Electromagnetic–Acoustic Sensing for Biomedical Applications

This paper reviews the theories and applications of electromagnetic–acoustic (EMA) techniques (covering light-induced photoacoustic, microwave-induced thermoacoustic, magnetic-modulated thermoacoustic, and X-ray-induced thermoacoustic) belonging to the more general area of electromagnetic (EM) hybrid techniques. The theories cover excitation of high-power EM field (laser, microwave, magnetic field, and X-ray) and subsequent acoustic wave generation. The applications of EMA methods include structural imaging, blood flowmetry, thermometry, dosimetry for radiation therapy, hemoglobin oxygen saturation (SO2) sensing, fingerprint imaging and sensing, glucose sensing, pH sensing, etc. Several other EM-related acoustic methods, including magnetoacoustic, magnetomotive ultrasound, and magnetomotive photoacoustic are also described. It is believed that EMA has great potential in both pre-clinical research and medical practice.

[1]  B. B. Bauer,et al.  Fundamentals of acoustics , 1963 .

[2]  Eung Je Woo,et al.  Magnetic resonance electrical impedance tomography (MREIT) for high-resolution conductivity imaging , 2008, Physiological measurement.

[3]  A. Kole,et al.  Fast assessment of lipid content in arteries in vivo by intravascular photoacoustic tomography , 2018, Scientific Reports.

[4]  Paul L Carson,et al.  Imaging of joints with laser-based photoacoustic tomography: an animal study. , 2006, Medical physics.

[5]  Minghua Xu,et al.  Thermoacoustic and Photoacoustic Tomography of Thick Biological Tissues toward Breast Imaging , 2005, Technology in cancer research & treatment.

[6]  Lihong V. Wang,et al.  Photoacoustic Doppler effect from flowing small light-absorbing particles. , 2007, Physical review letters.

[7]  Jianfeng Zeng,et al.  A Self‐Assembled Albumin‐Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging , 2015, Advanced materials.

[8]  Hao Zhang,et al.  Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy , 2007 .

[9]  Li Lin,et al.  In vivo photoacoustic tomography of myoglobin oxygen saturation , 2015, Journal of biomedical optics.

[10]  Lihong V. Wang,et al.  Small-Animal Whole-Body Photoacoustic Tomography: A Review , 2014, IEEE Transactions on Biomedical Engineering.

[11]  Junjie Yao,et al.  Absolute photoacoustic thermometry in deep tissue. , 2013, Optics letters.

[12]  Joanna Brunker,et al.  Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids , 2016, Scientific Reports.

[13]  Xin Cai,et al.  Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. , 2011, ACS nano.

[14]  Yong Zhou,et al.  Cross-correlation-based transverse flow measurements using optical resolution photoacoustic microscopy with a digital micromirror device , 2013, Journal of biomedical optics.

[15]  Lihong V. Wang,et al.  Nonlinear photoacoustic spectroscopy of hemoglobin. , 2015, Applied physics letters.

[16]  S. Emelianov,et al.  Photoacoustic imaging and temperature measurement for photothermal cancer therapy. , 2008, Journal of biomedical optics.

[17]  Lihong V. Wang,et al.  Functional transcranial brain imaging by optical-resolution photoacoustic microscopy. , 2009, Journal of biomedical optics.

[18]  Vasilis Ntziachristos,et al.  Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography , 2012, Physics in medicine and biology.

[19]  Pierre Léger,et al.  Experimental evaluation of x‐ray acoustic computed tomography for radiotherapy dosimetry applications , 2017, Medical physics.

[20]  Michael C. Kolios,et al.  Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation , 2017, Photoacoustics.

[21]  Paul Kumar Upputuri,et al.  A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging. , 2017, Journal of visualized experiments : JoVE.

[22]  Geng Ku,et al.  Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. , 2006, Journal of biomedical optics.

[23]  Lihong V. Wang,et al.  Tutorial on Photoacoustic Microscopy and Computed Tomography , 2008, IEEE Journal of Selected Topics in Quantum Electronics.

[24]  Yuanjin Zheng,et al.  Noninvasive photoacoustic measurement of glucose by data fusion. , 2017, The Analyst.

