Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

[1]  A. Lawrence.  By the book , 2017 .

[2]  Jian Wang,et al.  Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing , 2014, Cell Research.

[3]  Jinfang Zhang,et al.  Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. , 2014, Biochimica et biophysica acta.

[4]  K. McGlynn,et al.  Risk of second primary cancers after testicular cancer in East and West Germany: A focus on contralateral testicular cancers , 2014, Asian journal of andrology.

[5]  S. Gabriel,et al.  Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.

[6]  Michael P. Schroeder,et al.  IntOGen-mutations identifies cancer drivers across tumor types , 2013, Nature Methods.

[7]  J. Auger,et al.  Impact of chemotherapy and radiotherapy for testicular germ cell tumors on spermatogenesis and sperm DNA: a multicenter prospective study from the CECOS network. , 2013, Fertility and sterility.

[8]  Nazneen Rahman,et al.  Meta-analysis identifies four new loci associated with testicular germ cell tumor , 2013, Nature Genetics.

[9]  A. Smit,et al.  Early development of the metabolic syndrome after chemotherapy for testicular cancer. , 2013, Annals of oncology : official journal of the European Society for Medical Oncology.

[10]  Trevor J Pugh,et al.  Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation , 2013, Nucleic acids research.

[11]  C. Perou,et al.  Micro-Scale Genomic DNA Copy Number Aberrations as Another Means of Mutagenesis in Breast Cancer , 2012, PloS one.

[12]  R. Chaganti,et al.  Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition , 2012, PloS one.

[13]  B. Nitzsche,et al.  Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer , 2012, British Journal of Cancer.

[14]  Tatsuya Kato,et al.  Overexpression of CDC20 predicts poor prognosis in primary non‐small cell lung cancer patients , 2012, Journal of surgical oncology.

[15]  A. Gonzalez-Perez,et al.  Functional impact bias reveals cancer drivers , 2012, Nucleic acids research.

[16]  P. Hwu,et al.  Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression , 2012, Journal of Hematology & Oncology.

[17]  F. Couch,et al.  Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. , 2012, Molecular cell.

[18]  John Quackenbush,et al.  Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV , 2011, Bioinform..

[19]  W. Hofmann,et al.  Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy , 2011, BMC Cancer.

[20]  G. Netto,et al.  Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays. , 2011, Genomics.

[21]  N. Camp,et al.  A role for XRCC2 gene polymorphisms in breast cancer risk and survival , 2011, Journal of Medical Genetics.

[22]  R. Huddart,et al.  Minimum regions of genomic imbalance in stage I testicular embryonal carcinoma and association of 22q loss with relapse , 2011, Genes, chromosomes & cancer.

[23]  B. Kaina,et al.  Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression , 2010, Molecular Cancer.

[24]  D. Bishop,et al.  The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. , 2010, Urologic oncology.

[25]  Deborah Hughes,et al.  Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer , 2010, Nature Genetics.

[26]  Jun Wang,et al.  C/EBPδ targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression , 2010, Proceedings of the National Academy of Sciences.

[27]  J. Hotaling,et al.  Male infertility: a risk factor for testicular cancer , 2009, Nature Reviews Urology.

[28]  Deborah Hughes,et al.  A genome-wide association study of testicular germ cell tumor , 2009, Nature Genetics.

[29]  V. Eusebi,et al.  Gene expression profiling in glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20 , 2008, Virchows Archiv.

[30]  H. Leffers,et al.  Origin of pluripotent germ cell tumours: The role of microenvironment during embryonic development , 2008, Molecular and Cellular Endocrinology.

[31]  E. Birney,et al.  Patterns of somatic mutation in human cancer genomes , 2007, Nature.

[32]  M. Lathrop,et al.  A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage. , 2007, Biochemical and biophysical research communications.

[33]  J. Ferlay,et al.  Interpreting the international trends in testicular seminoma and nonseminoma incidence , 2006, Nature Clinical Practice Urology.

[34]  Richard Lugg,et al.  Sequence analysis of the protein kinase gene family in human testicular germ‐cell tumors of adolescents and adults , 2006, Genes, chromosomes & cancer.

[35]  M. Pike,et al.  The Y deletion gr/gr and susceptibility to testicular germ cell tumor. , 2005, American journal of human genetics.

[36]  Y. Mizutani,et al.  KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors. , 2005, Biochemical and biophysical research communications.

[37]  R. Huddart,et al.  Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. , 2005, Cancer research.

