Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

[1]  David S Nirschl,et al.  Efficient and library-friendly synthesis of furo- and thieno[2,3-d] pyrimidin-4-amine derivatives by microwave irradiation , 2010 .

[2]  S. Batra,et al.  Search for new pharmacophores for antimalarial activity. Part III: synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines. , 2009, European journal of medicinal chemistry.

[3]  Kaori Fukuzawa,et al.  Discovery of boron-conjugated 4-anilinoquinazoline as a prolonged inhibitor of EGFR tyrosine kinase. , 2009, Organic & biomolecular chemistry.

[4]  B. Jean-Claude,et al.  Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2. , 2009, Bioorganic & medicinal chemistry letters.

[5]  Trent E Balius,et al.  Quantitative prediction of fold resistance for inhibitors of EGFR. , 2009, Biochemistry.

[6]  P. Carlier,et al.  Microwave-induced by-products in the synthesis of 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile , 2009 .

[7]  Richard J. Fitzmaurice,et al.  Microwave enhanced synthesis , 2009 .

[8]  C. Oliver Kappe,et al.  Controlled microwave heating in modern organic synthesis: highlights from the 2004–2008 literature , 2009, Molecular Diversity.

[9]  Mark B. Anderson,et al.  Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. , 2009, Journal of medicinal chemistry.

[10]  S. Srivastava,et al.  Synthesis of quinazolines as tyrosine kinase inhibitors. , 2009, Anti-cancer agents in medicinal chemistry.

[11]  F. Da Settimo,et al.  Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship analysis, and virtual screening studies. , 2009, Journal of medicinal chemistry.

[12]  T. Besson,et al.  Decomposition of formamide assisted by microwaves, a tool for synthesis of nitrogen-containing heterocycles , 2008 .

[13]  Mark B. Anderson,et al.  Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. , 2008, Journal of medicinal chemistry.

[14]  T. Besson,et al.  Microwave-assisted synthesis of bioactive quinazolines and quinazolinones. , 2007, Combinatorial chemistry & high throughput screening.

[15]  V. Chandregowda,et al.  Convergent Approach for Commercial Synthesis of Gefitinib and Erlotinib , 2007 .

[16]  S. Skvortsov,et al.  MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. , 2007, Cancer research.

[17]  B. Jean-Claude,et al.  The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR). , 2006, Journal of medicinal chemistry.

[18]  P. Guiry,et al.  Synthesis of Quinazolinones and Quinazolines , 2005 .

[19]  D. Lesieur,et al.  Pictet–Spengler heterocyclizations via microwave-assisted degradation of DMSO , 2005 .

[20]  V. Jendrossek,et al.  4-Anilinoquinazolines with Lavendustin A subunit as inhibitors of epidermal growth factor receptor tyrosine kinase: syntheses, chemical and pharmacological properties. , 2004, European journal of medicinal chemistry.

[21]  Ying Han,et al.  Efficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation. , 2004, Organic letters.

[22]  J. Bergman,et al.  Recent Developments in the Field of Quinazoline Chemistry , 2003 .

[23]  A. Loupy.  Microwaves in organic synthesis , 2002 .

[24]  T. Besson,et al.  ChemInform Abstract: Microwave-Assisted Niementowski Reaction. Back to the Roots. , 2002 .

[25]  R. Nilakantan,et al.  6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity. , 2001, Journal of medicinal chemistry.

[26]  A. Hallberg,et al.  Microwave-assisted high-speed chemistry: a new technique in drug discovery. , 2001, Drug discovery today.

[27]  J. Suwiński,et al.  Synthesis of 4-Arylaminoquinazolines and 2-Aryl-4-arylaminoquinazolines from 2-Aminobenzonitrile, Anilines and Formic Acid or Benzaldehydes , 2000 .

[28]  P. D. Cook,et al.  Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents. , 1999, Journal of medicinal chemistry.

[29]  Y. Wataya,et al.  New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite. , 1999, Journal of medicinal chemistry.

[30]  M. Malamas,et al.  Quinazolineacetic acids and related analogues as aldose reductase inhibitors. , 1991, Journal of medicinal chemistry.

[31]  A. Bhaduri,et al.  Drugs acting on the central nervous system. Syntheses of substituted quinazolones and quinazolines and triazepino- and triazocinoquinazolones. , 1968, Journal of medicinal chemistry.

[32]  S. Niementowski.  Synthesen von Chinazolinverbindungen , 1894 .

[33]  S. Batra,et al.  Search for new pharmacophores for antimalarial activity. Part II: synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines. , 2009, Bioorganic & medicinal chemistry.

[34]  J. Schanche.  Microwave synthesis solutions from personal chemistry , 2004, Molecular Diversity.

[35]  Laura Favretto,et al.  Milestone's microwave labstation , 2004, Molecular Diversity.

[36]  J. Doug Ferguson,et al.  Focused™ microwave instrumentation from CEM corporation , 2004, Molecular Diversity.

[37]  A. Ganong,et al.  Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists. , 2001, Bioorganic & medicinal chemistry letters.