Brief exposures of human body lice to sublethal amounts of ivermectin over‐transcribes detoxification genes involved in tolerance

Transcriptional profiling results, using our non‐invasive induction assay {short exposure intervals (2–5 h) to sublethal amounts of insecticides [

[1]  E. Kirkness,et al.  Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism , 2010, Insect molecular biology.

[2]  Evgeny M. Zdobnov,et al.  Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle , 2010, Proceedings of the National Academy of Sciences.

[3]  B. Giraudeau,et al.  Oral ivermectin versus malathion lotion for difficult-to-treat head lice. , 2010, The New England journal of medicine.

[4]  J. Clark,et al.  Cross-strain comparison of cypermethrin-induced cytochrome P450 transcription under different induction conditions in diamondback moth , 2010 .

[5]  M. Davey,et al.  Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans. , 2009, International journal for parasitology.

[6]  Balázs Sarkadi,et al.  The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). , 2008, Drug discovery today.

[7]  H. Ranson,et al.  Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti: impact on larval tolerance to chemical insecticides. , 2008, Insect biochemistry and molecular biology.

[8]  M. Sutcliffe,et al.  Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2 , 2008, Insect molecular biology.

[9]  J. Clark,et al.  A New Ivermectin Formulation Topically Kills Permethrin-Resistant Human Head Lice (Anoplura: Pediculidae) , 2008, Journal of medical entomology.

[10]  R. Prichard,et al.  ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development , 2007, Parasitology.

[11]  N. Macdonald,et al.  Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans , 2007, Archives of Toxicology.

[12]  M. Alvinerie,et al.  Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[13]  P. Batterham,et al.  A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital. , 2006, Insect biochemistry and molecular biology.

[14]  J. Edman,et al.  An improved in vitro rearing system for the human head louse allows the determination of resistance to formulated pediculicides , 2006 .

[15]  G. Szakács,et al.  Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. , 2006, Physiological reviews.

[16]  Supratim Choudhuri,et al.  Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters , 2006, International journal of toxicology.

[17]  J. Clark,et al.  Esterase-mediated malathion resistance in the human head louse, Pediculus capitis (Anoplura: Pediculidae) , 2006 .

[18]  M. Alvinerie,et al.  Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). , 2006, Chemico-biological interactions.

[19]  F C Kafatos,et al.  Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure , 2005, Insect molecular biology.

[20]  John Vontas,et al.  The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  W. Muir,et al.  Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster , 2005, Insect molecular biology.

[22]  M. Agosin.  Insect cytochrome P-450 , 1976, Molecular and Cellular Biochemistry.

[23]  R. Feyereisen,et al.  4.1 – Insect Cytochrome P450 , 2005 .

[24]  T. J. Cook,et al.  Effect of chlorpyrifos on efflux transporter gene expression and function in Caco-2 cells. , 2004, Toxicology in vitro : an international journal published in association with BIBRA.

[25]  J. Clark,et al.  Permethrin-resistant human head lice, Pediculus capitis, and their treatment. , 2003, Archives of dermatology.

[26]  W. S. Pray.  Pediculicide Resistance in Head Lice: A Survey , 2003 .

[27]  M. Kreitman,et al.  Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus , 2002, Insect molecular biology.

[28]  Daniel Strickman,et al.  The past and present threat of rickettsial diseases to military medicine and international public health. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  J. O. Nelson,et al.  Selective induction of abamectin metabolism by dexamethasone, 3-methylcholanthrene, and phenobarbital in Colorado potato beetle, Leptinotarsa decemlineata (Say) , 2002 .

[30]  A. Nappi,et al.  Dexamethasone Inhibition of the Cellular Immune Response of Drosophila melanogaster Against a Parasitoid , 2002, The Journal of parasitology.

[31]  K. Gage,et al.  Bacterial and Rickettsial Diseases , 2000 .

[32]  D. Raoult,et al.  The body louse as a vector of reemerging human diseases. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[33]  D. Raoult,et al.  Chronic Bartonella quintana bacteremia in homeless patients. , 1999, The New England journal of medicine.

[34]  M. Molento,et al.  Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. , 1998, Molecular and biochemical parasitology.

[35]  J. Woda,et al.  Role of Cytochrome P450 Isoforms in the Metabolism of Abamectin and Ivermectin in Rats , 1996 .

[36]  C. Kasper,et al.  Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[37]  P. Borst,et al.  Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. , 1995, The Journal of clinical investigation.

[38]  L. Benet,et al.  Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy , 1995, Molecular carcinogenesis.

[39]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[40]  K. Weiss.  The role of rickettsioses in history , 1988 .

[41]  A. Devonshire,et al.  A carboxylesterase with broad substrate specificity causes organophosphorus, carbamate and pyrethroid resistance in peach-potato aphids (Myzus persicae) , 1982 .