IκBε provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression

Kearns et al. 2006. J. Cell Biol. doi:10.1083/jcb.200510155 [OpenUrl][1][Abstract/FREE Full Text][2] [1]: {openurl}?query=rft_id%253Dinfo%253Adoi%252F10.1083%252Fjcb.200510155%26rft_id%253Dinfo%253Apmid%252F16735576%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%

[1]  Inder M Verma,et al.  NF-kappaB regulation in the immune system. , 2002, Nature reviews. Immunology.

[2]  S. Ghosh,et al.  Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B , 1996, Molecular and cellular biology.

[3]  J. Liao,et al.  A functional role of I kappa B-epsilon in endothelial cell activation. , 2000, Journal of immunology.

[4]  A. Hoffmann,et al.  The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. , 2002, Science.

[5]  S. Gerondakis,et al.  Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. , 1999, Oncogene.

[6]  Andre Levchenko,et al.  Comment on "Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression" , 2005, Science.

[7]  David Baltimore,et al.  Achieving stability of lipopolysaccharide-induced NF-kappaB activation. , 2005, Science.

[8]  M J May,et al.  NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.

[9]  I. Verma,et al.  Inflammation-associated cancer: NF-kappaB is the lynchpin. , 2005, Trends in immunology.

[10]  H. Stein,et al.  Inactivating I kappa B epsilon mutations in Hodgkin/Reed–Sternberg cells , 2003, The Journal of pathology.

[11]  A. Israël,et al.  IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. , 1999, Journal of immunology.

[12]  David Baltimore,et al.  Genetic analysis of NF‐κB/Rel transcription factors defines functional specificities , 2003, The EMBO journal.

[13]  R. Corley,et al.  Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation. , 2005, Journal of immunology.

[14]  S. Ghosh,et al.  Regulation of IkappaB beta in WEHI 231 mature B cells , 1997, Molecular and cellular biology.

[15]  G P Nolan,et al.  The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. , 1993, Genes & development.

[16]  M. Karin,et al.  The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. , 2004, Cancer letters.