PATHWAY-BASED THERAPIES FOR AGE-RELATED MACULAR DEGENERATION: An Integrated Survey of Emerging Treatment Alternatives
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[1] S. Ennis,et al. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case–control study , 2008, The Lancet.
[2] T. Lamb,et al. Dark adaptation and the retinoid cycle of vision , 2004, Progress in Retinal and Eye Research.
[3] M. Lavail,et al. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[4] Justine R. Smith,et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 , 2008, Nature.
[5] R. Bhisitkul,et al. Iron homeostasis and toxicity in retinal degeneration , 2007, Progress in Retinal and Eye Research.
[6] H. Sumner,et al. The complement system and host defense against Pseudomonas endophthalmitis. , 1985, Investigative ophthalmology & visual science.
[7] M Ancukiewicz,et al. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. , 2000, Cancer research.
[8] K. Ingold,et al. beta-Carotene: an unusual type of lipid antioxidant. , 1984, Science.
[9] A. Kassoff. Laser treatment in patients with bilateral large drusen: the complications of age-related macular degeneration prevention trial. , 2006, Ophthalmology.
[10] K. Palczewski,et al. Retinol Dehydrogenase (RDH12) Protects Photoreceptors from Light-induced Degeneration in Mice* , 2006, Journal of Biological Chemistry.
[11] Jian Ge,et al. CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD , 2005, PLoS medicine.
[12] B. Ahlemeyer,et al. Stimulation of 5-HT1A receptor inhibits apoptosis induced by serum deprivation in cultured neurons from chick embryo. , 1997, Brain research.
[13] H. Hammes,et al. N(epsilon)(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration. , 1999, Investigative ophthalmology & visual science.
[14] L. V. Johnson,et al. Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. , 2001, Experimental eye research.
[15] Y. Courtois,et al. Protection against light-induced retinal degeneration by an inhibitor of NO synthase. , 1993, Neuroreport.
[16] Maria-Thereza R. Perez,et al. CNTF+BDNF treatment and neuroprotective pathways in the rd1 mouse retina , 2007, Brain Research.
[17] N. Orr,et al. A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration , 2006, Nature Genetics.
[18] V. Sheffield,et al. Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration , 1998, Nature Genetics.
[19] P. Campochiaro,et al. Oxidative damage in age-related macular degeneration. , 2007, Histology and histopathology.
[20] Philip J Rosenfeld,et al. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration. , 2005, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.
[21] M. Pangburn,et al. Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury* , 2009, The Journal of Biological Chemistry.
[22] T. Schoen,et al. Evidence for an Insulin‐Like Growth Factor Autocrine‐Paracrine System in the Retinal Photoreceptor‐Pigment Epithelial Cell Complex , 1991, Journal of neurochemistry.
[23] N. Yoshimura,et al. Insulin-like growth factor-related genes, receptors, and binding proteins in cultured human retinal pigment epithelial cells. , 1994, Investigative ophthalmology & visual science.
[24] M. Kaiser-Kupfer,et al. Pilot trial of the safety, tolerability, and retinoid levels of N-(4-hydroxyphenyl) retinamide in combination with tamoxifen in patients at high risk for developing invasive breast cancer. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] L. Berghe,et al. Ocular cell transfection with the human basic fibroblast growth factor gene delays photoreceptor cell degeneration in RCS rats. , 2000, Human gene therapy.
[26] C. Mailhos,et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. , 2006, The American journal of pathology.
[27] H. Gao,et al. Basic fibroblast growth factor: increased gene expression in inherited and light-induced photoreceptor degeneration. , 1996, Experimental eye research.
[28] Y. Hao,et al. Verteporfin photodynamic therapy combined with intravitreal bevacizumab for neovascular age-related macular degeneration. , 2009, Ophthalmology.
[29] Alexander J. Rivest,et al. The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[30] R. Allikmets,et al. Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. , 2000, American journal of human genetics.
