2-Octyl Cyanoacrylate Adhesive for the Prevention of Central Venous Catheter Infections: A Proof of Concept

Colonization of central venous catheters (CVC)s by microorganisms is an event that precedes central line associated bloodstream infection (CLABSI). The average rate of CLABSI among critically ill patients in the United States is 0.9-3.4 infections per 1000 catheter days [1,2]. With 250,000 cases of CLABSI occurring annually and costing $6000 to $90,000 per event, there is significant interest in reducing this occurrence [2,3]. CLABSI originates from both intraluminal and extraluminal sources. Extraluminal colonization is thought to be due to organisms present at the catheter insertion site and likely reflects the quality of aseptic technique utilized upon catheter insertion in addition to insertion site care [4]. Daily maintenance of the sterility of the catheter insertion site is an intervention that may be underappreciated. Currently recommended catheter insertion site maintenance techniques for the prevention of CLABSI involve using either sterile gauze or sterile, transparent, semipermeable dressings to cover the site [5].

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