High-fiber diets in the treatment of diabetes mellitus.

Eight patients with insulin-requiring diabetes were given, in random order, a diet containing 3 g and one containing 20 g of crude fiber. Each diet was maintained for 10 days and was the same in calories, carbohydrate, fat, and protein. Insulin dose was kept constant. Mean plasma glucose on the low-fiber diet was 169.4 +/- 11.7 mg/dl, significantly higher (P less than 0.001) than the value of 120.8 +/- 10.1 on the high-fiber diet. Hypoglycemic reactions were more common on the high-fiber diet. Weight remained essentially constant on both diets. Mean serum glucagon level on the high-fiber diet was significantly lower (P less than 0.001) than on the low-fiber diet, while serum free insulin levels were unchanged. These data indicate that substantial changes in fiber content of the diabetic diet may lead to marked changes in diabetic control and that increasing dietary fiber may be a useful means of lowering plasma glucose in some diabetic patients.

[1]  F. Ismail-Beigi,et al.  Effects of cellulose added to diets of low and high fiber content upon the metabolism of calcium, magnesium, zinc and phosphorus by man. , 1977, The Journal of nutrition.

[2]  D L Horwitz,et al.  Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics , 1977, Diabetes.

[3]  J. Anderson,et al.  Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men. , 1976, The American journal of clinical nutrition.

[4]  D. Goff,et al.  UNABSORBABLE CARBOHYDRATES AND DIABETES: DECREASED POST-PRANDIAL HYPERGLYCÆMIA , 1976, The Lancet.

[5]  I. Persson,et al.  Effect of Prolonged Bran Administration on Serum Levels of Cholesterol, Ionized Calcium and Iron in the Elderly , 1976, Journal of the American Geriatrics Society.

[6]  F. Ismail-Beigi,et al.  Decreased absorption of calcium, magnesium, zinc and phosphorus by humans due to increased fiber and phosphorus consumption as wheat bread. , 1976, The Journal of nutrition.

[7]  A. Brodribb,et al.  Diverticular disease: three studies. Part III - Metabolic effect of bran in patients with diverticular disease. , 1976, British medical journal.

[8]  H. Trowell,et al.  Dietary-fiber Hypothesis of the Etiology of Diabetes Mellitus , 1975, Diabetes.

[9]  D. Horwitz,et al.  Raw Diet in Diabetes Mellitus , 1975 .

[10]  D. Burkitt,et al.  Dietary fiber and disease. , 1974, JAMA.

[11]  Jeffrys Db.  The effect of dietary fibre on the response to orally administered glucose. , 1974 .

[12]  D. Southgate.  Fibre and the other unavailable carbohydrates and their effects on the energy value of the diet , 1973, Proceedings of the Nutrition Society.

[13]  K. Nasr,et al.  Effects of purified phytate and phytate-rich bread upon metabolism of zinc, calcium, phosphorus, and nitrogen in man. , 1973, Lancet.

[14]  K. Alberti,et al.  Decrease in postprandial insulin and glucose concentrations by guar and pectin. , 1977, Annals of internal medicine.

[15]  A. Moses,et al.  Water intoxication and thioridazine (Mellaril) , 1975, Annals of internal medicine.

[16]  J. Douglass.  Raw diet and insulin requirements. , 1975, Annals of internal medicine.

[17]  W. Drucker,et al.  Metabolism of intravenous fructose and glucose in normal and diabetic subjects. , 1952, The Journal of clinical investigation.