Integration of Genomics into the Electronic Health Record: Mapping Terra Incognita

Successfully realizing the vision of genomic medicine will require management of large amounts of complex data. The electronic health record (EHR) is destined to play a critical role in the translation of genomic information into clinical care. The papers in this special issue explore the challenges associated with the implementation of genomics in the EHR. The proposed solutions are meant to provide guidance for those responsible for moving genomics into the clinic.

[1]  Wendy A. Wolf,et al.  The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies , 2011, BMC Medical Genomics.

[2]  Keith Marsolo,et al.  Clinical genomics in the world of the electronic health record , 2013, Genetics in Medicine.

[3]  C. Chute,et al.  Electronic Medical Records for Genetic Research: Results of the eMERGE Consortium , 2011, Science Translational Medicine.

[4]  George Hripcsak,et al.  Opportunities for genomic clinical decision support interventions , 2013, Genetics in Medicine.

[5]  Andrew G. Ury,et al.  Storing and interpreting genomic information in widely deployed electronic health record systems , 2013, Genetics in Medicine.

[6]  Hhs Centers for Medicare Medicare Services.  Medicare and Medicaid programs; electronic health record incentive program. Final rule. , 2010, Federal register.

[7]  Iftikhar J. Kullo,et al.  Ethical, legal, and social implications of incorporating genomic information into electronic health records , 2013, Genetics in Medicine.

[8]  D M Roden,et al.  Electronic Medical Records as a Tool in Clinical Pharmacology: Opportunities and Challenges , 2012, Clinical pharmacology and therapeutics.

[9]  Melissa A. Basford,et al.  The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future , 2013, Genetics in Medicine.

[10]  D. Holdstock.  Past, present--and future? , 2005, Medicine, conflict, and survival.

[11]  Kevin B. Johnson,et al.  Electronic health record design and implementation for pharmacogenomics: a local perspective , 2013, Genetics in Medicine.

[12]  Matthew S. Lebo,et al.  A survey of informatics approaches to whole-exome and whole-genome clinical reporting in the electronic health record , 2013, Genetics in Medicine.

[13]  J. Mega,et al.  Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update , 2013, Clinical pharmacology and therapeutics.

[14]  Abel N. Kho,et al.  Practical challenges in integrating genomic data into the electronic health record , 2013, Genetics in Medicine.

[15]  Joseph L. Kannry,et al.  Commercial versus In-Situ Usability Testing of Healthcare Information Systems: Towards "Public" Usability Testing in Healthcare Organizations , 2013, ITCH.

[16]  D. Mrazek,et al.  Facilitating clinical implementation of pharmacogenomics. , 2011, JAMA.

[17]  C. Pui,et al.  Pharmacogenomics and Individualized Medicine: Translating Science Into Practice , 2012, Clinical pharmacology and therapeutics.

[18]  J. Pulley,et al.  Community engagement in biobanking: Experiences from the eMERGE Network , 2010, Genomics, society, and policy.

[19]  Christopher G. Chute,et al.  Some experiences and opportunities for big data in translational research , 2013, Genetics in Medicine.

[20]  Medicare and Medicaid programs; electronic health record incentive program--stage 2. Final rule. , 2012, Federal register.

[21]  Erica A. Bowton,et al.  Stakeholder engagement: a key component of integrating genomic information into electronic health records , 2013, Genetics in Medicine.

[22]  M. Whirl‐Carrillo,et al.  Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing , 2011, Clinical pharmacology and therapeutics.