[31] R. Frank,et al. Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. , 1999, American journal of ophthalmology.
[32] M. Gilmore,et al. Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. , 2005, Investigative ophthalmology & visual science.
[33] T Michael Redmond,et al. Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[34] C. Gravel,et al. Pigment Epithelium-Derived Factor Delays the Death of Photoreceptors in Mouse Models of Inherited Retinal Degenerations , 1999, Neurobiology of Disease.
[35] Alston Callahan,et al. The role of inflammation in the pathogenesis of age-related macular degeneration. , 2006, Survey of ophthalmology.
[36] M. Daly,et al. Variation near complement factor I is associated with risk of advanced AMD , 2009, European Journal of Human Genetics.
[37] J. Haines,et al. Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. , 2006, American journal of human genetics.
[38] F. Formelli,et al. Effect of the synthetic retinoid fenretinide on dark adaptation and the ocular surface. , 1994, Journal of the National Cancer Institute.
[39] Ying Chen,et al. RPE65 is the isomerohydrolase in the retinoid visual cycle. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[40] L. Mariani,et al. Chemoprevention of Breast Cancer with Fenretinide (4-HPR): Study of Long-Term Visual and Ophthalmologic Tolerability , 1996, Tumori.
[41] S. Horiuchi,et al. Advanced glycation end products in age-related macular degeneration. , 1998, Archives of ophthalmology.
[42] P. Campochiaro,et al. Blockade of sphingosine‐1‐phosphate reduces macrophage influx and retinal and choroidal neovascularization , 2009, Journal of cellular physiology.
[43] P. Campochiaro,et al. Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib. , 2009, Archives of ophthalmology.
[44] Yun Li,et al. CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration , 2006, Nature Genetics.
[45] P. Koehl,et al. Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential , 2007, BMC Molecular Biology.
[46] J. Lupski,et al. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. , 1997, Science.
[47] K. Palczewski,et al. Characterization of a Dehydrogenase Activity Responsible for Oxidation of 11-cis-Retinol in the Retinal Pigment Epithelium of Mice with a Disrupted RDH5 Gene , 2001, The Journal of Biological Chemistry.
[48] Y. Jang,et al. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium , 2006, Proceedings of the National Academy of Sciences.
[49] T. Léveillard,et al. Identification and characterization of rod-derived cone viability factor , 2004, Nature Genetics.
[50] S. Parodi,et al. Factors affecting plasma retinol decline during long-term administration of the synthetic retinoid fenretinide in breast cancer patients. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[51] M. Akimoto,et al. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats. , 1999, Investigative ophthalmology & visual science.
[52] M. Clerici,et al. Five-year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[53] Z. Nie,et al. Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[54] D. Bok,et al. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. , 2005, Investigative ophthalmology & visual science.
[55] R. T. Smith,et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[56] J. Ott,et al. Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.
[57] P. Sieving,et al. Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[58] D. Shima,et al. RGS5 expression is a quantitative measure of pericyte coverage of blood vessels , 2007, Angiogenesis.
[59] John D Lambris,et al. Drusen complement components C3a and C5a promote choroidal neovascularization. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[60] J. Nathans,et al. Identification and Characterization of All-trans-retinol Dehydrogenase from Photoreceptor Outer Segments, the Visual Cycle Enzyme That Reduces All-trans-retinal to All-trans-retinol* , 2000, The Journal of Biological Chemistry.
[61] Masaru Miyagi,et al. Drusen proteome analysis: An approach to the etiology of age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[62] B. Glasgow,et al. Complement system and host defense against staphylococcal endophthalmitis. , 1994, Investigative ophthalmology & visual science.
[63] R. Wen,et al. α2-Adrenergic Agonists Induce Basic Fibroblast Growth Factor Expression in Photoreceptors In Vivo and Ameliorate Light Damage , 1996, The Journal of Neuroscience.
