromal cells and cytokines: association with the expression of bcl‐2 protein , 1999, British journal of haematology.

[25]  T. Lebien,et al.  Development of a model for evaluating the interaction between human pre-B acute lymphoblastic leukemic cells and the bone marrow stromal cell microenvironment. , 1998, Blood.

[26]  A. Sarris,et al.  MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures. , 1998, Blood.

[27]  S. J. Myers,et al.  Organization and Differential Expression of the Human Monocyte Chemoattractant Protein 1 Receptor Gene , 1997, The Journal of Biological Chemistry.

[28]  H. Broxmeyer,et al.  Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue , 1996, The Journal of experimental medicine.

[29]  D. Campana,et al.  Molecular interactions between human B-cell progenitors and the bone marrow microenvironment. , 1996, Experimental cell research.

[30]  B. Torok-Storb,et al.  Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. , 1995, Blood.

[31]  F. Behm,et al.  Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. , 1994, Blood.

[32]  K. Byth,et al.  Analysis of the mechanism of adhesion of precursor-B acute lymphoblastic leukemia cells to bone marrow fibroblasts. , 1993, Blood.

[33]  M. Fey,et al.  Constitutive expression of interleukin-8 and its receptor in human myeloid and lymphoid leukemia , 1993 .

[34]  E. Wayner,et al.  Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1) , 1993 .

[35]  A. Cerami,et al.  Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression. , 1993, Journal of immunology.

[36]  W. Wood,et al.  Characterization of two high affinity human interleukin-8 receptors. , 1992, The Journal of biological chemistry.

[37]  B. Longenecker,et al.  Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. , 1992, Blood.

[38]  F. Behm,et al.  Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia. , 1992, Blood.

[39]  R. V. van Etten,et al.  Aberrant cytokine signaling in leukemia. , 2007, Oncogene.

[40]  K. Seeger,et al.  Interaction of bone marrow stromal cells with lymphoblasts and effects of predinsolone on cytokine expression. , 2005, Leukemia research.

[41]  E. Estey,et al.  bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 21, 2013. For personal use , 2000 .

[42]  J. Liu,et al.  [Study on the expression of interleukin-8 and its receptors in acute leukemia]. , 1999, Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.

[43]  E. Wayner,et al.  Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1). , 1993, Blood.