2,4 Dinitrophenol Attenuates Mitochondrial Dysfunction and Improves Neurobehavioral Outcomes Postanoxia in Neonatal Rats

[1]  Z. Erpapazoglou,et al.  From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration , 2017, Neurochemistry International.

[2]  Sairam Krishnamurthy,et al.  Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits , 2016, International Journal of Developmental Neuroscience.

[3]  F. Groenendaal,et al.  Drugs for neuroprotection after birth asphyxia: Pharmacologic adjuncts to hypothermia. , 2016, Seminars in perinatology.

[4]  Xian Wang,et al.  Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration , 2015, Protein & Cell.

[5]  Sairam Krishnamurthy,et al.  Characterization of mitochondrial bioenergetics in neonatal anoxic model of rats , 2015, Journal of Bioenergetics and Biomembranes.

[6]  J. Smeitink,et al.  Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V. , 2014, Biochimica et biophysica acta.

[7]  Ajit S. Divakaruni,et al.  Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. , 2014, Molecular metabolism.

[8]  F. Piquard,et al.  Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations. , 2014, Journal of applied physiology.

[9]  Alistair J. Gunn,et al.  The mechanisms and treatment of asphyxial encephalopathy , 2013, Front. Neurosci..

[10]  K. Storey,et al.  The mitochondrial uncoupler 2,4-dinitrophenol attenuates sodium nitroprusside-induced toxicity in Drosophila melanogaster: potential involvement of free radicals. , 2013, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[11]  V. Borutaite,et al.  In the eye of the storm: mitochondrial damage during heart and brain ischaemia , 2013, The FEBS journal.

[12]  V. Ten,et al.  Nelfinavir Inhibits Intra-Mitochondrial Calcium Influx and Protects Brain against Hypoxic-Ischemic Injury in Neonatal Mice , 2013, PloS one.

[13]  E. Hilario,et al.  Neuroprotective Therapies after Perinatal Hypoxic-Ischemic Brain Injury , 2013, Brain sciences.

[14]  G. Cheng,et al.  Mitochondria in traumatic brain injury and mitochondrial‐targeted multipotential therapeutic strategies , 2012, British journal of pharmacology.

[15]  P. Dargan,et al.  2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death , 2011, Journal of Medical Toxicology.

[16]  A. Somov,et al.  Reversible mitochondrial uncoupling in the cold phase during liver preservation/reperfusion reduces oxidative injury in the rat model. , 2010, Cryobiology.

[17]  S. Scheff,et al.  Age-related changes in mitochondrial respiration and oxidative damage in the cerebral cortex of the Fischer 344 rat , 2010, Mechanisms of Ageing and Development.

[18]  Alexander Sasha Rabchevsky,et al.  Differential effects of the mitochondrial uncoupling agent, 2,4‐dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury , 2009, Journal of neuroscience research.

[19]  B. Tharakan,et al.  Caspases - an update. , 2008, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[20]  T. Pozzan,et al.  Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. , 2007, Trends in cell biology.

[21]  Vidya N. Nukala,et al.  Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents. , 2007, Journal of neurotrauma.

[22]  S. L. Mehta,et al.  Molecular targets in cerebral ischemia for developing novel therapeutics , 2007, Brain Research Reviews.

[23]  L. Fan,et al.  Hypoxia-ischemia induced neurological dysfunction and brain injury in the neonatal rat , 2005, Behavioural Brain Research.

[24]  L. Pettigrew,et al.  The mitochondrial uncoupler 2,4‐dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia , 2005, Journal of neurochemistry.

[25]  Margaret A. Johnson,et al.  Methods of microphotometric assay of succinate dehydrogenase and cytochromec oxidase activities for use on human skeletal muscle , 1989, The Histochemical Journal.

[26]  C. Barnstable,et al.  Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. , 2003, Endocrinology.

[27]  Shu-Gui Huang,et al.  Development of a High Throughput Screening Assay for Mitochondrial Membrane Potential in Living Cells , 2002, Journal of biomolecular screening.

[28]  M. Brand,et al.  Mitochondrial uncoupling as a target for drug development for the treatment of obesity , 2001, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[29]  K. Blomgren,et al.  Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. , 2000, Brain research. Developmental brain research.

[30]  S. Berman,et al.  Dopamine Oxidation Alters Mitochondrial Respiration and Induces Permeability Transition in Brain Mitochondria , 1999, Journal of neurochemistry.

[31]  R. Busto,et al.  Cytochrome C Is Released from Mitochondria Into the Cytosol after Cerebral Anoxia or Ischemia , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[32]  R. McGivern,et al.  Behavioral sequelae in young rats of acute intermittent antenatal hypoxia. , 1992, Neurotoxicology and teratology.

[33]  K. Davies,et al.  The oxidative inactivation of mitochondrial electron transport chain components and ATPase. , 1990, The Journal of biological chemistry.

[34]  B. Storrie,et al.  Isolation of subcellular organelles. , 1990, Methods in enzymology.

[35]  J. Parks,et al.  Mitochondrial function after asphyxia in newborn lambs. , 1989, Stroke.

[36]  S. Hopfer,et al.  Increased lipid peroxidation in tissues of nickel chloride-treated rats. , 1985, Annals of clinical and laboratory science.

[37]  P N Viswanathan,et al.  A modified spectrophotometric assay of superoxide dismutase. , 1984, Indian journal of biochemistry & biophysics.

[38]  S. Tannenbaum,et al.  Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. , 1982, Analytical biochemistry.

[39]  J. Rice,et al.  The influence of immaturity on hypoxic‐ischemic brain damage in the rat , 1981, Annals of neurology.

[40]  R. Feigal,et al.  Mitrochondrial NADH dehydrogenase in cystic fibrosis. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[42]  R. Houghton,et al.  Studies on energy-linked reactions: modified mitochondrial ATPase of oligomycin-resistant mutants of Saccharomyces cerevisiae. , 1974, European journal of biochemistry.

[43]  D. L. Harris,et al.  Some observations on the photometric estimation of mitochondrial volume. , 1958, Biochimica et biophysica acta.

[44]  I W SIZER,et al.  A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. , 1952, The Journal of biological chemistry.

[45]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[46]  R. Koch,et al.  Dinitrophenol on Liver Function. , 1935, California and western medicine.

[47]  W. Boardman Rapidly Developing Cataracts After Dinitrophenol. , 1935, California and western medicine.

[48]  M. Tainter,et al.  Use of Dinitrophenol in Nutritional Disorders : A Critical Survey of Clinical Results. , 1934, American journal of public health and the nation's health.

[49]  E. King,et al.  The colorimetric determination of phosphorus. , 1932, The Biochemical journal.