[64] M. Kaiser-Kupfer,et al. Abnormal retinal function associated with fenretinide, a synthetic retinoid. , 1986, Archives of ophthalmology.
[65] R. Molday,et al. N-Retinylidene-phosphatidylethanolamine Is the Preferred Retinoid Substrate for the Photoreceptor-specific ABC Transporter ABCA4 (ABCR)* , 2004, Journal of Biological Chemistry.
[66] M. Schwartz,et al. Weekly Vaccination with Copaxone (Glatiramer Acetate) as a Potential Therapy for Dry Age-Related Macular Degeneration , 2008, Current eye research.
[67] I. Nir,et al. Expression of Bcl-2 Protects against Photoreceptor Degeneration in retinal degeneration slow (rds) Mice , 2000, The Journal of Neuroscience.
[68] M. Kaiser-Kupfer,et al. Effects of fenretinide (4-HPR) on dark adaptation. , 1998, Archives of ophthalmology.
[69] Krzysztof Palczewski,et al. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye , 2004, The Journal of cell biology.
[70] Ren Sun,et al. Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs. , 2009, Integrative biology : quantitative biosciences from nano to macro.
[71] R. Sun,et al. Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm , 2008, Proceedings of the National Academy of Sciences.
[72] Susan Schneider,et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. , 2006, The New England journal of medicine.
[73] L. Boni,et al. Phase I trial and pharmacokinetics of fenretinide in children with neuroblastoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[74] Arturo Santos,et al. TWELVE-MONTH SAFETY AND VISUAL ACUITY RESULTS FROM A FEASIBILITY STUDY OF INTRAOCULAR, EPIRETINAL RADIATION THERAPY FOR THE TREATMENT OF SUBFOVEAL CNV SECONDARY TO AMD , 2009, Retina.
[75] L. V. Johnson,et al. Soluble and mature amyloid fibrils in drusen deposits. , 2010, Investigative ophthalmology & visual science.
[76] W Malone,et al. Tolerability of the synthetic retinoid Fenretinide (HPR). , 1989, European journal of cancer & clinical oncology.
[77] K. Palczewski,et al. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. , 2004, The Journal of cell biology.
[78] M. Tytell,et al. Retinal uptake of intravitreally injected Hsc/Hsp70 and its effect on susceptibility to light damage. , 2001, Molecular vision.
[79] M. Lavail,et al. Free Radical Trap Phenyl-N-tert-Butylnitrone Protects against Light Damage But Does Not Rescue P23H and S334ter Rhodopsin Transgenic Rats from Inherited Retinal Degeneration , 2003, The Journal of Neuroscience.
[80] S. Sivaprasad,et al. Estimation of systemic complement C3 activity in age-related macular degeneration. , 2007, Archives of ophthalmology.
[81] B. Garmy-Susini,et al. Integrins in angiogenesis and lymphangiogenesis , 2008, Nature Reviews Cancer.
[82] Bala Ramesh,et al. Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. , 2003, Archives of biochemistry and biophysics.
[83] M. Lavail,et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. , 1998, Investigative ophthalmology & visual science.
[84] Weng Tao,et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[85] G. Travis,et al. Rpe65 Is the Retinoid Isomerase in Bovine Retinal Pigment Epithelium , 2005, Cell.
[86] H. Allore,et al. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina. , 2006, Experimental eye research.
[87] Jian-xing Ma,et al. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. , 2009, Investigative ophthalmology & visual science.
[88] A. Milam,et al. Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. , 2003, Archives of ophthalmology.
[89] D. Weeks,et al. Susceptibility genes for age-related maculopathy on chromosome 10q26. , 2005, American journal of human genetics.
[90] Robert F Mullins,et al. A role for local inflammation in the formation of drusen in the aging eye. , 2002, American journal of ophthalmology.
[91] S. Tobimatsu,et al. Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats , 2003, Gene Therapy.