[25]  Lihong V. Wang,et al.  In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature. , 2009, Journal of biomedical optics.

[26]  Daniel Razansky,et al.  Virtual craniotomy for high-resolution optoacoustic brain microscopy , 2018, Scientific Reports.

[27]  Xu Li,et al.  B-Scan Based Acoustic Source Reconstruction for Magnetoacoustic Tomography With Magnetic Induction (MAT-MI) , 2011, IEEE Transactions on Biomedical Engineering.

[28]  Robert A Kruger,et al.  Thermoacoustic molecular imaging of small animals. , 2003, Molecular imaging.

[29]  Lihong V. Wang,et al.  Imaging of high-intensity focused ultrasound-induced lesions in soft biological tissue using thermoacoustic tomography. , 2004, Medical physics.

[30]  P. Beard,et al.  Erratum: Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids , 2016, Scientific Reports.

[31]  G. Ku,et al.  Microwave-induced thermoacoustic tomography using multi-sector scanning. , 2001, Medical physics.

[32]  Lihong V. Wang,et al.  Microwave-induced acoustic imaging of biological tissues , 1999 .

[33]  Francis A. Duck,et al.  Physical properties of tissue : a comprehensive reference book , 1990 .

[34]  Liangzhong Xiang,et al.  X-ray-induced acoustic computed tomography with an ultrasound transducer ring-array , 2017 .

[35]  Heather K. Hunt,et al.  Hand-held optoacoustic imaging: A review , 2018, Photoacoustics.

[36]  A. Oraevsky,et al.  Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications , 2017, International journal of molecular sciences.

[37]  M. Heilemann,et al.  Subdiffraction-resolution fluorescence imaging with conventional fluorescent probes. , 2008, Angewandte Chemie.

[38]  Richard Su,et al.  Whole-body three-dimensional optoacoustic tomography system for small animals. , 2009, Journal of biomedical optics.

[39]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[40]  Lihong V. Wang,et al.  Thermoacoustic and photoacoustic sensing of temperature. , 2009, Journal of biomedical optics.

[41]  Benjamin S. Goldschmidt,et al.  Gold nanoparticle mediated detection of prostate cancer cells using photoacoustic flowmetry with optical reflectance. , 2010, Journal of biomedical nanotechnology.

[42]  Stanislav Emelianov,et al.  Magneto-photo-acoustic imaging , 2011 .

[43]  Jean-Yves Chapelon,et al.  Lorentz force electrical impedance tomography , 2013, 1402.2573.

[44]  Junjie Yao,et al.  Functional photoacoustic microscopy of pH , 2011, Photonics West - Biomedical Optics.

[45]  Xosé Luís Deán-Ben,et al.  Volumetric Optoacoustic Temperature Mapping in Photothermal Therapy , 2017, Scientific Reports.

[46]  R. Kruger,et al.  Photoacoustic ultrasound (PAUS)--reconstruction tomography. , 1995, Medical physics.

[47]  Lihong V. Wang,et al.  Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. , 2008, Optics letters.

[48]  Gareth R Williams,et al.  Glucose- and temperature-sensitive nanoparticles for insulin delivery , 2017, International journal of nanomedicine.

[49]  Kwan Kyu Park,et al.  Fingerprint imaging of dry finger using photoacoustics. , 2017, The Journal of the Acoustical Society of America.

[50]  Eric A. Hoffman,et al.  Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images , 2001, IEEE Transactions on Medical Imaging.

[51]  A. Bell On the production and reproduction of sound by light , 1880, American Journal of Science.

[52]  Junjie Yao,et al.  Sensitivity of photoacoustic microscopy , 2014, Photoacoustics.

[53]  Mainul Hossain,et al.  Nanoparticle location and material dependent dose enhancement in X-ray radiation therapy. , 2012, The journal of physical chemistry. C, Nanomaterials and interfaces.

[54]  Yuanjin Zheng,et al.  Modulatable magnetically mediated thermoacoustic imaging with magnetic nanoparticles , 2015 .

[55]  J. Bacri,et al.  Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. , 2007, Journal of the American Chemical Society.

