论文信息 - Haploview: analysis and visualization of LD and haplotype maps

Haploview: analysis and visualization of LD and haplotype maps

UNLABELLED Research over the last few years has revealed significant haplotype structure in the human genome. The characterization of these patterns, particularly in the context of medical genetic association studies, is becoming a routine research activity. Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface. AVAILABILITY http://www.broad.mit.edu/mpg/haploview/ CONTACT jcbarret@broad.mit.edu

[1] Pardis C Sabeti,et al. Linkage disequilibrium in the human genome , 2001, Nature.

[2] J. Akey,et al. Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. , 2002, American journal of human genetics.

[3] M. Daly,et al. High-resolution haplotype structure in the human genome , 2001, Nature Genetics.

[4] Steuart Rorke,et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness , 2002, Nature.

[5] S. Gabriel,et al. The Structure of Haplotype Blocks in the Human Genome , 2002, Science.

[6] P. Donnelly,et al. The Fine-Scale Structure of Recombination Rate Variation in the Human Genome , 2004, Science.

[7] Thomas Lengauer,et al. Genetic variation in DLG5 is associated with inflammatory bowel disease , 2004, Nature Genetics.

[8] M. Daly,et al. Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[9] Toshihiro Tanaka. The International HapMap Project , 2003, Nature.

[10] Sinead B. O'Leary,et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease , 2001, Nature Genetics.