Your evidence? Machine learning algorithms for medical diagnosis and prediction

Computer systems for medical diagnosis based on machine learning are not mere science fiction. Despite undisputed potential benefits, such systems may also raise problems. Two (interconnected) issues are particularly significant from an ethical point of view: The first issue is that epistemic opacity is at odds with a common desire for understanding and potentially undermines information rights. The second (related) issue concerns the assignment of responsibility in cases of failure. The core of the two issues seems to be that understanding and responsibility are concepts that are intrinsically tied to the discursive practice of giving and asking for reasons. The challenge is to find ways to make the outcomes of machine learning algorithms compatible with our discursive practice. This comes down to the claim that we should try to integrate discursive elements into machine learning algorithms. Under the title of “explainable AI” initiatives heading in this direction are already under way. Extensive research in this field is needed for finding adequate solutions.

[1]  Paul Humphreys,et al.  The philosophical novelty of computer simulation methods , 2009, Synthese.

[2]  Simon B. Eickhoff,et al.  Sex classification by resting state brain connectivity , 2019 .

[3]  Daniel S. Margulies,et al.  Predicting brain-age from multimodal imaging data captures cognitive impairment , 2016, NeuroImage.

[4]  Sebastian Thrun,et al.  Dermatologist-level classification of skin cancer with deep neural networks , 2017, Nature.

[5]  Rishabh Choudhary,et al.  Comprehensive Review On Supervised Machine Learning Algorithms , 2017, 2017 International Conference on Machine Learning and Data Science (MLDS).

[6]  R. Brandom,et al.  Articulating Reasons: An Introduction to Inferentialism , 2002 .

[7]  Brian F. Hutton,et al.  NeuroImage: Clinical , 2022 .

[8]  Geoffrey E. Hinton Learning multiple layers of representation , 2007, Trends in Cognitive Sciences.

[9]  Trevor Hastie,et al.  An Introduction to Statistical Learning , 2013, Springer Texts in Statistics.

[10]  Edmund L. Gettier Is Justified True Belief Knowledge? , 1963, Arguing About Knowledge.

[11]  John P. A. Ioannidis,et al.  Exploration, Inference, and Prediction in Neuroscience and Biomedicine , 2019, Trends in Neurosciences.

[12]  Radford M. Neal Pattern Recognition and Machine Learning , 2007, Technometrics.

[13]  Andreas K. Maier,et al.  Precision Learning: Towards Use of Known Operators in Neural Networks , 2018, 2018 24th International Conference on Pattern Recognition (ICPR).

[14]  Namkug Kim,et al.  Deep into the Brain: Artificial Intelligence in Stroke Imaging , 2017, Journal of stroke.

[15]  Vahab Youssofzadeh,et al.  Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses , 2017, Front. Hum. Neurosci..

[16]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[17]  Christoph Kelp,et al.  Understanding phenomena , 2015, Synthese.

[18]  Janaina Mourão-Miranda,et al.  Making Individual Prognoses in Psychiatry Using Neuroimaging and Machine Learning. , 2018, Biological psychiatry. Cognitive neuroscience and neuroimaging.

[19]  Luciano Floridi,et al.  Why a Right to Explanation of Automated Decision-Making Does Not Exist in the General Data Protection Regulation , 2017 .

[20]  S. Rauch,et al.  Clinical Applications of Neuroimaging in Psychiatric Disorders. , 2018, The American journal of psychiatry.

[21]  Davide Castelvecchi,et al.  Can we open the black box of AI? , 2016, Nature.

[22]  Igor Kononenko,et al.  Machine learning for medical diagnosis: history, state of the art and perspective , 2001, Artif. Intell. Medicine.

[23]  Michael I. Jordan,et al.  Machine learning: Trends, perspectives, and prospects , 2015, Science.

[24]  Sven Nyholm,et al.  Attributing Agency to Automated Systems: Reflections on Human–Robot Collaborations and Responsibility-Loci , 2017, Science and Engineering Ethics.

[25]  P. Saint Raymond,et al.  Regulations , 1994, Intertax.

[26]  Gaël Varoquaux,et al.  Cross-validation failure: Small sample sizes lead to large error bars , 2017, NeuroImage.

[27]  Andreas Matthias,et al.  The responsibility gap: Ascribing responsibility for the actions of learning automata , 2004, Ethics and Information Technology.

[28]  Solon Barocas,et al.  The Intuitive Appeal of Explainable Machines , 2018 .

[29]  R. Whelan,et al.  When Optimism Hurts: Inflated Predictions in Psychiatric Neuroimaging , 2014, Biological Psychiatry.

[30]  Simon B Eickhoff,et al.  Sex Classification by Resting State Brain Connectivity , 2019, bioRxiv.

[31]  B. Franke,et al.  From estimating activation locality to predicting disorder: A review of pattern recognition for neuroimaging-based psychiatric diagnostics , 2015, Neuroscience & Biobehavioral Reviews.

[32]  W. Lycan Epistemic value , 2004, Synthese.

[33]  A. Meyer-Lindenberg,et al.  Machine Learning for Precision Psychiatry: Opportunities and Challenges. , 2017, Biological psychiatry. Cognitive neuroscience and neuroimaging.

[34]  Heikki Huttunen,et al.  Machine learning framework for early MRI-based Alzheimer's conversion prediction in MCI subjects , 2015, NeuroImage.

[35]  Rauf Izmailov,et al.  Synergy of Monotonic Rules , 2016, J. Mach. Learn. Res..

[36]  M. Cannarsa Ethics Guidelines for Trustworthy AI , 2021, The Cambridge Handbook of Lawyering in the Digital Age.

[37]  Fanwen Meng,et al.  Recognition of Schizophrenia with Regularized Support Vector Machine and Sequential Region of Interest Selection using Structural Magnetic Resonance Imaging , 2018, Scientific Reports.

[38]  S. Eickhoff,et al.  Predicting personality from network-based resting-state functional connectivity , 2018, Brain Structure and Function.

[39]  Dick J. Veltman,et al.  Predicting the Naturalistic Course of Major Depressive Disorder Using Clinical and Multimodal Neuroimaging Information: A Multivariate Pattern Recognition Study , 2015, Biological Psychiatry.

[40]  Vince D. Calhoun,et al.  Single subject prediction of brain disorders in neuroimaging: Promises and pitfalls , 2017, NeuroImage.

[41]  Jonathan L. Kvanvig,et al.  The value of knowledge and the pursuit of understanding , 2003 .

[42]  Julia Powles,et al.  "Meaningful Information" and the Right to Explanation , 2017, FAT.

[43]  King-Sun Fu,et al.  Pattern Recognition and Machine Learning , 2012 .

[44]  Mert R. Sabuncu,et al.  Do Deep Neural Networks Outperform Kernel Regression for Functional Connectivity Prediction of Behavior? , 2018, bioRxiv.