The German Cancer Research Center and the Steinbeis Transfer Center for Medical Informatics in Heidelberg, Germany, cooperatively developed the teleradiology system MEDICUS-2. This project was running from mid 1994 until mid 1996 [1]. The System is in use since 1/96 in 13 medical institutions. More than 50 thousand images have been processed with MEDICUS in the last twelve month. The experience gained from the MEDICUS system [2] is the basis for a second generation teleradiology system CHILI which is again a joint development of the Steinbeis Transfer Center for Medical Informatics and the German Cancer Research Center in Heidelberg. This paper describes the new design of the second generation system which is a completely new development.