Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With Novel and Very Rare Partners.

[1]  Marilyn M. Li,et al.  Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma , 2022, Acta neuropathologica communications.

[2]  K. Schalper,et al.  Tumor cell SYK expression modulates the tumor immune microenvironment composition in human cancer via TNF-α dependent signaling , 2022, Journal for ImmunoTherapy of Cancer.

[3]  T. Shibata,et al.  Co-expression of ERG and CD31 in a subset of CIC-rearranged sarcoma: a potential diagnostic pitfall , 2022, Modern Pathology.

[4]  A. Folpe,et al.  Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor , 2021, Modern Pathology.

[5]  Liang Jiang,et al.  CIC-NUTM1 Sarcomas Affecting the Spine: A Subset of CIC-Rearranged Sarcomas Commonly Present in the Axial Skeleton. , 2021, Archives of pathology & laboratory medicine.

[6]  S. Rossi,et al.  A novel BRD4‐LEUTX fusion in a pediatric sarcoma with epithelioid morphology and diffuse S100 expression , 2021, Genes, chromosomes & cancer.

[7]  A. Chinnaiyan,et al.  A novel ATXN1-DUX4 fusion expands the spectrum of ‘CIC-rearranged sarcoma’ of the CNS to include non-CIC alterations , 2021, Acta Neuropathologica.

[8]  David T. W. Jones,et al.  Sarcoma classification by DNA methylation profiling , 2021, Nature Communications.

[9]  J. Zeng,et al.  Case Report: A Unique Case of Pediatric Central Nervous System Embryonal Tumor Harboring the CIC–LEUTX Fusion, Germline NBN Variant and Somatic TSC2 Mutation: Expanding the Spectrum of CIC-Rearranged Neoplasia , 2020, Frontiers in Oncology.

[10]  J. Blay,et al.  SRF Fusions Other Than With RELA Expand the Molecular Definition of SRF-fused Perivascular Tumors , 2020, The American journal of surgical pathology.

[11]  A. Chinnaiyan,et al.  Clinical Sequencing of High-Grade Undifferentiated Sarcomas: A Case Series and Report of an Aggressive Primary Cardiac Tumor With Multiple Oncogenic Drivers. , 2020, JCO precision oncology.

[12]  Eric W Prince,et al.  Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors , 2020, Pediatric blood & cancer.

[13]  Liliana Villafania,et al.  Reliable Clinical MLH1 Promoter Hypermethylation Assessment using a High-Throughput Genome-Wide Methylation Array Platform. , 2019, The Journal of molecular diagnostics : JMD.

[14]  F. Tirode,et al.  Brain tumor with an ATXN1-NUTM1 fusion gene expands the histologic spectrum of NUTM1-rearranged neoplasia , 2019, Acta Neuropathologica Communications.

[15]  F. Tirode,et al.  Clinicopathologic Features of CIC-NUTM1 Sarcomas, a New Molecular Variant of the Family of CIC-Fused Sarcomas , 2019, The American journal of surgical pathology.

[16]  M. Ladanyi,et al.  Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma , 2018, Modern Pathology.

[17]  O. Delattre,et al.  Transcriptomic definition of molecular subgroups of small round cell sarcomas , 2018, The Journal of pathology.

[18]  T. Shibata,et al.  CIC break‐apart fluorescence in‐situ hybridization misses a subset of CIC–DUX4 sarcomas: a clinicopathological and molecular study , 2017, Histopathology.

[19]  T. Shibata,et al.  NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma. , 2017, Human pathology.

[20]  C. Antonescu,et al.  Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome: A Clinicopathologic and Molecular Study of 115 Cases , 2017, The American journal of surgical pathology.

[21]  C. Antonescu,et al.  ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements , 2017, Genes, chromosomes & cancer.

[22]  Donavan T. Cheng,et al.  Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients , 2017, Nature Medicine.

[23]  Maxime W. C. Rousseaux,et al.  Disruption of the ATXN1–CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans , 2017, Nature Genetics.

[24]  J. Tyner,et al.  Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma , 2017, Clinical Cancer Research.

[25]  Dafydd G. Thomas,et al.  The utility of ETV1, ETV4 and ETV5 RNA in‐situ hybridization in the diagnosis of CIC–DUX sarcomas , 2017, Histopathology.

[26]  C. Fletcher,et al.  Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics , 2016, Modern Pathology.

[27]  Narasimhan P. Agaram,et al.  Recurrent CIC Gene Abnormalities in Angiosarcomas: A Molecular Study of 120 Cases With Concurrent Investigation of PLCG1, KDR, MYC, and FLT4 Gene Alterations , 2016, The American journal of surgical pathology.

[28]  M. Kodaira,et al.  CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas , 2016, The American journal of surgical pathology.

[29]  Roland Eils,et al.  New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs , 2016, Cell.

[30]  Narasimhan P. Agaram,et al.  A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases , 2015, The American journal of surgical pathology.

[31]  K. Kolibaba,et al.  An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia. , 2015, Blood.

[32]  D. Solomon,et al.  Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. , 2014, The American journal of surgical pathology.

[33]  Y. Totoki,et al.  A Novel CIC-FOXO4 Gene Fusion in Undifferentiated Small Round Cell Sarcoma: A Genetically Distinct Variant of Ewing-like Sarcoma , 2014, The American journal of surgical pathology.

[34]  C. Antonescu,et al.  Distinct transcriptional signature and immunoprofile of CIC‐DUX4 fusion–positive round cell tumors compared to EWSR1‐rearranged ewing sarcomas: Further evidence toward distinct pathologic entities , 2014, Genes, chromosomes & cancer.

[35]  Rafael A. Irizarry,et al.  Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays , 2014, Bioinform..

[36]  T. Taki,et al.  The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy‐related acute myeloid leukemia with t(8;19)(p11;q13) , 2014, Genes, chromosomes & cancer.

[37]  Kai Ye,et al.  MSIsensor: microsatellite instability detection using paired tumor-normal sequence data , 2014, Bioinform..

[38]  R. Janknecht,et al.  ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. , 2012, Biochimica et biophysica acta.

[39]  C. Antonescu,et al.  High prevalence of CIC fusion with double‐homeobox (DUX4) transcription factors in EWSR1‐negative undifferentiated small blue round cell sarcomas , 2012, Genes, chromosomes & cancer.

[40]  Xiao Zhang,et al.  Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis , 2010, BMC Bioinformatics.

[41]  A. Prescott,et al.  ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa , 2010, The Biochemical journal.

[42]  M. Shago,et al.  Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event. , 2009, Cancer genetics and cytogenetics.

[43]  P. Abbe,et al.  Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. , 2009, Cancer research.

[44]  Elspeth A Bruford,et al.  Classification and nomenclature of all human homeobox genes , 2007, BMC Biology.

[45]  Z. Paroush,et al.  A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling , 2007, The EMBO journal.

[46]  H. Aburatani,et al.  Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. , 2006, Human molecular genetics.

[47]  G. Jiménez,et al.  Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. , 2000, Genes & development.

[48]  R. McKay,et al.  Establishment and Characterization of a Human Primitive Neuroectodermal Tumor Cell Line from the Cerebral Hemisphere , 1992, Journal of neuropathology and experimental neurology.

[49]  Dafydd G. Thomas,et al.  CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression , 2015, Modern Pathology.

[50]  H. Earp,et al.  TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. , 2008, Advances in cancer research.