Clinical study of RDW and prognosis in sepsis new borns.

Aims of the present study were to investigate the relationship between red blood cell volume distribution width (RDW) and severity of the disease with prognosis in sepsis newborns. RDW, clinical features and prognosis in 97 sepsis newborns were analyzed retrospectively. Fifity-eightsepsis newborns showed increase of RDW with the incidence of 59.79%, including 13 cases from sepsis group, 23 cases from severe sepsis group and 22 cases from septic shock group (the same order below), with the incidence of RDW increase of 31.71%, 76.67% and 84.62%, respectively, and the differences were significantly significant (P 0.05). The incidence of RDW increase in survival group (49.32%) was significantly lower than that in the death group (91.67%). The neonatal critical illness score (NCIS) was negatively correlated with RDW increase in newborns, while the mortality was positively correlated with RDW increase (P<0.001). RDW increase in newborns with severe sepsis and septic shock has a higher incidence, and the level of RDW increase is closely associated with the prognosis.

[1]  Sabina Hunziker,et al.  Red cell distribution width and mortality in newly hospitalized patients. , 2012, The American journal of medicine.

[2]  K. Christopher,et al.  Red cell distribution width and all-cause mortality in critically ill patients* , 2011, Critical care medicine.

[3]  K. Chien,et al.  Red blood cell distribution width and risk of cardiovascular events and mortality in a community cohort in Taiwan. , 2010, American journal of epidemiology.

[4]  Z. Prohászka,et al.  Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. , 2009, American heart journal.

[5]  S. Manzano-Fernández,et al.  Red blood cell distribution width predicts long‐term outcome regardless of anaemia status in acute heart failure patients , 2009, European journal of heart failure.

[6]  M. Pfeffer,et al.  Red blood cell distribution width and mortality risk in a community-based prospective cohort. , 2009, Archives of internal medicine.

[7]  G. Lippi,et al.  Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients , 2008, Scandinavian journal of clinical and laboratory investigation.

[8]  中华医学会儿科学分会急救学组,et al.  [Recommended protocol for diagnosis and treatment of septic shock in children]. , 2006, Zhonghua er ke za zhi = Chinese journal of pediatrics.

[9]  J. Carcillo,et al.  Scope and epidemiology of pediatric sepsis , 2005, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[10]  A. Randolph,et al.  International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics* , 2005, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[11]  T. Kara,et al.  Humoral response in patients with chronic heart failure. , 1998, International journal of cardiology.

[12]  M. Monti,et al.  Influence of Acute Inflammation on Iron and Nutritional Status Indexes in Older Inpatients , 1995, Journal of the American Geriatrics Society.

[13]  ScienceDirect.  The Journal of emergency medicine , 1983 .