Ewing sarcoma as a second malignant neoplasm after acute lymphoblastic leukemia

Second malignant neoplasms (SMNs) are being increasingly recognized. This report describes a case of a 7‐year‐old girl with a history of acute lymphoblastic leukemia (ALL) who presented with a mass in her humerus that was diagnosed as Ewing sarcoma. Second malignant neoplasms are relatively rare in survivors of ALL treated without radiation. Even more unusual is the development of Ewing sarcoma as the SMN. Pediatr Blood Cancer 2005; 45:57–59. © 2005 Wiley‐Liss, Inc.

[1]  M. Relling,et al.  Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. , 2003, The New England journal of medicine.

[2]  L. Robison,et al.  Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. , 2002, Blood.

[3]  M. Schrappe,et al.  Secondary neoplasms subsequent to Berlin-Frankfurt-Münster therapy of acute lymphoblastic leukemia in childhood: significantly lower risk without cranial radiotherapy. , 2000, Blood.

[4]  M. Hudson,et al.  Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  H. B. Marsden,et al.  Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. , 1996, Journal of the National Cancer Institute.

[6]  L. Robison,et al.  Second tumors after treatment of childhood malignancies. , 1993, Hematology/oncology clinics of North America.

[7]  R. Gelber,et al.  Incidence of secondary acute myelogenous leukemia after treatment of childhood acute lymphoblastic leukemia , 1992, Cancer.

[8]  R. Nygaard,et al.  Second Malignant Neoplasms in Patients Treated for Childhood Leukemia: A Population‐based Cohort Study from the Nordic Countries , 1991, Acta paediatrica Scandinavica.

[9]  L. Robison,et al.  Second neoplasms after acute lymphoblastic leukemia in childhood. , 1991, The New England journal of medicine.

[10]  F. Behm,et al.  Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. , 1989, The New England journal of medicine.