[56]  Wolfgang Drexler,et al.  Optical coherence tomography: Technology and applications , 2013, 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC.

[57]  S. Colak,et al.  Clinical optical tomography and NIR spectroscopy for breast cancer detection , 1999 .

[58]  Lihong V. Wang,et al.  Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo , 2007, SPIE BiOS.

[59]  Quan Zhou,et al.  Microwave-induced thermoacoustic scanning CT for high-contrast and noninvasive breast cancer imaging. , 2008, Medical physics.

[60]  Wei R. Chen,et al.  Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis. , 2013, Medical physics.

[61]  Lihong V. Wang,et al.  Biomedical Optics: Principles and Imaging , 2007 .

[62]  S. Emelianov,et al.  Dynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators , 2017, Nature Communications.

[63]  Xueding Wang,et al.  Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy. , 2013, The Analyst.

[64]  Kanyi Pu,et al.  Semiconducting oligomer nanoparticle as activatable photoacoustic probe with amplified brightness for in vivo imaging of pH , 2018, Nanomedicine: Nanotechnology, Biology and Medicine.

[65]  L V Wang,et al.  Scanning microwave-induced thermoacoustic tomography: signal, resolution, and contrast. , 2001, Medical physics.

[66]  Puxiang Lai,et al.  Photoacoustic imaging in oxygen detection , 2017 .

[67]  Chulhong Kim,et al.  Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo , 2014, Medical & Biological Engineering & Computing.

[68]  Xueding Wang,et al.  In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging , 2017, Nature Communications.

[69]  I. El Naqa,et al.  Feasibility of X-Ray Acoustic Computed Tomography as a Tool for Noninvasive Volumetric In Vivo Dosimetry , 2014 .

[70]  Junjie Yao,et al.  Transverse flow imaging based on photoacoustic Doppler bandwidth broadening. , 2010, Journal of biomedical optics.

[71]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.

[72]  Ben Mijnheer,et al.  In vivo dosimetry in external beam radiotherapy. , 2013, Medical physics.

[73]  L V Wang,et al.  Realtime photoacoustic microscopy of murine cardiovascular dynamics. , 2008, Optics express.

[74]  Huabei Jiang,et al.  4-D Photoacoustic Tomography , 2013, Scientific Reports.

[75]  L V Wang,et al.  Scanning thermoacoustic tomography in biological tissue. , 2000, Medical physics.

[76]  Qifa Zhou,et al.  In vivo label-free photoacoustic microscopy of cell nuclei by excitation of DNA and RNA. , 2010, Optics letters.

[77]  Da Xing,et al.  Microwave-induced thermoacoustic computed tomography with a clinical contrast agent of NMG2[Gd(DTPA)] , 2012 .

[78]  Konstantin I Maslov,et al.  Handheld photoacoustic microscopy to detect melanoma depth in vivo. , 2014, Optics letters.

[79]  Richard Su,et al.  Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models , 2012, Journal of biomedical optics.

[80]  Da Xing,et al.  Thermoacoustic molecular tomography with magnetic nanoparticle contrast agents for targeted tumor detection. , 2010, Medical physics.

[81]  Meng Zhou,et al.  Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode , 2018, Sensors.

[82]  Sheng-Wen Huang,et al.  Photoacoustic flow measurements by use of laser-induced shape transitions of gold nanorods. , 2005, Optics letters.

[83]  F. D. de Mul,et al.  Three-dimensional photoacoustic imaging of blood vessels in tissue. , 1998, Optics letters.

[84]  H Griffiths,et al.  Magnetic Induction Tomography: A Measuring System for Biological Tissues , 1999, Annals of the New York Academy of Sciences.

[85]  C. Lafon,et al.  Imaging of shear waves induced by Lorentz force in soft tissues. , 2014, Physical review letters.

[86]  Yuanjin Zheng,et al.  Magnetoacoustic microscopic imaging of conductive objects and nanoparticles distribution , 2017 .

[87]  Xianjin Dai,et al.  Wearable 3-D Photoacoustic Tomography for Functional Brain Imaging in Behaving Rats , 2016, Scientific Reports.

