CELL, MEETS SILICON: BIOCHIPS FÜR DIE PREDIKATIVE THERAPIEPLANUNG UND INTERVENTION

Sl ' . Malignanl grovvth of lumor cclls and their i m . i s i v c hchuv lor is charactcn/ed by a myriad of sysleLutors aiul kooperative proeesses. In this conlext, pos i t r .mslu t io iKi l effeets induced by ihe extracellular cMMiomncn i play a decisive role in intluencing the therapeutk· success. Essenlial physical paramcters for tesimt! the exlraeellular environment are the extent of acid i t u a t i o n of tuinor eells and their oxygen consumplion. These parameters exert, äs a result of evolution, global legulatory funetions and also control the enzymatic setup and aclivily of cells. Of great assistance in evaluating the nialignant potential of cells and tissues and in developing suitable individualized therapeutic concepts are the Implementation of planar multiparametric microsensor arrays in glass and silicon lechnology, on which cells and tissues ean be directly cultivated. Such array N\ stems are being developed by our group and are presentK m tnal Operation. New technical developments and reeent results are to presented.