[92] S. Lippman,et al. A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[93] E. Keshet,et al. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. , 1998, Development.
[94] Robert F. Mullins,et al. An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration , 2001, Progress in Retinal and Eye Research.
[95] H. Kaplan,et al. Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. , 2000, Investigative ophthalmology & visual science.
[96] A. Decensi,et al. Long-term effects of fenretinide on retinal function. , 1997, European journal of cancer.
[97] G. Parmigiani,et al. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. , 2008, The New England journal of medicine.
[98] P. Mitchell,et al. Mitochondrial DNA haplogroups and age-related maculopathy. , 2007, Archives of ophthalmology.
[99] R. Avery,et al. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. , 2006, Ophthalmology.
[100] U. Schlötzer-Schrehardt,et al. Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. , 2007, Molecular immunology.
[101] C Bellman,et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. , 2001, Investigative ophthalmology & visual science.
[102] P. Campochiaro,et al. Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. , 2000, Investigative ophthalmology & visual science.
[103] Susan M. Chang,et al. Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[104] P. Campochiaro,et al. AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. , 2002, Investigative ophthalmology & visual science.
[105] J. Gilbert,et al. Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration , 2005, Science.
[106] Ian J Constable,et al. Lipofuscin of the retinal pigment epithelium: A review , 1995, Eye.
[107] H. Hammes,et al. Nε(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration , 1999 .
[108] E. Chaum. Retinal neuroprotection by growth factors: A mechanistic perspective , 2003, Journal of cellular biochemistry.
[109] C. Barnstable,et al. PEDF: a multifaceted neurotrophic factor , 2003, Nature Reviews Neuroscience.
[110] C. Gravel,et al. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. , 1997, Human gene therapy.
[111] I. Morita,et al. Novel mechanism for age‐related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF , 2001, Journal of cellular physiology.
[112] Marco A Zarbin,et al. Current concepts in the pathogenesis of age-related macular degeneration. , 2004, Archives of ophthalmology.
[113] D. Organisciak,et al. Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations. , 2003, Investigative ophthalmology & visual science.
[114] Lars G Fritsche,et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. , 2005, Human molecular genetics.
[115] Alexander J. Rivest,et al. The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[116] K. Palczewski,et al. Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice* , 2009, Journal of Biological Chemistry.
[117] Chi Pui Pang,et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. , 2007, Science.
[118] S. Russell,et al. Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[119] J. Haines,et al. Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. , 2007, Human molecular genetics.
[120] P. Campochiaro,et al. Neurotrophic signaling in normal and degenerating rodent retinas. , 2001, Experimental eye research.
[121] I. Deary,et al. Complement C3 variant and the risk of age-related macular degeneration. , 2007, The New England journal of medicine.
[122] M. Lavail,et al. Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina. , 1998, Current eye research.
[123] J. Ott,et al. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. , 2008, Ophthalmology.
[124] M. Lavail,et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[125] D. Birch,et al. Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice , 1999, Cell.
[126] Laura A. Hecker,et al. Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration. , 2009, Investigative ophthalmology & visual science.
[127] Jennifer I. Lim,et al. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. , 2001, Archives of ophthalmology.
[128] M. Zarbin. Should corticosteroids be considered as part of the standard care with photodynamic therapy? , 2006, Archives of ophthalmology.
[129] M. Lavail,et al. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[130] P. Campochiaro,et al. Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). , 2001, Human gene therapy.
[131] Joe G Hollyfield,et al. Oxidative damage–induced inflammation initiates age-related macular degeneration , 2008, Nature Medicine.
[132] M. Dittmar,et al. L-NAME protects against acute light damage in albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats. , 2003, Experimental eye research.
[133] K. Palczewski,et al. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. , 2009, Investigative ophthalmology & visual science.
[134] R. Russell. The enigma of beta-carotene in carcinogenesis: what can be learned from animal studies. , 2004, The Journal of nutrition.
