4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: identifying clinical candidates.

[1]  Jay Liu,et al.  Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications. , 2012, Bioorganic & medicinal chemistry letters.

[2]  D. Delorme,et al.  N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models. , 2009, Bioorganic & Medicinal Chemistry Letters.

[3]  T. Graczyk,et al.  Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859). , 2008, Journal of medicinal chemistry.

[4]  E. Jutkiewicz,et al.  Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats , 2002, Psychopharmacology.

[5]  A. Cavalli,et al.  Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. , 2002, Journal of medicinal chemistry.

[6]  S. Yue,et al.  N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. , 2000, Journal of medicinal chemistry.

[7]  G. Dondio Development of novel pain relief agents acting through the selective activation of the delta-opioid receptor. , 2000, Farmaco.

[8]  H. Nagase,et al.  Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67). , 1998, Chemical & pharmaceutical bulletin.

[9]  J. Flippen-Anderson,et al.  Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. , 1994, Journal of medicinal chemistry.

[10]  M. Millan Multiple opioid systems and pain , 1986, Pain.