[88]  J. Shah,et al.  Hall effect imaging , 1998, IEEE Transactions on Biomedical Engineering.

[89]  G. B. Christison,et al.  Glucose determination by a pulsed photoacoustic technique: an experimental study using a gelatin-based tissue phantom. , 1993, Physics in medicine and biology.

[90]  Yuanjin Zheng,et al.  GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy , 2018 .

[91]  M. Schweiger,et al.  Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans. , 2007, Optics express.

[92]  Yuanjin Zheng,et al.  Portable photoacoustic system for noninvasive blood temperature measurement , 2018, 2018 IEEE International Symposium on Circuits and Systems (ISCAS).

[93]  Joel W Y Tan,et al.  Correction to Ion-Selective Nanosensor for Photoacoustic and Fluorescence Imaging of Potassium. , 2017, Analytical chemistry.

[94]  Vasilis Ntziachristos,et al.  Fast Fourier backprojection for frequency-domain optoacoustic tomography. , 2014, Optics letters.

[95]  Ekaterina I. Galanzha,et al.  Circulating Tumor Cell Detection and Capture by Photoacoustic Flow Cytometry in Vivo and ex Vivo , 2013, Cancers.

[96]  R. Cubeddu,et al.  In vivo absorption and scattering spectroscopy of biological tissues , 2003, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[97]  Dinh Tuan Vo Biomedical photonics handbook , 2003 .

[98]  Manojit Pramanik,et al.  Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons. , 2010, Biomaterials.

[99]  Da-Kang Yao,et al.  Label-free photoacoustic microscopy of cytochromes , 2013, Journal of biomedical optics.

[100]  Issam El Naqa,et al.  Characterization of X-Ray Acoustic Computed Tomography for Applications in Radiotherapy Dosimetry , 2018, IEEE Transactions on Radiation and Plasma Medical Sciences.

[101]  Lihong V. Wang,et al.  Grueneisen relaxation photoacoustic microscopy. , 2014, Physical review letters.

[102]  Yuan Xu,et al.  Exact frequency-domain reconstruction for thermoacoustic tomography. I. Planar geometry , 2002, IEEE Transactions on Medical Imaging.

[103]  Markus W. Sigrist,et al.  Mid-Infrared Photoacoustic Detection of Glucose in Human Skin: Towards Non-Invasive Diagnostics , 2016, Sensors.

[104]  Mark A. Anastasio,et al.  Label-free photoacoustic tomography of whole mouse brain structures ex vivo , 2016, Neurophotonics.

[105]  Michael C. Kolios,et al.  Photoacoustic detection and optical spectroscopy of high-intensity focused ultrasound-induced thermal lesions in biologic tissue. , 2014, Medical physics.

[106]  Dan Wu,et al.  Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review , 2014, International journal of molecular sciences.

[107]  Sarah E Bohndiek,et al.  Contrast agents for molecular photoacoustic imaging , 2016, Nature Methods.

[108]  W. R. Adey,et al.  Tissue interactions with nonionizing electromagnetic fields. , 1981, Physiological reviews.

[109]  Hao Xin,et al.  Microwave-Induced Thermoacoustic Imaging Model for Potential Breast Cancer Detection , 2012, IEEE Transactions on Biomedical Engineering.

[110]  Yuanjin Zheng,et al.  Single-Wavelength Blood Oxygen Saturation Sensing With Combined Optical Absorption and Scattering , 2016, IEEE Sensors Journal.

[111]  Junjie Yao,et al.  Photoacoustic microscopy , 2013, Laser & photonics reviews.

[112]  Junjie Yao,et al.  Photoacoustic brain imaging: from microscopic to macroscopic scales , 2014, Neurophotonics.

[113]  Minghua Xu,et al.  Exact frequency-domain reconstruction for thermoacoustic tomography. II. Cylindrical geometry , 2002, IEEE Transactions on Medical Imaging.

[114]  F. Barnes,et al.  Handbook of biological effects of electromagnetic fields , 2007 .

[115]  Mohammad Mehrmohammadi,et al.  Pulsed Magneto-motive Ultrasound Imaging Using Ultrasmall Magnetic Nanoprobes , 2011, Molecular imaging.