[135] P. Lacal,et al. Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for theα 5β1 integrin , 2003, Journal of Cell Science.
[136] Yan Li,et al. Retinal preconditioning and the induction of heat-shock protein 27. , 2003, Investigative ophthalmology & visual science.
[137] C. Grimm,et al. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration , 2005, Progress in Retinal and Eye Research.
[138] R. T. Smith,et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration , 2006, Nature Genetics.
[139] W. Benedict,et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. , 1999, Science.
[140] T. Li,et al. Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration. , 1996, Investigative ophthalmology & visual science.
[141] A. Augustin,et al. TRIPLE THERAPY FOR CHOROIDAL NEOVASCULARIZATION DUE TO AGE-RELATED MACULAR DEGENERATION: Verteporfin PDT, Bevacizumab, and Dexamethasone , 2007, Retina.
[142] K. Nakanishi,et al. A2E, a byproduct of the visual cycle , 2003, Vision Research.
[143] G. Aguirre,et al. Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. , 2005, Molecular vision.
[144] P. Sieving,et al. Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats. , 2001, Investigative ophthalmology & visual science.
[145] L. Mariani,et al. Safety of the synthetic retinoid fenretinide: long-term results from a controlled clinical trial for the prevention of contralateral breast cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[146] P. Campochiaro,et al. Oxidative Stress Modulates Complement Factor H Expression in Retinal Pigmented Epithelial Cells by Acetylation of FOXO3* , 2007, Journal of Biological Chemistry.
[147] Gonçalo R. Abecasis,et al. A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration , 2007, Proceedings of the National Academy of Sciences.
[148] J. Tombran-Tink,et al. In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. , 2001, Investigative ophthalmology & visual science.
[149] Johanna M Seddon,et al. Variation in complement factor 3 is associated with risk of age-related macular degeneration , 2007, Nature Genetics.
[150] C. Grimm,et al. Constitutive Overexpression of Human Erythropoietin Protects the Mouse Retina against Induced But Not Inherited Retinal Degeneration , 2004, The Journal of Neuroscience.
[151] P. Sieving,et al. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[152] Ivana K. Kim,et al. Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes. , 1999, Investigative ophthalmology & visual science.
[153] J. Krieglstein,et al. Neuroprotective effect of 5-HT1A receptor agonist, Bay X 3702, demonstrated in vitro and in vivo. , 1998, European journal of pharmacology.
[154] S. Fisher,et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk , 2005 .
[155] H. Prats,et al. Intravitreous transplantation of encapsulated fibroblasts secreting the human fibroblast growth factor 2 delays photoreceptor cell degeneration in Royal College of Surgeons rats. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[156] M. Pizzichetta,et al. Plasma retinol level reduction by the synthetic retinoid fenretinide: a one year follow-up study of breast cancer patients. , 1989, Cancer research.
[157] W. Hauswirth,et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. , 2002, Experimental eye research.
[158] D. Gospodarowicz,et al. Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells. , 1987, Biochemical and biophysical research communications.
[159] H. Allore,et al. CREB1/ATF1 activation in photoreceptor degeneration and protection. , 2009, Investigative ophthalmology & visual science.
[160] J. Thurman,et al. The Central Role of the Alternative Complement Pathway in Human Disease1 , 2006, The Journal of Immunology.
[161] S. Baruchel,et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. , 2000, The Journal of clinical investigation.
[162] K. Eng,et al. Ranibizumab in neovascular age-related macular degeneration , 2006, Clinical interventions in aging.
[163] L. Baglietto,et al. Randomized trial of fenretinide in superficial bladder cancer using DNA flow cytometry as an intermediate end point. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[164] P. Sieving,et al. Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism. , 2009, Investigative ophthalmology & visual science.
[165] John D Lambris,et al. Interaction between the coagulation and complement system. , 2008, Advances in experimental medicine and biology.