[38]  P. Todd Stukenberg,et al.  Two Complexes of Spindle Checkpoint Proteins Containing Cdc20 and Mad2 Assemble during Mitosis Independently of the Kinetochore in Saccharomyces cerevisiae , 2005, Eukaryotic Cell.

[39]  M. Marangolo,et al.  Germ cell tumours of the testis. , 2005, Critical reviews in oncology/hematology.

[40]  K. Hemminki,et al.  Familial risk in testicular cancer as a clue to a heritable and environmental aetiology , 2004, British Journal of Cancer.

[41]  J. Veltman,et al.  12p-Amplicon structure analysis in testicular germ cell tumors of adolescents and adults by array CGH , 2003, Oncogene.

[42]  P. Brown,et al.  A-Kinase Anchoring Protein 4 Binding Proteins in the Fibrous Sheath of the Sperm Flagellum , 2003, Biology of reproduction.

[43]  R. Huddart,et al.  Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2–p12.1 , 2003, Oncogene.

[44]  W. Willis,et al.  Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. , 2002, Developmental biology.

[45]  R. Wilson,et al.  The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men , 2001, Nature Genetics.

[46]  R. Huddart,et al.  Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults , 2001, British Journal of Cancer.

[47]  S. Henikoff,et al.  Predicting deleterious amino acid substitutions. , 2001, Genome research.

[48]  Warren C. Lathe,et al.  Prediction of deleterious human alleles. , 2001, Human molecular genetics.

[49]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[50]  C. Bokemeyer,et al.  Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis. , 2000, The American journal of pathology.

[51]  V. Prasad,et al.  T Cells On , 1998, Science.

[52]  J. Moul,et al.  Immunohistochemical and mutational analysis of the p53 tumour suppressor gene and the bcl‐2 oncogene in primary testicular germ cell tumours , 1998, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[53]  A. Sandberg,et al.  Reviews of chromosome studies in urological tumors. III. Cytogenetics and genes in testicular tumors. , 1996, The Journal of urology.

[54]  R. Wooster,et al.  Microsatellite instability in human testicular germ cell tumours. , 1995, British Journal of Cancer.

[55]  J. Hansen,et al.  Cancer incidence in men with Klinefelter syndrome. , 1995, British Journal of Cancer.

[56]  Yongjiang Ma,et al.  p53 Gene Mutations in Chinese Human Testicular Seminoma , 1993 .

[57]  H. Tesch,et al.  Point mutations in the conserved regions of the p53 tumour suppressor gene do not account for the transforming process in the Jurkat acute lymphoblastic leukemia T-cells. , 1992, Leukemia.

[58]  D. Forman,et al.  Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis. , 1992, British Journal of Cancer.

[59]  J. Nurnberger,et al.  A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. , 1991, Nucleic acids research.

[60]  H. Chemes,et al.  Dysplasia of the fibrous sheath: an ultrastructural defect of human spermatozoa associated with sperm immotility and primary sterility. , 1987, Fertility and sterility.

[61]  N. B. Atkin,et al.  i(12p): specific chromosomal marker in seminoma and malignant teratoma of the testis? , 1983, Cancer genetics and cytogenetics.

[62]  N. B. Atkin,et al.  SPECIFIC CHROMOSOME CHANGE, i(12p), IN TESTICULAR TUMOURS? , 1982, The Lancet.

[63]  K. Dieckmann,et al.  Changes in epidemiologic features of testicular germ cell cancer: age at diagnosis and relative frequency of seminoma are constantly and significantly increasing. , 2014, Urologic oncology.

[64]  Steven A. Roberts,et al.  Mutational heterogeneity in cancer and the search for new cancer genes , 2014 .

[65]  D. Bishop,et al.  Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. , 2013 .

[66]  P. Schubert,et al.  Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. , 2005, Clinical laboratory.

[67]  O. Cummings,et al.  KIT mutations are common in testicular seminomas. , 2004, The American journal of pathology.

[68]  黒田 知子,et al.  The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men , 2002 .

[69]  N. Heerema,et al.  Triple-color FISH analysis of 12p amplification in testicular germ-cell tumors using 12p band-specific painting probes , 1998, Journal of Molecular Medicine.

[70]  A. Horwich,et al.  Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change. , 1998, British Journal of Cancer.

[71]  Daizong Li,et al.  p53 gene mutations in Chinese human testicular seminoma. , 1993, The Journal of urology.

[72]  R. Shepherd.  Germ cell tumours of the testis. , 1966, Clinical radiology.