[116]  Soo Chin Liew,et al.  Observation of ultrasonic emission from edges of therapeutic X-ray beams , 1991, Physics in medicine and biology.

[117]  Jong Seob Jeong,et al.  Electromagnetic acoustic imaging , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[118]  G. B. Christison,et al.  Laser photoacoustic determination of physiological glucose concentrations in human whole blood , 1993, Medical and Biological Engineering and Computing.

[119]  D. Xing,et al.  Three-dimensional thermoacoustic imaging for early breast cancer detection. , 2012, Medical physics.

[120]  Huabei Jiang,et al.  Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography , 2008, Physics in medicine and biology.

[121]  García,et al.  Theory for the photoacoustic response to x-ray absorption. , 1988, Physical review letters.

[122]  S. Jacques Optical properties of biological tissues: a review , 2013, Physics in medicine and biology.

[123]  Junjie Yao,et al.  Double-illumination photoacoustic microscopy. , 2012, Optics letters.

[124]  Yuan Xu,et al.  Rhesus monkey brain imaging through intact skull with thermoacoustic tomography , 2006, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[125]  Yuta Suzuki,et al.  Motionless volumetric photoacoustic microscopy with spatially invariant resolution , 2017, Nature Communications.

[126]  Y. Saijo,et al.  Visualization of murine lymph vessels using photoacoustic imaging with contrast agents , 2018, Photoacoustics.

[127]  Lihong V. Wang,et al.  High-speed label-free functional photoacoustic microscopy of mouse brain in action , 2015, Nature Methods.

[128]  G. Westmeyer,et al.  Magnetoacoustic Sensing of Magnetic Nanoparticles. , 2016, Physical review letters.

[129]  Vasilis Ntziachristos,et al.  Calcium Sensor for Photoacoustic Imaging. , 2017, Journal of the American Chemical Society.

[130]  Lei Xing,et al.  X-ray acoustic computed tomography with pulsed x-ray beam from a medical linear accelerator. , 2012, Medical physics.

[131]  Lihong V. Wang,et al.  Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo , 2012, Nature Medicine.

[132]  Gurneet S. Sangha,et al.  In vivo photoacoustic lipid imaging in mice using the second near-infrared window. , 2017, Biomedical optics express.

[133]  R A Kruger,et al.  Thermoacoustic computed tomography--technical considerations. , 1999, Medical physics.

[134]  Wanwan Li,et al.  Gold nanoparticles for photoacoustic imaging. , 2015, Nanomedicine.

[135]  Lihong V. Wang,et al.  Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging , 2006, Nature Biotechnology.

[136]  J. Y. Sim,et al.  In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products , 2018, Scientific Reports.

[137]  Thomas Kelly,et al.  In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells. , 2009, Nature nanotechnology.

[138]  A. Villringer,et al.  Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults , 1993, Neuroscience Letters.

[139]  Lei Xing,et al.  High Resolution X-ray-Induced Acoustic Tomography , 2016, Scientific Reports.

[140]  S. Emelianov,et al.  Photoacoustic Imaging for Cancer Detection and Staging. , 2013, Current molecular imaging.

[141]  Qifa Zhou,et al.  Optimal ultraviolet wavelength for in vivo photoacoustic imaging of cell nuclei. , 2012, Journal of biomedical optics.

[142]  P. Kochanek,et al.  Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. , 1986, Stroke.

[143]  Zhuang Liu,et al.  Carbon nanotubes as photoacoustic molecular imaging agents in living mice. , 2008, Nature nanotechnology.

[144]  Minghua Xu,et al.  Time-domain reconstruction for thermoacoustic tomography in a spherical geometry , 2002, IEEE Transactions on Medical Imaging.

[145]  D. Corfield,et al.  Microwave Tomography for Brain Imaging: Feasibility Assessment for Stroke Detection , 2008 .

[146]  Junjie Yao,et al.  In vivo Photoacoustic Tomography of Total Blood Flow and Potential Imaging of Cancer Angiogenesis and Hypermetabolism , 2012, Technology in cancer research & treatment.